JCI - Citations to Why there are two cyclooxygenase isozymes

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Why there are two cyclooxygenase isozymes

William L. Smith, Robert Langenbach

William L. Smith, Robert Langenbach

Published June 15, 2001
Citation Information: J Clin Invest. 2001;107(12):1491-1495. https://doi.org/10.1172/JCI13271.

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Citations to this article (123)

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Ameliorative effect of aqueous avocado seed extract against chromium-induced oxidative stress and cellular damage in rabbit kidney. Okail HA, Anjum S, Emam NM, Abdel-Gaber R, Dkhil MA, El-Ashram S, Ibrahim MA	Food Science & Nutrition	2024
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Aspirin Hypersensitivity in Patients with Coronary Artery Disease: An Updated Review and Practical Recommendations Cappannoli L, Colantuono S, Animati FM, Fracassi F, Galli M, Aurigemma C, Romagnoli E, Montone RA, Lunardi M, Paraggio L, Ierardi C, Baglivo I, Caruso C, Trani C, Burzotta F	Biomolecules	2024
Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent Daré RG, Kolanthai E, Neal CJ, Fu Y, Seal S, Nakamura CV, Lautenschlager SO	Antioxidants	2023
Polyunsaturated Fatty Acids: Conversion to Lipid Mediators, Roles in Inflammatory Diseases and Dietary Sources Harwood JL	International journal of molecular sciences	2023
Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models. Das D, Qiao D, Liu Z, Xie L, Li Y, Wang J, Jia J, Cao Y, Hong J	ACS Medicinal Chemistry Letters	2023
Visual quantification of prostaglandin E(2) discharge from a single cell. Watabe T, Yamahira S, Matsuda M, Terai K	Cell structure and function	2023
EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones. Musa A, Mostafa EM, Bukhari SNA, Alotaibi NH, El-Ghorab AH, Farouk A, Nayl AA, Ghoneim MM, Abdelgawad MA	Molecules (Basel, Switzerland)	2022
Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention. Ozleyen A, Yilmaz YB, Donmez S, Atalay HN, Antika G, Tumer TB	Journal of Cancer Research and Clinical Oncology	2022
The Efficacy and Safety of Celecoxib in Addition to Standard Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Ye SY, Li JY, Li TH, Song YX, Sun JX, Chen XW, Zhao JH, Li Y, Wu ZH, Gao P, Huang XZ	Current Oncology	2022
Quercitrin neutralizes sPLA2IIa activity, reduces the inflammatory IL-6 level in PC3 cell lines, and exhibits anti-tumor activity in the EAC-bearing mice model. Sophiya P, Urs D, K Lone J, Giresha AS, Krishna Ram H, Manjunatha JG, El-Serehy HA, Narayanappa M, Shankar J, Bhardwaj R, Ahmad Guru S, Dharmappa KK	Frontiers in pharmacology	2022
Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice Pundalik S, Hanumappa KR, Giresha AS, Urs D, Rajashekarappa S, Muniyappa N, Jamballi G M, Kuaramkote Shivanna D, S Meti R, Anekere Dasappa Setty S, Thippegowda PB, Krishnappa DK	Journal of inflammation research	2022
Prostaglandin E2 Regulates Bipotent Monocyte-Dendritic Progenitor Cell Lineage-Commitment P Singh, LM Pelus	Stem Cell Reviews and Reports	2021
Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis YQ Xu, X Long, M Han, MQ Huang, JF Lu, XD Sun, W Han	World journal of clinical cases	2021
Biochemical characterization of the cyclooxygenase enzyme in penaeid shrimp P Tobwor, P Deenarn, T Pruksatrakul, S Jiemsup, S Yongkiettrakul, V Vichai, M Phromson, S Chaiyapechara, W Jangsutthivorawat, P Yotbuntueng, OG Hargreaves, W Wimuttisuk, A Hofmann	PloS one	2021
Two glyoxylate reductase isoforms are functionally redundant but required under high photorespiration conditions in rice Z Zhang, X Liang, L Lu, Z Xu, J Huang, H He, X Peng	BMC plant biology	2020
Oxidation of polyunsaturated fatty acids to produce lipid mediators J Harwood, E Lloyd-Evans, WW Christie, JL Harwood	Essays in Biochemistry	2020
Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs CA Rouzer, LJ Marnett	Chemical Reviews	2020
Myrrh induces the apoptosis and inhibits the proliferation and migration of gastric cancer cells through down-regulating cyclooxygenase-2 expression M Sun, J Hua, G Liu, P Huang, N Liu, X He	Bioscience Reports	2020
