Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
Thanyaphong Na Nakorn, … , Irving L. Weissman, Koichi Akashi
Thanyaphong Na Nakorn, … , Irving L. Weissman, Koichi Akashi
Published June 15, 2002
Citation Information: J Clin Invest. 2002;109(12):1579-1585. https://doi.org/10.1172/JCI15272.
View: Text | PDF
Article Development Article has an altmetric score of 12

Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S

  • Text
  • PDF
Abstract

Whole-body irradiation at the minimal lethal dose causes bone marrow failure and death within 12–18 days. To identify the principal components of the hematopoietic system that are radioprotective, we transplanted lethally irradiated mice with purified progenitors: common myeloid progenitors (CMPs), megakaryocyte/erythrocyte-restricted progenitors (MEPs), or granulocyte/monocyte-restricted progenitors (GMPs). Transplanted CMPs gave rise to cells both of the granulocyte/monocyte (GM) series and the megakaryocyte/erythrocyte series, whereas GMPs or MEPs showed reconstitution of only GM or ME cells, respectively. CMPs and MEPs but not GMPs protected mice in a dose-dependent manner, suggesting that erythrocytes, platelets, or both are the critical effectors of radioprotection. Accordingly, CMPs and MEPs formed robust colonies in recipient bone marrow and spleen, whereas GMPs formed small colonies that rapidly disappeared. Direct comparisons of spleen CFU (CFU-S) potentials among each progenitor subset showed that MEPs contain the vast majority of day 8 CFU-S activity, suggesting that day 8 CFU-S are the precursors of radioprotective cell subsets. All animals radioprotected for 30 days subsequently survived for at least 6 months post-transplant, and showed only host-derived hematopoiesis after 30 days. These findings suggest that rare hematopoietic stem cells survive myeloablation that can eventually repopulate irradiated hosts if myeloerythroid-restricted progenitors transiently rescue ablated animals through the critical window of bone marrow failure.

Authors

Thanyaphong Na Nakorn, David Traver, Irving L. Weissman, Koichi Akashi

×

Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Total
Citations: 2 1 4 4 2 4 3 5 5 2 7 4 7 9 5 4 3 2 3 2 2 2 82
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (82)

