We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON). On an atherogenic diet, PON activity decreased by 52%, and apoJ levels increased 2.8-fold in fatty streak susceptible mice, C57BL/6J (BL/6), but not in fatty streak resistant mice, C3H/HeJ (C3H). Plasma PON activity was also significantly decreased, and apoJ levels were markedly increased in apolipoprotein E knockout mice on the chow diet, resulting in a 9.2-fold increase in the apoJ/PON ratio as compared to controls. Furthermore, a dramatic increase in the apoJ/PON ratio (over 100-fold) was observed in LDL receptor knockout mice when they were fed a 0.15%-cholesterol-enriched diet. Injection of mildly oxidized LDL (but not native LDL) into BL/6 mice (but not in C3H mice) on a chow diet resulted in a 59% decrease in PON activity (P < 0.01) and a 3.6-fold increase in apoJ levels (P < 0.01). When an acute phase reaction was induced in rabbits, or the rabbits were placed on an atherogenic diet, hepatic mRNA for apoJ was increased by 2.7-fold and 2.8-fold, respectively. Treatment of HepG2 cells in culture with mildly oxidized LDL (but not native LDL) resulted in reduced mRNA levels for PON (3.0-fold decrease) and increased mRNA levels for apoJ (2.0-fold increase). In normolipidemic patients with angiographically documented coronary artery disease who did not have diabetes and were not on lipid-lowering medication (n = 14), the total cholesterol/HDL cholesterol ratio was 3.1+/-0.9 as compared to 2.9+/-0.4 in the controls (n = 19). This difference was not statistically significant. In contrast, the apoJ/PON ratio was 3.0+/-0.4 in the patients compared to 0.72+/-0.2 in the controls (P < 0.009). In a subset of these normolipidemic patients (n = 5), the PON activity was low (48+/-6.6 versus 98+/-17 U/ml for controls; P < 0.009), despite similar normal HDL levels, and the HDL from these patients failed to protect against LDL oxidation in co-cultures of human artery wall cells. We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and (b) the apoJ/PON ratio may prove to be a better predictor of atherosclerosis than the total cholesterol/HDL cholesterol ratio.
M Navab, S Hama-Levy, B J Van Lenten, G C Fonarow, C J Cardinez, L W Castellani, M L Brennan, A J Lusis, A M Fogelman, B N La Du
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Molecular and Cellular Biochemistry | 2009 |
The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour
A Skoczyńska, R Poręba, A Steinmentz-Beck, H Martynowicz, A Affelska-Jercha, B Turczyn, A Wojakowska, I Jędrychowska |
International Journal of Occupational Medicine and Environmental Health | 2009 |
Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status
A Nagila, T Permpongpaiboon, S Tantrarongroj, P Porapakkham, K Chinwattana, S Deakin, S Porntadavity |
Pharmacological Reports | 2009 |
The Association between Cardiorespiratory Fitness, Inflammation Marker and Stroke Risk Factor in Chronic Stroke Patients
shinyuna, 임강일, 김효중 |
Journal of adapted physical activity and exercise | 2009 |
Effect of some analgesics on Paraoxonase-1 purified from human serum
D EKİNCİ, Ş BEYDEMİR |
Journal of Enzyme Inhibition and Medicinal Chemistry | 2009 |
Inflammatory lipids as a target for therapy in the rheumatic diseases
M McMahon, E Brahn |
Expert Opinion on Investigational Drugs | 2008 |
Paraoxonase 1: Genetics and Activities During Aging
F Marchegiani, M Marra, F Olivieri, M Cardelli, RW James, M Boemi, C Franceschi |
Rejuvenation Research | 2008 |
Determination of paraoxonase 1 status without the use of toxic organophosphate substrates
RJ Richter, GP Jarvik, CE Furlong |
Circulation. Cardiovascular genetics | 2008 |
Small dense LDL oxidation in hypertensives and diabetics and prediction of Metabolic Syndrome
