Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.
S Shiozawa, … , K Tanaka, K Hino
S Shiozawa, … , K Tanaka, K Hino
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1210-1216. https://doi.org/10.1172/JCI119277.
View: Text | PDF
Research Article Article has an altmetric score of 3

Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.

  • Text
  • PDF
Abstract

Features characteristic to rheumatoid joint destruction, including synovial overgrowth and bone resorption, are experimentally produced by augmenting c-fos gene expression. We tested here if arthritic joint destruction was inhibited upon inactivation of the c-fos/AP-1 signal by administering short double-stranded AP-1 DNA oligonucleotides into mice with collagen-induced arthritis to compete for the binding of AP-1 in vivo at the promoter binding site. Arthritic joint destruction was inhibited in a sequence-specific and dose-dependent manner by oligonucleotides containing the AP-1 sequence. The oligonucleotides inhibited gene expression at the transcriptional level. Nucleotide sequences besides AP-1 also appeared to be important structurally for binding of AP-1 onto DNA and for the stability of oligonucleotides against nucleases. Immunohistochemical chase experiment administering biotinylated oligonucleotides into arthritic mice showed that AP-1 oligonucleotides reached the inflamed joint. Thus, activation of c-fos/AP-1 appears essentially important in arthritic joint destruction.

Authors

S Shiozawa, K Shimizu, K Tanaka, K Hino

×

Total citations by year

Year: 2024 2023 2021 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1995 Total
Citations: 1 2 1 2 3 1 1 2 2 3 2 3 2 1 2 3 6 2 7 2 11 9 6 3 1 78
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (78)

