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D J Berg, … , M W Leach, D Rennick
Published August 15, 1996
Citation Information: J Clin Invest. 1996;98(4):1010-1020. https://doi.org/10.1172/JCI118861.
Citation Information: J Clin Invest. 1996;98(4):1010-1020. https://doi.org/10.1172/JCI118861.
Abstract
We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-). Our longitudinal studies showed that inflammatory changes first appear in the cecum, ascending and transverse colon of 3-wk-old mutants. As the disease progressed, lesions appeared in the remainder of the colon and in the rectum. Some aged IL-10-/- mice also developed inflammation in the small intestine. Prolonged disease with transmural lesions and a high incidence of colorectal adenocarcinomas (60%) was observed in 6-mo-old mutants. Mechanistic studies have associated uncontrolled cytokine production by activated macrophages and CD4+ Th1-like T cells with the enterocolitis exhibited by IL-10-/- mice. A major role for a pathogenic Th1 response was further suggested by showing that anti-IFNgamma antibody (Ab) treatment significantly attenuated intestinal inflammation in young IL-10-/- mice. When weanlings were treated with IL-10, they failed to develop any signs of intestinal inflammation. Interestingly, IL-10 treatment of adults was not curative but did ameliorate disease progression. Our studies have also shown that inheritable factors strongly influence the disease susceptibility of IL-10-/- mice. In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain.
Authors
D J Berg, N Davidson, R Kühn, W Müller, S Menon, G Holland, L Thompson-Snipes, M W Leach, D Rennick
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Citations to this article (939)
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IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma
Y Gao, J Lu, C Zeng, J Yang, B Huang, N Zhang, L Li, X Fu |
Clinical and Experimental Medicine | 2020 |
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Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il -10 –/– Mice
M Xie, J Yang, J Zhang, HL Sherman, Z Zhang, LM Minter, BD Hammock, Y Park, G Zhang |
Journal of Agricultural and Food Chemistry | 2020 |
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Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain
M Zurita-Turk, BM Souza, CP de Castro, VB Pereira, VP da Cunha, TM Preisser, AM de Faria, DC Machado, A Miyoshi |
BMC Biotechnology | 2020 |
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Intermittent hypoxia induces tumor immune escape in murine S180 solid tumors via the upregulation of TGF-β1 in mice
L Ma, W Shan, X Ding, P Yang, A Rozjan, Q Yao |
Sleep and Breathing | 2020 |
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ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
S Kim, JY Lee, SG Shin, JK Kim, P Silwal, YJ Kim, NR Shin, PS Kim, M Won, SH Lee, SY Kim, M Sasai, M Yamamoto, JM Kim, JW Bae, EK Jo |
Autophagy | 2020 |
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Cyberlindnera jadinii Yeast as a Protein Source for Weaned Piglets—Impact on Immune Response and Gut Microbiota
L Lagos, AK Bekkelund, A Skugor, R Ånestad, CP Åkesson, CM Press, M Øverland |
Frontiers in immunology | 2020 |
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Effect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats
F Alimahdi, N Shahrokhi, MK Hadad, G Asadikaram, M Abolhasani |
2020 | |
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Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells
Yoshiyuki Mishima, Akihiko Oka, Bo Liu, Jeremy Herzog, Chang Soo Eun, Ting-Jia Fan, Emily Bulik-Sullivan, Ian M Carroll, Hansen J Jonathan, Liang Chen, Justin Wilson, Nancy C. Fisher, Jenny Pan-Yun Ting, Tomonori Nochi, Angela Wahl, J. Victor Garcia, Christopher Karp, R. Balfour Sartor |
Journal of Clinical Investigation | 2019 |
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Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease
WC Reisdorf, Q Xie, X Zeng, W Xie, N Rajpal, B Hoang, ME Burgert, V Kumar, MR Hurle, DK Rajpal, S ODonnell, TT MacDonald, A Vossenkämper, L Wang, M Reilly, BJ Votta, Y Sanchez, P Agarwal, F D'Acquisto |
PloS one | 2019 |
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Natural Killer Cell-Derived IL-10 Prevents Liver Damage During Sustained Murine Cytomegalovirus Infection
AK Ali, AK Komal, SM Almutairi, SH Lee |
Frontiers in immunology | 2019 |
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T lymphocytes in the intestinal mucosa: defense and tolerance
