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A Rohlmann, … , R E Hammer, J Herz
Published February 1, 1998
Citation Information: J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240.
Citation Information: J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240.
Abstract
The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been postulated to participate in a number of diverse physiological and pathological processes ranging from the homeostasis of plasma lipoproteins, atherosclerosis, and fibrinolysis to neuronal regeneration and survival. It has not been possible to demonstrate in vivo the physiological significance of LRP for each of these complex processes by a conventional gene knockout approach because LRP is essential for embryonic development. Here we have used the Cre/loxP recombination system to achieve inducible, tissue-specific and quantitative disruption of the LRP gene in adult mice. Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation. In normal animals, this caused a compensatory upregulation of the LDL receptor in the liver. Conditional gene targeting has thus allowed us to isolate a specific physiological function of LRP for in vivo analysis and has provided unequivocal evidence for another LDL receptor-independent cholesterol clearance pathway in liver.
Authors
A Rohlmann, M Gotthardt, R E Hammer, J Herz
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Virology | 2014 |
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A low-density lipoprotein receptor-related protein (LRP)-like molecule identified from Chlamys farreri participated in immune response against bacterial infection
R Liu, L Wang, Y Sun, L Wang, H Zhang, L Song |
Fish & Shellfish Immunology | 2014 |
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The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression
HJ Kim, JH Moon, HM Kim, MR Yun, BH Jeon, BW Lee, ES Kang, HC Lee, BS Cha |
Metabolism | 2014 |
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Specific Deletion of LDL Receptor-Related Protein on Macrophages Has Skewed In Vivo Effects on Cytokine Production by Invariant Natural Killer T Cells
R Covarrubias, AJ Wilhelm, AS Major, F Trottein |
PloS one | 2014 |
|
Apolipoproteins E and AV Mediate Lipoprotein Clearance by Hepatic Proteoglycans
Jon C. Gonzales, Philip L.S.M. Gordts, Erin M. Foley, Jeffrey D. Esko |
Journal of Clinical Investigation | 2013 |
|
The regulation of ApoB metabolism by insulin
ME Haas, AD Attie, SB Biddinger |
Trends in Endocrinology & Metabolism | 2013 |
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Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction
E Wan, XY Yeap, S Dehn, R Terry, M Novak, S Zhang, S Iwata, X Han, S Homma, K Drosatos, J Lomasney, DM Engman, SD Miller, DE Vaughan, JP Morrow, R Kishore, EB Thorp |
Circulation research | 2013 |
|
Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism
JH Moon, HJ Kim, HM Kim, SH Choi, S Lim, YJ Park, HC Jang, BS Cha |
Thyroid | 2013 |
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Liver-Specific Phospholipid Transfer Protein Deficiency Reduces High-Density Lipoprotein and Non-High-Density Lipoprotein Production in Mice
A Yazdanyar, W Quan, W Jin, XC Jiang |
Arteriosclerosis, thrombosis, and vascular biology | 2013 |
|
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease
DJ Felmlee, ML Hafirassou, M Lefevre, TF Baumert, C Schuster |
Viruses | 2013 |
|
Hepatic Remnant Lipoprotein Clearance by Heparan Sulfate Proteoglycans and Low-Density Lipoprotein Receptors Depend on Dietary Conditions in Mice
EM Foley, PL Gordts, KI Stanford, JC Gonzales, R Lawrence, N Stoddard, JD Esko |
Arteriosclerosis, thrombosis, and vascular biology | 2013 |
|
Evaluation of a method of preparation of lipid emulsions as a model for chylomicron-like particles
A Antelo, JS Perona |
Journal of Liposome Research | 2013 |
|
Low-density lipoprotein receptors in liver: Old acquaintances and a newcomer
U Pieper-Fürst, F Lammert |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 |
|
Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages
P May, HH Bock, JR Nofer |
Cell and Tissue Research | 2013 |
|
Biodistribution of AAV8 Vectors Expressing Human Low-Density Lipoprotein Receptor in a Mouse Model of Homozygous Familial Hypercholesterolemia
SJ Chen, J Sanmiguel, M Lock, D McMenamin, C Draper, MP Limberis, SH Kassim, S Somanathan, P Bell, JC Johnston, DJ Rader, JM Wilson |
Human Gene Therapy Clinical Development | 2013 |
|
Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors
ND Staudt, M Jo, J Hu, JM Bristow, DP Pizzo, A Gaultier, SR VandenBerg, SL Gonias |
Cancer research | 2013 |
|
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
alanna strong, Qiurong Ding, Andrew Edmondson, John Millar, Katherine Sachs, Xiaoyu Li, Arthi Kumaravel, Margaret Ye Wang, ding ai, Liang Guo, Eric Alexander, David Nguyen, Sissel Lund-Katz, Michael C. Phillips, Carlos Morales, Alan R. Tall, Sekar Kathiresan, Edward A. Fisher, Kiran Musunuru, Daniel J. Rader |
Journal of Clinical Investigation | 2012 |
|
Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression
Z Li, T Ding, X Pan, Y Li, R Li, PE Sanders, MS Kuo, MM Hussain, G Cao, XC Jiang |
The Journal of biological chemistry | 2012 |
|
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
T Kanekiyo, CC Liu, M Shinohara, J Li, G Bu |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2012 |
|
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
G Xu, CC Green, SE Fromholt, DR Borchelt |
Alzheimer's research & therapy | 2012 |
|
Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
A Laatsch, M Panteli, M Sornsakrin, B Hoffzimmer, T Grewal, J Heeren |
PloS one | 2012 |
|
Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice
A Yazdanyar, XC Jiang |
Hepatology | 2012 |
|
Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
PL Gordts, A Bartelt, SK Nilsson, W Annaert, C Christoffersen, LB Nielsen, J Heeren, AJ Roebroek |
PloS one | 2012 |
|
RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
S Zhang, X Zhou, RA Lang, F Guo |
PloS one | 2012 |
|
Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing
JA Larios, MP Marzolo |
Frontiers in Biology | 2012 |
|
Lactoferrin and its hydrolysate bind directly to the oleate-activated form of the lipolysis stimulated lipoprotein receptor
N Ahmad, JM Girardet, S Akbar, MC Lanhers, C Paris, FT Yen, C Corbier |
FEBS Journal | 2012 |
|
El metabolismo del colesterol: cada vez más complejo
J Sanhueza, R Valenzuela, A Valenzuela |
Grasas y Aceites | 2012 |
|
Knock Down of Low Density Lipoprotein Receptor-related Protein 1(Lrp1) by RNAi Inhibits The Commitment of C3H10T1/2 Pluripotent Stem Cells to Preadipocyte*: Knock Down of Low Density Lipoprotein Receptor-related Protein 1(Lrp1) by RNAi Inhibits The Commitment of C3H10T1/2 Pluripotent Stem Cells to Preadipocyte*
JW CHEN, L GUO |
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012 |
|
The role of apolipoprotein A5 in obesity and the metabolic syndrome: Association of apoA5 with metabolic diseases