Title and authors Publication Year
The universal role of adaptive transcription in health and disease.
Lissek T
The FEBS journal 2024
Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis.
Smith MH, Gao VR, Periyakoil PK, Kochen A, DiCarlo EF, Goodman SM, Norman TM, Donlin LT, Leslie CS, Rudensky AY
Nature Immunology 2023
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome.
Guo Z, Zhu Y, Xiao H, Dai R, Yang W, Xue W, Zhang X, Hao B, Liao S
Biological research 2023
Engineered synthetic cell penetrating peptide with intracellular anti‐inflammatory bioactivity: An in vitro and in vivo study
JY Lee, DW Lee, BS Jo, KS Park, YS Park, CP Chung, YJ Park
Journal of biomedical materials research. Part A 2021
Follistatin-like 1 in Cardiovascular Disease and Inflammation
MM Peters, TA Meijs, W Gathier, PA Doevendans, JP Sluijter, SA Chamuleau, K Neef
Mini reviews in medicinal chemistry 2019
Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes
Q Jia, T Wang, X Wang, H Xu, Y Liu, Y Wang, Q Shi, Q Liang
Frontiers in pharmacology 2019
Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-κB signaling inhibition
SA Lee, SM Moon, SH Han, EJ Hwang, BR Park, JS Kim, DK Kim, CS Kim
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2018
Potential in vitro and ex vivo targeting of bZIP53 involved in stress response and seed maturation in Arabidopsis thaliana by five designed peptide inhibitors
P Jain, K Shah, V Rishi
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2018
Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review
AM Carvalho, L Heimfarth, KA Santos, AG Guimarães, L Picot, JR Almeida, JS Quintans, LJ Quintans-Júnior
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes
NM Khan, A Haseeb, MY Ansari, TM Haqqi
Scientific Reports 2017
Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes: Harpagoside inhibits IL-6 and c-FOS/AP-1
A Haseeb, MY Ansari, TM Haqqi
Journal of Orthopaedic Research 2016
Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)
N Ye, Y Ding, C Wild, Q Shen, J Zhou
Journal of Medicinal Chemistry 2014
Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity
YS Chen, HM Yu, JJ Shie, TJ Cheng, CY Wu, JM Fang, CH Wong
Bioorganic & Medicinal Chemistry 2014
Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression
HP Lee, SY Huang, YY Lin, HM Wang, YH Jean, SF Wu, CY Duh, ZH Wen
Marine drugs 2013
N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats
H Jawed, S Jamall, SU Shah, K Perveen, F Hanif, SU Simjee
Molecular and Cellular Biochemistry 2013
c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
M Guma, GS Firestein
The open rheumatology journal 2012
Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions
JL Yap, J Chauhan, KY Jung, L Chen, EV Prochownik, S Fletcher
MedChemComm 2012
A Systems Approach to Rheumatoid Arthritis
S You, CS Cho, I Lee, L Hood, D Hwang, WU Kim, MA Mancini
PloS one 2012
Pathogenesis of Joint Destruction in Rheumatoid Arthritis
S Shiozawa, K Tsumiyama, K Yoshida, A Hashiramoto
Archivum Immunologiae et Therapiae Experimentalis 2011
A mixture of Trachelospermi caulis and Moutan cortex radicis extracts suppresses collagen-induced arthritis in mice by inhibiting NF-κB and AP-1 : Anti-arthritic herbal mixture
HS Kim, AR Kim, JM Lee, SN Kim, JH Choi, DK Kim, JH Kim, B Kim, E Her, YM Yang, HS Kim, YM Kim, WS Choi
Journal of Pharmacy and Pharmacology 2011
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
B Bartok, GS Firestein
Immunological Reviews 2010
Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B
A Hashiramoto, M Murata, T Kawazoe, K Yoshida, C Akiyama, K Shiozawa, S Shiozawa
Rheumatology 2010
Interactions between the genes that regulate the body clock and those that worsen rheumatoid arthritis
S Shiozawa, A Hashiramoto
Expert Review of Clinical Immunology 2010
IL-3 inhibits TNF-alpha-induced bone resorption and prevents inflammatory arthritis
SD Yogesha, SM Khapli, RK Srivastava, LS Mangashetti, ST Pote, GC Mishra, MR Wani
Journal of immunology (Baltimore, Md. : 1950) 2009
Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α
A Hashiramoto, T Yamane, K Tsumiyama, K Yoshida, K Komai, H Yamada, F Yamazaki, M Doi, H Okamura, S Shiozawa
Journal of immunology (Baltimore, Md. : 1950) 2009
