Citations to this article
Citation Information: J Clin Invest. 2020;130(4):1595-1607. https://doi.org/10.1172/JCI129209.
Abstract
Hematological malignancies have long been at the forefront of the development of novel immune-based treatment strategies. The earliest successful efforts originated from the extensive body of work in the field of allogeneic hematopoietic stem cell transplantation. These efforts laid the foundation for the recent exciting era of cancer immunotherapy, which includes immune checkpoint blockade, personal neoantigen vaccines, and adoptive T cell transfer. At the heart of the specificity of these novel strategies is the recognition of target antigens presented by malignant cells to T cells. Here, we review the advances in systematic identification of minor histocompatibility antigens and neoantigens arising from personal somatic alterations or recurrent driver mutations. These exciting efforts pave the path for the implementation of personalized combinatorial cancer therapy.
Authors
Livius Penter, Catherine J. Wu
Citations to this article (9)
| Title and authors | Publication | Year |
|---|---|---|
|
Single-cell genomics-based immune and disease monitoring in blood malignancies
Rathgeber AC, Ludwig LS, Penter L |
2024 | |
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Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations.
Penter L, Cieri N, Maurer K, Kwok M, Lyu H, Lu WS, Oliveira G, Gohil SH, Leshchiner I, Lareau CA, Ludwig LS, Neuberg DS, Kim HT, Li S, Bullinger L, Ritz J, Getz G, Garcia JS, Soiffer RJ, Livak KJ, Wu CJ |
Blood cancer discovery | 2024 |
|
Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease
Penter L, Liu Y, Wolff JO, Yang L, Taing L, Jhaveri A, Southard J, Patel M, Cullen NM, Pfaff KL, Cieri N, Oliveira G, Kim-Schulze S, Ranasinghe S, Leonard R, Robertson T, Morgan EA, Chen HX, Song MH, Thurin M, Li S, Rodig SJ, Cibulskis C, Gabriel S, Bachireddy P, Ritz J, Streicher H, Neuberg DS, Hodi FS, Davids MS, Gnjatic S, Livak KJ, Altreuter J, Michor F, Soiffer RJ, Garcia JS, Wu CJ |
Blood | 2023 |
|
Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics
L Penter, S Gohil, C Wu |
Frontiers in immunology | 2022 |
|
What do cancer-specific T cells ‘see’?
Shah S, Al-Omari A, Cook KW, Paston SJ, Durrant LG, Brentville VA |
2022 | |
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation
L Penter, Y Zhang, A Savell, T Huang, N Cieri, EM Thrash, S Kim-Schulze, A Jhaveri, J Fu, S Ranasinghe, S Li, W Zhang, ES Hathaway, M Nazzaro, HT Kim, H Chen, M Thurin, SJ Rodig, M Severgnini, C Cibulskis, S Gabriel, KJ Livak, C Cutler, JH Antin, S Nikiforow, J Koreth, VT Ho, P Armand, J Ritz, H Streicher, D Neuberg, FS Hodi, S Gnjatic, RJ Soiffer, XS Liu, MS Davids, P Bachireddy, CJ Wu |
Blood | 2021 |
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Coevolving JAK2V617F+ relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case
L Penter, SH Gohil, T Huang, EM Thrash, D Schmidt, S Li, M Severgnini, D Neuberg, FS Hodi, KJ Livak, R Zeiser, P Bachireddy, CJ Wu |
Blood Advances | 2021 |
|
Immune Escape and Immunotherapy of Acute Myeloid Leukemia
Luca Vago, Ivana Gojo |
Journal of Clinical Investigation | 2020 |
|
Evolution and new frontiers of histology in bio‐medical research
M Mazzarini, M Falchi, D Bani, AR Migliaccio |
Microscopy Research and Technique | 2020 |
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