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Citations to this article

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
A Rohlmann, … , R E Hammer, J Herz
A Rohlmann, … , R E Hammer, J Herz
Published February 1, 1998
Citation Information: J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240.
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Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

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Abstract

The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been postulated to participate in a number of diverse physiological and pathological processes ranging from the homeostasis of plasma lipoproteins, atherosclerosis, and fibrinolysis to neuronal regeneration and survival. It has not been possible to demonstrate in vivo the physiological significance of LRP for each of these complex processes by a conventional gene knockout approach because LRP is essential for embryonic development. Here we have used the Cre/loxP recombination system to achieve inducible, tissue-specific and quantitative disruption of the LRP gene in adult mice. Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation. In normal animals, this caused a compensatory upregulation of the LDL receptor in the liver. Conditional gene targeting has thus allowed us to isolate a specific physiological function of LRP for in vivo analysis and has provided unequivocal evidence for another LDL receptor-independent cholesterol clearance pathway in liver.

Authors

A Rohlmann, M Gotthardt, R E Hammer, J Herz

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DK Strickland, DT Au, P Cunfer, SC Muratoglu
Arteriosclerosis, thrombosis, and vascular biology 2014
Hyperlipoproteinemia Type 3: The Forgotten Phenotype
PN Hopkins, EA Brinton, MN Nanjee
Current Atherosclerosis Reports 2014
More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration
C Lane-Donovan, GT Philips, J Herz
Neuron 2014
Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo
BS Barrett, K Guo, MS Harper, SX Li, KJ Heilman, NO Davidson, ML Santiago
Virology 2014
A low-density lipoprotein receptor-related protein (LRP)-like molecule identified from Chlamys farreri participated in immune response against bacterial infection
R Liu, L Wang, Y Sun, L Wang, H Zhang, L Song
Fish & Shellfish Immunology 2014
The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression
HJ Kim, JH Moon, HM Kim, MR Yun, BH Jeon, BW Lee, ES Kang, HC Lee, BS Cha
Metabolism 2014
Specific Deletion of LDL Receptor-Related Protein on Macrophages Has Skewed In Vivo Effects on Cytokine Production by Invariant Natural Killer T Cells
R Covarrubias, AJ Wilhelm, AS Major, F Trottein
PloS one 2014
Apolipoproteins E and AV Mediate Lipoprotein Clearance by Hepatic Proteoglycans
Jon C. Gonzales, Philip L.S.M. Gordts, Erin M. Foley, Jeffrey D. Esko
Journal of Clinical Investigation 2013
The regulation of ApoB metabolism by insulin
ME Haas, AD Attie, SB Biddinger
Trends in Endocrinology & Metabolism 2013
Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction
E Wan, XY Yeap, S Dehn, R Terry, M Novak, S Zhang, S Iwata, X Han, S Homma, K Drosatos, J Lomasney, DM Engman, SD Miller, DE Vaughan, JP Morrow, R Kishore, EB Thorp
Circulation research 2013
Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism
JH Moon, HJ Kim, HM Kim, SH Choi, S Lim, YJ Park, HC Jang, BS Cha
Thyroid 2013
Liver-Specific Phospholipid Transfer Protein Deficiency Reduces High-Density Lipoprotein and Non-High-Density Lipoprotein Production in Mice
A Yazdanyar, W Quan, W Jin, XC Jiang
Arteriosclerosis, thrombosis, and vascular biology 2013
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease
DJ Felmlee, ML Hafirassou, M Lefevre, TF Baumert, C Schuster
Viruses 2013
Hepatic Remnant Lipoprotein Clearance by Heparan Sulfate Proteoglycans and Low-Density Lipoprotein Receptors Depend on Dietary Conditions in Mice
EM Foley, PL Gordts, KI Stanford, JC Gonzales, R Lawrence, N Stoddard, JD Esko
Arteriosclerosis, thrombosis, and vascular biology 2013
Evaluation of a method of preparation of lipid emulsions as a model for chylomicron-like particles
A Antelo, JS Perona
Journal of Liposome Research 2013
Low-density lipoprotein receptors in liver: Old acquaintances and a newcomer
U Pieper-Fürst, F Lammert
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2013
Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages
P May, HH Bock, JR Nofer
Cell and Tissue Research 2013
Biodistribution of AAV8 Vectors Expressing Human Low-Density Lipoprotein Receptor in a Mouse Model of Homozygous Familial Hypercholesterolemia
SJ Chen, J Sanmiguel, M Lock, D McMenamin, C Draper, MP Limberis, SH Kassim, S Somanathan, P Bell, JC Johnston, DJ Rader, JM Wilson
Human Gene Therapy Clinical Development 2013
Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors
ND Staudt, M Jo, J Hu, JM Bristow, DP Pizzo, A Gaultier, SR VandenBerg, SL Gonias
Cancer research 2013
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
alanna strong, Qiurong Ding, Andrew Edmondson, John Millar, Katherine Sachs, Xiaoyu Li, Arthi Kumaravel, Margaret Ye Wang, ding ai, Liang Guo, Eric Alexander, David Nguyen, Sissel Lund-Katz, Michael C. Phillips, Carlos Morales, Alan R. Tall, Sekar Kathiresan, Edward A. Fisher, Kiran Musunuru, Daniel J. Rader
Journal of Clinical Investigation 2012
Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression
Z Li, T Ding, X Pan, Y Li, R Li, PE Sanders, MS Kuo, MM Hussain, G Cao, XC Jiang
The Journal of biological chemistry 2012
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
T Kanekiyo, CC Liu, M Shinohara, J Li, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
G Xu, CC Green, SE Fromholt, DR Borchelt
Alzheimer's research & therapy 2012
Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
A Laatsch, M Panteli, M Sornsakrin, B Hoffzimmer, T Grewal, J Heeren
PloS one 2012
Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice
A Yazdanyar, XC Jiang
Hepatology 2012
Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
PL Gordts, A Bartelt, SK Nilsson, W Annaert, C Christoffersen, LB Nielsen, J Heeren, AJ Roebroek
PloS one 2012
RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
S Zhang, X Zhou, RA Lang, F Guo
PloS one 2012
Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing
JA Larios, MP Marzolo
Frontiers in Biology 2012
Lactoferrin and its hydrolysate bind directly to the oleate-activated form of the lipolysis stimulated lipoprotein receptor
N Ahmad, JM Girardet, S Akbar, MC Lanhers, C Paris, FT Yen, C Corbier
FEBS Journal 2012
El metabolismo del colesterol: cada vez más complejo
J Sanhueza, R Valenzuela, A Valenzuela
Grasas y Aceites 2012
Knock Down of Low Density Lipoprotein Receptor-related Protein 1(Lrp1) by RNAi Inhibits The Commitment of C3H10T1/2 Pluripotent Stem Cells to Preadipocyte*: Knock Down of Low Density Lipoprotein Receptor-related Protein 1(Lrp1) by RNAi Inhibits The Commitment of C3H10T1/2 Pluripotent Stem Cells to Preadipocyte*