J Nishtha, I Naseem, J Ahmad |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | 2008 |
Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus
RT Iborra, IC Ribeiro, MQ Neves, AM Charf, SA Lottenberg, CE Negrão, ER Nakandakare, M Passarelli |
Scandinavian Journal of Medicine & Science in Sports | 2008 |
Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo
HA Alici, D Ekinci, Ş Beydemir |
Clinical Biochemistry | 2008 |
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke
BC Demirdöğen, A Türkanoğlu, S Bek, Y Sanisoğlu, Ş Demirkaya, O Vural, E Arınç, O Adalı |
Clinical Biochemistry | 2008 |
The role of dysfunctional HDL in atherosclerosis
M Navab, ST Reddy, BJ van Lenten, GM Anantharamaiah, AM Fogelman |
Journal of lipid research | 2008 |
The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism
B Mackness, M Mackness, M Aviram, G Paragh |
2008 | |
Clinical Chemistry of the Laboratory Mouse
W. Quimby F, H. Luong R |
The Mouse in Biomedical Research | 2007 |
Intrinsic enzymes of high-density lipoprotein
NA Le, MF Walter |
Journal of Clinical Lipidology | 2007 |
Paraoxonase Activity in Glomerulonephritic Patients
M Gullulu, S Kahvecioglu, M Dirican, I Akdag, N Ocak, C Demircan, K Dilek, A Ersoy, M Yavuz, M Yurtkuran |
Renal Failure | 2007 |
Sex differences in the relation of HDL cholesterol to progression of carotid intima-media thickness: The Los Angeles Atherosclerosis Study
AZ Fan, JH Dwyer |
Atherosclerosis | 2007 |
Peptide Mimetics of Apolipoproteins Improve HDL Function
M Navab, GM Anantharamaiah, ST Reddy, BJ van Lenten, GM Buga, AM Fogelman |
Journal of Clinical Lipidology | 2007 |
Aspirin is a substrate for paraoxonase-like activity: Implications in atherosclerosis
N Santanam, S Parthasarathy |
Atherosclerosis | 2007 |
Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract
Z Hashim, S Zarina |
Clinical Biochemistry | 2007 |
Análisis de la actividad paraoxonasa (PON1) y de los polimorfismos PON1 192 y PON1 55 en la población prepuberal del Estudio Cuatro Provincias
C Garcés, L López-Simón, R Rubio, M Benavente, B Cano, E Viturro, M Oya |
Clínica e Investigación en Arteriosclerosis | 2007 |
Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits
BJ van Lenten, AC Wagner, M Navab, GM Anantharamaiah, S Hama, ST Reddy, AM Fogelman |
Journal of lipid research | 2007 |
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
L Gaidukov, DS Tawfik |
Journal of lipid research | 2007 |
High‐Density Lipoproteins: From Basic Biology to Clinical Aspects
CJ Fielding |
2007 | |
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
A Kontush, MJ Chapman |
Pharmacological reviews | 2006 |
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease
PD Sarkar, S T.M., B Madhusudhan |
Clinica Chimica Acta | 2006 |
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus
MR Lakshman, CS Gottipati, SJ Narasimhan, J Munoz, P Marmillot, ES Nylen |
Metabolism | 2006 |
Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention
M Navab, GM Anantharamaiah, ST Reddy, AM Fogelman |
Nature Clinical Practice Cardiovascular Medicine | 2006 |
Reduced flow-mediated vasodilation as a marker for cardiovascular complications in lupus patients
E Kiss, P Soltesz, H Der, Z Kocsis, T Tarr, H Bhattoa, Y Shoenfeld, G Szegedi |
Journal of Autoimmunity | 2006 |
Serum Apolipoprotein J in Health, Coronary Heart Disease and Type 2 Diabetes Mellitus
T Kujiraoka, H Hattori, Y Miwa, M Ishihara, T Ueno, J Ishii, M Tsuji, T Iwasaki, Y Sasaguri, T Fujioka, S Saito, M Tsushima, T Maruyama, IP Miller, NE Miller, T Egashira |
Journal of Atherosclerosis and Thrombosis | 2006 |
Oral amphipathic peptides as therapeutic agents
ST Reddy, GM Anantharamaiah, M Navab, S Hama, G Hough, V Grijalva, DW Garber, G Datta, AM Fogelman |
