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Citations to this article

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
M Navab, … , A M Fogelman, B N La Du
M Navab, … , A M Fogelman, B N La Du
Published April 15, 1997
Citation Information: J Clin Invest. 1997;99(8):2005-2019. https://doi.org/10.1172/JCI119369.
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Research Article Article has an altmetric score of 6

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.

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Abstract

We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON). On an atherogenic diet, PON activity decreased by 52%, and apoJ levels increased 2.8-fold in fatty streak susceptible mice, C57BL/6J (BL/6), but not in fatty streak resistant mice, C3H/HeJ (C3H). Plasma PON activity was also significantly decreased, and apoJ levels were markedly increased in apolipoprotein E knockout mice on the chow diet, resulting in a 9.2-fold increase in the apoJ/PON ratio as compared to controls. Furthermore, a dramatic increase in the apoJ/PON ratio (over 100-fold) was observed in LDL receptor knockout mice when they were fed a 0.15%-cholesterol-enriched diet. Injection of mildly oxidized LDL (but not native LDL) into BL/6 mice (but not in C3H mice) on a chow diet resulted in a 59% decrease in PON activity (P < 0.01) and a 3.6-fold increase in apoJ levels (P < 0.01). When an acute phase reaction was induced in rabbits, or the rabbits were placed on an atherogenic diet, hepatic mRNA for apoJ was increased by 2.7-fold and 2.8-fold, respectively. Treatment of HepG2 cells in culture with mildly oxidized LDL (but not native LDL) resulted in reduced mRNA levels for PON (3.0-fold decrease) and increased mRNA levels for apoJ (2.0-fold increase). In normolipidemic patients with angiographically documented coronary artery disease who did not have diabetes and were not on lipid-lowering medication (n = 14), the total cholesterol/HDL cholesterol ratio was 3.1+/-0.9 as compared to 2.9+/-0.4 in the controls (n = 19). This difference was not statistically significant. In contrast, the apoJ/PON ratio was 3.0+/-0.4 in the patients compared to 0.72+/-0.2 in the controls (P < 0.009). In a subset of these normolipidemic patients (n = 5), the PON activity was low (48+/-6.6 versus 98+/-17 U/ml for controls; P < 0.009), despite similar normal HDL levels, and the HDL from these patients failed to protect against LDL oxidation in co-cultures of human artery wall cells. We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and (b) the apoJ/PON ratio may prove to be a better predictor of atherosclerosis than the total cholesterol/HDL cholesterol ratio.

Authors

M Navab, S Hama-Levy, B J Van Lenten, G C Fonarow, C J Cardinez, L W Castellani, M L Brennan, A J Lusis, A M Fogelman, B N La Du

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J Watanabe, V Grijalva, S Hama, K Barbour, FG Berger, M Navab, AM Fogelman, ST Reddy
The Journal of biological chemistry 2009
Clusterin: A forgotten player in Alzheimer's disease
T Nuutinen, T Suuronen, A Kauppinen, A Salminen
Brain Research Reviews 2009
Variation in paraoxonase-1 activity and atherosclerosis
H Soran, NN Younis, V Charlton-Menys, P Durrington
Current Opinion in Lipidology 2009
Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population
BC Demirdöğen, SÌ Demirkaya, A Türkanoğlu, S Bek, E Arınç, O Adalı
Cell Biochemistry and Function 2009
In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes
L Gaidukov, D Bar, S Yacobson, E Naftali, O Kaufman, R Tabakman, DS Tawfik, E Levy-Nissenbaum