H Ma, W Tao, S Zhu |
Cellular and Molecular Immunology | 2019 |
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Immune Cell Infiltration into the Eye Is Controlled by IL-10 in Recoverin-Induced Autoimmune Retinopathy
E Nikoopour, C Lin, S Sheskey, JR Heckenlively, SK Lundy |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
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Top-100 highest-cited original articles in inflammatory bowel disease: A bibliometric analysis
X Chen, K Yang, Y Xu, K Li |
Medicine | 2019 |
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Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways
R Hurtubise, C Audiger, MC Dominguez-Punaro, G Chabot-Roy, G Chognard, L Raymond-Marchand, L Coderre, S Chemtob, SW Michnick, JD Rioux, S Lesage |
Cytokine | 2019 |
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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
WV Graham, W He, AM Marchiando, J Zha, G Singh, HS Li, A Biswas, ML Ong, ZH Jiang, W Choi, H Zuccola, Y Wang, J Griffith, J Wu, HJ Rosenberg, Y Wang, SB Snapper, D Ostrov, SC Meredith, LW Miller, JR Turner |
Nature Medicine | 2019 |
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Regulatory cytokine function in the respiratory tract
WJ Branchett, CM Lloyd |
Mucosal Immunology | 2019 |
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Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
B Ruder, R Atreya, C Becker |
International journal of molecular sciences | 2019 |
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Immune regulation and cytotoxic T cell activation of IL-10 agonists – Preclinical and clinical experience
M Oft |
Seminars in Immunology | 2019 |
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The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice
L Berkowitz, C Pardo-Roa, G Ramírez, OP Vallejos, VP Sebastián, CA Riedel, M Álvarez-Lobos, SM Bueno, M Chamaillard |
PloS one | 2019 |
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Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice
L Berkowitz, C Pardo-Roa, GA Salazar, F Salazar-Echegarai, JP Miranda, G Ramírez, JL Chávez, AM Kalergis, SM Bueno, M Álvarez-Lobos |
Frontiers in immunology | 2019 |
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Noncoding RNAs in inflammation and colorectal cancer
Ma S, Long T, Huang WJ |
RNA biology | 2019 |
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1,25‑Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b
X Zhu, Y Zhu, C Li, J Yu, DD Ren, S Qiu, Y Nie, X Yu, X Xu, W Zhu |
International Immunopharmacology | 2019 |
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Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis
M Kim, B Gu, MC Madison, HW Song, K Norwood, AA Hill, WJ Wu, D Corry, F Kheradmand, GE Diehl |
Frontiers in immunology | 2019 |
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Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line
R Gundamaraju, R Vemuri, WC Chong, AC Bulmer, R Eri |
International journal of medical sciences | 2019 |
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Pegylated Interleukin-10: Clinical Development of an Immunoregulatory Cytokine for Use in Cancer Therapeutics
K Autio, M Oft |
Current Oncology Reports | 2019 |
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Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma
K Choucair, JD Kelso, JR Duff, CS Cassidy, MT Albrethsen, M Ashraf, C Verghese, M Oft, FC Brunicardi, L Dworkin, J Nemunaitis |
Case reports in oncology | 2019 |
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Composition of the Intestinal Microbiota Determines the Outcome of Virus-Triggered Colitis in Mice
S Bolsega, M Basic, A Smoczek, M Buettner, C Eberl, D Ahrens, KA Odum, B Stecher, A Bleich |
Frontiers in immunology | 2019 |
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Colorectal carcinoma in the course of inflammatory bowel diseases
A Hnatyszyn, S Hryhorowicz, M Kaczmarek-Ryś, E Lis, R Słomski, RJ Scott, A Pławski |
Hereditary cancer in clinical practice | 2019 |
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IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole
ÁC Cevey, FN Penas, CD Soto, GA Mirkin, NB Goren |
Frontiers in immunology | 2019 |
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Chronic Model of Inflammatory Bowel Disease in IL-10 -/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging
H Wang, JG Vilches-Moure, S Cherkaoui, I Tardy, C Alleaume, T Bettinger, A Lutz, R Paulmurugan |
Theranostics | 2019 |
