Research Article
Peer Wulff, Volker Vallon, Dan Yang Huang, Harald Völkl, Fang Yu, Kerstin Richter, Martina Jansen, Michaela Schlünz, Karin Klingel, Johannes Loffing, Gunther Kauselmann, Michael R. Bösl, Florian Lang, Dietmar Kuhl
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SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells.
Fels B, Fischer F, Herrnboeck L, Beckers D, Niedzielski L, Roche P, Straeter A, Alesutan I, Borutta JT, Jaisser F, Staub O, Voelkl J, Kusche-Vihrog K |
Pflugers Archiv : European journal of physiology | 2025 |
Effect of dissolved oxygen and ammonia nitrogen on Culter alburnus: Physiology, biochemistry, and molecular analyses.
Shun C, Wen-Ping J, Shi-Li L, Jian-Bo Z, Mei-Li C, Xiao-Ying H, Miao P, Fei L |
Heliyon | 2024 |
Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake.
Jung HJ, Pham TD, Su XT, Grigore TV, Hoenderop JG, Olauson H, Wall SM, Ellison DH, Welling PA, Al-Qusairi L |
Scientific Reports | 2024 |
Biomechanical dysregulation of SGK-1 dependent aortic pathologic markers in hypertension
Gedney JR, Mattia V, Figueroa M, Barksdale C, Fannin E, Silverman J, Xiong Y, Mukherjee R, Jones JA, Ruddy JM |
Frontiers in Cardiovascular Medicine | 2024 |
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity.
Yang C, Isaeva E, Shimada S, Kurth T, Stumpf M, Zheleznova NN, Staruschenko A, Dash RK, Cowley AW Jr |
American journal of physiology. Renal physiology | 2024 |
How Does Aldosterone Work?
Palmer LG |
2023 | |
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation
Gu W, Zheng H, Canessa CM |
The Journal of biological chemistry | 2023 |
Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium
Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DC, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D |
Journal of the American Society of Nephrology : JASN | 2023 |
Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.
Staub O, Debonneville A, Stifanelli M, Juffre A, Maillard MP, Gumz ML, Al-Qusairi L |
American journal of physiology. Renal physiology | 2023 |
The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice
Aidan W. Porter, Diep Nguyen, Dennis Clayton, Wily G Ruiz, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, Lubika J. Nkashama, Arohan R. Subramanya, Sebastien Gingras, Thomas Kleyman, Gerard Apodaca, Linda M. Hendershot, Jeffrey L Brodsky, Teresa M. Buck |
JCI Insight | 2022 |
Mosaic theory revised: inflammation and salt play central roles in arterial hypertension
F Hengel, J Benitah, U Wenzel |
Cellular and Molecular Immunology | 2022 |
FAM111A is dispensable for electrolyte homeostasis in mice
B Ilenwabor, H Schigt, A Kompatscher, C Bos, M Zuidscherwoude, B van der Eerden, J Hoenderop, J de Baaij |
Scientific Reports | 2022 |
Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology
Pearce D, Manis AD, Nesterov V, Korbmacher C |
2022 | |
Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway
Ehret E, Jäger Y, Sergi C, Mérillat AM, Peyrollaz T, Anand D, Wang Q, Ino F, Maillard M, Kellenberger S, Gautschi I, Szabo R, Bugge TH, Vogel LK, Hummler E, Frateschi S |
International journal of molecular sciences | 2022 |
Regulation of oocyte maturation: Role of conserved ERK signaling
Das D, Arur S |
Molecular Reproduction and Development | 2022 |
Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis
Stadt MM, Layton AT |
Frontiers in physiology | 2022 |
The mTOR–Autophagy Axis and the Control of Metabolism
N Deleyto-Seldas, A Efeyan |
Frontiers in Cell and Developmental Biology | 2021 |
SGK1, autophagy and cancer: an overview.