Expert Opinion on Investigational Drugs | 2006 |
Isolation and characterization of human apolipoprotein M-containing lipoproteins
C Christoffersen, LB Nielsen, O Axler, A Andersson, AH Johnsen, B Dahlbäck |
Journal of lipid research | 2006 |
Effects of caloric restriction and gender on rat serum paraoxonase 1 activity
E Thomàs-Moyà, M Gianotti, I Lladó, AM Proenza |
The Journal of Nutritional Biochemistry | 2006 |
Statins and Modulation of Oxidative Stress
J Beltowski |
Toxicology Mechanisms and Methods | 2005 |
Oxidative inactivation of paraoxonase—implications in diabetes mellitus and atherosclerosis
SA Karabina, AN Lehner, E Frank, S Parthasarathy, N Santanam |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2005 |
Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
Y Miwa, S Takiuchi, K Kamide, M Yoshii, T Horio, C Tanaka, M Banno, T Miyata, T Sasaguri, Y Kawano |
Biochemical and Biophysical Research Communications | 2005 |
Thematic review series: The Immune System and Atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
A Chait, CY Han, JF Oram, JW Heinecke |
Journal of lipid research | 2005 |
Anti-Inflammatory Properties of HDL
BJ Ansell, M Navab, KE Watson, GC Fonarow, AM Fogelman |
Reviews in Endocrine and Metabolic Disorders | 2004 |
The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity
RW James, SP Deakin |
Free radical biology & medicine | 2004 |
Serum paraoxonase activity before and after treatment of thyrotoxicosis
F Raiszadeh, M Solati, A Etemadi, F Azizi |
Clinical Endocrinology | 2004 |
Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?
M Mackness, B Mackness |
Free radical biology & medicine | 2004 |
Paraoxonase, a cardioprotective enzyme: continuing issues
GS Getz, CA Reardon |
Current Opinion in Lipidology | 2004 |
Human apolipoprotein A-I and A-I mimetic peptides: potential for atherosclerosis reversal
M Navab, GM Anantharamaiah, ST Reddy, BJ van Lenten, G Datta, D Garber, AM Fogelman |
Current Opinion in Lipidology | 2004 |
The Antioxidant Function of High Density Lipoproteins: A New Paradigm in Atherosclerosis
M Tomás, G Latorre, M Sentí, J Marrugat |
Revista Española de Cardiología (English Edition) | 2004 |
Función antioxidante de las lipoproteínas de alta densidad: un nuevo paradigma en la arteriosclerosis
M Tomás, G Latorre, M Sentí, J Marrugat |
Revista Española de Cardiología | 2004 |
Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
M Navab, GM Ananthramaiah, ST Reddy, BJ van Lenten, BJ Ansell, GC Fonarow, K Vahabzadeh, S Hama, G Hough, N Kamranpour, JA Berliner, AJ Lusis, AM Fogelman |
Journal of lipid research | 2004 |
Distribution Spectrum of Paraoxonase Activity in HDL Fractions
C Bergmeier, R Siekmeier, W Gross |
Clinical chemistry | 2004 |
Light, but not heavy alcohol drinking, stimulates paraoxonase by upregulating liver mRNA in rats and humans
MN Rao, P Marmillot, M Gong, DA Palmer, LB Seeff, DB Strader, MR Lakshman |
Metabolism | 2003 |
Circulating lipoproteins as proinflammatory and anti-inflammatory particles in atherogenesis
PT Kovanen, MO Pentik??inen |
Current Opinion in Lipidology | 2003 |
Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism
LG Costa, TB Cole, GP Jarvik, CE Furlong |
Annual Review of Medicine | 2003 |
Relationships between polymorphisms of the human serum paraoxonase gene and insulin sensitivity in Japanese patients with Type 2 diabetes
Y Ikeda, T Suehiro, F Ohsaki, K Arii, Y Kumon, K Hashimoto |
Diabetes Research and Clinical Practice | 2003 |
Coenzyme Q10, antioxidant status and ApoE isoforms
M Battino, S Giunta, L Galeazzi, R Galeazzi, F Mosca, C Santolini, F Principi, G Ferretti, T Bacchetti, R Bencivenga, M Piani, G Riganello, GP Littarru |
BioFactors | 2003 |
Paraoxonasa, ¿algo más que una enzima?