XY Zheng, SP Zhao, H Yan |
Biological Reviews | 2012 |
|
Macrophage LRP1 contributes to the clearance of von Willebrand factor
G Rastegarlari, JN Pegon, C Casari, S Odouard, AM Navarrete, N Saint-Lu, BJ van Vlijmen, P Legendre, OD Christophe, CV Denis, PJ Lenting |
Blood | 2012 |
|
Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia
JH Moon, HJ Kim, HM Kim, AH Yang, BW Lee, ES Kang, HC Lee, BS Cha |
Journal of Molecular Endocrinology | 2012 |
|
Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
PL Gordts, A Bartelt, SK Nilsson, W Annaert, C Christoffersen, LB Nielsen, J Heeren, AJ Roebroek, B He |
PloS one | 2012 |
|
Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
A Laatsch, M Panteli, M Sornsakrin, B Hoffzimmer, T Grewal, J Heeren, L Johannes |
PloS one | 2012 |
|
RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
S Zhang, X Zhou, RA Lang, F Guo, A Gaggar |
PloS one | 2012 |
|
Fate-tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Yann Malato, Syed Naqvi, Nina Schürmann, Raymond Ng, Bruce Wang, Joan Zape, Mark A Kay, Dirk Grimm, Holger Willenbring |
Journal of Clinical Investigation | 2011 |
|
Shedding of syndecan-1 from human hepatocytes alters VLDL clearance
Y Deng, EM Foley, JC Gonzales, PL Gordts, Y Li, JD Esko |
Hepatology | 2011 |
|
Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice*
JE Basford, L Wancata, SM Hofmann, RA Silva, WS Davidson, PN Howles, DY Hui |
The Journal of biological chemistry | 2011 |
|
Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway
SC Muratoglu, S Belgrave, AP Lillis, M Migliorini, S Robinson, E Smith, L Zhang, DK Strickland |
PloS one | 2011 |
|
Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin αMβ2
S Ranganathan, C Cao, J Catania, M Migliorini, L Zhang, DK Strickland |
The Journal of biological chemistry | 2011 |
|
Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins
M Matsuo, RB Campenot, DE Vance, K Ueda, JE Vance |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 |
|
Role for LAMP-2 in endosomal cholesterol transport
A Schneede, CK Schmidt, M Hölttä-Vuori, J Heeren, M Willenborg, J Blanz, M Domanskyy, B Breiden, S Brodesser, J Landgrebe, K Sandhoff, E Ikonen, P Saftig, EL Eskelinen |
Journal of Cellular and Molecular Medicine | 2011 |
|
Brown adipose tissue activity controls triglyceride clearance
A Bartelt, OT Bruns, R Reimer, H Hohenberg, H Ittrich, K Peldschus, MG Kaul, UI Tromsdorf, H Weller, C Waurisch, A Eychmüller, PL Gordts, F Rinninger, K Bruegelmann, B Freund, P Nielsen, M Merkel, J Heeren |
Nature Medicine | 2011 |
|
Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C high Monocytosis: Evidence That the Effects Are Not Apolipoprotein E Dependent
PG Yancey, Y Ding, D Fan, JL Blakemore, Y Zhang, L Ding, J Zhang, MR Linton, S Fazio |
Circulation | 2011 |
|
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system
Q Liu, J Zhang, C Zerbinatti, Y Zhan, BJ Kolber, J Herz, LJ Muglia, G Bu |
PLoS Biology | 2011 |
|
Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor
JH Moon, SB Kang, JS Park, BW Lee, ES Kang, CW Ahn, HC Lee, BS Cha |
Metabolism | 2011 |
|
Uptake of Dietary Retinoids at the Maternal-Fetal Barrier
L Wassef, L Quadro |
The Journal of biological chemistry | 2011 |
|
Pathophysiology of hypertriglyceridemia
HC Hassing, RP Surendran, HL Mooij, ES Stroes, M Nieuwdorp, GM Dallinga-Thie |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 |
|
Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
Q Liu, J Zhang, C Zerbinatti, Y Zhan, BJ Kolber, J Herz, LJ Muglia, G Bu, S O'Rahilly |
PLoS Biology | 2011 |
|
Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway
SC Muratoglu, S Belgrave, AP Lillis, M Migliorini, S Robinson, E Smith, L Zhang, DK Strickland, PH Reitsma |
PloS one | 2011 |
|
Uptake of Dietary Retinoids at the Maternal-Fetal Barrier: IN VIVO EVIDENCE FOR THE ROLE OF LIPOPROTEIN LIPASE AND ALTERNATIVE PATHWAYS
L Wassef, L Quadro |
The Journal of biological chemistry | 2011 |
|
Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin α M β 2: IDENTIFICATION OF BINDING SITES WITHIN α M β 2 FOR LRP1
S Ranganathan, C Cao, J Catania, M Migliorini, L Zhang, DK Strickland |
The Journal of biological chemistry | 2011 |
|
Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice
JE Basford, L Wancata, SM Hofmann, RA Silva, WS Davidson, PN Howles, DY Hui |
The Journal of biological chemistry | 2011 |
|
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family
M Dieckmann, MF Dietrich, J Herz |
Biological Chemistry | 2010 |
|
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration
Q Liu, J Trotter, J Zhang, MM Peters, H Cheng, J Bao, X Han, EJ Weeber, G Bu |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
|
Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation
PG Yancey, J Blakemore, L Ding, D Fan, CD Overton, Y Zhang, MR Linton, S Fazio |
Arteriosclerosis, thrombosis, and vascular biology | 2010 |
|
Cellular uptake of steroid carrier proteins—Mechanisms and implications
TE Willnow, A Nykjaer |
Molecular and Cellular Endocrinology | 2010 |
|
Recent insights into factors affecting remnant lipoprotein uptake
KJ Williams, K Chen |
Current Opinion in Lipidology | 2010 |
|
Sleisenger and Fordtran's Gastrointestinal and Liver Disease
C Högenauer, HF Hammer |
Sleisenger and Fordtran's Gastrointestinal and Liver Disease | 2010 |
|
Recent insights into factors affecting remnant lipoprotein uptake:
KJ Williams, K Chen |
Current Opinion in Lipidology | 2010 |
|
Syndecan-1, the Primary Heparan Sulfate Proteoglycan Mediating Hepatic Triglyceride-Rich Lipoprotein Clearance In Vivo
Kristin I. Stanford, Joseph R. Bishop, Erin M. Foley, Jon C. Gonzalez, Ingrid R. Niesman, Joseph L. Witztum, Jeffrey D. Esko |
Journal of Clinical Investigation | 2009 |
|
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway
RA Fuentealba, Q Liu, T Kanekiyo, J Zhang, G Bu |
The Journal of biological chemistry | 2009 |
|
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
C Zhang, J An, DK Strickland, M Yepes |
The American Journal of Pathology | 2009 |
|
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
A Laatsch, M Merkel, PJ Talmud, T Grewal, U Beisiegel, J Heeren |
Atherosclerosis | 2009 |
|
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
JJ Ludtke, AV Sokoloff, S Wong, G Zhang, DK Strickland, JA Wolff |
Drug Delivery | 2009 |
|
Smooth Muscle LDL Receptor-Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation
JE Basford, ZW Moore, L Zhou, J Herz, DY Hui |
Arteriosclerosis, thrombosis, and vascular biology | 2009 |
|
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
JC McCann, BN Ames |
The American journal of clinical nutrition | 2009 |
|
The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight
GM Dallinga-Thie, R Franssen, HL Mooij, ME Visser, HC Hassing, F Peelman, JJ Kastelein, M Péterfy, M Nieuwdorp |
Atherosclerosis | 2009 |
|
LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export
L Zhou, HY Choi, WP Li, F Xu, J Herz |
PloS one | 2009 |
|
The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?