BMC clinical pharmacology 2009
Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation
HD Kaur, MP Bansal
Lipids in Health and Disease 2009
Effect of efavirenz on high-density lipoprotein antioxidant properties in HIV-infected patients
SA Pereira, JR Batuca, U Caixas, T Branco, J Delgado-Alves, I Germano, F Lampreia, EC Monteiro
British Journal of Clinical Pharmacology 2009
Cathepsin B inhibition improves lung injury associated to d-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice
F Oztay, S Gezginci-Oktayoglu, BB Bayrak, R Yanardag, S Bolkent
Molecular and Cellular Biochemistry 2009
The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour
A Skoczyńska, R Poręba, A Steinmentz-Beck, H Martynowicz, A Affelska-Jercha, B Turczyn, A Wojakowska, I Jędrychowska
International Journal of Occupational Medicine and Environmental Health 2009
Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status
A Nagila, T Permpongpaiboon, S Tantrarongroj, P Porapakkham, K Chinwattana, S Deakin, S Porntadavity
Pharmacological Reports 2009
The Association between Cardiorespiratory Fitness, Inflammation Marker and Stroke Risk Factor in Chronic Stroke Patients
shinyuna, 임강일, 김효중
Journal of adapted physical activity and exercise 2009
Effect of some analgesics on Paraoxonase-1 purified from human serum
D EKİNCİ, Ş BEYDEMİR
Journal of Enzyme Inhibition and Medicinal Chemistry 2009
Inflammatory lipids as a target for therapy in the rheumatic diseases
M McMahon, E Brahn
Expert Opinion on Investigational Drugs 2008
Paraoxonase 1: Genetics and Activities During Aging
F Marchegiani, M Marra, F Olivieri, M Cardelli, RW James, M Boemi, C Franceschi
Rejuvenation Research 2008
Determination of paraoxonase 1 status without the use of toxic organophosphate substrates
RJ Richter, GP Jarvik, CE Furlong
Circulation. Cardiovascular genetics 2008
Small dense LDL oxidation in hypertensives and diabetics and prediction of Metabolic Syndrome
J Nishtha, I Naseem, J Ahmad
Diabetes and Metabolic Syndrome: Clinical Research and Reviews 2008
Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus
RT Iborra, IC Ribeiro, MQ Neves, AM Charf, SA Lottenberg, CE Negrão, ER Nakandakare, M Passarelli
Scandinavian Journal of Medicine & Science in Sports 2008
Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo
HA Alici, D Ekinci, Ş Beydemir
Clinical Biochemistry 2008
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke
BC Demirdöğen, A Türkanoğlu, S Bek, Y Sanisoğlu, Ş Demirkaya, O Vural, E Arınç, O Adalı
Clinical Biochemistry 2008
The role of dysfunctional HDL in atherosclerosis
M Navab, ST Reddy, BJ van Lenten, GM Anantharamaiah, AM Fogelman
Journal of lipid research 2008
The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism
B Mackness, M Mackness, M Aviram, G Paragh
2008
Clinical Chemistry of the Laboratory Mouse
W. Quimby F, H. Luong R
The Mouse in Biomedical Research 2007
Intrinsic enzymes of high-density lipoprotein
NA Le, MF Walter
Journal of Clinical Lipidology 2007
Paraoxonase Activity in Glomerulonephritic Patients
M Gullulu, S Kahvecioglu, M Dirican, I Akdag, N Ocak, C Demircan, K Dilek, A Ersoy, M Yavuz, M Yurtkuran
Renal Failure 2007
Sex differences in the relation of HDL cholesterol to progression of carotid intima-media thickness: The Los Angeles Atherosclerosis Study
AZ Fan, JH Dwyer
Atherosclerosis 2007
Peptide Mimetics of Apolipoproteins Improve HDL Function
M Navab, GM Anantharamaiah, ST Reddy, BJ van Lenten, GM Buga, AM Fogelman
Journal of Clinical Lipidology 2007