Ghani MJ |
Molecular Biology Reports | 2021 |
Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway
J Li, L Liu, X Zhou, X Lu, X Liu, G Li, J Long |
Frontiers in pharmacology | 2020 |
The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms
V Dattilo, R Amato, N Perrotti, M Gennarelli |
Frontiers in Genetics | 2020 |
Aldosterone‐induced microRNAs act as feedback regulators of mineralocorticoid receptor signaling in kidney epithelia
N OzbakiYagan, X Liu, AJ Bodnar, J Ho, MB Butterworth |
The FASEB Journal | 2020 |
The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star
R Zhu, G Yang, Z Cao, K Shen, L Zheng, J Xiao, L You, T Zhang |
Therapeutic advances in medical oncology | 2020 |
Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy
I Guerriero, G Monaco, V Coppola, A Orlacchio |
Pharmaceuticals (Basel, Switzerland) | 2020 |
Behavioral effects of SGK1 knockout in VTA and dopamine neurons
MA Doyle, AR Stark, G Fejes-Tóth, A Náray-Fejes-Tóth, MS Mazei-Robison |
Scientific Reports | 2020 |
Dietary Habits Bursting into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies
R Scrivo, C Perricone, A Altobelli, C Castellani, L Tinti, F Conti, G Valesini |
Nutrients | 2019 |
Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ TH Cells
F Siracusa, N Schaltenberg, EJ Villablanca, S Huber, N Gagliani |
Frontiers in immunology | 2019 |
Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury
W Deng, CY Li, J Tong, J He, Y Zhao, DX Wang |
Molecular medicine reports | 2019 |
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity
L D'Antona, V Dattilo, G Catalogna, D Scumaci, CV Fiumara, F Musumeci, G Perrotti, S Schenone, R Tallerico, CB Spoleti, N Costa, R Iuliano, G Cuda, R Amato, N Perrotti |
Translational oncology | 2019 |
Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes
F Alsaeedi, R Wilson, C Candlish, I Ibrahim, AC Leitch, TM Abdelghany, C Wilson, L Armstrong, MC Wright, YW Zheng |
PloS one | 2019 |
The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron
A Spirli, L Cheval, A Debonneville, D Penton, C Ronzaud, M Maillard, A Doucet, J Loffing, O Staub |
Physiological Reports | 2019 |
SGK1 Attenuates Oxidative Stress-Induced Renal Tubular Epithelial Cell Injury by Regulating Mitochondrial Function
D Jiang, C Fu, J Xiao, Z Zhang, J Zou, Z Ye, X Zhang |
Oxidative medicine and cellular longevity | 2019 |
SGK1 induces vascular smooth muscle cell calcification through NF-kB signaling
jakob voelkl, Trang T. D. Luong, Rashad Tuffaha, Katharina Musculus, Tilman Auer, Xiaoming Lian, Christoph Daniel, Daniel Zickler, Beate Boehme, Michael Sacherer, Bernhard Metzler, Dietmar Kuhl, Maik Gollasch, Kerstin Amann, Dominik N. Müller, Burkert Pieske, Florian Lang, ioana alesutan |
Journal of Clinical Investigation | 2018 |
SGK1 Inhibits Autophagy in Murine Muscle Tissue
T Zuleger, J Heinzelbecker, Z Takacs, C Hunter, J Voelkl, F Lang, T Proikas-Cezanne |
Oxidative medicine and cellular longevity | 2018 |
Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms
W Manosroi, GH Williams |
Endocrine reviews | 2018 |
Akt3 Inhibits Adipogenesis and Protects from Diet-Induced Obesity via Novel Signaling Pathway
liang ding, Lifang Zhang, Sudipta Biswas, Rebecca Schugar, J Brown, Tatiana V. Byzova, Eugene A. Podrez |
JCI Insight | 2017 |
Dietary NaCl affects bleomycin-induced lung fibrosis in mice
W Chen, D Pilling, RH Gomer |
Experimental Lung Research | 2017 |
The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond
PL Lee, SM Jung, DA Guertin |
Trends in Endocrinology & Metabolism | 2017 |
Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron
P Rashmi, GL Colussi, M Ng, X Wu, A Kidwai, D Pearce |
Kidney International | 2017 |
Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders
VJ Bezzerides, A Zhang, L Xiao, B Simonson, SA Khedkar, S Baba, F Ottaviano, S Lynch, K Hessler, AC Rigby, D Milan, S Das, A Rosenzweig |
Scientific Reports | 2017 |
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation
V Dattilo, L DAntona, C Talarico, M Capula, G Catalogna, R Iuliano, S Schenone, S Roperto, C Bianco, N Perrotti, R Amato |
Scientific Reports | 2017 |
Aldosterone regulates a 5ʹ variant sgk1 transcript via a shared hormone response element in the sgk1 5ʹ regulatory region