PJ Babin, GF Gibbons |
Progress in Lipid Research | 2009 |
|
Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice
P Narvekar, MB Diaz, A Krones-Herzig, U Hardeland, D Strzoda, S Stöhr, M Frohme, S Herzig |
Diabetes | 2009 |
|
Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
I López-Soldado, M Avella, KM Botham |
Metabolism: clinical and experimental | 2009 |
|
Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels
Z Li, Y Li, M Chakraborty, Y Fan, HH Bui, DA Peake, MS Kuo, X Xiao, G Cao, XC Jiang |
The Journal of biological chemistry | 2009 |
|
Lycopene
L Rao, E Mackinnon, A Rao |
Lycopene | 2009 |
|
Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis
SM Reekmans, T Pflanzner, PL Gordts, S Isbert, P Zimmermann, W Annaert, S Weggen, AJ Roebroek, CU Pietrzik |
Cellular and Molecular Life Sciences | 2009 |
|
Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice
J Liu, H Zhang, Z Li, TK Hailemariam, M Chakraborty, K Jiang, D Qiu, HH Bui, DA Peake, MS Kuo, R Wadgaonkar, G Cao, XC Jiang |
Arteriosclerosis, thrombosis, and vascular biology | 2009 |
|
The DNA Damage Response: Implications on Cancer Formation and Treatment
KK Khanna, Y Shiloh |
2009 | |
|
Molecular processes that handle – and mishandle – dietary lipids
Kevin Jon Williams |
Journal of Clinical Investigation | 2008 |
|
Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes
IJ Goldberg, Y Hu, HL Noh, J Wei, LA Huggins, MG Rackmill, H Hamai, BN Reid, WS Blaner, LS Huang |
Diabetes | 2008 |
|
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
AP Lillis, LB van Duyn, JE Murphy-Ullrich, DK Strickland |
Physiological reviews | 2008 |
|
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis
MF Galliano, E Toulza, N Jonca, SL Gonias, G Serre, M Guerrin |
PloS one | 2008 |
|
Handbook of Prebiotics
F Guarner |
Handbook of Prebiotics | 2008 |
|
Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse
Z Yates, EJ Tarling, SC Langley-Evans, AM Salter |
British Journal of Nutrition | 2008 |
|
Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism
JR Bishop, KI Stanford, JD Esko |
Current Opinion in Lipidology | 2008 |
|
Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells
J Prawitt, A Niemeier, M Kassem, U Beisiegel, J Heeren |
Experimental Cell Research | 2008 |
|
Heparan Sulphate Biosynthesis and Disease
S Nadanaka, H Kitagawa |
Journal of Biochemistry | 2008 |
|
Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function
A Niemeier, D Niedzielska, R Secer, A Schilling, M Merkel, C Enrich, PC Rensen, J Heeren |
Bone | 2008 |
|
Binding of α2ML1 to the Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Reveals a New Role for LRP1 in the Human Epidermis
MF Galliano, E Toulza, N Jonca, SL Gonias, G Serre, M Guerrin, P Sommer |
PloS one | 2008 |
|
The hepatic uptake of VLDL in lrp − ldlr −/− vldlr −/− mice is regulated by LPL activity and involves proteoglycans and SR-BI
L Hu, CC van der Hoogt, SM Santo, R Out, KE Kypreos, BJ van Vlijmen, TJ van Berkel, JA Romijn, LM Havekes, KW van Dijk, PC Rensen |
Journal of lipid research | 2008 |
|
Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice
M Hoekstra, B Lammers, R Out, Z Li, MV Eck, TJ Berkel |
Molecular Pharmaceutics | 2008 |
|
Molecular Mechanisms of Parasite Invasion
BA Burleigh, D Soldati-Favre |
2008 | |
|
Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).