JW CHEN, L GUO
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 2012
The role of apolipoprotein A5 in obesity and the metabolic syndrome: Association of apoA5 with metabolic diseases
XY Zheng, SP Zhao, H Yan
Biological Reviews 2012
Macrophage LRP1 contributes to the clearance of von Willebrand factor
G Rastegarlari, JN Pegon, C Casari, S Odouard, AM Navarrete, N Saint-Lu, BJ van Vlijmen, P Legendre, OD Christophe, CV Denis, PJ Lenting
Blood 2012
Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia
JH Moon, HJ Kim, HM Kim, AH Yang, BW Lee, ES Kang, HC Lee, BS Cha
Journal of Molecular Endocrinology 2012
Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
PL Gordts, A Bartelt, SK Nilsson, W Annaert, C Christoffersen, LB Nielsen, J Heeren, AJ Roebroek, B He
PloS one 2012
Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
A Laatsch, M Panteli, M Sornsakrin, B Hoffzimmer, T Grewal, J Heeren, L Johannes
PloS one 2012
RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
S Zhang, X Zhou, RA Lang, F Guo, A Gaggar
PloS one 2012
Fate-tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Yann Malato, Syed Naqvi, Nina Schürmann, Raymond Ng, Bruce Wang, Joan Zape, Mark A Kay, Dirk Grimm, Holger Willenbring
Journal of Clinical Investigation 2011
Shedding of syndecan-1 from human hepatocytes alters VLDL clearance
Y Deng, EM Foley, JC Gonzales, PL Gordts, Y Li, JD Esko
Hepatology 2011
Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice*
JE Basford, L Wancata, SM Hofmann, RA Silva, WS Davidson, PN Howles, DY Hui
The Journal of biological chemistry 2011
Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway
SC Muratoglu, S Belgrave, AP Lillis, M Migliorini, S Robinson, E Smith, L Zhang, DK Strickland
PloS one 2011
Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin αMβ2
S Ranganathan, C Cao, J Catania, M Migliorini, L Zhang, DK Strickland
The Journal of biological chemistry 2011
Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins
M Matsuo, RB Campenot, DE Vance, K Ueda, JE Vance
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2011
Role for LAMP-2 in endosomal cholesterol transport
A Schneede, CK Schmidt, M Hölttä-Vuori, J Heeren, M Willenborg, J Blanz, M Domanskyy, B Breiden, S Brodesser, J Landgrebe, K Sandhoff, E Ikonen, P Saftig, EL Eskelinen
Journal of Cellular and Molecular Medicine 2011
Brown adipose tissue activity controls triglyceride clearance
A Bartelt, OT Bruns, R Reimer, H Hohenberg, H Ittrich, K Peldschus, MG Kaul, UI Tromsdorf, H Weller, C Waurisch, A Eychmüller, PL Gordts, F Rinninger, K Bruegelmann, B Freund, P Nielsen, M Merkel, J Heeren
Nature Medicine 2011
Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C high Monocytosis: Evidence That the Effects Are Not Apolipoprotein E Dependent
PG Yancey, Y Ding, D Fan, JL Blakemore, Y Zhang, L Ding, J Zhang, MR Linton, S Fazio
Circulation 2011
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system
Q Liu, J Zhang, C Zerbinatti, Y Zhan, BJ Kolber, J Herz, LJ Muglia, G Bu
PLoS Biology 2011
Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor
JH Moon, SB Kang, JS Park, BW Lee, ES Kang, CW Ahn, HC Lee, BS Cha
Metabolism 2011
Uptake of Dietary Retinoids at the Maternal-Fetal Barrier
L Wassef, L Quadro
The Journal of biological chemistry 2011
Pathophysiology of hypertriglyceridemia
HC Hassing, RP Surendran, HL Mooij, ES Stroes, M Nieuwdorp, GM Dallinga-Thie
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2011
Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
Q Liu, J Zhang, C Zerbinatti, Y Zhan, BJ Kolber, J Herz, LJ Muglia, G Bu, S O'Rahilly
PLoS Biology 2011
Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway
SC Muratoglu, S Belgrave, AP Lillis, M Migliorini, S Robinson, E Smith, L Zhang, DK Strickland, PH Reitsma
PloS one 2011
Uptake of Dietary Retinoids at the Maternal-Fetal Barrier: IN VIVO EVIDENCE FOR THE ROLE OF LIPOPROTEIN LIPASE AND ALTERNATIVE PATHWAYS
L Wassef, L Quadro
The Journal of biological chemistry 2011
Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin α M β 2: IDENTIFICATION OF BINDING SITES WITHIN α M β 2 FOR LRP1
S Ranganathan, C Cao, J Catania, M Migliorini, L Zhang, DK Strickland
The Journal of biological chemistry 2011
Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice
JE Basford, L Wancata, SM Hofmann, RA Silva, WS Davidson, PN Howles, DY Hui
The Journal of biological chemistry 2011
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family
M Dieckmann, MF Dietrich, J Herz
Biological Chemistry 2010
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration
Q Liu, J Trotter, J Zhang, MM Peters, H Cheng, J Bao, X Han, EJ Weeber, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation
PG Yancey, J Blakemore, L Ding, D Fan, CD Overton, Y Zhang, MR Linton, S Fazio
Arteriosclerosis, thrombosis, and vascular biology 2010
Cellular uptake of steroid carrier proteins—Mechanisms and implications
TE Willnow, A Nykjaer
Molecular and Cellular Endocrinology 2010
Recent insights into factors affecting remnant lipoprotein uptake
KJ Williams, K Chen
Current Opinion in Lipidology 2010
Sleisenger and Fordtran's Gastrointestinal and Liver Disease
C Högenauer, HF Hammer
Sleisenger and Fordtran's Gastrointestinal and Liver Disease 2010
Recent insights into factors affecting remnant lipoprotein uptake:
KJ Williams, K Chen
Current Opinion in Lipidology 2010
Syndecan-1, the Primary Heparan Sulfate Proteoglycan Mediating Hepatic Triglyceride-Rich Lipoprotein Clearance In Vivo
Kristin I. Stanford, Joseph R. Bishop, Erin M. Foley, Jon C. Gonzalez, Ingrid R. Niesman, Joseph L. Witztum, Jeffrey D. Esko
Journal of Clinical Investigation 2009
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway
RA Fuentealba, Q Liu, T Kanekiyo, J Zhang, G Bu
The Journal of biological chemistry 2009
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
C Zhang, J An, DK Strickland, M Yepes
The American Journal of Pathology 2009
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
A Laatsch, M Merkel, PJ Talmud, T Grewal, U Beisiegel, J Heeren
Atherosclerosis 2009
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
JJ Ludtke, AV Sokoloff, S Wong, G Zhang, DK Strickland, JA Wolff
Drug Delivery 2009
Smooth Muscle LDL Receptor-Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation
JE Basford, ZW Moore, L Zhou, J Herz, DY Hui
Arteriosclerosis, thrombosis, and vascular biology 2009
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
JC McCann, BN Ames
The American journal of clinical nutrition 2009
The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight
GM Dallinga-Thie, R Franssen, HL Mooij, ME Visser, HC Hassing, F Peelman, JJ Kastelein, M Péterfy, M Nieuwdorp
Atherosclerosis 2009
LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export
L Zhou, HY Choi, WP Li, F Xu, J Herz
PloS one 2009
The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?