NS Raikwar, CP Thomas |
Physiological Reports | 2017 |
Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology
L Aragao-Santiago, CE Gomez-Sanchez, P Mulatero, A Spyroglou, M Reincke, TA Williams |
Endocrinology | 2017 |
A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells
S Kulkarni, S Goel-Bhattacharya, S Sengupta, BH Cochran |
Molecular cancer research : MCR | 2017 |
Inhibitors of the proteasome stimulate the epithelial sodium channel (ENaC) through SGK1 and mimic the effect of aldosterone
MK Mansley, C Korbmacher, M Bertog |
Pflügers Archiv - European Journal of Physiology | 2017 |
mTORC2 critically regulates renal potassium handling
Florian Grahammer, Viacheslav Nesterov, Azaz Ahmed, Frederic Steinhardt, Lukas Sandner, Frederic Arnold, Tomke Cordts, Silvio Negrea, Marko Bertog, Markus Ruegg, Michael Hall, Gerd Walz, Christoph Korbmacher, Ferruh Artunc, Tobias Huber |
Journal of Clinical Investigation | 2016 |
Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis
Y Lou, F Zhang, Y Luo, L Wang, S Huang, F Jin |
International journal of molecular sciences | 2016 |
Renal tubular SGK1 deficiency causes impaired K + excretion via loss of regulation of NEDD4-2/WNK1 and ENaC
L Al-Qusairi, D Basquin, A Roy, M Stifanelli, RD Rajaram, A Debonneville, I Nita, M Maillard, J Loffing, AR Subramanya, O Staub |
American journal of physiology. Renal physiology | 2016 |
Th17/Treg Imbalance Induced by Dietary Salt Variation Indicates Inflammation of Target Organs in Humans
T Luo, W Ji, F Yuan, Z Guo, Y Li, Y Dong, Y Ma, X Zhou, Y Li |
Scientific Reports | 2016 |
Iohexol plasma clearance, a simple and reliable method to measure renal function in conscious mice
S Luis-Lima, AE Rodríguez-Rodríguez, C Martín-Higueras, C Sierra-Ramos, F Carrara, MR Arnau, DA de la Rosa, E Salido, F Gaspari, E Porrini |
Pflügers Archiv - European Journal of Physiology | 2016 |
Role of serum- and glucocorticoid-inducible kinases in stroke
K Inoue, T Leng, T Yang, Z Zeng, T Ueki, ZG Xiong |
Journal of Neurochemistry | 2016 |
Coordinated Control of ENaC and Na+,K+-ATPase in Renal Collecting Duct
E Feraille, E Dizin |
Journal of the American Society of Nephrology : JASN | 2016 |
Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans
H Wang, X Jiang, J Wu, L Zhang, J Huang, Y Zhang, X Zou, B Liang |
Genetics | 2016 |
SGK1 regulation by miR-466g in cortical collecting duct cells
ME Jacobs, PP Kathpalia, Y Chen, SV Thomas, EJ Noonan, AC Pao |
American journal of physiology. Renal physiology | 2016 |
Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study
D Zhang, D Gu, J He, JE Hixson, DC Rao, C Li, H He, J Chen, J Huang, J Chen, TK Rice, S Chen, TN Kelly |
American Journal of Hypertension | 2016 |
SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone
L Yang, G Frindt, F Lang, D Kuhl, V Vallon, LG Palmer |
American journal of physiology. Renal physiology | 2016 |
SGK1: The Dark Side of PI3K Signaling.
Di Cristofano A |
Current topics in developmental biology | 2016 |
Integrated Compensatory Network is Activated in Absence of NCC Phosphorylation
Paul Grimm, Yoskaly Lazo-Fernandez, Eric Delpire, Susan M Wall, Susan Dorsey, Edward Weinman, Richard Coleman, James B. Wade, Paul A. Welling |
Journal of Clinical Investigation | 2015 |
High salt reduces the activation of IL-4+IL-13 stimulated macrophages
Katrina Binger, Matthias Gebhardt, Matthias Heinig, Carola Rintisch, Agnes Schröder, Wolfgang Neuhofer, Karl Hilgers, Arndt Manzel, Christian Schwartz, Markus Kleinewietfeld, Jakob Voelkl, Valentin Schatz, Ralf Linker, Florian Lang, David Voehringer, Mark Wright, Norbert Hubner, Ralf Dechend, Jonathan Jantsch, Jens Titze, Dominik N. Müller |
Journal of Clinical Investigation | 2015 |
Regulation of the epithelial Na + channel by the mTORC2/SGK1 pathway: FIGURE 1:
F Lang, D Pearce |
Nephrology Dialysis Transplantation | 2015 |
Vitamins & Hormones
L Chen, X Zhang, W Zhang |
Vitamins & Hormones | 2015 |
Dietary potassium and the renal control of salt balance and blood pressure
D Penton, J Czogalla, J Loffing |
Pflügers Archiv - European Journal of Physiology | 2015 |
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.
Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R |
Oncotarget | 2015 |
mTORC2 Regulates Renal Tubule Sodium Uptake In Vivo Via ENaC
Catherine Gleason, Gustavo Frindt, Chih-Jen Cheng, Michael Ng, Atif Kidwai, Priyanka Rashmi, Florian Lang, Michel Baum, Lawrence Palmer, David Pearce |
Journal of Clinical Investigation | 2014 |
Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study
A Edwards, H Castrop, K Laghmani, V Vallon, AT Layton |
American journal of physiology. Renal physiology | 2014 |
mTOR signaling in tumorigenesis
K Xu, P Liu, W Wei |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system
BA Heller, M Ghidinelli, J Voelkl, S Einheber, R Smith, E Grund, G Morahan, D Chandler, L Kalaydjieva, F Giancotti, RH King, AN Fejes-Toth, G Fejes-Toth, ML Feltri, F Lang, JL Salzer |
The Journal of Cell Biology | 2014 |
The Role of Fatty Acid Oxidation in the Metabolic Reprograming of Activated T-Cells
CA Byersdorfer |
Frontiers in immunology | 2014 |
Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension
G Wang, E Yang, KJ Smith, Y Zeng, G Ji, R Connon, NA Fangue, JJ Cai |
Frontiers in Genetics | 2014 |
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
C Wu, N Yosef, T Thalhamer, C Zhu, S Xiao, Y Kishi, A Regev, VK Kuchroo |
Nature | 2013 |
Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells
S Gotoh, M Negishi |
The Journal of pharmacology and experimental therapeutics | 2013 |
Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
E Zarrinpashneh, T Poggioli, P Sarathchandra, J Lexow, L Monassier, C Terracciano, F Lang, F Damilano, JQ Zhou, A Rosenzweig, N Rosenthal, MP Santini, M Vinciguerra |
PloS one | 2013 |
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
E Andres-Mateos, H Brinkmeier, TN Burks, R Mejias, DC Files, M Steinberger, A Soleimani, R Marx, JL Simmers, B Lin, EF Hedderick, TG Marr, BM Lin, C Hourdé, LA Leinwand, D Kuhl, M Föller, S Vogelsang, I Hernandez-Diaz, DK Vaughan, DA de la Rosa, F Lang, RD Cohn |
EMBO Molecular Medicine | 2012 |
Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1
GB Watt, NA Ismail, AG Caballero, SC Land, SM Wilson |
British Journal of Pharmacology | 2012 |
Nedd4-2 and the Regulation of Epithelial Sodium Transport
D Rotin, O Staub |
Frontiers in physiology | 2012 |
Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation
W Kawarazaki, M Nagase, S Yoshida, M Takeuchi, K Ishizawa, N Ayuzawa, K Ueda, T Fujita |
Journal of the American Society of Nephrology : JASN | 2012 |
A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct
NS Raikwar, KZ Liu, CP Thomas |
American journal of physiology. Renal physiology | 2012 |
Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways
JS Mo, JH Yoon, JA Hong, MY Kim, EJ Ann, JS Ahn, SM Kim, HJ Baek, F Lang, EJ Choi, HS Park, J Kanellopoulos |
PloS one | 2012 |
Pathological Role of Serum- and Glucocorticoid-Regulated Kinase 1 in Adverse Ventricular Remodeling
S Das, T Aiba, M Rosenberg, K Hessler, C Xiao, PA Quintero, FG Ottaviano, AC Knight, EL Graham, P Boström, MR Morissette, F del Monte, MJ Begley, LC Cantley, PT Ellinor, GF Tomaselli, A Rosenzweig |
Circulation | 2012 |
Scaffold Protein Connector Enhancer of Kinase Suppressor of Ras Isoform 3 (CNK3) Coordinates Assembly of a Multiprotein Epithelial Sodium Channel (ENaC)-regulatory Complex
R Soundararajan, T Ziera, E Koo, K Ling, J Wang, SA Borden, D Pearce |
The Journal of biological chemistry | 2012 |
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway
Shigeru Shibata, Shengyu Mu, Hiroo Kawarazaki, Kazuhiko Muraoka, Ken-ichi Ishizawa, Shigetaka Yoshida, Wakako Kawarazaki, Maki Takeuchi, Nobuhiro Ayusawa, Jun Miyoshi, Yoshimi Takai, Akira Ishikawa, Tatsuo Shimosawa, Katsuyuki Ando, Miki Nagase, Toshiro Fujita |
Journal of Clinical Investigation | 2011 |
Frontier of epilepsy research - mTOR signaling pathway