Navazesh M, Mulligan R, Karim R, Mack WJ, Ram S, Seirawan H, Greenspan J, Greenspan D, Phelan J, Alves M |
Oral Diseases | 2008 |
|
Preservation of VLDL remnant clearance attenuates the phenotype of autosomal recessive hypercholesterolemia
Christopher Jones, Rita Garuti1, Peter Michaely, Wei-Ping Li, Nobuyo Maeda, Jonathan C. Cohen, Joachim Herz, and Helen H. Hobbs |
Journal of Clinical Investigation | 2007 |
|
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
Jennifer M. MacArthur Joseph R. Bishop Kristin I. Stanford Lianchun Wang André Bensadoun Joseph L. Witztum Jeffrey D. Esko |
Journal of Clinical Investigation | 2007 |
|
Adipocyte LRP1 expression modulates postprandial lipid transport, glucose homeostasis, and adiposity
Susanna M. Hofmann, Li Zhou, Diego Perez-Tilve, Todd Greer, Erin Grant, Lauren Wancata, Andrew Thomas, Paul T. Pfluger, Joshua E. Basford, Dean Gilham Joachim Herz, Matthias H. Tschoep, David Y. Hui |
Journal of Clinical Investigation | 2007 |
|
Atherogenic remnant lipoproteins: trap, transfer, and internalization role for proteoglycans
Robert W. Mahley, Yadong Huang |
Journal of Clinical Investigation | 2007 |
|
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
Q Liu, CV Zerbinatti, J Zhang, HS Hoe, B Wang, SL Cole, J Herz, L Muglia, G Bu |
Neuron | 2007 |
|
Handbook of Experimental Pharmacology
HH Bock, J Herz, P May |
Handbook of experimental pharmacology | 2007 |
|
Protein Kinase C-α–Mediated Regulation of Low-Density Lipoprotein Receptor–Related Protein and Urokinase Increases Astrocytoma Invasion
S Amos, M Mut, CG diPierro, JE Carpenter, A Xiao, ZA Kohutek, GT Redpath, Y Zhao, J Wang, ME Shaffrey, IM Hussaini |
Cancer research | 2007 |
|
Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family
SK Nilsson, A Lookene, JA Beckstead, J Gliemann, RO Ryan, G Olivecrona |
Biochemistry | 2007 |
|
Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein
L Hu, N Bovenschen, LM Havekes, BJ van Vlijmen, JT Tamsma |
Journal of Thrombosis and Haemostasis | 2007 |
|
Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils
JS Perona, M Avella, KM Botham, V Ruiz-Gutierrez |
British Journal of Nutrition | 2007 |
|
Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions
MG Mameza, JM Lockard, E Zamora, M Hillefors, ZS Lavina, BB Kaplan |
Journal of Neurochemistry | 2007 |
|
Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
I Usynin, C Klotz, U Frevert |
Cellular Microbiology | 2007 |
|
Incorporation of lycopene into chylomicron remnant-like particles inhibits their uptake by HepG2 cells
F Bejta, M Napolitano, KM Botham, E Bravo |
Life Sciences | 2007 |
|
Avian apolipoprotein A-V binds to LDL receptor gene family members
A Dichlberger, LA Cogburn, J Nimpf, WJ Schneider |
Journal of lipid research | 2007 |
|
Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway
LC Wilsie, AM Gonzales, RA Orlando |
Lipids in Health and Disease | 2006 |
|
Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver
C Tamaki, S Ohtsuki, T Iwatsubo, T Hashimoto, K Yamada, C Yabuki, T Terasaki |
Pharmaceutical Research | 2006 |
|
Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes
LJ Raggatt, SC Jefcoat, I Choudhury, S Williams, M Tiku, NC Partridge |
Osteoarthritis and Cartilage | 2006 |
|
LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
S Azhar, S Medicherla, WJ Shen, Y Fujioka, LG Fong, E Reaven, AD Cooper |
Journal of lipid research | 2006 |
|
Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development
AJ Roebroek, S Reekmans, A Lauwers, N Feyaerts, L Smeijers, D Hartmann |
Molecular and cellular biology | 2006 |
|
Combined hyperlipidemia/hyperalphalipoproteinemia associated with premature spontaneous atherosclerosis in mice lacking hepatic lipase and low density lipoprotein receptor
D Barcat, A Amadio, A Palos-Pinto, D Daret, P Benlian, M Darmon, AM Bérard |
Atherosclerosis | 2006 |
|
Low-density lipoprotein receptor-related protein (LRP)-mediated clearance of activated blood coagulation co-factors and proteases: clearance mechanism or regulation?
DK Strickland, L Medved |
Journal of Thrombosis and Haemostasis | 2006 |
|
Functional Role of the Low-Density Lipoprotein Receptor-Related Protein in Alzheimer’s Disease
E Waldron, S Jaeger, CU Pietrzik |
Neurodegenerative Diseases | 2006 |
|
Genetics and molecular biology: Motive studies in mice – two NPXY motifs in the intracellular domain of lipoprotein receptor-related protein 1 exhibit differential importance during fetal development
JM Knisely, G Bu |
Current Opinion in Lipidology | 2006 |
|
Influencia de los factores genéticos y ambientales en el metabolismo lipídico y riesgo cardiovascular asociado al gen apoE
JA Moreno, J López-Miranda, F Pérez-Jiménez |
Medicina Clínica | 2006 |
|
Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism
NS Raikwar, WK Cho, RF Bowen, MA Deeg |
American journal of physiology. Endocrinology and metabolism | 2006 |
|
Uptake of triacylglycerol-rich lipoproteins of differing triacylglycerol molecular species and unsaponifiable content by liver cells
JS Perona, M Avella, KM Botham, V Ruiz-Gutierrez |
British Journal of Nutrition | 2006 |
|
Schoenheimer Effect explained - Feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
Luke J. Engelking, Guosheng Liang, Robert E. Hammer, Kiyosumi Takaishi, Hiroshi Kuriyama, Bret M. Evers, Wei-Ping Li, Jay D. Horton, Joseph L. Goldstein, and Michael S. Brown |
Journal of Clinical Investigation | 2005 |
|
Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure
C Kim, ND Vaziri |
Kidney International | 2005 |
|
Treatment of dyslipidaemia in HIV-infected persons
O Manuel, R Thiébaut, R Darioli, PE Tarr |
Expert Opinion on Pharmacotherapy | 2005 |
|
Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
Kevin Jon Williams, Ming-Lin Liu, Yanqing Zhu, Xiangsheng Xu, William R Davidson, Peter McCue, Kumar Sharma |
Diabetes | 2005 |
|
Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Controls Endocytosis and c-CBL-mediated Ubiquitination of the Platelet-derived Growth Factor Receptor β (PDGFRβ)
Y Takayama, P May, RG Anderson, J Herz |
The Journal of biological chemistry | 2005 |
|
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice
KE Kypreos, VI Zannis |
Journal of lipid research | 2005 |
|
Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
SM Santo, PC Rensen, JR Goudriaan, A Bensadoun, N Bovenschen, PJ Voshol, LM Havekes, BJ van Vlijmen |