Aspirin is a substrate for paraoxonase-like activity: Implications in atherosclerosis
N Santanam, S Parthasarathy
Atherosclerosis 2007
Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract
Z Hashim, S Zarina
Clinical Biochemistry 2007
Análisis de la actividad paraoxonasa (PON1) y de los polimorfismos PON1 192 y PON1 55 en la población prepuberal del Estudio Cuatro Provincias
C Garcés, L López-Simón, R Rubio, M Benavente, B Cano, E Viturro, M Oya
Clínica e Investigación en Arteriosclerosis 2007
Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits
BJ van Lenten, AC Wagner, M Navab, GM Anantharamaiah, S Hama, ST Reddy, AM Fogelman
Journal of lipid research 2007
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
L Gaidukov, DS Tawfik
Journal of lipid research 2007
High‐Density Lipoproteins: From Basic Biology to Clinical Aspects
CJ Fielding
2007
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
A Kontush, MJ Chapman
Pharmacological reviews 2006
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease
PD Sarkar, S T.M., B Madhusudhan
Clinica Chimica Acta 2006
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus
MR Lakshman, CS Gottipati, SJ Narasimhan, J Munoz, P Marmillot, ES Nylen
Metabolism 2006
Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention
M Navab, GM Anantharamaiah, ST Reddy, AM Fogelman
Nature Clinical Practice Cardiovascular Medicine 2006
Reduced flow-mediated vasodilation as a marker for cardiovascular complications in lupus patients
E Kiss, P Soltesz, H Der, Z Kocsis, T Tarr, H Bhattoa, Y Shoenfeld, G Szegedi
Journal of Autoimmunity 2006
Serum Apolipoprotein J in Health, Coronary Heart Disease and Type 2 Diabetes Mellitus
T Kujiraoka, H Hattori, Y Miwa, M Ishihara, T Ueno, J Ishii, M Tsuji, T Iwasaki, Y Sasaguri, T Fujioka, S Saito, M Tsushima, T Maruyama, IP Miller, NE Miller, T Egashira
Journal of Atherosclerosis and Thrombosis 2006
Oral amphipathic peptides as therapeutic agents
ST Reddy, GM Anantharamaiah, M Navab, S Hama, G Hough, V Grijalva, DW Garber, G Datta, AM Fogelman
Expert Opinion on Investigational Drugs 2006
Isolation and characterization of human apolipoprotein M-containing lipoproteins
C Christoffersen, LB Nielsen, O Axler, A Andersson, AH Johnsen, B Dahlbäck
Journal of lipid research 2006
Effects of caloric restriction and gender on rat serum paraoxonase 1 activity
E Thomàs-Moyà, M Gianotti, I Lladó, AM Proenza
The Journal of Nutritional Biochemistry 2006
Statins and Modulation of Oxidative Stress
J Beltowski
Toxicology Mechanisms and Methods 2005
Oxidative inactivation of paraoxonase—implications in diabetes mellitus and atherosclerosis
SA Karabina, AN Lehner, E Frank, S Parthasarathy, N Santanam
Biochimica et Biophysica Acta (BBA) - General Subjects 2005
Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
Y Miwa, S Takiuchi, K Kamide, M Yoshii, T Horio, C Tanaka, M Banno, T Miyata, T Sasaguri, Y Kawano
Biochemical and Biophysical Research Communications 2005
Thematic review series: The Immune System and Atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
A Chait, CY Han, JF Oram, JW Heinecke
Journal of lipid research 2005
Anti-Inflammatory Properties of HDL
BJ Ansell, M Navab, KE Watson, GC Fonarow, AM Fogelman
Reviews in Endocrine and Metabolic Disorders 2004
The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity
RW James, SP Deakin
Free radical biology & medicine 2004
Serum paraoxonase activity before and after treatment of thyrotoxicosis
F Raiszadeh, M Solati, A Etemadi, F Azizi
Clinical Endocrinology 2004
Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?