PJ Babin, GF Gibbons
Progress in Lipid Research 2009
Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice
P Narvekar, MB Diaz, A Krones-Herzig, U Hardeland, D Strzoda, S Stöhr, M Frohme, S Herzig
Diabetes 2009
Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
I López-Soldado, M Avella, KM Botham
Metabolism: clinical and experimental 2009
Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels
Z Li, Y Li, M Chakraborty, Y Fan, HH Bui, DA Peake, MS Kuo, X Xiao, G Cao, XC Jiang
The Journal of biological chemistry 2009
Lycopene
L Rao, E Mackinnon, A Rao
Lycopene 2009
Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis
SM Reekmans, T Pflanzner, PL Gordts, S Isbert, P Zimmermann, W Annaert, S Weggen, AJ Roebroek, CU Pietrzik
Cellular and Molecular Life Sciences 2009
Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice
J Liu, H Zhang, Z Li, TK Hailemariam, M Chakraborty, K Jiang, D Qiu, HH Bui, DA Peake, MS Kuo, R Wadgaonkar, G Cao, XC Jiang
Arteriosclerosis, thrombosis, and vascular biology 2009
The DNA Damage Response: Implications on Cancer Formation and Treatment
KK Khanna, Y Shiloh
2009
Molecular processes that handle – and mishandle – dietary lipids
Kevin Jon Williams
Journal of Clinical Investigation 2008
Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes
IJ Goldberg, Y Hu, HL Noh, J Wei, LA Huggins, MG Rackmill, H Hamai, BN Reid, WS Blaner, LS Huang
Diabetes 2008
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
AP Lillis, LB van Duyn, JE Murphy-Ullrich, DK Strickland
Physiological reviews 2008
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis
MF Galliano, E Toulza, N Jonca, SL Gonias, G Serre, M Guerrin
PloS one 2008
Handbook of Prebiotics
F Guarner
Handbook of Prebiotics 2008
Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse
Z Yates, EJ Tarling, SC Langley-Evans, AM Salter
British Journal of Nutrition 2008
Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism
JR Bishop, KI Stanford, JD Esko
Current Opinion in Lipidology 2008
Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells
J Prawitt, A Niemeier, M Kassem, U Beisiegel, J Heeren
Experimental Cell Research 2008
Heparan Sulphate Biosynthesis and Disease
S Nadanaka, H Kitagawa
Journal of Biochemistry 2008
Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function
A Niemeier, D Niedzielska, R Secer, A Schilling, M Merkel, C Enrich, PC Rensen, J Heeren
Bone 2008
Binding of α2ML1 to the Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Reveals a New Role for LRP1 in the Human Epidermis
MF Galliano, E Toulza, N Jonca, SL Gonias, G Serre, M Guerrin, P Sommer
PloS one 2008
The hepatic uptake of VLDL in lrp − ldlr −/− vldlr −/− mice is regulated by LPL activity and involves proteoglycans and SR-BI
L Hu, CC van der Hoogt, SM Santo, R Out, KE Kypreos, BJ van Vlijmen, TJ van Berkel, JA Romijn, LM Havekes, KW van Dijk, PC Rensen
Journal of lipid research 2008
Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice
M Hoekstra, B Lammers, R Out, Z Li, MV Eck, TJ Berkel
Molecular Pharmaceutics 2008
Molecular Mechanisms of Parasite Invasion
BA Burleigh, D Soldati-Favre
2008
Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).