A Canales, FJ Sánchez-Muniz |
Medicina Clínica | 2003 |
Effect of homocysteinylation on human high-density lipoproteins: A correlation with paraoxonase activity
G Ferretti, T Bacchetti, E Marotti, G Curatola |
Metabolism | 2003 |
Serum paraoxonase 1 activity is decreased in thyroid dysfunction
F Azizi, F Raiszadeh, M Solati, A Etemadi, M Rahmani, M Arabi |
Journal of Endocrinological Investigation | 2003 |
Benzo[a]pyrene Enhances Lipid Peroxidation Induced DNA Damage in Aorta of Apolipoprotein E Knockout Mice
R Godschalk, D Curfs, H Bartsch, FJ Schooten, J Nair |
Free Radical Research | 2003 |
Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia:
S Biasioli, R Schiavon, L Petrosino, ED Fanti, G Cavalcanti, P Battaglia, A Fasolin |
ASAIO journal (American Society for Artificial Internal Organs : 1992) | 2003 |
HDL and arteriosclerosis: beyond reverse cholesterol transport
JR Nofer, B Kehrel, M Fobker, B Levkau, G Assmann, A Eckardstein |
Atherosclerosis | 2002 |
Oxidized lipids as mediators of coronary heart disease
M Navab, SY Hama, ST Ready, CJ Ng, BJ van Lenten, H Laks, AM Fogelman |
Current Opinion in Lipidology | 2002 |
Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls
B Mackness, PN Durrington, AJ Boulton, D Hine, MI Mackness |
European Journal of Clinical Investigation | 2002 |
Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis
MA Sogorb, E Vilanova |
Toxicology Letters | 2002 |
Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction
IP Trougakos, M Poulakou, M Stathatos, A Chalikia, A Melidonis, ES Gonos |
Experimental Gerontology | 2002 |
HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism
R Schiavon, P Battaglia, ED Fanti, A Fasolin, S Biasioli, L Targa, G Guidi |
Clinica Chimica Acta | 2002 |
Paraoxonase 1 Overexpression in Mice and Its Effect on High-Density Lipoproteins
MN Oda, JK Bielicki, TT Ho, T Berger, EM Rubin, TM Forte |
Biochemical and Biophysical Research Communications | 2002 |
HDL or not HDL, that is the question
RW James |
European Journal of Clinical Investigation | 2002 |
Paraoxonase and coronary heart disease
MI Mackness, B Mackness, PN Durrington |
Atherosclerosis Supplements | 2002 |
Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage
N Ferré, J Camps, E Prats, E Vilella, A Paul, L Figuera, J Joven |
Clinical chemistry | 2002 |
El título de anticuerpos anti-LDL oxidada no está relacionado con la actividad paraoxonasa en suero ni con sus polimorfismos genéticos en sujetos normales y en pacientes con infarto de miocardio
N Ferré, M Tous, J Camps, J Joven |
Clínica e Investigación en Arteriosclerosis | 2002 |
Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity
RA Girton, DP Sundin, ME Rosenberg |
American journal of physiology. Renal physiology | 2002 |
Dietary Modifications and Gene Polymorphisms Alter Serum Paraoxonase Activity in Healthy Women
M Rantala, ML Silaste, A Tuominen, J Kaikkonen, JT Salonen, G Alfthan, A Aro, YA Kesäniemi |
The Journal of nutrition | 2002 |
Paraoxonase (PON1) in Health and Disease
LG Costa, CE Furlong |
2002 | |
Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
TM Forte, G Subbanagounder, JA Berliner, PJ Blanche, AO Clermont, Z Jia, MN Oda, RM Krauss, JK Bielicki |
Journal of lipid research | 2002 |
Increased atherosclerosis in myeloperoxidase-deficient mice
Marie-Luise Brennan, Melissa M. Anderson, Diana M. Shih, Xiao-Dan Qu, Asha C. Mehta, Lesley L. Lim, Weibin Shi, Jason S. Jacob, Jan R. Crowley, Stanley L. Hazen, Xuping Wang, Jay W. Heinecke, Aldons J. Lusis |
Journal of Clinical Investigation | 2001 |
Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?
