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Citations to this article

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
A Rohlmann, … , R E Hammer, J Herz
A Rohlmann, … , R E Hammer, J Herz
Published February 1, 1998
Citation Information: J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240.
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Research Article Article has an altmetric score of 9

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

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Abstract

The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been postulated to participate in a number of diverse physiological and pathological processes ranging from the homeostasis of plasma lipoproteins, atherosclerosis, and fibrinolysis to neuronal regeneration and survival. It has not been possible to demonstrate in vivo the physiological significance of LRP for each of these complex processes by a conventional gene knockout approach because LRP is essential for embryonic development. Here we have used the Cre/loxP recombination system to achieve inducible, tissue-specific and quantitative disruption of the LRP gene in adult mice. Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation. In normal animals, this caused a compensatory upregulation of the LDL receptor in the liver. Conditional gene targeting has thus allowed us to isolate a specific physiological function of LRP for in vivo analysis and has provided unequivocal evidence for another LDL receptor-independent cholesterol clearance pathway in liver.

Authors

A Rohlmann, M Gotthardt, R E Hammer, J Herz

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Citations to this article in year 2019 (8)

Title and authors Publication Year
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance
Melinde Wijers, Paolo Zanoni, Nalan Liv, Dyonne Y. Vos, Michelle Y Jäckstein, Marieke Smit, Sanne Wilbrink, Justina C. Wolters, Ydwine Y.T. van der Veen, N.C.A. Huijkman, Daphne Dekker, Niels J Kloosterhuis, Theo H. van Dijk, Daniel Billadeau, Folkert Kuipers, Judith Klumperman, Arnold von Eckardstein, Jan Albert Kuivenhoven, Bart van de Sluis
JCI Insight 2019
Lipoprotein receptor signalling in atherosclerosis
C Mineo
Cardiovascular Research 2019
Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye
EE Bres, A Faissner
Frontiers in Cell and Developmental Biology 2019
LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing
C Brifault, HJ Kwon, WM Campana, SL Gonias
Glia 2019
Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism
G Reyes-Soffer, C Sztalryd, RB Horenstein, S Holleran, A Matveyenko, T Thomas, R Nandakumar, C Ngai, W Karmally, HN Ginsberg, R Ramakrishnan, TI Pollin
Arteriosclerosis, thrombosis, and vascular biology 2019
Critical Role of SREBP (Sterol Regulatory Element-Binding Protein)-1c Large-VLDL (Very Low-Density Lipoprotein) Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency
M Takanashi, T Kimura, C Li, M Tanaka, A Matsuhashi, H Yoshida, A Noda, P Xu, S Takase, S Okazaki, Y Iizuka, H Kumagai, Y Ikeda, T Gotoda, M Takahashi, H Yagyu, S Ishibashi, T Yamauchi, T Kadowaki, G Liang, H Okazaki
Arteriosclerosis, thrombosis, and vascular biology 2019
Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia
P Shrestha, B van de Sluis, RP Dullaart, J van den Born
Cellular Signalling 2019
High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor–related protein 1 requires lysines 80, 88, and 207
M Migliorini, SH Li, A Zhou, CD Emal, DA Lawrence, DK Strickland
The Journal of biological chemistry 2019

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