M Mackness, B Mackness
Free radical biology & medicine 2004
Paraoxonase, a cardioprotective enzyme: continuing issues
GS Getz, CA Reardon
Current Opinion in Lipidology 2004
Human apolipoprotein A-I and A-I mimetic peptides: potential for atherosclerosis reversal
M Navab, GM Anantharamaiah, ST Reddy, BJ van Lenten, G Datta, D Garber, AM Fogelman
Current Opinion in Lipidology 2004
The Antioxidant Function of High Density Lipoproteins: A New Paradigm in Atherosclerosis
M Tomás, G Latorre, M Sentí, J Marrugat
Revista Española de Cardiología (English Edition) 2004
Función antioxidante de las lipoproteínas de alta densidad: un nuevo paradigma en la arteriosclerosis
M Tomás, G Latorre, M Sentí, J Marrugat
Revista Española de Cardiología 2004
Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
M Navab, GM Ananthramaiah, ST Reddy, BJ van Lenten, BJ Ansell, GC Fonarow, K Vahabzadeh, S Hama, G Hough, N Kamranpour, JA Berliner, AJ Lusis, AM Fogelman
Journal of lipid research 2004
Distribution Spectrum of Paraoxonase Activity in HDL Fractions
C Bergmeier, R Siekmeier, W Gross
Clinical chemistry 2004
Light, but not heavy alcohol drinking, stimulates paraoxonase by upregulating liver mRNA in rats and humans
MN Rao, P Marmillot, M Gong, DA Palmer, LB Seeff, DB Strader, MR Lakshman
Metabolism 2003
Circulating lipoproteins as proinflammatory and anti-inflammatory particles in atherogenesis
PT Kovanen, MO Pentik??inen
Current Opinion in Lipidology 2003
Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism
LG Costa, TB Cole, GP Jarvik, CE Furlong
Annual Review of Medicine 2003
Relationships between polymorphisms of the human serum paraoxonase gene and insulin sensitivity in Japanese patients with Type 2 diabetes
Y Ikeda, T Suehiro, F Ohsaki, K Arii, Y Kumon, K Hashimoto
Diabetes Research and Clinical Practice 2003
Coenzyme Q10, antioxidant status and ApoE isoforms
M Battino, S Giunta, L Galeazzi, R Galeazzi, F Mosca, C Santolini, F Principi, G Ferretti, T Bacchetti, R Bencivenga, M Piani, G Riganello, GP Littarru
BioFactors 2003
Paraoxonasa, ¿algo más que una enzima?
A Canales, FJ Sánchez-Muniz
Medicina Clínica 2003
Effect of homocysteinylation on human high-density lipoproteins: A correlation with paraoxonase activity
G Ferretti, T Bacchetti, E Marotti, G Curatola
Metabolism 2003
Serum paraoxonase 1 activity is decreased in thyroid dysfunction
F Azizi, F Raiszadeh, M Solati, A Etemadi, M Rahmani, M Arabi
Journal of Endocrinological Investigation 2003
Benzo[a]pyrene Enhances Lipid Peroxidation Induced DNA Damage in Aorta of Apolipoprotein E Knockout Mice
R Godschalk, D Curfs, H Bartsch, FJ Schooten, J Nair
Free Radical Research 2003
Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia:
S Biasioli, R Schiavon, L Petrosino, ED Fanti, G Cavalcanti, P Battaglia, A Fasolin
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2003
HDL and arteriosclerosis: beyond reverse cholesterol transport
JR Nofer, B Kehrel, M Fobker, B Levkau, G Assmann, A Eckardstein
Atherosclerosis 2002
Oxidized lipids as mediators of coronary heart disease
M Navab, SY Hama, ST Ready, CJ Ng, BJ van Lenten, H Laks, AM Fogelman
Current Opinion in Lipidology 2002
Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls
B Mackness, PN Durrington, AJ Boulton, D Hine, MI Mackness
European Journal of Clinical Investigation 2002
Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis
MA Sogorb, E Vilanova
Toxicology Letters 2002
Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction
IP Trougakos, M Poulakou, M Stathatos, A Chalikia, A Melidonis, ES Gonos
Experimental Gerontology 2002
HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism
R Schiavon, P Battaglia, ED Fanti, A Fasolin, S Biasioli, L Targa, G Guidi
Clinica Chimica Acta 2002
Paraoxonase 1 Overexpression in Mice and Its Effect on High-Density Lipoproteins
MN Oda, JK Bielicki, TT Ho, T Berger, EM Rubin, TM Forte
Biochemical and Biophysical Research Communications 2002
HDL or not HDL, that is the question
RW James
European Journal of Clinical Investigation 2002
Paraoxonase and coronary heart disease
MI Mackness, B Mackness, PN Durrington
Atherosclerosis Supplements 2002
Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage
N Ferré, J Camps, E Prats, E Vilella, A Paul, L Figuera, J Joven
Clinical chemistry 2002
El título de anticuerpos anti-LDL oxidada no está relacionado con la actividad paraoxonasa en suero ni con sus polimorfismos genéticos en sujetos normales y en pacientes con infarto de miocardio
