Multisystem inflammatory syndrome in children (MIS-C) is a rare but deadly new disease in children that rapidly progresses to hyperinflammation and shock, and can lead to multiple organ failure if unrecognized. It has been found to be temporally associated with the COVID-19 pandemic and is often associated with SARS-CoV-2 exposure in children. In this issue of the JCI, Porritt, Paschold, et al. identify restricted T cell receptor (TCR) β-chain variable domain (Vβ) usage in patients with severe MIS-C, indicating a potential role for SARS-CoV-2 as a superantigen. These findings suggest that a blood test that determines the presence of specific TCRβ variable gene (TRBV) segments may identify patients at risk for severe MIS-C.
Theodore Kouo, Worarat Chaisawangwong
Title and authors | Publication | Year |
---|---|---|
Superantigens and SARS-CoV-2
A Hamdy, A Leonardi |
Pathogens | 2022 |
SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
E Gusev, A Sarapultsev, L Solomatina, V Chereshnev |
International journal of molecular sciences | 2022 |
An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives
Ghosh A, Kar PK, Gautam A, Gupta R, Singh R, Chakravarti R, Ravichandiran V, Ghosh Dastidar S, Ghosh D, Roy S |
2022 | |
SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity
Amormino C, Tedeschi V, Paldino G, Arcieri S, Fiorillo MT, Paiardini A, Tuosto L, Kunkl M |
Cells | 2022 |
COVID‐19 induced pityriasis rubra pilaris: A superantigenic disease?
Aromolo IF, Pisapia A, Riva D, Barberi F, Marzano AV, Moltrasio C, Romagnuolo M |
Journal of the European Academy of Dermatology and Venereology | 2022 |
Pathophysiology of Post-COVID syndromes: a new perspective
Batiha GE, Al-kuraishy HM, Al-Gareeb AI, Welson NN |
Virology Journal | 2022 |
COVID-19 disease and immune dysregulation
Davitt E, Davitt C, Mazer MB, Areti SS, Hotchkiss RS, Remy KE |
Best practice & research. Clinical haematology | 2022 |
Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action.
Gao Y, Wang L, Wang L, Lu F |
Virologica Sinica | 2022 |
Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children
Santos-Rebouças CB, Piergiorge RM, dos Santos Ferreira C, Seixas Zeitel RD, Gerber AL, Rodrigues MC, Guimarães AP, Silva RM, Fonseca AR, Souza RC, de Souza AT, Rossi ÁD, Porto LC, Cardoso CC, de Vasconcelos AT |
Molecular Medicine | 2022 |
Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis With Mucosal Involvement Following COVID-19 Pneumonia
Ta H, Awada H, Kang P, Gilbert N, Haller N, Mostow E, Lane J, Singh I |
Cureus | 2022 |
Role of Superantigens in Various Childhood Inflammatory Diseases.
Noorbakhsh S, Ashouri S, Moradkhani M |
Infectious disorders drug targets | 2022 |