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Citations to this article

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?
Y Zhou, … , M Wheelock, C H Damsky
Y Zhou, … , M Wheelock, C H Damsky
Published May 1, 1997
Citation Information: J Clin Invest. 1997;99(9):2139-2151. https://doi.org/10.1172/JCI119387.
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Research Article Article has an altmetric score of 15

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

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Abstract

Establishment of the human placenta requires that fetal cytotrophoblast stem cells in anchoring chorionic villi become invasive. These cytotrophoblasts aggregate into cell columns and invade both the uterine interstitium and vasculature, anchoring the fetus to the mother and establishing blood flow to the placenta. Cytotrophoblasts colonizing spiral arterioles replace maternal endothelium as far as the first third of the myometrium. We show here that differentiating cytotrophoblasts transform their adhesion receptor phenotype so as to resemble the endothelial cells they replace. Cytotrophoblasts in cell columns show reduced E-cadherin staining and express VE-(endothelial) cadherin, platelet-endothelial adhesion molecule-1, vascular endothelial adhesion molecule-1, and alpha-4-integrins. Cytotrophoblasts in the uterine interstitium and maternal vasculature continue to express these receptors, and, like endothelial cells during angiogenesis, also stain for alphaVbeta3. In functional studies, alphaVbeta3 and VE-cadherin enhance, while E-cadherin restrains, cytotrophoblast invasiveness. Cytotrophoblasts expressing alpha4 integrins bound immobilized VCAM-1 in vitro, suggesting that this receptor-pair could mediate cytotrophoblast-endothelium or cytotrophoblast-cytotrophoblast interactions in vivo, during endovascular invasion. In the pregnancy disorder preeclampsia, in which endovascular invasion remains superficial, cytotrophoblasts fail to express most of these endothelial markers (Zhou et al., 1997. J. Clin. Invest. 99:2152-2164.), suggesting that this adhesion phenotype switch is required for successful endovascular invasion and normal placentation.

Authors

Y Zhou, S J Fisher, M Janatpour, O Genbacev, E Dejana, M Wheelock, C H Damsky

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1995 1994 1991 Total
Citations: 3 7 11 14 15 24 22 22 29 23 26 28 36 20 25 24 30 35 31 34 35 32 34 24 23 30 23 16 4 1 1 1 683
Citation information
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Citations to this article in year 2008 (35)

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Blockade of adhesion molecule CD146 causes pregnancy failure in mice
Q Liu, B Zhang, X Zhao, Y Zhang, Y Liu, X Yan
Journal of Cellular Physiology 2008
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Stem Cell Reviews 2008
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E Chinni, D Colaizzo, M Margaglione, C Rubini, RL D'Ambrosio, F Giuliani, GD Vagno, E Grandone
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Placenta 2008
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Clinics in Perinatology 2008
Endovascular Trophoblast Invasion, Spiral Artery Remodelling and Uteroplacental Haemodynamics in a Transgenic Rat Model of Pre-eclampsia
N Geusens, S Verlohren, C Luyten, M Taube, L Hering, L Vercruysse, M Hanssens, JW Dudenhausen, R Dechend, R Pijnenborg
Placenta 2008
Accumulation of Uterine CD16(−) Natural Killer (NK) Cells: Friends, Foes, or Jekyll-and-Hyde Relationship for the Conceptus?
K Kitaya
Immunological Investigations 2008
Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: Soluble Tie-2
F Gotsch, R Romero, JP Kusanovic, T Chaiworapongsa, M Dombrowski, O Erez, NG Than, S Mazaki-Tovi, P Mittal, J Espinoza, SS Hassan
Journal of Maternal-Fetal and Neonatal Medicine 2008
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Journal of Obstetrics and Gynaecology Canada 2008
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L Anton, KB Brosnihan
Therapeutic advances in cardiovascular disease 2008
Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia
E Abe, K Matsubara, K Oka, Y Kusanagi, M Ito
Gynecologic and Obstetric Investigation 2008
Decorin-Mediated Inhibition of Proliferation and Migration of the Human Trophoblast via Different Tyrosine Kinase Receptors
D Iacob, J Cai, M Tsonis, A Babwah, C Chakraborty, RN Bhattacharjee, PK Lala
Endocrinology 2008
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Human Cytomegalovirus
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2008
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Stem Cell Reviews and Reports 2008

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