N Ferré, M Tous, J Camps, J Joven
Clínica e Investigación en Arteriosclerosis 2002
Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity
RA Girton, DP Sundin, ME Rosenberg
American journal of physiology. Renal physiology 2002
Dietary Modifications and Gene Polymorphisms Alter Serum Paraoxonase Activity in Healthy Women
M Rantala, ML Silaste, A Tuominen, J Kaikkonen, JT Salonen, G Alfthan, A Aro, YA Kesäniemi
The Journal of nutrition 2002
Paraoxonase (PON1) in Health and Disease
LG Costa, CE Furlong
2002
Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
TM Forte, G Subbanagounder, JA Berliner, PJ Blanche, AO Clermont, Z Jia, MN Oda, RM Krauss, JK Bielicki
Journal of lipid research 2002
Increased atherosclerosis in myeloperoxidase-deficient mice
Marie-Luise Brennan, Melissa M. Anderson, Diana M. Shih, Xiao-Dan Qu, Asha C. Mehta, Lesley L. Lim, Weibin Shi, Jason S. Jacob, Jan R. Crowley, Stanley L. Hazen, Xuping Wang, Jay W. Heinecke, Aldons J. Lusis
Journal of Clinical Investigation 2001
Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?
B Mackness, GK Davies, W Turkie, E Lee, DH Roberts, E Hill, C Roberts, PN Durrington, MI Mackness
Arteriosclerosis, thrombosis, and vascular biology 2001
Oxidized LDL and HDL: antagonists in atherothrombosis
A Mertens, P Holvoet
The FASEB Journal 2001
Gemfibrozil treatment potentiates oxidative resistance of high-density lipoprotein in hypertriglyceridemic patients
MF Chen, TD Wang, HT Yeh, HC Hsu, YT Lee
European Journal of Clinical Investigation 2001
Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice
F Parhami, Y Tintut, WG Beamer, N Gharavi, W Goodman, LL Demer
Journal of Bone and Mineral Research 2001
A high density lipoprotein from Piaractus mesopotamicus, pacu, (Osteichthyes, Characidae), is associated with paraoxonase activity
E Folly, VL Bastos, MV Alves, JC Bastos, GC Atella
Biochimie 2001
Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging
C Milochevitch, A Khalil
Prostaglandins, Leukotrienes and Essential Fatty Acids 2001
Genetic variations of the paraoxonase gene in patients with coronary artery disease
SH Hong, J Song, WK Min, JQ Kim
Clinical Biochemistry 2001
Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide
G Datta, M Chaddha, S Hama, M Navab, AM Fogelman, DW Garber, VK Mishra, RM Epand, RF Epand, S Lund-Katz, MC Phillips, JP Segrest, GM Anantharamaiah
Journal of lipid research 2001
A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
M Navab, SY Hama, GP Hough, G Subbanagounder, ST Reddy, AM Fogelman
Journal of lipid research 2001
Role of oxidized low-density lipoprotein in the atherosclerosis of uremia
TB Drüeke, TN Khoa, ZA Massy, V Witko-Sarsat, B Lacour, B Descamps-Latscha
Kidney International 2001
Expression of multiple forms of clusterin during light-induced retinal degeneration
P Wong, T Ulyanova, DT Organisciak, S Bennett, J Lakins, JM Arnold, RK Kutty, M Tenniswood, T vanVeen, RM Darrow, G Chader
Current Eye Research 2001
HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids
M Navab, JA Berliner, G Subbanagounder, S Hama, AJ Lusis, LW Castellani, S Reddy, D Shih, W Shi, AD Watson, BJ Lenten, D Vora, AM Fogelman
Arteriosclerosis, thrombosis, and vascular biology 2001
High-Density Lipoprotein Loses Its Anti-Inflammatory Properties During Acute Influenza A Infection
BJ Lenten, AC Wagner, DP Nayak, S Hama, M Navab, AM Fogelman
Circulation 2001
Human Paraoxonase-3 Is an HDL-Associated Enzyme With Biological Activity Similar to Paraoxonase-1 Protein but Is Not Regulated by Oxidized Lipids
ST Reddy, DJ Wadleigh, V Grijalva, C Ng, S Hama, A Gangopadhyay, DM Shih, AJ Lusis, M Navab, AM Fogelman
Arteriosclerosis, thrombosis, and vascular biology 2001
The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes
AJ Wallace, WH Sutherland, JI Mann, SM Williams
European Journal of Clinical Nutrition 2001
Cysteine Substitutions in Apolipoprotein A-I Primary Structure Modulate Paraoxonase Activity
MN Oda, JK Bielicki, T Berger, TM Forte
Biochemistry 2001
Atherogenic Diet and Minimally Oxidized Low Density Lipoprotein Inhibit Osteogenic and Promote Adipogenic Differentiation of Marrow Stromal Cells
F Parhami, SM Jackson, Y Tintut, V Le, JP Balucan, M Territo, LL Demer
Journal of Bone and Mineral Research 2000
The iron hypothesis:does iron play a role in atherosclerosis?