Navazesh M, Mulligan R, Karim R, Mack WJ, Ram S, Seirawan H, Greenspan J, Greenspan D, Phelan J, Alves M
Oral Diseases 2008
Preservation of VLDL remnant clearance attenuates the phenotype of autosomal recessive hypercholesterolemia
Christopher Jones, Rita Garuti1, Peter Michaely, Wei-Ping Li, Nobuyo Maeda, Jonathan C. Cohen, Joachim Herz, and Helen H. Hobbs
Journal of Clinical Investigation 2007
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
Jennifer M. MacArthur Joseph R. Bishop Kristin I. Stanford Lianchun Wang André Bensadoun Joseph L. Witztum Jeffrey D. Esko
Journal of Clinical Investigation 2007
Adipocyte LRP1 expression modulates postprandial lipid transport, glucose homeostasis, and adiposity
Susanna M. Hofmann, Li Zhou, Diego Perez-Tilve, Todd Greer, Erin Grant, Lauren Wancata, Andrew Thomas, Paul T. Pfluger, Joshua E. Basford, Dean Gilham Joachim Herz, Matthias H. Tschoep, David Y. Hui
Journal of Clinical Investigation 2007
Atherogenic remnant lipoproteins: trap, transfer, and internalization role for proteoglycans
Robert W. Mahley, Yadong Huang
Journal of Clinical Investigation 2007
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
Q Liu, CV Zerbinatti, J Zhang, HS Hoe, B Wang, SL Cole, J Herz, L Muglia, G Bu
Neuron 2007
Handbook of Experimental Pharmacology
HH Bock, J Herz, P May
Handbook of experimental pharmacology 2007
Protein Kinase C-α–Mediated Regulation of Low-Density Lipoprotein Receptor–Related Protein and Urokinase Increases Astrocytoma Invasion
S Amos, M Mut, CG diPierro, JE Carpenter, A Xiao, ZA Kohutek, GT Redpath, Y Zhao, J Wang, ME Shaffrey, IM Hussaini
Cancer research 2007
Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family
SK Nilsson, A Lookene, JA Beckstead, J Gliemann, RO Ryan, G Olivecrona
Biochemistry 2007
Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein
L Hu, N Bovenschen, LM Havekes, BJ van Vlijmen, JT Tamsma
Journal of Thrombosis and Haemostasis 2007
Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils
JS Perona, M Avella, KM Botham, V Ruiz-Gutierrez
British Journal of Nutrition 2007
Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions
MG Mameza, JM Lockard, E Zamora, M Hillefors, ZS Lavina, BB Kaplan
Journal of Neurochemistry 2007
Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
I Usynin, C Klotz, U Frevert
Cellular Microbiology 2007
Incorporation of lycopene into chylomicron remnant-like particles inhibits their uptake by HepG2 cells
F Bejta, M Napolitano, KM Botham, E Bravo
Life Sciences 2007
Avian apolipoprotein A-V binds to LDL receptor gene family members
A Dichlberger, LA Cogburn, J Nimpf, WJ Schneider
Journal of lipid research 2007
Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway
LC Wilsie, AM Gonzales, RA Orlando
Lipids in Health and Disease 2006
Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver
C Tamaki, S Ohtsuki, T Iwatsubo, T Hashimoto, K Yamada, C Yabuki, T Terasaki
Pharmaceutical Research 2006
Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes
LJ Raggatt, SC Jefcoat, I Choudhury, S Williams, M Tiku, NC Partridge
Osteoarthritis and Cartilage 2006
LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
S Azhar, S Medicherla, WJ Shen, Y Fujioka, LG Fong, E Reaven, AD Cooper
Journal of lipid research 2006
Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development
AJ Roebroek, S Reekmans, A Lauwers, N Feyaerts, L Smeijers, D Hartmann
Molecular and cellular biology 2006
Combined hyperlipidemia/hyperalphalipoproteinemia associated with premature spontaneous atherosclerosis in mice lacking hepatic lipase and low density lipoprotein receptor
D Barcat, A Amadio, A Palos-Pinto, D Daret, P Benlian, M Darmon, AM Bérard
Atherosclerosis 2006
Low-density lipoprotein receptor-related protein (LRP)-mediated clearance of activated blood coagulation co-factors and proteases: clearance mechanism or regulation?
DK Strickland, L Medved
Journal of Thrombosis and Haemostasis 2006
Functional Role of the Low-Density Lipoprotein Receptor-Related Protein in Alzheimer’s Disease
E Waldron, S Jaeger, CU Pietrzik
Neurodegenerative Diseases 2006
Genetics and molecular biology: Motive studies in mice – two NPXY motifs in the intracellular domain of lipoprotein receptor-related protein 1 exhibit differential importance during fetal development
JM Knisely, G Bu
Current Opinion in Lipidology 2006
Influencia de los factores genéticos y ambientales en el metabolismo lipídico y riesgo cardiovascular asociado al gen apoE
JA Moreno, J López-Miranda, F Pérez-Jiménez
Medicina Clínica 2006
Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism
NS Raikwar, WK Cho, RF Bowen, MA Deeg
American journal of physiology. Endocrinology and metabolism 2006
Uptake of triacylglycerol-rich lipoproteins of differing triacylglycerol molecular species and unsaponifiable content by liver cells
JS Perona, M Avella, KM Botham, V Ruiz-Gutierrez
British Journal of Nutrition 2006
Schoenheimer Effect explained - Feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
Luke J. Engelking, Guosheng Liang, Robert E. Hammer, Kiyosumi Takaishi, Hiroshi Kuriyama, Bret M. Evers, Wei-Ping Li, Jay D. Horton, Joseph L. Goldstein, and Michael S. Brown
Journal of Clinical Investigation 2005
Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure
C Kim, ND Vaziri
Kidney International 2005
Treatment of dyslipidaemia in HIV-infected persons
O Manuel, R Thiébaut, R Darioli, PE Tarr
Expert Opinion on Pharmacotherapy 2005
Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
Kevin Jon Williams, Ming-Lin Liu, Yanqing Zhu, Xiangsheng Xu, William R Davidson, Peter McCue, Kumar Sharma
Diabetes 2005
Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Controls Endocytosis and c-CBL-mediated Ubiquitination of the Platelet-derived Growth Factor Receptor β (PDGFRβ)
Y Takayama, P May, RG Anderson, J Herz
The Journal of biological chemistry 2005
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice
KE Kypreos, VI Zannis
Journal of lipid research 2005
Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
SM Santo, PC Rensen, JR Goudriaan, A Bensadoun, N Bovenschen, PJ Voshol, LM Havekes, BJ van Vlijmen
