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Citations to this article

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?
Y Zhou, … , M Wheelock, C H Damsky
Y Zhou, … , M Wheelock, C H Damsky
Published May 1, 1997
Citation Information: J Clin Invest. 1997;99(9):2139-2151. https://doi.org/10.1172/JCI119387.
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Research Article Article has an altmetric score of 15

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

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Abstract

Establishment of the human placenta requires that fetal cytotrophoblast stem cells in anchoring chorionic villi become invasive. These cytotrophoblasts aggregate into cell columns and invade both the uterine interstitium and vasculature, anchoring the fetus to the mother and establishing blood flow to the placenta. Cytotrophoblasts colonizing spiral arterioles replace maternal endothelium as far as the first third of the myometrium. We show here that differentiating cytotrophoblasts transform their adhesion receptor phenotype so as to resemble the endothelial cells they replace. Cytotrophoblasts in cell columns show reduced E-cadherin staining and express VE-(endothelial) cadherin, platelet-endothelial adhesion molecule-1, vascular endothelial adhesion molecule-1, and alpha-4-integrins. Cytotrophoblasts in the uterine interstitium and maternal vasculature continue to express these receptors, and, like endothelial cells during angiogenesis, also stain for alphaVbeta3. In functional studies, alphaVbeta3 and VE-cadherin enhance, while E-cadherin restrains, cytotrophoblast invasiveness. Cytotrophoblasts expressing alpha4 integrins bound immobilized VCAM-1 in vitro, suggesting that this receptor-pair could mediate cytotrophoblast-endothelium or cytotrophoblast-cytotrophoblast interactions in vivo, during endovascular invasion. In the pregnancy disorder preeclampsia, in which endovascular invasion remains superficial, cytotrophoblasts fail to express most of these endothelial markers (Zhou et al., 1997. J. Clin. Invest. 99:2152-2164.), suggesting that this adhesion phenotype switch is required for successful endovascular invasion and normal placentation.

Authors

Y Zhou, S J Fisher, M Janatpour, O Genbacev, E Dejana, M Wheelock, C H Damsky

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1995 1994 1991 Total
Citations: 3 7 11 14 15 24 22 22 29 23 26 28 36 20 25 24 30 35 31 34 35 32 34 24 23 30 23 16 4 1 1 1 683
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Citations to this article in year 2016 (23)

Title and authors Publication Year
Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia
B LaMarca, LM Amaral, AC Harmon, DC Cornelius, JL Faulkner, MW Cunningham
Current Hypertension Reports 2016
Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction
T Tomimatsu, K Mimura, M Endo, K Kumasawa, T Kimura
Hypertension Research 2016
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
M Pinto, P Sotomayor, G Carrasco-Avino, A Corvalan, G Owen
International journal of molecular sciences 2016
Notch1 controls development of the extravillous trophoblast lineage in the human placenta
S Haider, G Meinhardt, L Saleh, C Fiala, J Pollheimer, M Knöfler
Proceedings of the National Academy of Sciences 2016
Local and systemic factors and implantation: what is the evidence?
C Fox, S Morin, JW Jeong, RT Scott, BA Lessey
Fertility and Sterility 2016
Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission
T Tabata, M Petitt, H Puerta-Guardo, D Michlmayr, C Wang, J Fang-Hoover, E Harris, L Pereira
Cell Host & Microbe 2016
Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
P Chedraui, EJ Solís, FR Pérez-López, F Schatz, U Kayisli, GS Escobar, R Loja-Chango, L Hidalgo, CJ Lockwood
Journal of Perinatal Medicine 2016
Increased expression of fatty acid binding protein 4 in preeclamptic Placenta and its relevance to preeclampsia
Y Yan, H Peng, P Wang, H Wang, M Dong
Placenta 2016
Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta
HR Kohan-Ghadr, L Kadam, C Jain, DR Armant, S Drewlo
Cell adhesion & migration 2016
Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic milieu in cultured cytotrophoblast cells
C Cawyer, SH Afroze, N Drever, S Allen, R Jones, DC Zawieja, T Kuehl, MN Uddin
Hypertension in Pregnancy 2016
First trimester trophoblasts forming endothelial-like tubes in vitro emulate a ‘blood vessel development’ gene expression profile
AR Highet, S Buckberry, BT Mayne, SM Khoda, T Bianco-Miotto, CT Roberts
Gene Expression Patterns 2016
Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation
O Genbacev, N Larocque, K Ona, A Prakobphol, T Garrido-Gomez, M Kapidzic, A Bárcena, M Gormley, SJ Fisher
Human Reproduction 2016
Intrauterine trophoblast migration: A comparative view of humans and rodents
JF Silva, R Serakides
Cell adhesion & migration 2016
Tumor-homing peptides as tools for targeted delivery of payloads to the placenta
A King, C Ndifon, S Lui, K Widdows, VR Kotamraju, L Agemy, T Teesalu, JD Glazier, F Cellesi, N Tirelli, JD Aplin, E Ruoslahti, LK Harris
Science Advances 2016
Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements
A Chatterjee, EC Macaulay, EJ Rodger, PA Stockwell, MF Parry, HE Roberts, TL Slatter, NA Hung, CJ Devenish, IM Morison
G3: Genes|Genomes|Genetics 2016
Acute kidney injury in pregnancy
C Praveen, A Kaul, RK Sharma
Clinical Queries Nephrology 2016
Macrophage polarisation affects their regulation of trophoblast behaviour
RJ Buckley, GS Whitley, IE Dumitriu, JE Cartwright
Placenta 2016
Advances in Experimental Medicine and Biology
C Bosco, E Díaz
Advances in experimental medicine and biology 2016
Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells
AR Lorenzon-Ojea, CR Guzzo, M Kapidzic, SJ Fisher, E Bevilacqua
Biology of reproduction 2016
Fetal microchimerism and prenatal diagnostic of genetic disorders
TM Lutsenko
Cell and Organ Transplantology 2016
Establishment of the Human Uteroplacental Circulation: A Historical Perspective
K Degner, RR Magness, DM Shah
Reproductive sciences (Thousand Oaks, Calif.) 2016
Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion: SYDE1 regulates placental development
HF Lo, CY Tsai, CP Chen, LJ Wang, YS Lee, CY Chen, CT Liang, ML Cheong, H Chen
The Journal of Pathology 2016
Obstetrie en gynaecologie
MJ Heineman, JL Evers, LF Massuger, EA Steegers
2016

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