Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
D J Berg, … , M W Leach, D Rennick
D J Berg, … , M W Leach, D Rennick
Published August 15, 1996
Citation Information: J Clin Invest. 1996;98(4):1010-1020. https://doi.org/10.1172/JCI118861.
View: Text | PDF
Research Article Article has an altmetric score of 17

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

  • Text
  • PDF
Abstract

We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-). Our longitudinal studies showed that inflammatory changes first appear in the cecum, ascending and transverse colon of 3-wk-old mutants. As the disease progressed, lesions appeared in the remainder of the colon and in the rectum. Some aged IL-10-/- mice also developed inflammation in the small intestine. Prolonged disease with transmural lesions and a high incidence of colorectal adenocarcinomas (60%) was observed in 6-mo-old mutants. Mechanistic studies have associated uncontrolled cytokine production by activated macrophages and CD4+ Th1-like T cells with the enterocolitis exhibited by IL-10-/- mice. A major role for a pathogenic Th1 response was further suggested by showing that anti-IFNgamma antibody (Ab) treatment significantly attenuated intestinal inflammation in young IL-10-/- mice. When weanlings were treated with IL-10, they failed to develop any signs of intestinal inflammation. Interestingly, IL-10 treatment of adults was not curative but did ameliorate disease progression. Our studies have also shown that inheritable factors strongly influence the disease susceptibility of IL-10-/- mice. In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain.

Authors

D J Berg, N Davidson, R Kühn, W Müller, S Menon, G Holland, L Thompson-Snipes, M W Leach, D Rennick

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1991 1985 Total
Citations: 5 13 15 20 43 20 35 22 20 41 41 44 49 37 50 39 45 54 42 26 30 33 37 29 34 38 38 28 8 1 1 938
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (20)

Title and authors Publication Year
MUC1-C drives stemness in progression of colitis to colorectal cancer
Wei Li, Ning Zhang, Caining Jin, Mark D. Long, Hasan Rajabi, Yota Yasumizu, Atsushi Fushimi, Nami Yamashita, Masayuki Hagiwara, Rongbin Zheng, Jin Wang, Ling Kui, Harpal Singh, Surender Kharbanda, Qiang Hu, Song Liu, Donald W. Kufe
JCI Insight 2020
C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
P Ding, L Li, L Li, X Lv, D Zhou, Q Wang, J Chen, C Yang, E Xu, W Dai, X Zhang, N Wang, Q Wang, W Zhang, L Zhang, Y Zhou, H Gu, Q Lei, X Zhou, W Hu
Theranostics 2020
Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models
E Mizoguchi, D Low, Y Ezaki, T Okada
Intestinal Research 2020
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis
LP Hale, SD Fugmann
PloS one 2020
Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases
M Covington, X He, M Scuron, J Li, R Collins, A Juvekar, N Shin, M Favata, K Gallagher, S Sarah, C Xue, M Peel, K Burke, J Oliver, B Fay, W Yao, T Huang, P Scherle, S Diamond, R Newton, Y Zhang, P Smith
European Journal of Pharmacology 2020
Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation
G Vincent, EA Novak, VS Siow, KE Cunningham, BD Griffith, TE Comerford, HL Mentrup, DB Stolz, P Loughran, S Ranganathan, KP Mollen
Antioxidants & Redox Signaling 2020
Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice
Y Malaisé, C Lencina, F Placide, V Bacquié, C Cartier, M Olier, M Buettner, M Wallbrecht, S Ménard, L Guzylack-Piriou
Food and Chemical Toxicology 2020
The development of colitis in Il10−/− mice is dependent on IL-22
DC Gunasekera, J Ma, V Vacharathit, P Shah, A Ramakrishnan, P Uprety, Z Shen, A Sheh, CF Brayton, MT Whary, JG Fox, JH Bream
Mucosal Immunology 2020
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
HX Wei, B Wang, B Li
Frontiers in immunology 2020
Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study
J Viña-Almunia, H Pellicer-Chover, B García-Mira, J Romero-Millán, D Peñarrocha-Oltra, M Peñarrocha-Diago
International Journal of Implant Dentistry 2020
Nicotine-induced autophagy via AMPK/mTOR pathway exerts protective effect in colitis mouse model
Q Gao, P Bi, D Luo, Y Guan, W Zeng, H Xiang, Q Mi, G Yang, X Li, B Yang
Chemico-Biological Interactions 2020
Local reinfusion of B10 cells is effective in the treatment of pustular psoriasis
J Lu, X Xu, Y Li, N Yu, Y Ding, Y Shi
Dermatologic Therapy 2020
IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease
J Rada, M Donato, FN Penas, CA Soto, ÁC Cevey, AV Pieralisi, R Gelpi, GA Mirkin, NB Goren
Frontiers in immunology 2020
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma
Y Gao, J Lu, C Zeng, J Yang, B Huang, N Zhang, L Li, X Fu
Clinical and Experimental Medicine 2020
Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il -10 –/– Mice
M Xie, J Yang, J Zhang, HL Sherman, Z Zhang, LM Minter, BD Hammock, Y Park, G Zhang
Journal of Agricultural and Food Chemistry 2020
Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain
M Zurita-Turk, BM Souza, CP de Castro, VB Pereira, VP da Cunha, TM Preisser, AM de Faria, DC Machado, A Miyoshi
BMC Biotechnology 2020
Intermittent hypoxia induces tumor immune escape in murine S180 solid tumors via the upregulation of TGF-β1 in mice
L Ma, W Shan, X Ding, P Yang, A Rozjan, Q Yao
Sleep and Breathing 2020
ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
S Kim, JY Lee, SG Shin, JK Kim, P Silwal, YJ Kim, NR Shin, PS Kim, M Won, SH Lee, SY Kim, M Sasai, M Yamamoto, JM Kim, JW Bae, EK Jo
Autophagy 2020
Cyberlindnera jadinii Yeast as a Protein Source for Weaned Piglets—Impact on Immune Response and Gut Microbiota
L Lagos, AK Bekkelund, A Skugor, R Ånestad, CP Åkesson, CM Press, M Øverland
Frontiers in immunology 2020
Effect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats
F Alimahdi, N Shahrokhi, MK Hadad, G Asadikaram, M Abolhasani
2020

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Blogged by 1
Referenced in 61 patents
Referenced in 1 Wikipedia pages
409 readers on Mendeley
See more details