Journal of lipid research 2005
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
J Ruiz, D Kouiavskaia, M Migliorini, S Robinson, EL Saenko, N Gorlatova, D Li, D Lawrence, BT Hyman, KH Weisgraber, DK Strickland
Journal of lipid research 2005
Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy
S Kim, CH Kim, ND Vaziri
American journal of physiology. Endocrinology and metabolism 2005
LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo
N Bovenschen, K Mertens, L Hu, LM Havekes, BJ van Vlijmen
Blood 2005
Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase
SJ Lee, S Kadambi, KC Yu, C David, S Azhar, AD Cooper, SY Choi
Journal of lipid research 2004
Hepatic low-density lipoprotein receptor–related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
SM Santo, NM Pires, LS Boesten, G Gerritsen, N Bovenschen, KW van Dijk, JW Jukema, HM Princen, A Bensadoun, WP Li, J Herz, LM Havekes, BJ van Vlijmen
Blood 2004
Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice
P May, A Rohlmann, HH Bock, K Zurhove, JD Marth, ED Schomburg, JL Noebels, U Beffert, JD Sweatt, EJ Weeber, J Herz
Molecular and cellular biology 2004
A novel ARH splice site mutation in a Mexican kindred with autosomal recessive hypercholesterolemia
S Canizales-Quinteros, CA Aguilar-Salinas, A Huertas-Vázquez, ML Ordóñez-Sánchez, M Rodríguez-Torres, JL Venturas-Gallegos, L Riba, S Ramírez-Jimenez, R Salas-Montiel, G Medina-Palacios, L Robles-Osorio, A Miliar-García, L Rosales-León, BH Ruiz-Ordaz, A Zentella-Dehesa, A Ferré-DAmare, FJ Gómez-Pérez, MT Tusié-Luna
Human Genetics 2004
Expression of LRP1 by Human Osteoblasts: A Mechanism for the Delivery of Lipoproteins and Vitamin K1 to Bone
A Niemeier, M Kassem, K Toedter, D Wendt, W Ruether, U Beisiegel, J Heeren
Journal of Bone and Mineral Research 2004
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation
S Mesli, S Javorschi, AM Bérard, M Landry, H Priddle, D Kivlichan, AJ Smith, FT Yen, BE Bihain, M Darmon
European Journal of Biochemistry 2004
Generation of a Mouse Expressing a Conditional Knockout of the Hepatocyte Growth Factor Gene: Demonstration of Impaired Liver Regeneration
D Phaneuf, AD Moscioni, C Leclair, SE Raper, JM Wilson
DNA and Cell Biology 2004
Genetic determinants of obesity-related lipid traits
GE Sonnenberg, GR Krakower, LJ Martin, M Olivier, AE Kwitek, AG Comuzzie, J Blangero, AH Kissebah
Journal of lipid research 2004
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
NS Chung, KM Wasan
Advanced Drug Delivery Reviews 2004
Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by ?MHC-Cre-mediated recombination
BV Skryabin, R Holtwick, L Fabritz, MN Kruse, I Veltrup, J Stypmann, P Kirchhof, K Sabrane, A Bubikat, M Vo?, M Kuhn
genesis 2004
Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
N Bovenschen, KW Dijk, LM Havekes, K Mertens, BJ Vlijmen
British Journal of Haematology 2004
HIV–Associated Lipodystrophy: Pathogenesis, Prognosis, Treatment, and Controversies
P Koutkia, S Grinspoon
Annual Review of Medicine 2004
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation: LSR gene and protein expression
S Mesli, S Javorschi, AM Bérard, M Landry, H Priddle, D Kivlichan, AJ Smith, FT Yen, BE Bihain, M Darmon
European Journal of Biochemistry 2004
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development
HH Petersen, J Hilpert, C Jacobsen, A Lauwers, AJ Roebroek, TE Willnow
FEBS Letters 2004
Cre-mediated conditional gene targeting to understand liver functions
D Metzger, P Chambon
Drug Discovery Today: Disease Models 2004
Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation
J Heeren, T Grewal, A Laatsch, N Becker, F Rinninger, KA Rye, U Beisiegel
The Journal of biological chemistry 2004
A Binding Site for Highly Sulfated Heparan Sulfate Is Identified in the N Terminus of the Circumsporozoite Protein: SIGNIFICANCE FOR MALARIAL SPOROZOITE ATTACHMENT TO HEPATOCYTES
JB Ancsin, R Kisilevsky
The Journal of biological chemistry 2004
Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor
C Knouff, O Briand, S Lestavel, V Clavey, M Altenburg, N Maeda
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2004
Obesity and post-prandial lipid metabolism. Feast or famine?
IJ Martins, TG Redgrave
The Journal of Nutritional Biochemistry 2004
Transgenic Models in Pharmacology
S Offermanns, L Hein
2004
Chylomicron remnants and oxidised low density lipoprotein have differential effects on the expression of mRNA for genes involved in human macrophage foam cell formation
KV Batt, L Patel, KM Botham, KE Suckling
Journal of Molecular Medicine 2004
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
P Boucher, M Gotthardt, WP Li, RG Anderson, J Herz
Science 2003
Mouse models as tools for dissecting disorders of lipoprotein metabolism
P Marschang, J Herz
Seminars in Cell & Developmental Biology 2003
Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling
DK Strickland, S Ranganathan
Journal of Thrombosis and Haemostasis 2003
Dyslipidemia in the era of HIV protease inhibitors
JH Stein
Progress in Cardiovascular Diseases 2003
Distribution of apolipoprotein E among lipoprotein fractions in the lactating cow
Y Takahashi, F Itoh, T Oohashi, T Miyamoto
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2003
Low Density Lipoprotein Receptor-related Protein-mediated Membrane Translocation of 12/15-Lipoxygenase Is Required for Oxidation of Low Density Lipoprotein by Macrophages
H Zhu, Y Takahashi, W Xu, H Kawajiri, T Murakami, M Yamamoto, S Iseki, T Iwasaki, H Hattori, T Yoshimoto
The Journal of biological chemistry 2003
The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism
LC Wilsie, RA Orlando
The Journal of biological chemistry 2003
On the Physiological Importance of Endoproteolysis of C AAX Proteins: HEART-SPECIFIC RCE1 KNOCKOUT MICE DEVELOP A LETHAL CARDIOMYOPATHY
MO Bergo, HD Lieu, BJ Gavino, P Ambroziak, JC Otto, PJ Casey, QM Walker, SG Young
The Journal of biological chemistry 2003
Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization
J Heeren, T Grewal, A Laatsch, D Rottke, F Rinninger, C Enrich, U Beisiegel
The Journal of biological chemistry 2003