B Mackness, GK Davies, W Turkie, E Lee, DH Roberts, E Hill, C Roberts, PN Durrington, MI Mackness |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Oxidized LDL and HDL: antagonists in atherothrombosis
A Mertens, P Holvoet |
The FASEB Journal | 2001 |
Gemfibrozil treatment potentiates oxidative resistance of high-density lipoprotein in hypertriglyceridemic patients
MF Chen, TD Wang, HT Yeh, HC Hsu, YT Lee |
European Journal of Clinical Investigation | 2001 |
Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice
F Parhami, Y Tintut, WG Beamer, N Gharavi, W Goodman, LL Demer |
Journal of Bone and Mineral Research | 2001 |
A high density lipoprotein from Piaractus mesopotamicus, pacu, (Osteichthyes, Characidae), is associated with paraoxonase activity
E Folly, VL Bastos, MV Alves, JC Bastos, GC Atella |
Biochimie | 2001 |
Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging
C Milochevitch, A Khalil |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2001 |
Genetic variations of the paraoxonase gene in patients with coronary artery disease
SH Hong, J Song, WK Min, JQ Kim |
Clinical Biochemistry | 2001 |
Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide
G Datta, M Chaddha, S Hama, M Navab, AM Fogelman, DW Garber, VK Mishra, RM Epand, RF Epand, S Lund-Katz, MC Phillips, JP Segrest, GM Anantharamaiah |
Journal of lipid research | 2001 |
A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
M Navab, SY Hama, GP Hough, G Subbanagounder, ST Reddy, AM Fogelman |
Journal of lipid research | 2001 |
Role of oxidized low-density lipoprotein in the atherosclerosis of uremia
TB Drüeke, TN Khoa, ZA Massy, V Witko-Sarsat, B Lacour, B Descamps-Latscha |
Kidney International | 2001 |
Expression of multiple forms of clusterin during light-induced retinal degeneration
P Wong, T Ulyanova, DT Organisciak, S Bennett, J Lakins, JM Arnold, RK Kutty, M Tenniswood, T vanVeen, RM Darrow, G Chader |
Current Eye Research | 2001 |
HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids
M Navab, JA Berliner, G Subbanagounder, S Hama, AJ Lusis, LW Castellani, S Reddy, D Shih, W Shi, AD Watson, BJ Lenten, D Vora, AM Fogelman |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
High-Density Lipoprotein Loses Its Anti-Inflammatory Properties During Acute Influenza A Infection
BJ Lenten, AC Wagner, DP Nayak, S Hama, M Navab, AM Fogelman |
Circulation | 2001 |
Human Paraoxonase-3 Is an HDL-Associated Enzyme With Biological Activity Similar to Paraoxonase-1 Protein but Is Not Regulated by Oxidized Lipids
ST Reddy, DJ Wadleigh, V Grijalva, C Ng, S Hama, A Gangopadhyay, DM Shih, AJ Lusis, M Navab, AM Fogelman |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes
AJ Wallace, WH Sutherland, JI Mann, SM Williams |
European Journal of Clinical Nutrition | 2001 |
Cysteine Substitutions in Apolipoprotein A-I Primary Structure Modulate Paraoxonase Activity
MN Oda, JK Bielicki, T Berger, TM Forte |
Biochemistry | 2001 |
Atherogenic Diet and Minimally Oxidized Low Density Lipoprotein Inhibit Osteogenic and Promote Adipogenic Differentiation of Marrow Stromal Cells
F Parhami, SM Jackson, Y Tintut, V Le, JP Balucan, M Territo, LL Demer |
Journal of Bone and Mineral Research | 2000 |
The iron hypothesis:does iron play a role in atherosclerosis?
