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Usage Information

Setting traps for NKG2A gives NK cell immunotherapy a fighting chance
Frank Cichocki, Jeffrey S. Miller
Frank Cichocki, Jeffrey S. Miller
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Setting traps for NKG2A gives NK cell immunotherapy a fighting chance

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Abstract

The equilibrium of signaling through activating and inhibitory receptors dictates whether a given NK cell will execute cellular cytotoxicity. In this issue of the JCI, Kamiya et al. describe a novel approach to efficiently inhibiting surface expression of the inhibitory receptor CD94/NK group 2 member A (NKG2A) through retention of the protein in the endoplasmic reticulum. In adoptive transfer experiments into tumor-bearing immunodeficient mice, NKG2Anull NK cells were significantly more effective at eliminating HLA-E–expressing tumor cells than NKG2A+ NK cells. This study provides proof of concept for a new immunotherapeutic approach using NKG2Anull NK cells.

Authors

Frank Cichocki, Jeffrey S. Miller

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Usage data is cumulative from October 2025 through October 2026.

Usage JCI PMC
Text version 1,073 70
PDF 422 16
Figure 250 0
Citation downloads 338 0
Totals 2,083 86
Total Views 2,169
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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