DG Meyers
Transfusion 2000
A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression
T Suehiro, T Nakamura, M Inoue, T Shiinoki, Y Ikeda, Y Kumon, M Shindo, H Tanaka, K Hashimoto
Atherosclerosis 2000
Paraoxonase Activity Is Reduced by a Pro-atherosclerotic Diet in Rabbits
M Mackness, A Bouiller, N Hennuyer, B Mackness, M Hall, A Tailleux, P Duriez, B Delfly, P Durrington, JC Fruchart, N Duverger, JM Caillaud, G Castro
Biochemical and Biophysical Research Communications 2000
Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice
W Shi, ME Haberland, ML Jien, DM Shih, AJ Lusis
Circulation 2000
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
M Navab, SY Hama, GM Anantharamaiah, K Hassan, GP Hough, AD Watson, ST Reddy, A Sevanian, GC Fonarow, AM Fogelman
Journal of lipid research 2000
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1
M Navab, SY Hama, CJ Cooke, GM Anantharamaiah, M Chaddha, L Jin, G Subbanagounder, KF Faull, ST Reddy, NE Miller, AM Fogelman
Journal of lipid research 2000
Short-term feeding of atherogenic diet to mice results in reduction of HDL and paraoxonase that may be mediated by an immune mechanism
CC Hedrick, K Hassan, GP Hough, JH Yoo, S Simzar, CR Quinto, SM Kim, A Dooley, S Langi, SY Hama, M Navab, JL Witztum, AM Fogelman
Arteriosclerosis, thrombosis, and vascular biology 2000
Oxidized Phospholipids Induce Changes in Hepatic Paraoxonase and ApoJ but Not Monocyte Chemoattractant Protein-1 via Interleukin-6
BJ van Lenten, AC Wagner, M Navab, AM Fogelman
The Journal of biological chemistry 2000
Dietary Fat Modulates Serum Paraoxonase 1 Activity in Rats
BJ Kudchodkar, AG Lacko, L Dory, TV Fungwe
The Journal of nutrition 2000
Tobacco Smoking Modifies Association Between Gln-Arg192 Polymorphism of Human Paraoxonase Gene and Risk of Myocardial Infarction
S Sen-Banerjee, X Siles, H Campos
Arteriosclerosis, thrombosis, and vascular biology 2000
Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia
JC Escolà-Gil, J Julve, À Marzal-Casacuberta, J Ordóñez-Llanos, F González-Sastre, F Blanco-Vaca
Journal of lipid research 2000
Apo A-I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
HM Dansky, SA Charlton, CB Barlow, M Tamminen, JD Smith, JS Frank, JL Breslow
Journal of Clinical Investigation 1999
Identification of clusterin sequences mediating renal tubular cell interactions
JR Silkensen, KM Skubitz, ME Rosenberg, AP Skubitz
Journal of Peptide Research 1999
Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients
O Hasselwander, DA Savage, D Mcmaster, CM Loughrey, PT Mcnamee, D Middleton, DP Nicholls, AP Maxwell, IS Young
Kidney International 1999
Atheroprotective mechanisms of HDL
O Stein, Y Stein
Atherosclerosis 1999
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
M Aviram, M Rosenblat, S Billecke, J Erogul, R Sorenson, CL Bisgaier, RS Newton, BL Du
Free radical biology & medicine 1999
Oxidized Low-Density Lipoprotein Induces Neuronal Death
JN Keller, KB Hanni, WR Markesbery
Journal of Neurochemistry 1999
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
HM Dansky, SA Charlton, JL Sikes, SC Heath, R Simantov, LF Levin, P Shu, KJ Moore, JL Breslow, JD Smith
Arteriosclerosis, thrombosis, and vascular biology 1999
Low serum paraoxonase: a risk factor for atherosclerotic disease?
