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Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
Kazuaki Miyake, … , Hiroshi Sakaue, Masato Kasuga
Kazuaki Miyake, … , Hiroshi Sakaue, Masato Kasuga
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1483-1491. https://doi.org/10.1172/JCI15880.
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Article Metabolism Article has an altmetric score of 3

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

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Abstract

Research Article

Authors

Kazuaki Miyake, Wataru Ogawa, Michihiro Matsumoto, Takehiro Nakamura, Hiroshi Sakaue, Masato Kasuga

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Figure 5

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Effects of Δp85 expression in the liver on insulin tolerance and pyruvat...
Effects of Δp85 expression in the liver on insulin tolerance and pyruvate challenge. (a) DNPI3K and LacZ mice were injected intraperitoneally with insulin, and blood glucose concentration was measured at the indicated times thereafter. Data are expressed as a percentage of the initial glucose concentration and are means ± SEM of values obtained from six mice. (b) DNPI3K and LacZ mice were deprived of food for 16 hours, orally administered with 3-MPA (or not), and, after 30 minutes, injected intraperitoneally with pyruvate. Blood glucose concentration was measured at the indicated times thereafter. Data are means ± SEM of values obtained from four mice. *P < 0.05 versus the corresponding value for LacZ mice.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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