Journal of lipid research | 2005 |
|
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
J Ruiz, D Kouiavskaia, M Migliorini, S Robinson, EL Saenko, N Gorlatova, D Li, D Lawrence, BT Hyman, KH Weisgraber, DK Strickland |
Journal of lipid research | 2005 |
|
Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy
S Kim, CH Kim, ND Vaziri |
American journal of physiology. Endocrinology and metabolism | 2005 |
|
LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo
N Bovenschen, K Mertens, L Hu, LM Havekes, BJ van Vlijmen |
Blood | 2005 |
|
Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase
SJ Lee, S Kadambi, KC Yu, C David, S Azhar, AD Cooper, SY Choi |
Journal of lipid research | 2004 |
|
Hepatic low-density lipoprotein receptor–related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
SM Santo, NM Pires, LS Boesten, G Gerritsen, N Bovenschen, KW van Dijk, JW Jukema, HM Princen, A Bensadoun, WP Li, J Herz, LM Havekes, BJ van Vlijmen |
Blood | 2004 |
|
Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice
P May, A Rohlmann, HH Bock, K Zurhove, JD Marth, ED Schomburg, JL Noebels, U Beffert, JD Sweatt, EJ Weeber, J Herz |
Molecular and cellular biology | 2004 |
|
A novel ARH splice site mutation in a Mexican kindred with autosomal recessive hypercholesterolemia
S Canizales-Quinteros, CA Aguilar-Salinas, A Huertas-Vázquez, ML Ordóñez-Sánchez, M Rodríguez-Torres, JL Venturas-Gallegos, L Riba, S Ramírez-Jimenez, R Salas-Montiel, G Medina-Palacios, L Robles-Osorio, A Miliar-García, L Rosales-León, BH Ruiz-Ordaz, A Zentella-Dehesa, A Ferré-DAmare, FJ Gómez-Pérez, MT Tusié-Luna |
Human Genetics | 2004 |
|
Expression of LRP1 by Human Osteoblasts: A Mechanism for the Delivery of Lipoproteins and Vitamin K1 to Bone
A Niemeier, M Kassem, K Toedter, D Wendt, W Ruether, U Beisiegel, J Heeren |
Journal of Bone and Mineral Research | 2004 |
|
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation
S Mesli, S Javorschi, AM Bérard, M Landry, H Priddle, D Kivlichan, AJ Smith, FT Yen, BE Bihain, M Darmon |
European Journal of Biochemistry | 2004 |
|
Generation of a Mouse Expressing a Conditional Knockout of the Hepatocyte Growth Factor Gene: Demonstration of Impaired Liver Regeneration
D Phaneuf, AD Moscioni, C Leclair, SE Raper, JM Wilson |
DNA and Cell Biology | 2004 |
|
Genetic determinants of obesity-related lipid traits
GE Sonnenberg, GR Krakower, LJ Martin, M Olivier, AE Kwitek, AG Comuzzie, J Blangero, AH Kissebah |
Journal of lipid research | 2004 |
|
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
NS Chung, KM Wasan |
Advanced Drug Delivery Reviews | 2004 |
|
Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by ?MHC-Cre-mediated recombination
BV Skryabin, R Holtwick, L Fabritz, MN Kruse, I Veltrup, J Stypmann, P Kirchhof, K Sabrane, A Bubikat, M Vo?, M Kuhn |
genesis | 2004 |
|
Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
N Bovenschen, KW Dijk, LM Havekes, K Mertens, BJ Vlijmen |
British Journal of Haematology | 2004 |
|
HIV–Associated Lipodystrophy: Pathogenesis, Prognosis, Treatment, and Controversies
P Koutkia, S Grinspoon |
Annual Review of Medicine | 2004 |
|
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation: LSR gene and protein expression
S Mesli, S Javorschi, AM Bérard, M Landry, H Priddle, D Kivlichan, AJ Smith, FT Yen, BE Bihain, M Darmon |
European Journal of Biochemistry | 2004 |
|
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development
HH Petersen, J Hilpert, C Jacobsen, A Lauwers, AJ Roebroek, TE Willnow |
FEBS Letters | 2004 |
|
Cre-mediated conditional gene targeting to understand liver functions
D Metzger, P Chambon |
Drug Discovery Today: Disease Models | 2004 |
|
Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation
J Heeren, T Grewal, A Laatsch, N Becker, F Rinninger, KA Rye, U Beisiegel |
The Journal of biological chemistry | 2004 |
|
A Binding Site for Highly Sulfated Heparan Sulfate Is Identified in the N Terminus of the Circumsporozoite Protein: SIGNIFICANCE FOR MALARIAL SPOROZOITE ATTACHMENT TO HEPATOCYTES
JB Ancsin, R Kisilevsky |
The Journal of biological chemistry | 2004 |
|
Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor
C Knouff, O Briand, S Lestavel, V Clavey, M Altenburg, N Maeda |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2004 |
|
Obesity and post-prandial lipid metabolism. Feast or famine?
IJ Martins, TG Redgrave |
The Journal of Nutritional Biochemistry | 2004 |
|
Transgenic Models in Pharmacology
S Offermanns, L Hein |
2004 | |
|
Chylomicron remnants and oxidised low density lipoprotein have differential effects on the expression of mRNA for genes involved in human macrophage foam cell formation
KV Batt, L Patel, KM Botham, KE Suckling |
Journal of Molecular Medicine | 2004 |
|
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
P Boucher, M Gotthardt, WP Li, RG Anderson, J Herz |
Science | 2003 |
|
Mouse models as tools for dissecting disorders of lipoprotein metabolism
P Marschang, J Herz |
Seminars in Cell & Developmental Biology | 2003 |
|
Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling
DK Strickland, S Ranganathan |
Journal of Thrombosis and Haemostasis | 2003 |
|
Dyslipidemia in the era of HIV protease inhibitors
JH Stein |
Progress in Cardiovascular Diseases | 2003 |
|
Distribution of apolipoprotein E among lipoprotein fractions in the lactating cow
Y Takahashi, F Itoh, T Oohashi, T Miyamoto |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2003 |
|
Low Density Lipoprotein Receptor-related Protein-mediated Membrane Translocation of 12/15-Lipoxygenase Is Required for Oxidation of Low Density Lipoprotein by Macrophages
H Zhu, Y Takahashi, W Xu, H Kawajiri, T Murakami, M Yamamoto, S Iseki, T Iwasaki, H Hattori, T Yoshimoto |
The Journal of biological chemistry | 2003 |
|
The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism
LC Wilsie, RA Orlando |
The Journal of biological chemistry | 2003 |
|
On the Physiological Importance of Endoproteolysis of C AAX Proteins: HEART-SPECIFIC RCE1 KNOCKOUT MICE DEVELOP A LETHAL CARDIOMYOPATHY
MO Bergo, HD Lieu, BJ Gavino, P Ambroziak, JC Otto, PJ Casey, QM Walker, SG Young |
The Journal of biological chemistry | 2003 |
|
Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization
J Heeren, T Grewal, A Laatsch, D Rottke, F Rinninger, C Enrich, U Beisiegel |
The Journal of biological chemistry | 2003 |