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
Y Aikawa, K Morimoto, T Yamamoto, H Chaki, A Hashiramoto, H Narita, S Hirono, S Shiozawa
Nature Biotechnology 2008
A triple altered collagen II peptide with consecutive substitutions of TCR contacting residues inhibits collagen-induced arthritis
ZQ Yao, R Li, ZG Li
Annals of the rheumatic diseases 2007
p38 MAP Kinase inhibitor
M NISHIKAWA, A MYOUI, T TOMITA, K TAKAHI, A NAMPEI, H YOSHIKAWA
Japanese Journal of Clinical Immunology 2007
Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo
Y Kunugiza, T Tomita, N Tomita, R Morishita, H Yoshikawa
Arthritis Research & Therapy 2006
Mechanisms of Disease: transcription factors in inflammatory arthritis
D Aud, SL Peng
Nature Clinical Practice Rheumatology 2006
Gene therapy for arthritis: What next?
CH Evans, SC Ghivizzani, PD Robbins
Arthritis & Rheumatism 2006
Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro
S Ahmed, N Wang, BB Hafeez, VK Cheruvu, TM Haqqi
The Journal of nutrition 2005
Use of local electroporation enhances methotrexate effects with minimum dose in adjuvant-induced arthritis
M Tada, K Inui, T Koike, K Takaoka
Arthritis & Rheumatism 2005
Herbal Medications Commonly Used in the Practice of Rheumatology: Mechanisms of Action, Efficacy, and Side Effects
AR Setty, LH Sigal
Seminars in Arthritis and Rheumatism 2005
Punica granatum L. Extract Inhibits IL-1β–Induced Expression of Matrix Metalloproteinases by Inhibiting the Activation of MAP Kinases and NF-κB in Human Chondrocytes In Vitro
S Ahmed, N Wang, BB Hafeez, VK Cheruvu, TM Haqqi
The Journal of nutrition 2005
Antirheumatic Therapy: Actions and Outcomes
RO Day, DE Fürst, PL van Riel, B Bresnihan
2005
Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model
K Tsuchida, H Chaki, T Takakura, H Kotsubo, T Tanaka, Y Aikawa, S Shiozawa, S Hirono
Journal of Medicinal Chemistry 2005
Ameliorative effects of follistatin-related protein/TSC-36/FSTL1 on joint inflammation in a mouse model of arthritis
D Kawabata, M Tanaka, T Fujii, H Umehara, Y Fujita, H Yoshifuji, T Mimori, S Ozaki
Arthritis & Rheumatism 2004
Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes
J Sylvester, A Liacini, WQ Li, M Zafarullah
Cellular Signalling 2004
Human wee1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: rheumatoid synovial cells overexpressing these genes go into aberrant mitosis
H Kawasaki, K Komai, M Nakamura, E Yamamoto, Z Ouyang, T Nakashima, T Morisawa, A Hashiramoto, K Shiozawa, H Ishikawa, M Kurosaka, S Shiozawa
Oncogene 2003
IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts
H Perlman, K Bradley, H Liu, S Cole, E Shamiyeh, RC Smith, K Walsh, S Fiore, AE Koch, GS Firestein, GK 3rd, RM Pope
Journal of immunology (Baltimore, Md. : 1950) 2003
Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential
JH der Thüsen, J Kuiper, TJ Berkel, EA Biessen
Pharmacological reviews 2003
Evolving concepts of rheumatoid arthritis
GS Firestein
Nature 2003
p21waf1/cip1 is down-regulated in conjunction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients
M Hikasa, E Yamamoto, H Kawasaki, K Komai, K Shiozawa, A Hashiramoto, Y Miura, S Shiozawa
Biochemical and Biophysical Research Communications 2003
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
M Nishikawa, A Myoui, T Tomita, K Takahi, A Nampei, H Yoshikawa
Arthritis & Rheumatism 2003
Regulation of matrix metalloproteinases: an overview
Sajal Chakraborti, Malay Mandal, Sudip Das, Amritlal Mandal, Tapati Chakraborti
Molecular and Cellular Biochemistry 2003
Cytokine inhibitors in the treatment of rheumatoid arthritis
C Gabay
Expert Opinion on Biological Therapy 2002
Matrix metalloproteinases as therapeutic targets in arthritic diseases: Bull's-eye or missing the mark?
JA Mengshol, KS Mix, CE Brinckerhoff
Arthritis & Rheumatism 2002
c-Fos/activator protein-1 transactivates wee1 kinase at G(1)/S to inhibit premature mitosis in antigen-specific Th1 cells
H Kawasaki, K Komai, Z Ouyang, M Murata, M Hikasa, M Ohgiri, S Shiozawa
The EMBO Journal 2001
PATHOGENESIS OF RHEUMATOID ARTHRITIS: THE ROLE OF SYNOVIOCYTES
Y Yamanishi, GS Firestein
Rheumatic Disease Clinics of North America 2001
Gene therapy for rheumatoid arthritis
E Gouze, SC Ghivizzani, PD Robbins, CH Evans