Non-inflammatory Physiology of “Inflammatory” Mediators – Unalamation, a New Paradigm KR Maddipati	Frontiers in immunology	2020
Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway MX Sun, XP He, PY Huang, Q Qi, WH Sun, GS Liu, J Hua	World journal of gastroenterology : WJG	2020
Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme M Kaur, B Kaur, J Kaur, A Kaur, R Bhatti, P Singh	Scientific Reports	2020
Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction S Kalantari, M Naji, M Nafar, H Yazdani-Kachooei, N Borumandnia, M Parvin	Bioimpacts	2019
Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site S Xu, J Uddin, S Banerjee, K Duggan, J Musee, JR Kiefer, K Ghebreselasie, CA Rouzer, LJ Marnett	The Journal of biological chemistry	2019
Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis C Xin, L Chu, L Zhang, D Geng, Y Wang, D Sun, P Sui, X Zhao, Z Gong, M Sui, W Zhang	Medical science monitor : international medical journal of experimental and clinical research	2019
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Prostaglandins in the pathogenesis of kidney diseases Y Li, W Xia, F Zhao, Z Wen, A Zhang, S Huang, Z Jia, Y Zhang	Oncotarget	2018
Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis P Dai, J Li, XP Ma, J Huang, JJ Meng, P Gong	OncoTargets and therapy	2018
Flipping the cyclooxygenase ( Ptgs ) genes reveals isoform-specific compensatory functions X Li, LL Mazaleuskaya, C Yuan, LL Ballantyne, H Meng, WL Smith, GA FitzGerald, CD Funk	Journal of lipid research	2017
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Molecular docking analysis of curcumin analogues with COX-2 MR Sohilait, HD Pranowo, W Haryadi	Bioinformation	2017
Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice X Li, LL Mazaleuskaya, LL Ballantyne, H Meng, GA FitzGerald, CD Funk	Journal of lipid research	2017
Disorders of the Gastrointestinal System Sanchez LC	Equine Internal Medicine	2017
Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective: Cardiovascular effects of COX-2 inhibitors C Patrono	British Journal of Clinical Pharmacology	2016
Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury L Yao, W Chen, C Han, T Wu	AJP Gastrointestinal and Liver Physiology	2016
Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials YY Zhou, ZG Hu, FJ Zeng, J Han, R Rosell	PloS one	2016
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE 2 production J Zhu, M Chaki, D Lu, C Ren, SS Wang, A Rauhauser, B Li, S Zimmerman, B Jun, Y Du, K Vadnagara, H Wang, S Elhadi, RJ Quigg, MK Topham, C Mohan, F Ozaltin, XJ Zhou, DK Marciano, NG Bazan, M Attanasio	American journal of physiology. Renal physiology	2016
Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA 2 β (Group VIA Phospholipase A 2 ) JW Ashley, WD Hancock, AJ Nelson, RN Bone, HM Tse, M Wohltmann, J Turk, S Ramanadham	The Journal of biological chemistry	2016
In vitro functional characterization of prostaglandin-endoperoxide synthase 2 during chondrocyte hypertrophic differentiation N Li, Q Wang, T Zhu, L Qiao, F Zhang, R Mi, B Wang, L Chen, J Gu, Y Lu, Q Zheng	Oncotarget	2016
ω-3 Fatty Acids and Cardiovascular Diseases: Effects, Mechanisms and Dietary Relevance H Maehre, IJ Jensen, E Elvevoll, KE Eilertsen	International journal of molecular sciences	2015
RETRACTED ARTICLE: Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Selenium in Bovine Mammary Epithelial Cells in Primary Culture Z Wei, M Yao, Y Li, Z Yang, X Feng	Inflammation	2014
Transcriptional approach to study porcine tracheal epithelial cells individually or dually infected with swine influenza virus and Streptococcus suis Y Dang, C Lachance, Y Wang, CA Gagnon, C Savard, M Segura, D Grenier, M Gottschalk	BMC veterinary research	2014
Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2 R Sood, G Flint-Ashtamker, D Borenstein, L Barki-Harrington	PloS one	2014
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The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin YY Jia, J Lu, Y Huang, G Liu, P Gao, YZ Wan, R Zhang, ZQ Zhang, RF Yang, X Tang, J Xu, X Wang, HZ Chen, DP Liu	PloS one	2014