Endocytosis of Hepatic Lipase and Lipoprotein Lipase into Rat Liver Hepatocytes in Vivo Is Mediated by the Low Density Lipoprotein Receptor-related Protein
M Vergés, A Bensadoun, J Herz, JD Belcher, RJ Havel
The Journal of biological chemistry 2003
The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes
A Makarova, I Mikhailenko, TH Bugge, K List, DA Lawrence, DK Strickland
The Journal of biological chemistry 2003
The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient “apoB-48-only” and “apoB-100-only” mice
HL Dichek, K Qian, N Agrawal
Journal of lipid research 2003
Modulation of the LDL receptor and LRP levels by HIV protease inhibitors
H Tran, S Robinson, I Mikhailenko, DK Strickland
Journal of lipid research 2003
Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice
A Schneider, Y Zhang, Y Guan, LS Davis, MD Breyer
American journal of physiology. Renal physiology 2003
Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor–related protein deficiency
N Bovenschen, J Herz, JM Grimbergen, PJ Lenting, LM Havekes, K Mertens, BJ van Vlijmen
Blood 2003
LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease
AC Sposito, RD Santos, W Hueb, LI Ventura, CC Vinagre, JA Ramires, RC Maranhão
Atherosclerosis 2002
LIPOPROTEINRECEPTORS IN THENERVOUSSYSTEM
J Herz, HH Bock
Annual Review of Biochemistry 2002
The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state
X Zheng, R Rivabene, C Cavallari, M Napolitano, M Avella, E Bravo, KM Botham
Free radical biology & medicine 2002
LDL-receptors expression in HIV-infected patients: relations to antiretroviral therapy, hormonal status, and presence of lipodystrophy
JM Petit, M Duong, L Duvillard, E Florentin, H Portier, G Lizard, JM Brun, P Gambert, B Verges
European Journal of Clinical Investigation 2002
Recent advances in inducible expression in transgenic mice
C Albanese, J Hulit, T Sakamaki, RG Pestell
Seminars in Cell & Developmental Biology 2002
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
T Fujino, H Asaba, MJ Kang, Y Ikeda, H Sone, S Takada, DH Kim, RX Ioka, M Ono, H Tomoyori, M Okubo, T Murase, A Kamataki, J Yamamoto, K Magoori, S Takahashi, Y Miyamoto, H Oishi, M Nose, M Okazaki, S Usui, K Imaizumi, M Yanagisawa, J Sakai, TT Yamamoto
Proceedings of the National Academy of Sciences 2002
Conditional alleles in mice: Practical considerations for tissue-specific knockouts
KM Kwan
genesis 2002
Diverse roles for the LDL receptor family
DK Strickland, SL Gonias, WS Argraves
Trends in Endocrinology & Metabolism 2002
Variation in the lipoprotein receptor-related protein, α2-macroglobulin and lipoprotein receptor-associatedprotein genes in relation to plasma lipid levels and riskof early myocardial infarction
P González, R Álvarez, JR Reguero, A Batalla, V Álvarez, A Cortina, GI Cubero, M García-Castro, E Coto
Coronary Artery Disease 2002
L IPOPROTEIN R ECEPTORS IN THE N ERVOUS S YSTEM
J Herz, HH Bock
Annual Review of Biochemistry 2002
Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle
P Boucher, PH Ducluzeau, P Davelu, F Andreelli, P Vallier, JP Riou, M Laville, H Vidal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2002
Regulation of Rac1 activation by the low density lipoprotein receptor–related protein
Z Ma, KS Thomas, DJ Webb, R Moravec, AM Salicioni, WM Mars, SL Gonias
The Journal of Cell Biology 2002
Apolipoprotein B Metabolism: Tracer Kinetics, Models, and Metabolic Studies
JR Burnett, PH Barrett
Critical Reviews in Clinical Laboratory Sciences 2002
Hypomorphic Apolipoprotein E Mice: A NEW MODEL OF CONDITIONAL GENE REPAIR TO EXAMINE APOLIPOPROTEIN E-MEDIATED METABOLISM
RL Raffaı̈, KH Weisgraber
The Journal of biological chemistry 2002
Of mice and models: improved animal models for biomedical research
E Bockamp, M Maringer, C Spangenberg, S Fees, S Fraser, L Eshkind, F Oesch, B Zabel
Physiological genomics 2002
New Perspectives on Atherogenesis: Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism
HN Ginsberg
Circulation 2002
Differential Role of Heparan Sulfate Proteoglycans on Aggregated LDL Uptake in Human Vascular Smooth Muscle Cells and Mouse Embryonic Fibroblasts
V Llorente-Cortés, M Otero-Viñas, L Badimon
Arteriosclerosis, thrombosis, and vascular biology 2002
Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux
TE Akiyama, S Sakai, G Lambert, CJ Nicol, K Matsusue, S Pimprale, YH Lee, M Ricote, CK Glass, HB Brewer, FJ Gonzalez
Molecular and cellular biology 2002
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
C Vasandani, AI Kafrouni, A Caronna, Y Bashmakov, M Gotthardt, JD Horton, DK Spady
Journal of lipid research 2002
LRP: A multifunctional scavenger and signaling receptor
Joachim Herz, Dudley K. Strickland
Journal of Clinical Investigation 2001
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
J Yang, JL Goldstein, RE Hammer, YA Moon, MS Brown, JD Horton
Proceedings of the National Academy of Sciences 2001
Protection from obesity in mice lacking the VLDL receptor
JR Goudriaan, PJ Tacken, VE Dahlmans, MJ Gijbels, KW van Dijk, LM Havekes, MC Jong
Arteriosclerosis, thrombosis, and vascular biology 2001
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
M Matsuda, BS Korn, RE Hammer, YA Moon, R Komuro, JD Horton, JL Goldstein, MS Brown, I Shimomura
Genes & development 2001
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis
MV Eck
Atherosclerosis 2001
The LDL Receptor Gene Family
J Herz
Neuron 2001
Intracellular metabolism of triglyceride-rich lipoproteins
J Heeren, U Beisiegel
Current Opinion in Lipidology 2001
Molecular mechanisms of apolipoprotein B mRNA editing
S Anant, NO Davidson
Current Opinion in Lipidology 2001
Antiretroviral therapy-associated hyperlipidaemia in HIV disease
V Mooser, A Carr
Current Opinion in Lipidology 2001
The differential hepatic uptake of chylomicron remnants of different fatty acid composition is not mediated by hepatic lipase
MS Lambert, MA Avell, Y Berhane, E Shervill, KM Botham
British Journal of Nutrition 2001
The fatty acid composition of chylomicron remnants influences their binding and internalization by isolated hepatocytes
MS Lambert, ML Avella, Y Berhane, E Shervill, KM Botham