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Sex-related Alterations of Gut Microbiota in the C57BL/6 Mouse Model of Inflammatory Bowel Disease
HJ Son, N Kim, CH Song, RH Nam, SI Choi, JS Kim, DH Lee |
Journal of Cancer Prevention | 2019 |
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Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis
S Mountford, A Ringleb, R Schwaiger, D Mayr, S Kobold, CA Dinarello, P Bufler |
Frontiers in immunology | 2019 |
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Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond
ML Hibbs, AL Raftery, E Tsantikos |
Growth Factors | 2019 |
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High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors
SE Norton, KA Ward-Hartstonge, JL McCall, JK Leman, ES Taylor, F Munro, MA Black, BF de St. Groth, HM McGuire, RA Kemp |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
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Validation studies for germ-free Smad3 -/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD
J Paik, S Meeker, CC Hsu, A Seamons, O Pershutkina, JM Snyder, T Brabb, L Maggio-Price |
Gut microbes | 2019 |
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Mechanisms by Which the Gut Microbiota Influences Cytokine Production and Modulates Host Inflammatory Responses
V Mendes, I Galvão, AT Vieira |
Journal of Interferon & Cytokine Research | 2019 |
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The Expanding Role of Anti-IL-12 and/or Anti-IL-23 Antibodies in the Treatment of Inflammatory Bowel Disease
Amir Kashani, David A Schwartz |
Gastroenterology & hepatology | 2019 |
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Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease
U Sharma, RK Olson, FN Erhart, L Zhang, J Meng, B Segura, S Banerjee, M Sharma, AK Saluja, S Ramakrishnan, MT Abreu, S Roy |
Journal of Crohn's & colitis | 2019 |
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Introduction to the Special Issue: Interleukin-10 “The surprising twists and turns of an anti-inflammatory cytokine on its way to the clinic”
J Geginat |
Seminars in Immunology | 2019 |
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Regulation of breathing pattern by IL-10
CE Giannakopoulou, A Sotiriou, M Dettoraki, M Yang, F Perlikos, D Toumpanakis, G Prezerakos, I Koutsourelakis, GA Kastis, V Vassilakopoulou, E Mizi, A Papalois, JJ Greer, T Vassilakopoulos |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2019 |
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ILC2s are the predominant source of intestinal ILC-derived IL-10
JK Bando, S Gilfillan, BD Luccia, JL Fachi, C Sécca, M Cella, M Colonna |
Journal of Experimental Medicine | 2019 |
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Validation studies for germ-free Smad3-/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD.
Paik J, Meeker S, Hsu CC, Seamons A, Pershutkina O, Snyder JM, Brabb T, Maggio-Price L |
Gut microbes | 2019 |
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PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
A Naing, JR Infante, KP Papadopoulos, IH Chan, C Shen, NP Ratti, B Rojo, KA Autio, DJ Wong, MR Patel, PA Ott, GS Falchook, S Pant, A Hung, KL Pekarek, V Wu, M Adamow, S McCauley, JB Mumm, P Wong, PV Vlasselaer, J Leveque, NM Tannir, M Oft |
Cancer Cell | 2018 |
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Immunological Approaches Towards Cancer and Inflammation: A Cross Talk
X Qu, Y Tang, S Hua |
Frontiers in immunology | 2018 |
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Mast Cells Exert Anti-Inflammatory Effects in an IL10 −/− Model of Spontaneous Colitis
EM Lennon, LB Borst, LL Edwards, AJ Moeser |
Mediators of Inflammation | 2018 |
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Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis
H Lenzen, J Qian, MP Manns, U Seidler, A Jörns |
Journal of Molecular Medicine | 2018 |
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Chronic Lymphocytic Leukemia–Derived IL-10 Suppresses Antitumor Immunity
SS Alhakeem, MK McKenna, KZ Oben, SK Noothi, JR Rivas, GC Hildebrandt, RA Fleischman, VM Rangnekar, N Muthusamy, S Bondada |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
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Hexokinase 2 is dispensable for T cell-dependent immunity
MM Mehta, SE Weinberg, EM Steinert, K Chhiba, CA Martinez, P Gao, HR Perlman, P Bryce, N Hay, NS Chandel |
Cancer & Metabolism | 2018 |
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The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis
A Cardoso, AG Castro, AC Martins, GM Carriche, V Murigneux, I Castro, A Cumano, P Vieira, M Saraiva |
Frontiers in immunology | 2018 |
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Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis
H Yoon, M Schaubeck, I Lagkouvardos, A Blesl, S Heinzlmeir, H Hahne, T Clavel, S Panda, C Ludwig, B Kuster, C Manichanh, P Kump, D Haller, G Hörmannsperger |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 |
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Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses
K Singh, LA Coburn, M Asim, DP Barry, MM Allaman, C Shi, MK Washington, PB Luis, C Schneider, AG Delgado, MB Piazuelo, JL Cleveland, AP Gobert, KT Wilson |
Cancer research | 2018 |
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Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis
KR Greenow, M Zverev, S May, H Kendrick, GT Williams, T Phesse, L Parry |
Oncotarget | 2018 |
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Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments
A Trouillet, E Dubus, J Dégardin, A Estivalet, I Ivkovic, D Godefroy, D García-Ayuso, M Simonutti, I Sahly, JA Sahel, A El-Amraoui, C Petit, S Picaud |
Scientific Reports | 2018 |
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Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease
PJ Koelink, ME Wildenberg, LW Stitt, BG Feagan, M Koldijk, AB van Wout, R Atreya, M Vieth, JF Brandse, S Duijst, AA Velde, GR DHaens, BG Levesque, GR van Brink |
Journal of Crohn's & colitis | 2018 |
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Gut Microbiota and Mucosal Immunity in the Neonate
M Dzidic, A Boix-Amorós, M Selma-Royo, A Mira, M Collado |
Medical Sciences | 2018 |
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Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn’s Disease
M Delday, I Mulder, ET Logan, G Grant |
Inflammatory Bowel Diseases | 2018 |
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Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation
B Shin, RL Kress, PA Kramer, VM Darley-Usmar, SL Bellis, LE Harrington |
Journal of Experimental Medicine | 2018 |
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Critical Role for the Microbiota in CX 3 CR1 + Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses
M Kim, C Galan, AA Hill, WJ Wu, H Fehlner-Peach, HW Song, D Schady, ML Bettini, KW Simpson, RS Longman, DR Littman, GE Diehl |
Immunity | 2018 |
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Fibrostenotic Inflammatory Bowel Disease
F Rieder |
2018 | |
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Dietary Nondigestible Polysaccharides Ameliorate Colitis by Improving Gut Microbiota and CD4 + Differentiation, as Well as Facilitating M2 Macrophage Polarization
H Wang, Y Wang, J Zhao, J Jiang, Y Zhou, P Shi, Q Liu, Y Sun |
JPEN. Journal of parenteral and enteral nutrition | 2018 |
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Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections
A Riba, M Olier, S Lacroix-Lamandé, C Lencina, V Bacquié, C Harkat, NV Langendonck, M Gillet, C Cartier, M Baron, C Sommer, V Mallet, M Zill, H Robert, F Laurent, S Ellero-Simatos, V Théodorou, S Ménard |
Brain, Behavior, and Immunity | 2018 |
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Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice
SJ Koh, JW Kim, BG Kim, KL Lee, DW Kim, JS Kim |
Carcinogenesis | 2018 |
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Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL-10-Deficient Mice
Y Kang, G Yang, S Zhang, CF Ross, MJ Zhu |
Molecular Nutrition & Food Research | 2018 |
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Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice
C Ring, R Klopfleisch, K Dahlke, M Basic, A Bleich, M Blaut |
Gut microbes | 2018 |
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Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development
R Kumar, JL Herold, D Schady, J Davis, S Kopetz, M Martinez-Moczygemba, BE Murray, F Han, Y Li, E Callaway, RS Chapkin, WM Dashwood, RH Dashwood, T Berry, C Mackenzie, Y Xu, PM Sullam |
PLoS pathogens | 2017 |
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Group III phospholipase A2 promotes colitis and colorectal cancer
R Murase, Y Taketomi, Y Miki, Y Nishito, M Saito, K Fukami, K Yamamoto, M Murakami |
Scientific Reports | 2017 |
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Transcriptional and functional profiling defines human small intestinal macrophage subsets
