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Citations to this article

SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children
Theodore Kouo, Worarat Chaisawangwong
Theodore Kouo, Worarat Chaisawangwong
Published April 12, 2021
Citation Information: J Clin Invest. 2021;131(10):e149327. https://doi.org/10.1172/JCI149327.
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Commentary Article has an altmetric score of 21

SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare but deadly new disease in children that rapidly progresses to hyperinflammation and shock, and can lead to multiple organ failure if unrecognized. It has been found to be temporally associated with the COVID-19 pandemic and is often associated with SARS-CoV-2 exposure in children. In this issue of the JCI, Porritt, Paschold, et al. identify restricted T cell receptor (TCR) β-chain variable domain (Vβ) usage in patients with severe MIS-C, indicating a potential role for SARS-CoV-2 as a superantigen. These findings suggest that a blood test that determines the presence of specific TCRβ variable gene (TRBV) segments may identify patients at risk for severe MIS-C.

Authors

Theodore Kouo, Worarat Chaisawangwong

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Total citations by year

Year: 2025 2024 2023 2022 2021 Total
Citations: 1 1 3 11 3 19
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2022 (11)

Title and authors Publication Year
Superantigens and SARS-CoV-2
A Hamdy, A Leonardi
Pathogens 2022
SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
E Gusev, A Sarapultsev, L Solomatina, V Chereshnev
International journal of molecular sciences 2022
An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives
Ghosh A, Kar PK, Gautam A, Gupta R, Singh R, Chakravarti R, Ravichandiran V, Ghosh Dastidar S, Ghosh D, Roy S
2022
SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity
Amormino C, Tedeschi V, Paldino G, Arcieri S, Fiorillo MT, Paiardini A, Tuosto L, Kunkl M
Cells 2022
COVID‐19 induced pityriasis rubra pilaris: A superantigenic disease?
Aromolo IF, Pisapia A, Riva D, Barberi F, Marzano AV, Moltrasio C, Romagnuolo M
Journal of the European Academy of Dermatology and Venereology 2022
Pathophysiology of Post-COVID syndromes: a new perspective
Batiha GE, Al-kuraishy HM, Al-Gareeb AI, Welson NN
Virology Journal 2022
COVID-19 disease and immune dysregulation
Davitt E, Davitt C, Mazer MB, Areti SS, Hotchkiss RS, Remy KE
Best practice & research. Clinical haematology 2022
Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action.
Gao Y, Wang L, Wang L, Lu F
Virologica Sinica 2022
Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children
Santos-Rebouças CB, Piergiorge RM, dos Santos Ferreira C, Seixas Zeitel RD, Gerber AL, Rodrigues MC, Guimarães AP, Silva RM, Fonseca AR, Souza RC, de Souza AT, Rossi ÁD, Porto LC, Cardoso CC, de Vasconcelos AT
Molecular Medicine 2022
Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis With Mucosal Involvement Following COVID-19 Pneumonia
Ta H, Awada H, Kang P, Gilbert N, Haller N, Mostow E, Lane J, Singh I
Cureus 2022
Role of Superantigens in Various Childhood Inflammatory Diseases.
Noorbakhsh S, Ashouri S, Moradkhani M
Infectious disorders drug targets 2022

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