DG Meyers |
Transfusion | 2000 |
A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression
T Suehiro, T Nakamura, M Inoue, T Shiinoki, Y Ikeda, Y Kumon, M Shindo, H Tanaka, K Hashimoto |
Atherosclerosis | 2000 |
Paraoxonase Activity Is Reduced by a Pro-atherosclerotic Diet in Rabbits
M Mackness, A Bouiller, N Hennuyer, B Mackness, M Hall, A Tailleux, P Duriez, B Delfly, P Durrington, JC Fruchart, N Duverger, JM Caillaud, G Castro |
Biochemical and Biophysical Research Communications | 2000 |
Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice
W Shi, ME Haberland, ML Jien, DM Shih, AJ Lusis |
Circulation | 2000 |
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
M Navab, SY Hama, GM Anantharamaiah, K Hassan, GP Hough, AD Watson, ST Reddy, A Sevanian, GC Fonarow, AM Fogelman |
Journal of lipid research | 2000 |
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1
M Navab, SY Hama, CJ Cooke, GM Anantharamaiah, M Chaddha, L Jin, G Subbanagounder, KF Faull, ST Reddy, NE Miller, AM Fogelman |
Journal of lipid research | 2000 |
Short-term feeding of atherogenic diet to mice results in reduction of HDL and paraoxonase that may be mediated by an immune mechanism
CC Hedrick, K Hassan, GP Hough, JH Yoo, S Simzar, CR Quinto, SM Kim, A Dooley, S Langi, SY Hama, M Navab, JL Witztum, AM Fogelman |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Oxidized Phospholipids Induce Changes in Hepatic Paraoxonase and ApoJ but Not Monocyte Chemoattractant Protein-1 via Interleukin-6
BJ van Lenten, AC Wagner, M Navab, AM Fogelman |
The Journal of biological chemistry | 2000 |
Dietary Fat Modulates Serum Paraoxonase 1 Activity in Rats
BJ Kudchodkar, AG Lacko, L Dory, TV Fungwe |
The Journal of nutrition | 2000 |
Tobacco Smoking Modifies Association Between Gln-Arg192 Polymorphism of Human Paraoxonase Gene and Risk of Myocardial Infarction
S Sen-Banerjee, X Siles, H Campos |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia
JC Escolà-Gil, J Julve, À Marzal-Casacuberta, J Ordóñez-Llanos, F González-Sastre, F Blanco-Vaca |
Journal of lipid research | 2000 |
Apo A-I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
HM Dansky, SA Charlton, CB Barlow, M Tamminen, JD Smith, JS Frank, JL Breslow |
Journal of Clinical Investigation | 1999 |
Identification of clusterin sequences mediating renal tubular cell interactions
JR Silkensen, KM Skubitz, ME Rosenberg, AP Skubitz |
Journal of Peptide Research | 1999 |
Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients
O Hasselwander, DA Savage, D Mcmaster, CM Loughrey, PT Mcnamee, D Middleton, DP Nicholls, AP Maxwell, IS Young |
Kidney International | 1999 |
Atheroprotective mechanisms of HDL
O Stein, Y Stein |
Atherosclerosis | 1999 |
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
M Aviram, M Rosenblat, S Billecke, J Erogul, R Sorenson, CL Bisgaier, RS Newton, BL Du |
Free radical biology & medicine | 1999 |
Oxidized Low-Density Lipoprotein Induces Neuronal Death
JN Keller, KB Hanni, WR Markesbery |
Journal of Neurochemistry | 1999 |
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
HM Dansky, SA Charlton, JL Sikes, SC Heath, R Simantov, LF Levin, P Shu, KJ Moore, JL Breslow, JD Smith |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Low serum paraoxonase: a risk factor for atherosclerotic disease?