CH Cho |
Experimental & molecular medicine | 2011 |
Regulation and dysregulation of epithelial Na+ channels
LG Palmer, A Patel, G Frindt |
Clinical and Experimental Nephrology | 2011 |
Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport
F Lang, V Vallon |
Clinical and Experimental Nephrology | 2011 |
Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1
Y Terada, S Ueda, K Hamada, Y Shimamura, K Ogata, K Inoue, Y Taniguchi, T Kagawa, T Horino, T Takao |
Clinical and Experimental Nephrology | 2011 |
The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport
R Soundararajan, D Pearce, T Ziera |
Molecular and Cellular Endocrinology | 2011 |
GPR48 increases mineralocorticoid receptor gene expression
J Wang, X Li, Y Ke, Y Lu, F Wang, N Fan, H Sun, H Zhang, R Liu, J Yang, L Ye, M Liu, G Ning |
Journal of the American Society of Nephrology : JASN | 2011 |
Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney
E Borsting, VP Cheng, CK Glass, V Vallon, R Cunard |
American journal of physiology. Renal physiology | 2011 |
SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D
R Rexhepaj, I Alesutan, S Gu, L Pelzl, M Eichenmüller, G Pathare, M Föller, D Kuhl, F Lang |
Pflügers Archiv - European Journal of Physiology | 2011 |
The WNK Kinase Network Regulating Sodium, Potassium, and Blood Pressure
EJ Hoorn, JH Nelson, JA McCormick, DH Ellison |
Journal of the American Society of Nephrology : JASN | 2011 |
Af17 Deficiency Increases Sodium Excretion and Decreases Blood Pressure
L Chen, H Wu, OM Pochynyuk, MR Reisenauer, Z Zhang, L Huang, OL Zaika, M Mamenko, W Zhang, Q Zhou, M Liu, Y Xia, W Zhang |
Journal of the American Society of Nephrology : JASN | 2011 |
Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na + /H + exchanger NHE3 by glucocorticoids
P He, SJ Lee, S Lin, U Seidler, F Lang, G Fejes-Toth, A Naray-Fejes-Toth, CC Yun, MB Omary |
Molecular biology of the cell | 2011 |
Stimulation of Ca 2+ -channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1)
A Eylenstein, EM Gehring, N Heise, E Shumilina, S Schmidt, K Szteyn, P Münzer, MK Nurbaeva, M Eichenmüller, L Tyan, I Regel, M Föller, D Kuhl, J Soboloff, R Penner, F Lang |
The FASEB Journal | 2011 |
Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes
K Wallace, Q Long, EA Fairhall, KA Charlton, MC Wright |
Journal of cell science | 2011 |
Transcription Factor NF-κB Regulates Expression of Pore-forming Ca 2+ Channel Unit, Orai1, and Its Activator, STIM1, to Control Ca 2+ Entry and Affect Cellular Functions
A Eylenstein, S Schmidt, S Gu, W Yang, E Schmid, EM Schmidt, I Alesutan, K Szteyn, I Regel, E Shumilina, F Lang |
The Journal of biological chemistry | 2011 |
mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel
M Lu, J Wang, HE Ives, D Pearce |
The Journal of biological chemistry | 2011 |
mTOR complex-2 activates ENaC by phosphorylating SGK1
M Lu, J Wang, KT Jones, HE Ives, ME Feldman, L Yao, KM Shokat, K Ashrafi, D Pearce |
Journal of the American Society of Nephrology : JASN | 2010 |
Regulation of sodium transport by ENaC in the kidney
LL Hamm, Z Feng, KS Hering-Smith |
Current Opinion in Nephrology and Hypertension | 2010 |
Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption
MK Mansley, SM Wilson |
British Journal of Pharmacology | 2010 |
Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2
MK Mansley, SM Wilson |
British Journal of Pharmacology | 2010 |
Role of the ubiquitin system in regulating ion transport
D Rotin, O Staub |
Pflügers Archiv - European Journal of Physiology | 2010 |
Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels
MR Reisenauer, SW Wang, Y Xia, W Zhang |
American journal of physiology. Renal physiology | 2010 |
Stimulation of ENaC Activity by Rosiglitazone is PPARγ-Dependent and Correlates with SGK1 Expression Increase