Title and authors Publication Year
Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype
Zhang Q, Olofzon R, Konturek-Ciesla A, Yuan O, Bryder D
eLife 2024
Autophagy prevents graft failure during murine graft-versus-host disease
Lineburg KE, Leveque-El Mouttie L, Hunter CR, Le Texier L, McGirr C, Teal B, Blazar BR, Lane SW, Hill GR, Lévesque JP, MacDonald KP
Blood Advances 2024
T-cell dependent reactive granulopoiesis is associated with neutropenia-induced alteration of gut microbiota
Xuanzhong Chen, Daigo Hashimoto, Ko Ebata, Shuichiro Takahashi, Yu Shimizu, Ryuga Shinozaki, Yuta Hasegawa, Ryo Kikuchi, Hajime Senjo, Kazuki Yoneda, Zixuan Zhang, Shinpei Harada, Eiko Hayase, Takahide Ara, Hiroyuki Ohigashi, Yoichiro Iwakura, Kiminori Nakamura, Tokiyoshi Ayabe, Takanori Teshima
Proceedings of the National Academy of Sciences 2022
Classes of Drugs that Mitigate Radiation Syndromes
ED Micewicz, RD Damoiseaux, G Deng, A Gomez, KS Iwamoto, ME Jung, C Nguyen, AJ Norris, JA Ratikan, P Ruchala, JW Sayre, D Schaue, JP Whitelegge, WH McBride
Frontiers in pharmacology 2021
CFU-S assay: a historical single-cell assay that offers modern insight into clonal hematopoiesis
A y Baena, B Manso, E Forsberg
Experimental Hematology 2021
Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity.
Zhang S, O'Neill A, Xie M, Wu P, Wang X, Bai H, Dong F, Wang J, Zhang Q, Suda T, Ema H
2021
Identification of the minimum requirements for successful haematopoietic stem cell transplantation.
Nishi K, Sakamaki T, Sadaoka K, Fujii M, Takaori-Kondo A, Chen JY, Miyanishi M
British Journal of Haematology 2021
Altered Erythro-Myeloid Progenitor Cells Are Highly Expanded in Intensively Regenerating Hematopoiesis
K Faltusová, CL Chen, T Heizer, M Báječný, K Szikszai, P Páral, F Savvulidi, N Renešová, E Nečas
Frontiers in Cell and Developmental Biology 2020
Radiation‐induced tissue damage and response
WH McBride, D Schaue
The Journal of Pathology 2020
Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output
S Singbrant, A Mattebo, M Sigvardsson, T Strid, J Flygare
Haematologica 2020
Radioprotection and Radiomitigation: From the Bench to Clinical Practice
E Obrador, R Salvador, JI Villaescusa, JM Soriano, JM Estrela, A Montoro
Biomedicines 2020
Are animal models a necessity for acute radiation syndrome drug discovery?
D Schaue, WH McBride
Expert Opinion on Drug Discovery 2019
Clonal and Quantitative In Vivo Assessment of Hematopoietic Stem Cell Differentiation Reveals Strong Erythroid Potential of Multipotent Cells
SW Boyer, S Rajendiran, AE Beaudin, S Smith-Berdan, PK Muthuswamy, J Perez-Cunningham, EW Martin, C Cheung, H Tsang, M Landon, EC Forsberg
Stem Cell Reports 2019
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration
HA Himburg, CM Termini, L Schlussel, J Kan, M Li, L Zhao, T Fang, JP Sasine, VY Chang, JP Chute
Cell Stem Cell 2018
Screening for genes that regulate the differentiation of human megakaryocytic lineage cells
F Zhu, M Feng, R Sinha, J Seita, Y Mori, IL Weissman
Proceedings of the National Academy of Sciences 2018
Polycomb complexes in normal and malignant hematopoiesis
VD Carlo, I Mocavini, LD Croce
The Journal of Cell Biology 2018
Cell cycle and differentiation of Sca-1 + and Sca-1 − hematopoietic stem and progenitor cells
P Páral, K Faltusová, M Molík, N Renešová, L Šefc, E Nečas
Cell cycle (Georgetown, Tex.) 2018
Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia
S Basilico, B Göttgens
Journal of Molecular Medicine 2017
4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues
ED Micewicz, K Kim, KS Iwamoto, JA Ratikan, G Cheng, GM Boxx, RD Damoiseaux, JP Whitelegge, P Ruchala, C Nguyen, P Purbey, J Loo, G Deng, ME Jung, JW Sayre, AJ Norris, D Schaue, WH McBride, R Amendola
PloS one 2017
Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow
E Bowers, A Slaughter, PS Frenette, R Kuick, OM Pello, D Lucas
Nature Medicine 2017
A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation
HA Himburg, J Sasine, X Yan, J Kan, H Dressman, JP Chute
Radiation Research 2016
Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme
R Zewdu, M Risolino, A Barbulescu, P Ramalingam, JM Butler, L Selleri
Journal of Anatomy 2016
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis
MI Carr, JE Roderick, HS Gannon, MA Kelliher, SN Jones
Cell Reports 2016
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
HA Himburg, PL Doan, M Quarmyne, X Yan, J Sasine, L Zhao, GV Hancock, J Kan, KA Pohl, E Tran, NJ Chao, JR Harris, JP Chute
Nature Medicine 2016
Notch-Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients: Expanded Cells Radiomitigate, Induce Tolerance
F Milano, F Merriam, I Nicoud, J Li, TA Gooley, S Heimfeld, S Imren, C Delaney
Stem Cells Translational Medicine 2016
The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates
VI Krivokrysenko, IA Toshkov, AS Gleiberman, P Krasnov, I Shyshynova, I Bespalov, RK Maitra, NV Narizhneva, VK Singh, MH Whitnall, AA Purmal, AN Shakhov, AV Gudkov, E Feinstein, M Lim
PloS one 2015
New Approaches to Radiation Protection
EM Rosen, R Day, VK Singh
Frontiers in Oncology 2015
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy
A Schumacher, B Denecke, T Braunschweig, J Stahlschmidt, S Ziegler, LO Brandenburg, MB Stope, A Martincuks, M Vogt, D Görtz, A Camporeale, V Poli, G Müller-Newen, TH Brümmendorf, P Ziegler
Journal of Hematology & Oncology 2015
Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation
H Cheng, S Hao, Y Liu, Y Pang, S Ma, F Dong, J Xu, G Zheng, S Li, W Yuan, T Cheng
Blood 2015
Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke
I Weissman
Philosophical Transactions of the Royal Society B: Biological Sciences 2015
Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors
J Riddell, R Gazit, BS Garrison, G Guo, A Saadatpour, PK Mandal, W Ebina, P Volchkov, GC Yuan, SH Orkin, DJ Rossi
Cell 2014
Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells
W Kim, KD Klarmann, JR Keller
Blood 2014
Hdac3 is essential for DNA replication and differentiation of hematopoietic stem and progenitor cells
Alyssa Summers, Melissa Fischer, Kristy Stengel, Yue Zhao, Jonathan Kaiser, Christina Wells, Aubrey Hunt, Srividya Bhaskara, Jessica Luzwick, Shilpa Simpathi, Xi Chen, Mary Ann Thompson, David Cortez, Scott Hiebert
Journal of Clinical Investigation 2013
Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow
LK Nabors, LD Wang, AJ Wagers, GS Kansas
Experimental Hematology 2013
Epidermal growth factor regulates hematopoietic regeneration after radiation injury
PL Doan, HA Himburg, K Helms, JL Russell, E Fixsen, M Quarmyne, JR Harris, D Deoliviera, JM Sullivan, NJ Chao, DG Kirsch, JP Chute
Nature Medicine 2013
Parp-2 is required to maintain hematopoiesis following sublethal  -irradiation in mice
J Farres, J Martin-Caballero, C Martinez, JJ Lozano, L Llacuna, C Ampurdanes, C Ruiz-Herguido, F Dantzer, V Schreiber, A Villunger, A Bigas, J Yelamos
Blood 2013
Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells
CH Olme, N Brown, R Finnon, SD Bouffler, C Badie
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2013
Erythropoiesis in the absence of adult hemoglobin
S Liu, SC McConnell, TM Ryan
Molecular and cellular biology 2013
KIT Receptor Gain-of-Function in Hematopoiesis Enhances Stem Cell Self-Renewal and Promotes Progenitor Cell Expansion: Kit Gain-of-Function Phenotypes in Hematopoiesis
S Deshpande, B Bosbach, Y Yozgat, CY Park, MA Moore, P Besmer
Stem Cells 2013
MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment
L Zhang, VG Sankaran, HF Lodish
Leukemia 2012
ZBTB1 is a determinant of lymphoid development
OM Siggs, X Li, Y Xia, B Beutler
Journal of Experimental Medicine 2012
Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation
E Manesso, J Teles, D Bryder, C Peterson
Journal of The Royal Society Interface 2012
Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation
Y Lim, M Hedayati, AA Merchant, Y Zhang, HH Yu, MB Kastan, W Matsui, TL DeWeese
International journal of radiation oncology, biology, physics 2012
Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias
BT Kvinlaug, WI Chan, L Bullinger, M Ramaswami, C Sears, D Foster, SE Lazic, R Okabe, A Benner, BH Lee, ID Silva, PJ Valk, R Delwel, SA Armstrong, H Döhner, DG Gilliland, BJ Huntly
Cancer research 2011
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification
MG Cornejo, V Mabialah, SM Sykes, T Khandan, CL Celso, CK Lopez, P Rivera-Muñoz, P Rameau, Z Tothova, JC Aster, RA DePinho, DT Scadden, DG Gilliland, T Mercher
Blood 2011
Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion
JM Perry, XC He, R Sugimura, JC Grindley, JS Haug, S Ding, L Li
Genes & development 2011
An ear punch model for studying the effect of radiation on wound healing
D DeOliveira, Y Jiao, JR Ross, K Corbin, Q Xiao, G Toncheva, C Anderson-Evans, TT Yoshizumi, BJ Chen, NJ Chao
International Journal of Radiation Biology 2011
Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis
CW Chen, M Sowden, Q Zhao, T Wiedmer, PJ Sims
Journal of leukocyte biology 2011
Medical Countermeasures for Platelet Regeneration after Radiation Exposure: Report of a Workshop and Guided Discussion Sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010
AL DiCarlo, M Poncz, DR Cassatt, JR Shah, CW Czarniecki, BW Maidment
Radiation Research 2011
Plasticity and maintenance of hematopoietic stem cells during development.
Kanji S, Pompili VJ, Das H
Recent Patents on Biotechnology 2011
Mitigation of hematologic radiation toxicity through pharmacological quiescence in mice
Soren Johnson, Chad Torrice, Jessica Bell, Kimberly Monahan, Qi Jiang, Yong Wang, Matthew Ramsey, Jian Jin, Kwok-Kin Wong, Lishan Su, Daohong Zhou, Norman Sharpless
Journal of Clinical Investigation 2010
Murine erythroid short term radioprotection requires a BMP4 dependent, self renewing population of stress erythroid progenitors
Omid Harandi, Shailaja Hegde, Dai-Chen Wu, Daniel Mckeone, Robert Paulson
Journal of Clinical Investigation 2010
Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity
GG Muramoto, JL Russell, R Safi, AB Salter, HA Himburg, P Daher, SK Meadows, P Doan, RW Storms, NJ Chao, DP McDonnell, JP Chute
Stem Cells 2010
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
L Shao, Y Sun, Z Zhang, W Feng, Y Gao, Z Cai, ZZ Wang, AT Look, WS Wu
Blood 2010
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
H Yu, H Shen, Y Yuan, R XuFeng, X Hu, SP Garrison, L Zhang, J Yu, GP Zambetti, T Cheng
Blood 2010
Evidence for organ-specific stem cell microenvironments
B Ghinassi, F Martelli, M Verrucci, E D'Amore, G Migliaccio, AM Vannucchi, R Hoffman, AR Migliaccio
Journal of Cellular Physiology 2010
Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
TA Davis, MR Landauer, SR Mog, M Barshishat-Kupper, SR Zins, MF Amare, RM Day
Experimental Hematology 2010
Endothelial cells mediate the regeneration of hematopoietic stem cells
B Li, AS Bailey, S Jiang, B Liu, DC Goldman, WH Fleming
Stem Cell Research 2010
Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation
X Cong, M Yan, X Yin, DE Zhang
Blood Cells, Molecules, and Diseases 2010
OTT-MAL activates RBPJ transcription and induces acute megakaryoblastic leukemia in a knock-in mouse model
Thomas Mercher1,2, Glen D. Raffel1, Sandra A. Moore1, Melanie G. Cornejo1, Dominique Baudry-Bluteau2, Nicolas Cagnard2, Jonathan L. Jesneck4, Yana Pikman1, Dana Cullen1, Ifor R. Williams3, Koichi Akashi4, Hirokazu Shigematsu4, Jean-Pierre Bourquin5, Marco Giovannini6, William Vainchenker7, Ross L. Levine1, Benjamin H. Lee1, Olivier A. Bernard2,*, D. Gary Gilliland1,8,*.
