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The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
Junichi Sadoshima, … , Dorothy E. Vatner, Stephen F. Vatner
Junichi Sadoshima, … , Dorothy E. Vatner, Stephen F. Vatner
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):271-279. https://doi.org/10.1172/JCI14938.
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Article Genetics

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

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Abstract

Research Article

Authors

Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner

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Figure 2

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Cardiac hypertrophy by pressure overload is preserved in MEKK1–/– mice. ...
Cardiac hypertrophy by pressure overload is preserved in MEKK1–/– mice. Transverse aortic banding or sham operation was applied in either control or MEKK1–/– mice. (a) Pressure gradient across the constriction at the transverse aorta was measured at 7 days. (b) LV weight (LVW) (mg)/body weight (BW) (g) was obtained at 7 and 14 days. *P < 0.001 vs. MEKK1+/+ mice with 14 days banding. (c) LVW (mg)/tibial length (TL) (mm) was obtained at 7 days. n = 5–10. (d) Cardiac myocyte cross-sectional area was obtained at 7 days. n = 5 for each group. The right panel shows the light micrographs of silver-stained 1-μm sections of LV myocardium from sham-operated and banded MEKK1–/– mice. (e) mRNA expression of atrial natriuretic factor (ANF) at 7 days was evaluated by Northern blot analyses. Densitometric analyses were performed. The mean of ANF/GAPDH in control mice subjected to 1 week of banding was expressed as 1. n = 5 for each group. NS, not significant.

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