S Renauld, K Tremblay, S Ait-Benichou, M Simoneau-Roy, H Garneau, O Staub, A Chraïbi |
The Journal of Membrane Biology | 2010 |
Role of Epithelial Sodium Channels and Their Regulators in Hypertension*
R Soundararajan, D Pearce, RP Hughey, TR Kleyman |
The Journal of biological chemistry | 2010 |
Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney
AC Pao, A Bhargava, FD Sole, R Quigley, X Shao, J Wang, S Thomas, J Zhang, M Shi, JW Funder, OW Moe, D Pearce |
AJP Renal Physiology | 2010 |
Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition
J Cheng, LD Truong, X Wu, D Kuhl, F Lang, J Du |
Kidney international. Supplement | 2010 |
Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Regulates Adipocyte Differentiation via Forkhead Box O1
ND Pietro, V Panel, S Hayes, A Bagattin, S Meruvu, A Pandolfi, L Hugendubler, G Fejes-Tóth, A Naray-Fejes-Tóth, E Mueller |
Molecular Endocrinology | 2010 |
Knockdown of Circadian Rhythm Gene Period 1 Dramatically Reduces Expression of the Renal Epithelial Sodium Channel
Michelle L. Gumz, Lisa R. Stow, I. Jeanette Lynch, Megan M. Greenlee, Alicia Rudin, Brian D. Cain, David R. Weaver and Charles S. Wingo |
Journal of Clinical Investigation | 2009 |
Akt2 and SGK3 are both determinants of postnatal hair follicle development
TM Mauro, JA McCormick, J Wang, KM Boini, L Ray, B Monks, MJ Birnbaum, F Lang, D Pearce |
The FASEB Journal | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)
J Loffing, C Korbmacher |
Pflügers Archiv - European Journal of Physiology | 2009 |
Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1
V Vallon, J Schroth, F Lang, D Kuhl, S Uchida |
American journal of physiology. Renal physiology | 2009 |
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1
KT Jones, ER Greer, D Pearce, K Ashrafi |
PLoS Biology | 2009 |
Regulation of a third conserved phosphorylation site in SGK1
W Chen, Y Chen, B Xu, YC Juang, S Stippec, Y Zhao, MH Cobb |
The Journal of biological chemistry | 2009 |
SGK1-sensitive renal tubular glucose reabsorption in diabetes
TF Ackermann, KM Boini, H Völkl, M Bhandaru, PM Bareiss, L Just, V Vallon, K Amann, D Kuhl, Y Feng, HP Hammes, F Lang |
American journal of physiology. Renal physiology | 2009 |
Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone
R Rexhepaj, A Rotte, DS Kempe, M Sopjani, M Föller, EM Gehring, M Bhandaru, I Gruner, AF Mack, I Rubio-Aliaga, AM Näßl, H Daniel, D Kuhl, F Lang |
Pflügers Archiv - European Journal of Physiology | 2009 |
Glucocorticoids can activate the α-ENaC gene promoter independently of SGK1
N McTavish, J Getty, A Burchell, SM Wilson |
Biochemical Journal | 2009 |
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
R Amato, L D’Antona, G Porciatti, V Agosti, M Menniti, C Rinaldo, N Costa, E Bellacchio, S Mattarocci, G Fuiano, S Soddu, MG Paggi, F Lang, N Perrotti |
Journal of Molecular Medicine | 2009 |
Regulation of the Ca2+ Channel TRPV6 by the Kinases SGK1, PKB/Akt, and PIKfyve
M Sopjani, A Kunert, K Czarkowski, F Klaus, J Laufer, M Föller, F Lang |
The Journal of Membrane Biology | 2009 |
Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein
A Náray-Fejes-Tóth, C Boyd, G Fejes-Tóth |
American journal of physiology. Renal physiology | 2008 |
A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons
MF Arteaga, T Coric, C Straub, CM Canessa |
Proceedings of the National Academy of Sciences | 2008 |
SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation
SK Inglis, M Gallacher, SG Brown, N McTavish, J Getty, EM Husband, JT Murray, SM Wilson |
Pflügers Archiv - European Journal of Physiology | 2008 |
Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARγ agonist pioglitazone
F Artunc, D Sandulache, O Nasir, KM Boini, B Friedrich, N Beier, E Dicks, S Pötzsch, K Klingel, K Amann, BL Blazer-Yost, W Scholz, T Risler, D Kuhl, F Lang |
Pflügers Archiv - European Journal of Physiology | 2008 |