M I Mackness, P N Durrington, A Ayub, B Mackness
Chemico-Biological Interactions 1999
Serum Paraoxonase After Myocardial Infarction
A Ayub, MI Mackness, S Arrol, B Mackness, J Patel, PN Durrington
Arteriosclerosis, thrombosis, and vascular biology 1999
Reduced Postprandial Serum Paraoxonase Activity After a Meal Rich in Used Cooking Fat
WH Sutherland, RJ Walker, SA de Jong, AM van Rij, V Phillips, HL Walker
Arteriosclerosis, thrombosis, and vascular biology 1999
Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q→R genetic polymorphism
H Cao, A Girard-Globa, F Berthezene, P Moulin
Journal of lipid research 1999
Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration
TM Forte, MN Oda, L Knoff, B Frei, J Suh, JA Harmony, WD Stuart, EM Rubin, DS Ng
Journal of lipid research 1999
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
M Aviram, M Rosenblat, CL Bisgaier, RS Newton, SL Primo-Parmo, BN la Du
Journal of Clinical Investigation 1998
Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties
GB Schwochau, KA Nath, ME Rosenberg
Kidney International 1998
High density associated enzymes: their role in vascular biology
M Navab, SY Hama, GP Hough, CC Hedrick, R Sorenson, BN la Du, JA Kobashigawa, GC Fonarow, JA Berliner, H Laks, AM Fogelman
Current Opinion in Lipidology 1998
Paraoxonase-Gene Polymorphisms Associated with Coronary Heart Disease: Support for the Oxidative Damage Hypothesis?
JW Heinecke, AJ Lusis
The American Journal of Human Genetics 1998
Paraoxonase as a Risk Marker for Cardiovascular Disease: Facts and Hypotheses
PM Laplaud, T Dantoine, MJ Chapman
Clinical Chemistry and Laboratory Medicine 1998
Lack of Protection against Oxidative Modification of LDL by Avian HDL
B Mackness, PN Durrington, MI Mackness
Biochemical and Biophysical Research Communications 1998
Human Serum Paraoxonase
B Mackness, PN Durrington, MI Mackness
General Pharmacology: The Vascular System 1998
Age-related increased susceptibility of high-density lipoproteins (HDL) to in vitro oxidation induced by γ-radiolysis of water
A Khalil, JP Jay-Gerin, T Fülöp
FEBS Letters 1998
Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification
B Mackness, M I Mackness, S Arrol, W Turkie, P N Durrington
FEBS Letters 1998
Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin
R A Memon, W M Holleran, A H Moser, T Seki, Y Uchida, J Fuller, J K Shigenaga, C Grunfeld, K R Feingold
Arteriosclerosis, thrombosis, and vascular biology 1998
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
DM Shih, L Gu, YR Xia, M Navab, WF Li, S Hama, LW Castellani, CE Furlong, LG Costa, AM Fogelman, AJ Lusis
Nature 1998
Paraoxonase PON1 Polymorphism Leu-Met54 Is Associated With Carotid Atherosclerosis: Results of the Austrian Stroke Prevention Study
H Schmidt, R Schmidt, K Niederkorn, A Gradert, M Schumacher, N Watzinger, HP Hartung, GM Kostner
Stroke; a journal of cerebral circulation 1998
Presence of paraoxonase in human interstitial fluid
M I Mackness, B Mackness, S Arrol, G Wood, D Bhatnagar, P N Durrington
FEBS Letters 1997

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