Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cε
Clyde W. Hodge, … , A. Leslie Morrow, Robert O. Messing
Clyde W. Hodge, … , A. Leslie Morrow, Robert O. Messing
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1003-1010. https://doi.org/10.1172/JCI15903.
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Article Neuroscience

Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cε

Abstract

Research Article

Authors

Clyde W. Hodge, Jacob Raber, Thomas McMahon, Helen Walter, Ana Maria Sanchez-Perez, M. Foster Olive, Kristin Mehmert, A. Leslie Morrow, Robert O. Messing

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Bicuculline increases anxiety-like behavior in PKCε-null mice. Data are ...
Bicuculline increases anxiety-like behavior in PKCε-null mice. Data are from 25 wild-type and 23 PKCε-null mice treated with saline and 20 wild-type and 19 PKCε-null mice treated with bicuculline. Two-factor ANOVA revealed main effects of treatment (F1,84 = 4.2, P = 0.043) on the percentage of total entries into the open arms (a) and genotype (F1,84 = 4.4, P = 0.039) on the percentage of time spent in the open arms (b). There were no significant effects of either factor on the number of closed-arm entries (c). *P < 0.05 compared with saline-treated wild-type mice, and P < 0.05 compared with saline-treated PKCε-null mice (Tukey’s test).