SGK1 dependence of insulin induced hypokalemia
KM Boini, D Graf, D Kuhl, D Häussinger, F Lang |
Pflügers Archiv - European Journal of Physiology | 2008 |
Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB/SGK-resistant GSK3
KM Boini, M Bhandaru, A Mack, F Lang |
Pflügers Archiv - European Journal of Physiology | 2008 |
Aldosterone-Stimulated SGK1 Activity Mediates Profibrotic Signaling in the Mesangium
Y Terada, H Kuwana, T Kobayashi, T Okado, N Suzuki, T Yoshimoto, Y Hirata, S Sasaki |
Journal of the American Society of Nephrology : JASN | 2008 |
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
JR Bayascas, S Wullschleger, K Sakamoto, JM García-Martínez, C Clacher, D Komander, DM van Aalten, KM Boini, F Lang, C Lipina, L Logie, C Sutherland, JA Chudek, JA van Diepen, PJ Voshol, JM Lucocq, DR Alessi |
Molecular and cellular biology | 2008 |
Aldosterone and glomerular podocyte injury
M Nagase, T Fujita |
Clinical and Experimental Nephrology | 2008 |
Aldosterone-induced SGK1 Phosphorylates AF9 and Relieves Dot1a-AF9-Mediated Transcriptional Repression of ENaCalpha
Wenzheng Zhang, Xuefeng Xia, Mary Rose Reisenauer, Timo Rieg, Florian Lang, Dietmar Kuhl,Volker Vallon, and Bruce C. Kone |
Journal of Clinical Investigation | 2007 |
Salt, sodium channels, and SGK1
David Pearce1 and Thomas R. Kleyman2 |
Journal of Clinical Investigation | 2007 |
Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion
C Sandu, F Artunc, F Grahammer, A Rotte, KM Boini, B Friedrich, D Sandulache, M Metzger, L Just, A Mack, T Skutella, R Rexhepaj, T Risler, P Wulff, D Kuhl, F Lang |
Pflügers Archiv - European Journal of Physiology | 2007 |
Genetics of salt-sensitive hypertension
P Strazzullo, F Galletti |
Current Hypertension Reports | 2007 |
Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1
MJ Kim, JS Chae, KJ Kim, SG Hwang, KW Yoon, EK Kim, HJ Yun, JH Cho, J Kim, BW Kim, HC Kim, SS Kang, F Lang, SG Cho, EJ Choi |
The EMBO Journal | 2007 |
SGK1 survival through various lives may save us all
FC Luft |
Journal of Molecular Medicine | 2007 |
Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP
B Zhao, R Lehr, AM Smallwood, TF Ho, K Maley, T Randall, MS Head, KK Koretke, CG Schnackenberg |
Protein Science | 2007 |
Multiple Translational Isoforms Give Functional Specificity to Serum- and Glucocorticoid-induced Kinase 1
MF Arteaga, DA de la Rosa, JA Alvarez, CM Canessa, JS Gutkind |
Molecular biology of the cell | 2007 |
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment
V Vallon, AW Wyatt, K Klingel, DY Huang, A Hussain, S Berchtold, B Friedrich, F Grahammer, RS Belaiba, A Görlach, P Wulff, J Daut, ND Dalton, J Ross, U Flögel, J Schrader, H Osswald, R Kandolf, D Kuhl, F Lang |
Journal of Molecular Medicine | 2006 |
Renal Ca2+ handling in sgk1 knockout mice
D Sandulache, F Grahammer, F Artunc, G Henke, A Hussain, O Nasir, A Mack, B Friedrich, V Vallon, P Wulff, D Kuhl, M Palmada, F Lang |
Pflügers Archiv - European Journal of Physiology | 2006 |
Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor
D Wang, H Zhang, F Lang, CC Yun |
American journal of physiology. Cell physiology | 2006 |
Mice heterozygous for beta-ENaC deletion have defective potassium excretion
XR Cao, PP Shi, RD Sigmund, RF Husted, CD Sigmund, RA Williamson, JB Stokes, B Yang |
American journal of physiology. Renal physiology | 2006 |
An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery
MF Arteaga, L Wang, T Ravid, M Hochstrasser, CM Canessa |
Proceedings of the National Academy of Sciences | 2006 |
The N-terminus of the serum- and glucocorticoid-inducible kinase Sgk1 specifies mitochondrial localization and rapid turnover
A Engelsberg, F Kobelt, D Kuhl |
Biochemical Journal | 2006 |
SGK1 is not required for regulation of colonic ENaC activity
R Rexhepaj, F Artunc, F Grahammer, O Nasir, C Sandu, B Friedrich, D Kuhl, F Lang |
