Citations to this article

SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children
Theodore Kouo, Worarat Chaisawangwong
Theodore Kouo, Worarat Chaisawangwong
Published April 12, 2021
Citation Information: J Clin Invest. 2021;131(10):e149327. https://doi.org/10.1172/JCI149327.
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SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare but deadly new disease in children that rapidly progresses to hyperinflammation and shock, and can lead to multiple organ failure if unrecognized. It has been found to be temporally associated with the COVID-19 pandemic and is often associated with SARS-CoV-2 exposure in children. In this issue of the JCI, Porritt, Paschold, et al. identify restricted T cell receptor (TCR) β-chain variable domain (Vβ) usage in patients with severe MIS-C, indicating a potential role for SARS-CoV-2 as a superantigen. These findings suggest that a blood test that determines the presence of specific TCRβ variable gene (TRBV) segments may identify patients at risk for severe MIS-C.

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Theodore Kouo, Worarat Chaisawangwong

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Citations to this article (19)

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