European Journal of Biochemistry 2001
Germ cell specific promoter drives ectopic transgene expression during embryogenesis
B Bhullar, JV Schmidt, T Truong, D Rancourt, FA van der Hoorn
Molecular Reproduction and Development 2001
Pregnancy Zone Protein–Tissue-Type Plasminogen Activator Complexes Bind to Low-Density Lipoprotein Receptor-Related Protein (LRP)
MC Sánchez, GA Chiabrando, MA Vides
Archives of Biochemistry and Biophysics 2001
Hyperlipidemia and inhibitors of HIV protease:
O Distler, DA Cooper, RJ Deckelbaum, SL Sturley
Current Opinion in Clinical Nutrition and Metabolic Care 2001
Stimulation of the in Vivo Production of Very Low Density Lipoproteins by Apolipoprotein E Is Independent of the Presence of the Low Density Lipoprotein Receptor
B Teusink, AR Mensenkamp, H der Boom, F Kuipers, KW van Dijk, LM Havekes
The Journal of biological chemistry 2001
Recognition of α 2 -Macroglobulin by the Low Density Lipoprotein Receptor-related Protein Requires the Cooperation of Two Ligand Binding Cluster Regions
I Mikhailenko, FD Battey, M Migliorini, JF Ruiz, K Argraves, M Moayeri, DK Strickland
The Journal of biological chemistry 2001
Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit: ITS OBLIGATE REQUIREMENT FOR THE STABLE EXPRESSION OF OLIGOMERIC RECEPTOR
R Tozawa, S Ishibashi, J Osuga, K Yamamoto, H Yagyu, K Ohashi, Y Tamura, N Yahagi, Y Iizuka, H Okazaki, K Harada, T Gotoda, H Shimano, S Kimura, R Nagai, N Yamada
The Journal of biological chemistry 2001
Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo
J Heeren, T Grewal, S Jäckle, U Beisiegel
The Journal of biological chemistry 2001
Metabolism of Chylomicron Cholesterol is Delayed by Estrogen. An In Vivo Study in the Rat
E Bravo, A Cantafora, M Avella, KM Botham
Experimental biology and medicine (Maywood, N.J.) 2001
Conditional control of gene expression in the mouse
M Lewandoski
Nature Reviews Genetics 2001
Neurodegenerative Disorders: Loss of Function Through Gain of Function
K Beyreuther, Y Christen, CL Masters
2001
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice
M Kawashiri, Y Zhang, D Usher, M Reilly, E Puré, DJ Rader
Journal of lipid research 2001
Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface
JW Burgess, YL Marcel
Journal of lipid research 2001
Delayed catabolism of apoB48 lipoproteins in streptozotocin-treated mice: evidence that diabetes leads to a selective alteration in the heparan sulfate proteoglycan pathway of chylomicron remnant degradation
Tetsu Ebara, Karin Conde, Yuko Kako, Yan Xu, Rajasekhar Ramakrishnan, Ira J. Goldberg, Neil S. Shachter
Journal of Clinical Investigation 2000
The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding
FH de Man, F Beer, A der Laarse, H Jansen, JA Leuven, JH Souverijn, TF Vroom, SC Schoormans, JC Fruchart, LM Havekes, AH Smelt
Atherosclerosis 2000
Responses to eating: lipoproteins, lipolytic products and atherosclerosis
IJ Goldberg, Y Kako, EP Lutz
Current Opinion in Lipidology 2000
Les animaux génétiquement modifiésÉtude du transport des lipides et de l'athérosclérose
N Baroukh, L Vergnes, M Aostos, M Mzakin, A Ochoa
Annales de l'Institut Pasteur/Actualités 2000
Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein
P Marshall, A Rohlmann, V Nussenzweig, J Herz, P Sinnis
Molecular and Biochemical Parasitology 2000
Spermatocyte-Specific Gene Excision by Targeted Expression of Cre Recombinase
H Ando, Y Haruna, J Miyazaki, M Okabe, Y Nakanishi
Biochemical and Biophysical Research Communications 2000
Cellular signalling by lipoprotein receptors
J Herz, M Gotthardt, TE Willnow
Current Opinion in Lipidology 2000
Lipodystrophy Syndrome in HIV Infection
GM Behrens, M Stoll, RE Schmidt
Drug Safety 2000
Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased
C Xie, DK Burns, SD Turley, JM Dietschy
Journal of Neuropathology and Experimental Neurology 2000
Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein Have Nonoverlapping Functions in Vivo
K Kawano, SC Qin, M Lin, AR Tall, X Jiang
The Journal of biological chemistry 2000
Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2
Z Yang, DK Strickland, P Bornstein
The Journal of biological chemistry 2000
Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP): EVIDENCE THAT LRP CONTRIBUTES TO THE PATHOGENESIS OF ALZHEIMER'S DISEASE
PG Ulery, J Beers, I Mikhailenko, RE Tanzi, GW Rebeck, BT Hyman, DK Strickland
The Journal of biological chemistry 2000
Uptake of Lipoproteins for Axonal Growth of Sympathetic Neurons
EI de Chaves, DE Vance, RB Campenot, RS Kiss, JE Vance
The Journal of biological chemistry 2000
Perlecan Heparan Sulfate Proteoglycan: A NOVEL RECEPTOR THAT MEDIATES A DISTINCT PATHWAY FOR LIGAND CATABOLISM
IV Fuki, RV Iozzo, KJ Williams
The Journal of biological chemistry 2000
Increased LDL Cholesterol and Atherosclerosis in LDL Receptor–Deficient Mice With Attenuated Expression of Scavenger Receptor B1
D Huszar, ML Varban, F Rinninger, R Feeley, T Arai, V Fairchild-Huntress, MJ Donovan, AR Tall
Arteriosclerosis, thrombosis, and vascular biology 2000
Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E
KC Yu, Y Jiang, W Chen, AD Cooper
Journal of lipid research 2000
Conditional Disruption of the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) Gene Leads to Loss of Target Gene Induction by the Aryl Hydrocarbon Receptor and Hypoxia-Inducible Factor 1α
S Tomita, CJ Sinal, SH Yim, FJ Gonzalez
Molecular Endocrinology 2000
A Novel Low-Density Lipoprotein Receptor-Related Protein Mediating Cellular Uptake of Apolipoprotein E-Enriched β-VLDL in Vitro ,
T Sugiyama, H Kumagai, Y Morikawa, Y Wada, A Sugiyama, K Yasuda, N Yokoi, S Tamura, T Kojima, T Nosaka, E Senba, S Kimura, T Kadowaki, T Kodama, T Kitamura
Biochemistry 2000
Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages
N Herijgers, MV Eck, SJ Korporaal, PM Hoogerbrugge, TJ Berkel
Journal of lipid research 2000
Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice
IJ Martins, E Hone, C Chi, U Seydel, RN Martins, TG Redgrave
Journal of lipid research 2000
Lipodystrophy Syndrome in HIV Infection: What is it, What Causes it and How Can it Be Managed?