Journal of Clinical Investigation 2009
Leukemia
CW So
Leukemia 2009
In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells
BJ Frisch, RL Porter, BJ Gigliotti, AJ Olm-Shipman, JM Weber, RJ O'Keefe, CT Jordan, LM Calvi
Blood 2009
Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene
H Zhao, TI Pestina, M Nasimuzzaman, P Mehta, PW Hargrove, DA Persons
Blood 2009
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
Y Zhang, J Wong, M Klinger, MT Tran, KM Shannon, N Killeen
Blood 2009
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease
AR Migliaccio, F Martelli, M Verrucci, G Migliaccio, AM Vannucchi, H Ni, M Xu, Y Jiang, B Nakamoto, T Papayannopoulou, R Hoffman
Experimental Hematology 2008
The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
IL Weissman, JA Shizuru
Blood 2008
Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells
KP Singh, A Wyman, FL Casado, RW Garrett, TA Gasiewicz
Carcinogenesis 2008
Deletion of Mtg16, a Target of t(16;21), Alters Hematopoietic Progenitor Cell Proliferation and Lineage Allocation
BJ Chyla, I Moreno-Miralles, MA Steapleton, MA Thompson, S Bhaskara, M Engel, SW Hiebert
Molecular and cellular biology 2008
Stem cell myths
T Magnus, Y Liu, GC Parker, MS Rao
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2007
Zebrafish as a model system to screen radiation modifiers
M Hwang, C Yong, L Moretti, B Lu
Current genomics 2007
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
V Jankovic, A Ciarrocchi, P Boccuni, T DeBlasio, R Benezra, SD Nimer
Proceedings of the National Academy of Sciences 2007
The Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
Adrienne M. Dorrance, Shujun Liu, Weifeng Yuan, Brian Becknell, Kristy J. Arnoczky, Martin Guimond, Matthew P. Strout, Lan Feng, Tatsuya Nakamura, Li Yu, Laura J. Rush, Michael Weinstein, Gustavo Leone, Lizhao Wu, Amy Ferketich, Susan P. Whitman, Guido Marcucci, and Michael A. Caligiuri
Journal of Clinical Investigation 2006
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
JP Chute, GG Muramoto, AB Salter, SK Meadows, DW Rickman, B Chen, HA Himburg, NJ Chao
Blood 2006
Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells
TR Katsumoto, J Duda, A Kim, Z Wardak, G Dranoff, DW Clapp, K Shannon
Journal of Experimental Medicine 2005
Marrow stromal cells from patients affected by MPS I differentially support haematopoietic progenitor cell development
MA Baxter, RF Wynn, L Schyma, DK Holmes, JE Wraith, LJ Fairbairn, I Bellantuono
Journal of Inherited Metabolic Disease 2005
Functional but Abnormal Adult Erythropoiesis in the Absence of the Stem Cell Leukemia Gene
MA Hall, NJ Slater, CG Begley, JM Salmon, LJ Stekelenburg, MP McCormack, SM Jane, DJ Curtis
Molecular and cellular biology 2005
Circulation and chemotaxis of fetal hematopoietic stem cells
JL Christensen, DE Wright, AJ Wagers, IL Weissman
PLoS Biology 2004
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
H Zeng, R Yücel, C Kosan, L Klein-Hitpass, T Möröy
The EMBO Journal 2004
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
E Passegué, CH Jamieson, LE Ailles, IL Weissman
Proceedings of the National Academy of Sciences 2003
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
A Cozzio, E Passegué, PM Ayton, H Karsunky, ML Cleary, IL Weissman
Genes & development 2003
Optomizing hematopoietic recovery following bone marrow transplantation
Ronald Paquette, Kenneth Dorshkind
Journal of Clinical Investigation 2002
Characterization of mouse clonogenic megakaryocyte progenitors
TN Nakorn, T Miyamoto, IL Weissman
Proceedings of the National Academy of Sciences 2002

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Blogged by 1
Posted by 1 X users
Referenced in 27 patents
37 readers on Mendeley
See more details