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Citations to this article

Hypoxia-inducible factors and obstructive sleep apnea
Nanduri R. Prabhakar, … , Ying-Jie Peng, Jayasri Nanduri
Nanduri R. Prabhakar, … , Ying-Jie Peng, Jayasri Nanduri
Published July 30, 2020
Citation Information: J Clin Invest. 2020;130(10):5042-5051. https://doi.org/10.1172/JCI137560.
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Hypoxia-inducible factors and obstructive sleep apnea

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Abstract

Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible factors (HIFs) in hypertension, type 2 diabetes (T2D), and cognitive decline in experimental models of IH patterned after O2 profiles seen in OSA. IH increases HIF-1α and decreases HIF-2α protein levels. Dysregulated HIFs increase reactive oxygen species (ROS) through HIF-1–dependent activation of pro-oxidant enzyme genes in addition to reduced transcription of antioxidant genes by HIF-2. ROS in turn activate chemoreflex and suppress baroreflex, thereby stimulating the sympathetic nervous system and causing hypertension. We also discuss how increased ROS generation by HIF-1 contributes to IH-induced insulin resistance and T2D as well as disrupted NMDA receptor signaling in the hippocampus, resulting in cognitive decline.

Authors

Nanduri R. Prabhakar, Ying-Jie Peng, Jayasri Nanduri

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 Total
Citations: 19 30 39 34 17 1 140
Citation information
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