Pflügers Archiv - European Journal of Physiology | 2006 |
PI3-Kinase-dependent electrogenic intestinal transport of glucose and amino acids
R Rexhepaj, F Artunc, M Metzger, T Skutella, F Lang |
Pflügers Archiv - European Journal of Physiology | 2006 |
Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3
N Strutz-Seebohm, G Seebohm, G Korniychuk, R Baltaev, O Ureche, M Striegel, F Lang |
Pflügers Archiv - European Journal of Physiology | 2006 |
The serum- and glucocorticoid-induced kinase in DOCA–salt hypertension
FC Luft |
Journal of Molecular Medicine | 2006 |
Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1
F Artunc, K Amann, O Nasir, B Friedrich, D Sandulache, N Jahovic, T Risler, V Vallon, P Wulff, D Kuhl, F Lang |
Journal of Molecular Medicine | 2006 |
Renal tubular transport and the genetic basis of hypertensive disease
F Lang, G Capasso, M Schwab, S Waldegger |
Clinical and Experimental Nephrology | 2005 |
Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited
J Gorelik, Y Zhang, D Sánchez, A Shevchuk, G Frolenkov, M Lab, D Klenerman, C Edwards, Y Korchev |
Proceedings of the National Academy of Sciences | 2005 |
Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1
D Wang, H Sun, F Lang, CC Yun |
American journal of physiology. Cell physiology | 2005 |
KESTREL: a powerful method for identifying the physiological substrates of protein kinases
P Cohen, A Knebel |
Biochemical Journal | 2005 |
WNK1 activates SGK1 to regulate the epithelial sodium channel
B Xu, S Stippec, PY Chu, A Lazrak, XJ Li, BH Lee, JM English, B Ortega, CL Huang, MH Cobb |
Proceedings of the National Academy of Sciences | 2005 |
Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT
DY Huang, KM Boini, PA Lang, F Grahammer, M Duszenko, B Heller-Stilb, U Warskulat, D Häussinger, F Lang, V Vallon |
Pflügers Archiv - European Journal of Physiology | 2005 |
Expression and insights on function of potassium channel TWIK-1 in mouse kidney
X Nie, I Arrighi, B Kaissling, I Pfaff, J Mann, J Barhanin, V Vallon |
Pflügers Archiv - European Journal of Physiology | 2005 |
Decreased intestinal glucose transport in the sgk3-knockout mouse
C Sandu, R Rexhepaj, F Grahammer, JA McCormick, G Henke, M Palmada, S Nammi, U Lang, M Metzger, L Just, T Skutella, K Dawson, J Wang, D Pearce, F Lang |
Pflügers Archiv - European Journal of Physiology | 2005 |
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development
JA McCormick, Y Feng, K Dawson, MJ Behne, B Yu, J Wang, AW Wyatt, G Henke, F Grahammer, TM Mauro, F Lang, D Pearce |
Molecular biology of the cell | 2004 |
Functional consequences at the single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice
V Vallon, K Richter, DY Huang, T Rieg, J Schnermann |
Pflügers Archiv - European Journal of Physiology | 2004 |
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3
JT Murray, DG Campbell, N Morrice, GC Auld, N Shpiro, R Marquez, M Peggie, J Bain, GB Bloomberg, F Grahammer, F Lang, P Wulff, D Kuhl, P Cohen |
Biochemical Journal | 2004 |
Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells
DA de la Rosa, TG Paunescu, WJ Els, SI Helman, CM Canessa |
The Journal of General Physiology | 2004 |
Regulation of the epithelial sodium channel by accessory proteins
K Gormley, Y Dong, GA Sagnella |
Biochemical Journal | 2003 |
Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection
R Sousa-Nunes, AA Rana, R Kettleborough, JM Brickman, M Clements, A Forrest, S Grimmond, P Avner, JC Smith, SL Dunwoodie, RS Beddington |
Genome research | 2003 |
Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney
DA de la Rosa, T Coric, N Todorovic, D Shao, T Wang, CM Canessa |
The Journal of Physiology | 2003 |
Sgk: an old enzyme revisited
N Farman, S Boulkroun, N Courtois-Coutry |
Journal of Clinical Investigation | 2002 |