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CEACAM1 and molecular signaling pathways to expand the liver transplant donor pool
Samer Tohme, David A. Geller
Samer Tohme, David A. Geller
Published April 20, 2020
Citation Information: J Clin Invest. 2020;130(5):2192-2194. https://doi.org/10.1172/JCI136679.
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Commentary

CEACAM1 and molecular signaling pathways to expand the liver transplant donor pool

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Abstract

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

Authors

Samer Tohme, David A. Geller

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