GM Behrens, M Stoll, RE Schmidt
Drug Safety 2000
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
M Raabe, MM Véniant, MA Sullivan, CH Zlot, J Björkegren, LB Nielsen, JS Wong, RL Hamilton, SG Young
Journal of Clinical Investigation 1999
Macrophages, lipoprotein metabolism, and atherosclerosis
MR Linton, S Fazio
Current Opinion in Lipidology 1999
Construction and in Vitro Functional Evaluation of a Low-Density Lipoprotein Receptor/Transferrin Fusion Protein as a Therapeutic Tool for Familial Hypercholesterolemia
F Parise, L Simone, MA Croce, M Ghisellini, R Battini, S Borghi, R Tiozzo, S Ferrari, S Calandra, S Ferrari
Human Gene Therapy 1999
Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
MC Jong, KW van Dijk, VE Dahlmans, HV der Boom, K Kobayashi, K Oka, G Siest, L Chan, MH Hofker, LM Havekes
Biochemical Journal 1999
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
K Sjögren, JL Liu, K Blad, S Skrtic, O Vidal, V Wallenius, D LeRoith, J Törnell, OG Isaksson, JO Jansson, C Ohlsson
Proceedings of the National Academy of Sciences 1999
ROLE OF THE ENTEROHEPATIC CIRCULATION OF BILE SALTS IN LIPOPROTEIN METABOLISM
AD Cooper
Gastroenterology Clinics of North America 1999
The low-density lipoprotein receptor family: Genetics, function, and evolution
WJ Schneider, J Nimpf, C Brandes, M Drexler
Current Atherosclerosis Reports 1999
Genetically modified animals in pharmacological research: future trends
U Rudolph, H Möhler
European Journal of Pharmacology 1999
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
MR Linton, S Fazio
Current Opinion in Lipidology 1999
Somatic gene therapy for dyslipidemias
M Belalcazar, L Chan
Journal of Laboratory and Clinical Medicine 1999
Liver gene disruptions: winners by KO?
AJ Smith, PJ Ronald, O Elferink
Journal of Hepatology 1999
An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
BJ van Vlijmen, A Rohlmann, ST Page, A Bensadoun, IS Bos, TJ van Berkel, LM Havekes, J Herz
The Journal of biological chemistry 1999
Characterization of the Soluble Form of the Low Density Lipoprotein Receptor-Related Protein (LRP)
KA Quinn, VJ Pye, YP Dai, CN Chesterman, DA Owensby
Experimental Cell Research 1999
Recycling of Apolipoprotein E in Mouse Liver
S Fazio, MR Linton, AH Hasty, LL Swift
The Journal of biological chemistry 1999
Molecular Cloning of a Lipolysis-stimulated Remnant Receptor Expressed in the Liver
FT Yen, M Masson, N Clossais-Besnard, P André, JM Grosset, L Bougueleret, JB Dumas, O Guerassimenko, BE Bihain
The Journal of biological chemistry 1999
Postprandial lipoprotein metabolism and atherosclerosis
F Karpe
Journal of Internal Medicine 1999
Lipoprotein receptors: new roles for ancient proteins
TE Willnow, A Nykjaer, J Herz
Nature Cell Biology 1999
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein
C Xie, SD Turley, PG Pentchev, JM Dietschy
American journal of physiology. Endocrinology and metabolism 1999
Hyperlipidemia of ApoE2(Arg 158 -Cys) and ApoE3-Leiden Transgenic Mice Is Modulated Predominantly by LDL Receptor Expression
KW van Dijk, BJ van Vlijmen, MP de Winther, B van t Hof, A van der Zee, H van der Boom, LM Havekes, MH Hofker
Arteriosclerosis, thrombosis, and vascular biology 1999
Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites
M Orth, W Weng, H Funke, A Steinmetz, G Assmann, M Nauck, J Dierkes, A Ambrosch, KH Weisgraber, RW Mahley, H Wieland, C Luley
Arteriosclerosis, thrombosis, and vascular biology 1999
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
RW Mahley, ZS Ji
Journal of lipid research 1999
In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
KW van Dijk, BJ van Vlijmen, HB van't Hof, A van der Zee, S Santamarina-Fojo, TJ van Berkel, LM Havekes, MH Hofker
Journal of lipid research 1999
Evaluation of the components of the chylomicron remnant removal mechanism by use of the isolated perfused mouse liver
KC Yu, Y Jiang, W Chen, AD Cooper
Journal of lipid research 1999
Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models
KW van Dijk, MH Hofker, LM Havekes
Current Atherosclerosis Reports 1999
Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E
J Osuga, M Yonemoto, N Yamada, H Shimano, H Yagyu, K Ohashi, K Harada, T Kamei, Y Yazaki, S Ishibashi
Journal of Clinical Investigation 1998
Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
MF Linton, AH Hasty, VR Babaev, S Fazio
Journal of Clinical Investigation 1998
Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice
MM Véniant, CH Zlot, RL Walzem, V Pierotti, R Driscoll, D Dichek, J Herz, SG Young
Journal of Clinical Investigation 1998
The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
S Santamarina-Fojo, C Haudenschild, M Amar
Current Opinion in Lipidology 1998
Receptor and non-receptor mediated uptake of chylomicron remnants by the liver
RJ Havel
Atherosclerosis 1998
A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
L Powell-Braxton, M Véniant, RD Latvala, KI Hirano, WB Won, J Ross, N Dybdal, CH Zlot, SG Young, NO Davidson
Nature Medicine 1998
Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP)
T Hiesberger, S Hüttler, A Rohlmann, W Schneider, K Sandhoff, J Herz
The EMBO Journal 1998
Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein
L Goretzki, BM Mueller
Biochemical Journal 1998
State of the art: Atherosclerosis in a limited edition
DJ Rader, GA FitzGerald
Nature Medicine 1998
The lipolysis stimulated receptor: a gene at last
BE Bihain, FT Yen
Current Opinion in Lipidology 1998
Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
JG Neels, IR Horn, BM Berg, H Pannekoek, AJ Zonneveld
Fibrinolysis and Proteolysis 1998
Studies in Interface Science
R Herold, R Dewitz, S Schürch, U Pison
Studies in Interface Science 1998
A Gene-targeted Mouse Model for Familial Hypobetalipoproteinemia: LOW LEVELS OF APOLIPOPROTEIN B mRNA IN ASSOCIATION WITH A NONSENSE MUTATION IN EXON 26 OF THE APOLIPOPROTEIN B GENE
E Kim, P Ambroziak, MM Véniant, RL Hamilton, SG Young
The Journal of biological chemistry 1998
Review
M Epstein
Renal Failure 1996

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