The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair C Huang, M Xue, H Chen, J Jiao, HR Herschman, RJ O'Keefe, X Zhang	PloS one	2014
Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond: Oxicam Molecular Pharmacology S Xu, CA Rouzer, LJ Marnett	IUBMB Life	2014
Down-regulation of Cyclooxygenase-2 by the Carboxyl Tail of the Angiotensin II Type 1 Receptor R Sood, W Minzel, G Rimon, S Tal, L Barki-Harrington	The Journal of biological chemistry	2014
Cloning and expression of prostaglandin E2 receptor subtype 1 (ep 1 ) in Bostrichthys sinensis XJ Lai, WS Hong, F Liu, YT Zhang,	Fish Physiology and Biochemistry	2014
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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model BI Yoon, WJ Bae, YS Choi, SJ Kim, US Ha, SH Hong, DW Sohn, SW Kim	Chinese Journal of Integrative Medicine	2013
Platelet Biology and Receptor Pathways G Cimmino, P Golino	Journal of Cardiovascular Translational Research	2013
Long term consumption of flaxseed enriched diet decreased ovarian cancer incidence and prostaglandin E2 in hens E Eilati, JM Bahr, DB Hales	Gynecologic Oncology	2013
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer S Li, X Zhao, Z Wu, Y Li, L Zhu, B Cui, X Dong, S Tian, F Hu, Y Zhao	Familial Cancer	2013
Lipid mediators and allergic diseases LB Fanning, JA Boyce	Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology	2013
Matrix Metalloproteinase-19 Is a Key Regulator of Lung Fibrosis in Mice and Humans G Yu, E Kovkarova-Naumovski, P Jara, A Parwani, D Kass, V Ruiz, C Lopez-Otín, IO Rosas, KF Gibson, S Cabrera, R Ramírez, SA Yousem, TJ Richards, LJ Chensny, M Selman, N Kaminski, A Pardo	American journal of respiratory and critical care medicine	2012
Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit PG Johnston, M Gillam-Krakauer, MP Fuller, J Reese	Clinics in Perinatology	2012
Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis B Sastre, V Pozo	Mediators of Inflammation	2012
Hepatitis C virus to hepatocellular carcinoma S Jahan, UA Ashfaq, M Qasim, S Khaliq, MJ Saleem, N Afzal	Infectious agents and cancer	2012
Intracellular Signal Transduction and Modification of the Tumor Microenvironment Induced by RET/PTCs in Papillary Thyroid Carcinoma E Menicali, S Moretti, P Voce, S Romagnoli, N Avenia, E Puxeddu	Frontiers in Endocrinology	2012
Synergistic Association of PTGS2 and CYP2E1 Genetic Polymorphisms with Lung Cancer Risk in Northeastern Chinese S Guo, X Li, M Gao, H Kong, Y Li, M Gu, X Dong, W Niu	PloS one	2012
Thromboxane Inhibitors Attenuate Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administrations AA Nanji, EC Liong, J Xiao, GL Tipoe	Alcoholism, clinical and experimental research	2012
Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages JK Lee, BC Sayers, KS Chun, HC Lao, JK Shipley-Phillips, JC Bonner, R Langenbach	Particle and Fibre Toxicology	2012
Vascular endothelial growth factor promotes the expression of cyclooxygenase 2 and matrix metalloproteinases in Lewis lung carcinoma cells J Hu, C Chen, Y Su, J DU, X Qian, Y Jin	Experimental and therapeutic medicine	2012
Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells P Singh, J Hoggatt, P Hu, JM Speth, S Fukuda, RM Breyer, LM Pelus	Blood	2011
Nr4a1 siRNA Expression Attenuates α-MSH Regulated Gene Expression in 3T3-L1 Adipocytes SC Wang, SA Myers, NA Eriksson, RL Fitzsimmons, GE Muscat	Molecular Endocrinology	2011
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis WL Smith, Y Urade, PJ Jakobsson	Chemical Reviews	2011
Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity D Milatovic, TJ Montine, M Aschner	NeuroToxicology	2011
Microsomal prostaglandin E synthase-1 (mPGES-1) promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis D Lu, C Han, T Wu	Oncogene	2011
Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma. Lucarelli AP, Martins MM, Montor W, Oliveira V, Galvão MA, Piato S		2011
Thromboxane and the thromboxane receptor in cardiovascular disease EM Smyth	Clinical Lipidology	2010
Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis EL Liclican, V Nguyen, AB Sullivan, K Gronert	Investigative ophthalmology & visual science	2010
Structural basis of fatty acid substrate binding to cyclooxygenase-2 AJ Vecchio, DM Simmons, MG Malkowski	The Journal of biological chemistry	2010
Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 at Ser34 Enhances Platelet-activating Factor Production in Endotoxin-stimulated Macrophages* R Morimoto, H Shindou, Y Oda, T Shimizu	The Journal of biological chemistry	2010
Characterization of proteins associating with 5’ terminus of PGHS-1 mRNA N Bunimov, O Laneuville	Cellular & Molecular Biology Letters	2010
Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17 VA Blaho, MW Buczynski, EA Dennis, CR Brown	Journal of immunology (Baltimore, Md. : 1950)	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Matrix Metalloproteinase (MMP)-1 and MMP-3 Induce Macrophage MMP-9: Evidence for the Role of TNF-α and Cyclooxygenase-2 M Steenport, KM Khan, B Du, SE Barnhard, AJ Dannenberg, DJ Falcone	Journal of immunology (Baltimore, Md. : 1950)	2009
Cyclooxygenases: structural and functional insights CA Rouzer, LJ Marnett	Journal of lipid research	2009
Two pathways for cyclooxygenase-2 protein degradation in vivo M Wada, TL Saunders, J Morrow, GL Milne, KP Walker, SK Dey, TG Brock, MR Opp, DM Aronoff, WL Smith	The Journal of biological chemistry	2009
Hepatoprotective and anti-inflammatory activities of Plantago major L I Türel, H Ozbek, R Erten, AC Oner, N Cengiz, O Yilmaz	Indian journal of pharmacology	2009
Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo AK Walduck, M Weber, C Wunder, S Juettner, M Stolte, M Vieth, B Wiedenmann, TF Meyer, M Naumann, M Hoecker	Molecular Cancer	2009
Recent progress on acyl CoA: lysophospholipid acyltransferase research H Shindou, D Hishikawa, T Harayama, K Yuki, T Shimizu	Journal of lipid research	2009
Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids CA Rouzer, LJ Marnett	The Journal of biological chemistry	2008
Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage N Zayed, X Li, N Chabane, M Benderdour, J Martel-Pelletier, JP Pelletier, N Duval, H Fahmi	Arthritis Research & Therapy	2008
Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1 T Ichikawa, J Zhang, K Chen, Y Liu, FJ Schopfer, PR Baker, BA Freeman, YE Chen, T Cui	Endocrinology	2008
Nitro-fatty acid formation and signaling BA Freeman, PR Baker, FJ Schopfer, SR Woodcock, A Napolitano, M d'Ischia	The Journal of biological chemistry	2008
Immune mechanisms in thyroid eye disease GM Lehmann, SE Feldon, TJ Smith, RP Phipps	Thyroid : official journal of the American Thyroid Association	2008
Fluid Secretion Caused by Aerolysin-Like Hemolysin of Aeromonas sobria in the Intestines Is Due to Stimulation of Production of Prostaglandin E2 via Cyclooxygenase 2 by Intestinal Cells Y Fujii, K Tsurumi, M Sato, E Takahashi, K Okamoto	Infection and immunity	2008
Nitric oxide mediates prostaglandins' deleterious effect on lipopolysaccharide-triggered murine fetal resorption J Aisemberg, C Vercelli, S Billi, ML Ribeiro, D Ogando, R Meiss, SM McCann, V Rettori, AM Franchi	Proceedings of the National Academy of Sciences	2007
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice WL Yang, KQ Cai, JL Smedberg, ER Smith, A Klein-Szanto, TC Hamilton, XX Xu	The American Journal of Pathology	2007
COX-2 and the vasculature: Angel or evil? C Cuccurullo, A Mezzetti, F Cipollone	Current Hypertension Reports	2007
Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase‐2 inhibitor, enoic acanthoic acid Jung HJ, Shim JS, Suh Y, Kim Y, Ono M, Kwon HJ	Cancer Science	2007
Expression of Cyclooxygenase-2 in Platelet-Monocyte Interactions Occurs via Combinational Regulation Involving Adhesion and Cytokine Signaling Dan A. Dixon, Neal D. Tolley, Kristi Bemis-Standoli, Mark L. Martinez, Andrew S. Weyrich, Jason D. Morrow, Stephen M. Prescott, and Guy A. Zimmerman	Journal of Clinical Investigation	2006
Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators T Cui, FJ Schopfer, J Zhang, K Chen, T Ichikawa, PR Baker, C Batthyany, BK Chacko, X Feng, RP Patel, A Agarwal, BA Freeman, YE Chen	The Journal of biological chemistry	2006
Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel CM McGinley, WA van der Donk	Journal of labelled compounds & radiopharmaceuticals	2006
Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results C Mascaux, B Martin, M Paesmans, T Berghmans, M Dusart, A Haller, P Lothaire, AP Meert, JJ Lafitte, JP Sculier	British Journal of Cancer	2006
Cyclooxygenase-2 inhibition: Vascular inflammation and cardiovascular risk F Cipollone, ML Fazia	Current Atherosclerosis Reports	2006
Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans MY Her, A El-Sohemy, MC Cornelis, TH Kim, SC Bae	Rheumatology International	2006
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2 R Esser, C Berry, Z Du, J Dawson, A Fox, RA Fujimoto, W Haston, EF Kimble, J Koehler, J Peppard, E Quadros, J Quintavalla, K Toscano, L Urban, J Duzer, X Zhang, S Zhou, PJ Marshall	British Journal of Pharmacology	2005
Pattern of apoptosis by NS398, a selective COX-2 inhibitor, in hepatocellular carcinoma cell lines MK Park, MK Kim, JC Kim, YK Sung	Cancer research and treatment : official journal of Korean Cancer Association	2005
Expression of Cyclooxygenase-2 mRNA and identification of its splice variant in human myometrium obtained from women in labor H Yinping, Y Duyun, W Ping, H Yanjun, Z Li, Z Xiaoyan, H Yunfeng, Y Ping, Z Daijuan, W Jingyuan	Journal of Huazhong University of Science and Technology [Medical Sciences]	2005
Regulation of cytosolic prostaglandin E synthase by phosphorylation T Kobayashi, Y Nakatani, T Tanioka, M Tsujimoto, S Nakajo, K Nakaya, M Murakami, I Kudo	Biochemical Journal	2004
Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms M Ouellet, JP Falgueyret, MD Percival	Biochemical Journal	2004
Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice. Su GL, Wang SC, Aminlari A, Tipoe GL, Steinstraesser L, Nanji A	Digestive Diseases and Sciences	2004
Disorders of the Gastrointestinal System Jones SL, Blikslager AT	Equine Internal Medicine	2004
Series Introduction: The expanding network of redox signaling: new observations, complexities, and perspectives RJ Soberman	Journal of Clinical Investigation	2003
Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells MG Sciulli, F Seta, S Tacconelli, ML Capone, E Ricciotti, G Pistritto, P Patrignani	British Journal of Pharmacology	2003
Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa S Fiorucci, L Santucci, JL Wallace, M Sardina, M Romano, P Soldato, A Morelli	Proceedings of the National Academy of Sciences	2003
The organization and consequences of eicosanoid signaling RJ Soberman, P Christmas	Journal of Clinical Investigation	2003
What is the Role of NSAIDs in Pre-emptive Analgesia?: EA Ochroch, IA Mardini, A Gottschalk	Drugs	2003
Opposite effects of cyclooxygenases-1 and -2 activity on the pressor response to angiotensin II Zhonghua Qi, Chuan-Ming Hao, Robert I. Langenbach, Richard M. Breyer, Reyadh Redha, Jason D. Morrow, Matthew D. Breyer	Journal of Clinical Investigation	2002
The Choreography of COXs in the kidney G.A. Fitzgerald	Journal of Clinical Investigation	2002
Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets B Rocca, P Secchiero, G Ciabattoni, FO Ranelletti, L Catani, L Guidotti, E Melloni, N Maggiano, G Zauli, C Patrono	Proceedings of the National Academy of Sciences	2002
Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition LE Hammond, PA Gallagher, S Wang, S Hiller, KD Kluckman, EL Posey-Marcos, N Maeda, RA Coleman	Molecular and cellular biology	2002
Regulated formation of eicosanoids Frank A. Fitzpatrick, Roy Soberman	Journal of Clinical Investigation	2001
Unorthodox routes to prostanoid formation: new twists in cyclooexygenase-initiated pathways Charles Serhan, Ernst Oliw	Journal of Clinical Investigation	2001
Genetic and pharmacological analysis of prostanoid receptor function Shuh Narumiya, Garrett A. Fitzgerald	Journal of Clinical Investigation	2001

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