Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils
Andrei L. Kindzelskii, … , Roberto Romero, Howard R. Petty
Andrei L. Kindzelskii, … , Roberto Romero, Howard R. Petty
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1801-1811. https://doi.org/10.1172/JCI15973.
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Article Cell biology

Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils

Abstract

Research Article

Authors

Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty

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The potential role of metabolic enzyme trafficking in ROM release is ill...
The potential role of metabolic enzyme trafficking in ROM release is illustrated. Conditions associated with resting (a), activated (b), and pregnancy (c) neutrophils are shown. ROMs are produced during all of these conditions, but ROM production is maximal for activated cells from nonpregnant women. Hexokinase and G-6-PDase have peripheral distributions in activated cells from nonpregnant women, thus allowing maximal cooperation in ROM release. m.t., microtubule; m.f., microfilament.