|
Endocytosis of Hepatic Lipase and Lipoprotein Lipase into Rat Liver Hepatocytes in Vivo Is Mediated by the Low Density Lipoprotein Receptor-related Protein
M Vergés, A Bensadoun, J Herz, JD Belcher, RJ Havel |
The Journal of biological chemistry | 2003 |
|
The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes
A Makarova, I Mikhailenko, TH Bugge, K List, DA Lawrence, DK Strickland |
The Journal of biological chemistry | 2003 |
|
The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient “apoB-48-only” and “apoB-100-only” mice
HL Dichek, K Qian, N Agrawal |
Journal of lipid research | 2003 |
|
Modulation of the LDL receptor and LRP levels by HIV protease inhibitors
H Tran, S Robinson, I Mikhailenko, DK Strickland |
Journal of lipid research | 2003 |
|
Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice
A Schneider, Y Zhang, Y Guan, LS Davis, MD Breyer |
American journal of physiology. Renal physiology | 2003 |
|
Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor–related protein deficiency
N Bovenschen, J Herz, JM Grimbergen, PJ Lenting, LM Havekes, K Mertens, BJ van Vlijmen |
Blood | 2003 |
|
LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease
AC Sposito, RD Santos, W Hueb, LI Ventura, CC Vinagre, JA Ramires, RC Maranhão |
Atherosclerosis | 2002 |
|
LIPOPROTEINRECEPTORS IN THENERVOUSSYSTEM
J Herz, HH Bock |
Annual Review of Biochemistry | 2002 |
|
The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state
X Zheng, R Rivabene, C Cavallari, M Napolitano, M Avella, E Bravo, KM Botham |
Free radical biology & medicine | 2002 |
|
LDL-receptors expression in HIV-infected patients: relations to antiretroviral therapy, hormonal status, and presence of lipodystrophy
JM Petit, M Duong, L Duvillard, E Florentin, H Portier, G Lizard, JM Brun, P Gambert, B Verges |
European Journal of Clinical Investigation | 2002 |
|
Recent advances in inducible expression in transgenic mice
C Albanese, J Hulit, T Sakamaki, RG Pestell |
Seminars in Cell & Developmental Biology | 2002 |
|
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
T Fujino, H Asaba, MJ Kang, Y Ikeda, H Sone, S Takada, DH Kim, RX Ioka, M Ono, H Tomoyori, M Okubo, T Murase, A Kamataki, J Yamamoto, K Magoori, S Takahashi, Y Miyamoto, H Oishi, M Nose, M Okazaki, S Usui, K Imaizumi, M Yanagisawa, J Sakai, TT Yamamoto |
Proceedings of the National Academy of Sciences | 2002 |
|
Conditional alleles in mice: Practical considerations for tissue-specific knockouts
KM Kwan |
genesis | 2002 |
|
Diverse roles for the LDL receptor family
DK Strickland, SL Gonias, WS Argraves |
Trends in Endocrinology & Metabolism | 2002 |
|
Variation in the lipoprotein receptor-related protein, α2-macroglobulin and lipoprotein receptor-associatedprotein genes in relation to plasma lipid levels and riskof early myocardial infarction
P González, R Álvarez, JR Reguero, A Batalla, V Álvarez, A Cortina, GI Cubero, M García-Castro, E Coto |
Coronary Artery Disease | 2002 |
|
L IPOPROTEIN R ECEPTORS IN THE N ERVOUS S YSTEM
J Herz, HH Bock |
Annual Review of Biochemistry | 2002 |
|
Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle
P Boucher, PH Ducluzeau, P Davelu, F Andreelli, P Vallier, JP Riou, M Laville, H Vidal |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2002 |
|
Regulation of Rac1 activation by the low density lipoprotein receptor–related protein
Z Ma, KS Thomas, DJ Webb, R Moravec, AM Salicioni, WM Mars, SL Gonias |
The Journal of Cell Biology | 2002 |
|
Apolipoprotein B Metabolism: Tracer Kinetics, Models, and Metabolic Studies
JR Burnett, PH Barrett |
Critical Reviews in Clinical Laboratory Sciences | 2002 |
|
Hypomorphic Apolipoprotein E Mice: A NEW MODEL OF CONDITIONAL GENE REPAIR TO EXAMINE APOLIPOPROTEIN E-MEDIATED METABOLISM
RL Raffaı̈, KH Weisgraber |
The Journal of biological chemistry | 2002 |
|
Of mice and models: improved animal models for biomedical research
E Bockamp, M Maringer, C Spangenberg, S Fees, S Fraser, L Eshkind, F Oesch, B Zabel |
Physiological genomics | 2002 |
|
New Perspectives on Atherogenesis: Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism
HN Ginsberg |
Circulation | 2002 |
|
Differential Role of Heparan Sulfate Proteoglycans on Aggregated LDL Uptake in Human Vascular Smooth Muscle Cells and Mouse Embryonic Fibroblasts
V Llorente-Cortés, M Otero-Viñas, L Badimon |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
|
Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux
TE Akiyama, S Sakai, G Lambert, CJ Nicol, K Matsusue, S Pimprale, YH Lee, M Ricote, CK Glass, HB Brewer, FJ Gonzalez |
Molecular and cellular biology | 2002 |
|
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
C Vasandani, AI Kafrouni, A Caronna, Y Bashmakov, M Gotthardt, JD Horton, DK Spady |
Journal of lipid research | 2002 |
|
LRP: A multifunctional scavenger and signaling receptor
Joachim Herz, Dudley K. Strickland |
Journal of Clinical Investigation | 2001 |
|
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
J Yang, JL Goldstein, RE Hammer, YA Moon, MS Brown, JD Horton |
Proceedings of the National Academy of Sciences | 2001 |
|
Protection from obesity in mice lacking the VLDL receptor
JR Goudriaan, PJ Tacken, VE Dahlmans, MJ Gijbels, KW van Dijk, LM Havekes, MC Jong |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
|
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
M Matsuda, BS Korn, RE Hammer, YA Moon, R Komuro, JD Horton, JL Goldstein, MS Brown, I Shimomura |
Genes & development | 2001 |
|
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis
MV Eck |
Atherosclerosis | 2001 |
|
The LDL Receptor Gene Family
J Herz |
Neuron | 2001 |
|
Intracellular metabolism of triglyceride-rich lipoproteins
J Heeren, U Beisiegel |
Current Opinion in Lipidology | 2001 |
|
Molecular mechanisms of apolipoprotein B mRNA editing
S Anant, NO Davidson |
Current Opinion in Lipidology | 2001 |
|
Antiretroviral therapy-associated hyperlipidaemia in HIV disease
V Mooser, A Carr |
Current Opinion in Lipidology | 2001 |
|
The differential hepatic uptake of chylomicron remnants of different fatty acid composition is not mediated by hepatic lipase
MS Lambert, MA Avell, Y Berhane, E Shervill, KM Botham |
British Journal of Nutrition | 2001 |
|
The fatty acid composition of chylomicron remnants influences their binding and internalization by isolated hepatocytes
MS Lambert, ML Avella, Y Berhane, E Shervill, KM Botham |
