Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils
Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty
Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty
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Article Cell biology

Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils

Abstract

Research Article

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Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty

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HMS activity in cells from nonpregnant and pregnant women with and witho...
HMS activity in cells from nonpregnant and pregnant women with and without treatment with 50 ng/ml LPS. The metabolism of 1-14C-glucose and 6-14C-glucose to 14CO2 was measured as described previously (39, 40). The cpm of 14CO2 formed from 6-14C-glucose was subtracted from the cpm of that formed from 1-14C-glucose. The cpm (HMS activity) is listed on the graph (mean ± SEM). LPS substantially increases HMS activity in cells from nonpregnant individuals (P < 0.001, paired two-tailed t test) but not from pregnant individuals (P > 0.01). n = 7.