Current Rheumatology Reports 2001
Proteases in invasion: matrix metalloproteinases
WG Stetler-Stevenson, AE Yu
Seminars in Cancer Biology 2001
Synergistic induction of matrix metalloproteinase 1 by interleukin-1? and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism
JB Catterall, S Carr�re, PJ Koshy, BA Degnan, WD Shingleton, CE Brinckerhoff, J Rutter, TE Cawston, AD Rowan
Arthritis & Rheumatism 2001
Gene therapy in rheumatic diseases
MJ Vervoordeldonk, PP Tak
Best Practice & Research Clinical Rheumatology 2001
In VivoInhibition of Cyclooxygenase-2 by a Selective Phosphorothioated Oligonucleotide
I Khan, FM Al-Awadi, N Thomas
Antisense and Nucleic Acid Drug Development 2001
Impact of transcription factors AP-1 and NF-κB on the outcome of experimental Staphylococcus aureus arthritis and sepsis
I Gjertsson, OH Hultgren, LV Collins, S Pettersson, A Tarkowski
Microbes and Infection 2001
GENE THERAPY FOR RHEUMATOID ARTHRITIS
JN Gouze, SC Ghivizzani, E Gouze, GD Palmer, OB Betz, PD Robbins, CH Evans, JH Herndon
Hand Surgery 2001
The possible role of c-fos expression in rheumatoid joint destruction
M Tsuji, M Tanaka, H Hayashi, S Koshiishi, K Fujii
Modern Rheumatology 2001
Therapeutic Immunosuppression
AW Thomson
2001
IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis
C Gabay
Expert Opinion on Investigational Drugs 2000
Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells
Y Okada, O Voznesensky, H Herschman, J Harrison, C Pilbeam
Journal of Cellular Biochemistry 2000
Spontaneous and cytokine regulated c-fos gene expression in rheumatoid synovial cells: resistance to cytokine stimulation when the c-fos gene is overexpressed
K Shimizu, H Kawasaki, T Morisawa, M Nakamura, E Yamamoto, N Yoshikawa, M Doita, K Shiozawa, S Yonehara, K Chihara, S Shiozawa
Annals of the rheumatic diseases 2000
Selective Inhibition of Cyclooxygenase-2 with Antisense Oligodeoxynucleotide Restricts Induction of Rat Adjuvant-Induced Arthritis
R Yamada, H Sano, T Hla, A Hashiramoto, Y Kawahito, S Mukai, M Kohno, Y Tsubouchi, M Inoue, A Komatsu, K Inoue, M Kondo
Biochemical and Biophysical Research Communications 2000
Inhibition Of Transcription Factors By Anti-Inflammatory And Anti-Rheumatic Drugs: Can Variability In Response Be Overcome?
ML Handel, LQ Nguyen, TP Lehmann
Clinical and Experimental Pharmacology and Physiology 2000
Inflammation and Native American medicine: the role of botanicals
AT Borchers, CL Keen, JS Stern, ME Gershwin
The American journal of clinical nutrition 2000
Gene Therapy in Inflammatory Diseases
CH Evans, PD Robbins
2000
Type IIA Secretory Phospholipase A 2 Up-Regulates Cyclooxygenase-2 and Amplifies Cytokine-Mediated Prostaglandin Production in Human Rheumatoid Synoviocytes
MJ Bidgood, OS Jamal, AM Cunningham, PM Brooks, KF Scott
Journal of immunology (Baltimore, Md. : 1950) 2000
Gene therapy for autoimmune disorders
C H Evans, S C Ghivizzani, T J Oligino, P D Robbins
Journal of Clinical Immunology 2000
The use of gene therapy in osteoarthritis: present and future
JC Fernandes, J Martel-Pelletier, JP Pelletier
Current Opinion in Orthopedics 1999
Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-κB
K Riehemann, B Behnke, K Schulze-Osthoff
FEBS Letters 1999
Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell
H Kawasaki, Y Nakata, G Suzuki, K Chihara, T Tokuhisa, S Shiozawa
International Immunology 1999
Signal transduction and transcription factors in rheumatic disease
GS Firestein, AM Manning
Arthritis & Rheumatism 1999
Regulation of matrix metalloproteinase expression in tumor invasion
J Westermarck, VM Kähäri
The FASEB Journal 1999
Mechanical Loading of Bones and Joints
HE Takahashi
1999
Structure of the human histamine H1 receptor gene
MD de Backer, I Loonen, P Verhasselt, JM Neefs, WH Luyten
Biochemical Journal 1998
Gene therapy in autoimmune diseases
CH Evans, JD Whalen, CH Evans, SC Ghivizzani, PD Robbins
Annals of the rheumatic diseases 1998
Treatment of rheumatoid arthritis with IL-1 inhibitors
C Gabay, WP Arend
Springer Seminars in Immunopathology 1998
Transcription factors
PJ Barnes, IM Adcock
Clinical & Experimental Allergy 1995

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 patents
15 readers on Mendeley
See more details