European Journal of Biochemistry | 2001 |
|
Germ cell specific promoter drives ectopic transgene expression during embryogenesis
B Bhullar, JV Schmidt, T Truong, D Rancourt, FA van der Hoorn |
Molecular Reproduction and Development | 2001 |
|
Pregnancy Zone Protein–Tissue-Type Plasminogen Activator Complexes Bind to Low-Density Lipoprotein Receptor-Related Protein (LRP)
MC Sánchez, GA Chiabrando, MA Vides |
Archives of Biochemistry and Biophysics | 2001 |
|
Hyperlipidemia and inhibitors of HIV protease:
O Distler, DA Cooper, RJ Deckelbaum, SL Sturley |
Current Opinion in Clinical Nutrition and Metabolic Care | 2001 |
|
Stimulation of the in Vivo Production of Very Low Density Lipoproteins by Apolipoprotein E Is Independent of the Presence of the Low Density Lipoprotein Receptor
B Teusink, AR Mensenkamp, H der Boom, F Kuipers, KW van Dijk, LM Havekes |
The Journal of biological chemistry | 2001 |
|
Recognition of α 2 -Macroglobulin by the Low Density Lipoprotein Receptor-related Protein Requires the Cooperation of Two Ligand Binding Cluster Regions
I Mikhailenko, FD Battey, M Migliorini, JF Ruiz, K Argraves, M Moayeri, DK Strickland |
The Journal of biological chemistry | 2001 |
|
Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit: ITS OBLIGATE REQUIREMENT FOR THE STABLE EXPRESSION OF OLIGOMERIC RECEPTOR
R Tozawa, S Ishibashi, J Osuga, K Yamamoto, H Yagyu, K Ohashi, Y Tamura, N Yahagi, Y Iizuka, H Okazaki, K Harada, T Gotoda, H Shimano, S Kimura, R Nagai, N Yamada |
The Journal of biological chemistry | 2001 |
|
Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo
J Heeren, T Grewal, S Jäckle, U Beisiegel |
The Journal of biological chemistry | 2001 |
|
Metabolism of Chylomicron Cholesterol is Delayed by Estrogen. An In Vivo Study in the Rat
E Bravo, A Cantafora, M Avella, KM Botham |
Experimental biology and medicine (Maywood, N.J.) | 2001 |
|
Conditional control of gene expression in the mouse
M Lewandoski |
Nature Reviews Genetics | 2001 |
|
Neurodegenerative Disorders: Loss of Function Through Gain of Function
K Beyreuther, Y Christen, CL Masters |
2001 | |
|
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice
M Kawashiri, Y Zhang, D Usher, M Reilly, E Puré, DJ Rader |
Journal of lipid research | 2001 |
|
Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface
JW Burgess, YL Marcel |
Journal of lipid research | 2001 |
|
Delayed catabolism of apoB48 lipoproteins in streptozotocin-treated mice: evidence that diabetes leads to a selective alteration in the heparan sulfate proteoglycan pathway of chylomicron remnant degradation
Tetsu Ebara, Karin Conde, Yuko Kako, Yan Xu, Rajasekhar Ramakrishnan, Ira J. Goldberg, Neil S. Shachter |
Journal of Clinical Investigation | 2000 |
|
The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding
FH de Man, F Beer, A der Laarse, H Jansen, JA Leuven, JH Souverijn, TF Vroom, SC Schoormans, JC Fruchart, LM Havekes, AH Smelt |
Atherosclerosis | 2000 |
|
Responses to eating: lipoproteins, lipolytic products and atherosclerosis
IJ Goldberg, Y Kako, EP Lutz |
Current Opinion in Lipidology | 2000 |
|
Les animaux génétiquement modifiésÉtude du transport des lipides et de l'athérosclérose
N Baroukh, L Vergnes, M Aostos, M Mzakin, A Ochoa |
Annales de l'Institut Pasteur/Actualités | 2000 |
|
Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein
P Marshall, A Rohlmann, V Nussenzweig, J Herz, P Sinnis |
Molecular and Biochemical Parasitology | 2000 |
|
Spermatocyte-Specific Gene Excision by Targeted Expression of Cre Recombinase
H Ando, Y Haruna, J Miyazaki, M Okabe, Y Nakanishi |
Biochemical and Biophysical Research Communications | 2000 |
|
Cellular signalling by lipoprotein receptors
J Herz, M Gotthardt, TE Willnow |
Current Opinion in Lipidology | 2000 |
|
Lipodystrophy Syndrome in HIV Infection
GM Behrens, M Stoll, RE Schmidt |
Drug Safety | 2000 |
|
Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased
C Xie, DK Burns, SD Turley, JM Dietschy |
Journal of Neuropathology and Experimental Neurology | 2000 |
|
Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein Have Nonoverlapping Functions in Vivo
K Kawano, SC Qin, M Lin, AR Tall, X Jiang |
The Journal of biological chemistry | 2000 |
|
Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2
Z Yang, DK Strickland, P Bornstein |
The Journal of biological chemistry | 2000 |
|
Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP): EVIDENCE THAT LRP CONTRIBUTES TO THE PATHOGENESIS OF ALZHEIMER'S DISEASE
PG Ulery, J Beers, I Mikhailenko, RE Tanzi, GW Rebeck, BT Hyman, DK Strickland |
The Journal of biological chemistry | 2000 |
|
Uptake of Lipoproteins for Axonal Growth of Sympathetic Neurons
EI de Chaves, DE Vance, RB Campenot, RS Kiss, JE Vance |
The Journal of biological chemistry | 2000 |
|
Perlecan Heparan Sulfate Proteoglycan: A NOVEL RECEPTOR THAT MEDIATES A DISTINCT PATHWAY FOR LIGAND CATABOLISM
IV Fuki, RV Iozzo, KJ Williams |
The Journal of biological chemistry | 2000 |
|
Increased LDL Cholesterol and Atherosclerosis in LDL Receptor–Deficient Mice With Attenuated Expression of Scavenger Receptor B1
D Huszar, ML Varban, F Rinninger, R Feeley, T Arai, V Fairchild-Huntress, MJ Donovan, AR Tall |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
|
Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E
KC Yu, Y Jiang, W Chen, AD Cooper |
Journal of lipid research | 2000 |
|
Conditional Disruption of the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) Gene Leads to Loss of Target Gene Induction by the Aryl Hydrocarbon Receptor and Hypoxia-Inducible Factor 1α
S Tomita, CJ Sinal, SH Yim, FJ Gonzalez |
Molecular Endocrinology | 2000 |
|
A Novel Low-Density Lipoprotein Receptor-Related Protein Mediating Cellular Uptake of Apolipoprotein E-Enriched β-VLDL in Vitro ,
T Sugiyama, H Kumagai, Y Morikawa, Y Wada, A Sugiyama, K Yasuda, N Yokoi, S Tamura, T Kojima, T Nosaka, E Senba, S Kimura, T Kadowaki, T Kodama, T Kitamura |
Biochemistry | 2000 |
|
Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages
N Herijgers, MV Eck, SJ Korporaal, PM Hoogerbrugge, TJ Berkel |
Journal of lipid research | 2000 |
|
Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice
IJ Martins, E Hone, C Chi, U Seydel, RN Martins, TG Redgrave |
Journal of lipid research | 2000 |
|
Lipodystrophy Syndrome in HIV Infection: What is it, What Causes it and How Can it Be Managed?