M I Mackness, P N Durrington, A Ayub, B Mackness |
Chemico-Biological Interactions | 1999 |
Serum Paraoxonase After Myocardial Infarction
A Ayub, MI Mackness, S Arrol, B Mackness, J Patel, PN Durrington |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Reduced Postprandial Serum Paraoxonase Activity After a Meal Rich in Used Cooking Fat
WH Sutherland, RJ Walker, SA de Jong, AM van Rij, V Phillips, HL Walker |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q→R genetic polymorphism
H Cao, A Girard-Globa, F Berthezene, P Moulin |
Journal of lipid research | 1999 |
Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration
TM Forte, MN Oda, L Knoff, B Frei, J Suh, JA Harmony, WD Stuart, EM Rubin, DS Ng |
Journal of lipid research | 1999 |
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
M Aviram, M Rosenblat, CL Bisgaier, RS Newton, SL Primo-Parmo, BN la Du |
Journal of Clinical Investigation | 1998 |
Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties
GB Schwochau, KA Nath, ME Rosenberg |
Kidney International | 1998 |
High density associated enzymes: their role in vascular biology
M Navab, SY Hama, GP Hough, CC Hedrick, R Sorenson, BN la Du, JA Kobashigawa, GC Fonarow, JA Berliner, H Laks, AM Fogelman |
Current Opinion in Lipidology | 1998 |
Paraoxonase-Gene Polymorphisms Associated with Coronary Heart Disease: Support for the Oxidative Damage Hypothesis?
JW Heinecke, AJ Lusis |
The American Journal of Human Genetics | 1998 |
Paraoxonase as a Risk Marker for Cardiovascular Disease: Facts and Hypotheses
PM Laplaud, T Dantoine, MJ Chapman |
Clinical Chemistry and Laboratory Medicine | 1998 |
Lack of Protection against Oxidative Modification of LDL by Avian HDL
B Mackness, PN Durrington, MI Mackness |
Biochemical and Biophysical Research Communications | 1998 |
Human Serum Paraoxonase
B Mackness, PN Durrington, MI Mackness |
General Pharmacology: The Vascular System | 1998 |
Age-related increased susceptibility of high-density lipoproteins (HDL) to in vitro oxidation induced by γ-radiolysis of water
A Khalil, JP Jay-Gerin, T Fülöp |
FEBS Letters | 1998 |
Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification
B Mackness, M I Mackness, S Arrol, W Turkie, P N Durrington |
FEBS Letters | 1998 |
Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin
R A Memon, W M Holleran, A H Moser, T Seki, Y Uchida, J Fuller, J K Shigenaga, C Grunfeld, K R Feingold |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
DM Shih, L Gu, YR Xia, M Navab, WF Li, S Hama, LW Castellani, CE Furlong, LG Costa, AM Fogelman, AJ Lusis |
Nature | 1998 |
Paraoxonase PON1 Polymorphism Leu-Met54 Is Associated With Carotid Atherosclerosis: Results of the Austrian Stroke Prevention Study
H Schmidt, R Schmidt, K Niederkorn, A Gradert, M Schumacher, N Watzinger, HP Hartung, GM Kostner |
Stroke; a journal of cerebral circulation | 1998 |
Presence of paraoxonase in human interstitial fluid
M I Mackness, B Mackness, S Arrol, G Wood, D Bhatnagar, P N Durrington |
FEBS Letters | 1997 |