GM Behrens, M Stoll, RE Schmidt |
Drug Safety | 2000 |
|
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
M Raabe, MM Véniant, MA Sullivan, CH Zlot, J Björkegren, LB Nielsen, JS Wong, RL Hamilton, SG Young |
Journal of Clinical Investigation | 1999 |
|
Macrophages, lipoprotein metabolism, and atherosclerosis
MR Linton, S Fazio |
Current Opinion in Lipidology | 1999 |
|
Construction and in Vitro Functional Evaluation of a Low-Density Lipoprotein Receptor/Transferrin Fusion Protein as a Therapeutic Tool for Familial Hypercholesterolemia
F Parise, L Simone, MA Croce, M Ghisellini, R Battini, S Borghi, R Tiozzo, S Ferrari, S Calandra, S Ferrari |
Human Gene Therapy | 1999 |
|
Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
MC Jong, KW van Dijk, VE Dahlmans, HV der Boom, K Kobayashi, K Oka, G Siest, L Chan, MH Hofker, LM Havekes |
Biochemical Journal | 1999 |
|
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
K Sjögren, JL Liu, K Blad, S Skrtic, O Vidal, V Wallenius, D LeRoith, J Törnell, OG Isaksson, JO Jansson, C Ohlsson |
Proceedings of the National Academy of Sciences | 1999 |
|
ROLE OF THE ENTEROHEPATIC CIRCULATION OF BILE SALTS IN LIPOPROTEIN METABOLISM
AD Cooper |
Gastroenterology Clinics of North America | 1999 |
|
The low-density lipoprotein receptor family: Genetics, function, and evolution
WJ Schneider, J Nimpf, C Brandes, M Drexler |
Current Atherosclerosis Reports | 1999 |
|
Genetically modified animals in pharmacological research: future trends
U Rudolph, H Möhler |
European Journal of Pharmacology | 1999 |
|
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
MR Linton, S Fazio |
Current Opinion in Lipidology | 1999 |
|
Somatic gene therapy for dyslipidemias
M Belalcazar, L Chan |
Journal of Laboratory and Clinical Medicine | 1999 |
|
Liver gene disruptions: winners by KO?
AJ Smith, PJ Ronald, O Elferink |
Journal of Hepatology | 1999 |
|
An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
BJ van Vlijmen, A Rohlmann, ST Page, A Bensadoun, IS Bos, TJ van Berkel, LM Havekes, J Herz |
The Journal of biological chemistry | 1999 |
|
Characterization of the Soluble Form of the Low Density Lipoprotein Receptor-Related Protein (LRP)
KA Quinn, VJ Pye, YP Dai, CN Chesterman, DA Owensby |
Experimental Cell Research | 1999 |
|
Recycling of Apolipoprotein E in Mouse Liver
S Fazio, MR Linton, AH Hasty, LL Swift |
The Journal of biological chemistry | 1999 |
|
Molecular Cloning of a Lipolysis-stimulated Remnant Receptor Expressed in the Liver
FT Yen, M Masson, N Clossais-Besnard, P André, JM Grosset, L Bougueleret, JB Dumas, O Guerassimenko, BE Bihain |
The Journal of biological chemistry | 1999 |
|
Postprandial lipoprotein metabolism and atherosclerosis
F Karpe |
Journal of Internal Medicine | 1999 |
|
Lipoprotein receptors: new roles for ancient proteins
TE Willnow, A Nykjaer, J Herz |
Nature Cell Biology | 1999 |
|
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein
C Xie, SD Turley, PG Pentchev, JM Dietschy |
American journal of physiology. Endocrinology and metabolism | 1999 |
|
Hyperlipidemia of ApoE2(Arg 158 -Cys) and ApoE3-Leiden Transgenic Mice Is Modulated Predominantly by LDL Receptor Expression
KW van Dijk, BJ van Vlijmen, MP de Winther, B van t Hof, A van der Zee, H van der Boom, LM Havekes, MH Hofker |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
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Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites
M Orth, W Weng, H Funke, A Steinmetz, G Assmann, M Nauck, J Dierkes, A Ambrosch, KH Weisgraber, RW Mahley, H Wieland, C Luley |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
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Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
RW Mahley, ZS Ji |
Journal of lipid research | 1999 |
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In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
KW van Dijk, BJ van Vlijmen, HB van't Hof, A van der Zee, S Santamarina-Fojo, TJ van Berkel, LM Havekes, MH Hofker |
Journal of lipid research | 1999 |
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Evaluation of the components of the chylomicron remnant removal mechanism by use of the isolated perfused mouse liver
KC Yu, Y Jiang, W Chen, AD Cooper |
Journal of lipid research | 1999 |
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Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models
KW van Dijk, MH Hofker, LM Havekes |
Current Atherosclerosis Reports | 1999 |
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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E
J Osuga, M Yonemoto, N Yamada, H Shimano, H Yagyu, K Ohashi, K Harada, T Kamei, Y Yazaki, S Ishibashi |
Journal of Clinical Investigation | 1998 |
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Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
MF Linton, AH Hasty, VR Babaev, S Fazio |
Journal of Clinical Investigation | 1998 |
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Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice
MM Véniant, CH Zlot, RL Walzem, V Pierotti, R Driscoll, D Dichek, J Herz, SG Young |
Journal of Clinical Investigation | 1998 |
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The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
S Santamarina-Fojo, C Haudenschild, M Amar |
Current Opinion in Lipidology | 1998 |
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Receptor and non-receptor mediated uptake of chylomicron remnants by the liver
RJ Havel |
Atherosclerosis | 1998 |
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A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
L Powell-Braxton, M Véniant, RD Latvala, KI Hirano, WB Won, J Ross, N Dybdal, CH Zlot, SG Young, NO Davidson |
Nature Medicine | 1998 |
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Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP)
T Hiesberger, S Hüttler, A Rohlmann, W Schneider, K Sandhoff, J Herz |
The EMBO Journal | 1998 |
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Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein
L Goretzki, BM Mueller |
Biochemical Journal | 1998 |
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State of the art: Atherosclerosis in a limited edition
DJ Rader, GA FitzGerald |
Nature Medicine | 1998 |
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The lipolysis stimulated receptor: a gene at last
BE Bihain, FT Yen |
Current Opinion in Lipidology | 1998 |
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Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
JG Neels, IR Horn, BM Berg, H Pannekoek, AJ Zonneveld |
Fibrinolysis and Proteolysis | 1998 |
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Studies in Interface Science
R Herold, R Dewitz, S Schürch, U Pison |
Studies in Interface Science | 1998 |
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A Gene-targeted Mouse Model for Familial Hypobetalipoproteinemia: LOW LEVELS OF APOLIPOPROTEIN B mRNA IN ASSOCIATION WITH A NONSENSE MUTATION IN EXON 26 OF THE APOLIPOPROTEIN B GENE
E Kim, P Ambroziak, MM Véniant, RL Hamilton, SG Young |
The Journal of biological chemistry | 1998 |
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Review
M Epstein |
Renal Failure | 1996 |
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