A Bujko, N Atlasy, OJ Landsverk, L Richter, S Yaqub, R Horneland, O Øyen, EM Aandahl, L Aabakken, HG Stunnenberg, ES Bækkevold, FL Jahnsen |
Journal of Experimental Medicine | 2017 |
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Inflammation and Colorectal Cancer
AG Long, ET Lundsmith, KE Hamilton |
Current Colorectal Cancer Reports | 2017 |
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ALOX15 as a suppressor of inflammation and cancer: Lost in the link
R Tian, X Zuo, J Jaoude, F Mao, J Colby, I Shureiqi |
Prostaglandins & Other Lipid Mediators | 2017 |
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Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice
EL Ma, AD Smith, N Desai, L Cheung, M Hanscom, BA Stoica, DJ Loane, T Shea-Donohue, AI Faden |
Brain, Behavior, and Immunity | 2017 |
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Developmental and Functional Control of Natural Killer Cells by Cytokines
Y Wu, Z Tian, H Wei |
Frontiers in immunology | 2017 |
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A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
SS Deepa, S Bhaskaran, S Espinoza, SV Brooks, A McArdle, MJ Jackson, HV Remmen, A Richardson |
GeroScience | 2017 |
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Regulatory T-cell heterogeneity and the cancer immune response
KA Ward-Hartstonge, RA Kemp |
IBMS BoneKEy | 2017 |
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Crohn's Disease and Ulcerative Colitis
DC Baumgart |
Crohn's Disease and Ulcerative Colitis | 2017 |
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Immunotherapy for Gastrointestinal Cancer
D Kerr, R Johnson |
Immunotherapy for Gastrointestinal Cancer | 2017 |
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Bistability of the cytokine-immune cell network in a cancer microenvironment
X Li, H Levine |
Convergent Science Physical Oncology | 2017 |
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Biomarkers in Cancer Screening and Early Detection
S Srivastava |
Biomarkers in Cancer Screening and Early Detection | 2017 |
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Microbiome, inflammation and colorectal cancer
J Chen, E Pitmon, K Wang |
Seminars in Immunology | 2017 |
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The commensal microbiota exacerbate infectious colitis in stressor-exposed mice
JD Galley, NM Parry, BM Ahmer, JG Fox, MT Bailey |
Brain, Behavior, and Immunity | 2017 |
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Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice
HW Hou, JM Wang, D Wang, R Wu, ZL Ji |
International journal of molecular medicine | 2017 |
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Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice
AF Schulfer, T Battaglia, Y Alvarez, L Bijnens, VE Ruiz, M Ho, S Robinson, T Ward, LM Cox, AB Rogers, D Knights, RB Sartor, MJ Blaser |
Nature Microbiology | 2017 |
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Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity
AM Patterson, IE Mulder, AJ Travis, A Lan, N Cerf-Bensussan, V Gaboriau-Routhiau, K Garden, E Logan, MI Delday, AG Coutts, E Monnais, VC Ferraria, R Inoue, G Grant, RI Aminov |
Frontiers in immunology | 2017 |
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Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
Y Wang, D Huang, KY Chen, M Cui, W Wang, X Huang, A Awadellah, Q Li, A Friedman, WW Xin, LD Martino, F Cominelli, A Miron, R Chan, JG Fox, Y Xu, X Shen, MF Kalady, S Markowitz, I Maillard, JB Lowe, W Xin, L Zhou |
Gastroenterology | 2017 |
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The molecular landscape of colitis-associated carcinogenesis
D Saraggi, M Fassan, C Mescoli, M Scarpa, N Valeri, A Michielan, R DIncá, M Rugge |
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver | 2017 |
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Commensal-Specific CD4+ Cells From Patients With Crohn’s Disease Have a T-Helper 17 Inflammatory Profile
E Calderón-Gómez, H Bassolas-Molina, R Mora-Buch, I Dotti, N Planell, M Esteller, M Gallego, M Martí, C Garcia-Martín, C Martínez-Torró, I Ordás, S Singh, J Panés, D Benítez-Ribas, A Salas |
Gastroenterology | 2016 |
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Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
K Bergstrom, X Liu, Y Zhao, N Gao, Q Wu, K Song, Y Cui, Y Li, JM McDaniel, S McGee, W Chen, MM Huycke, CW Houchen, LA Zenewicz, CM West, H Chen, J Braun, J Fu, L Xia |
Gastroenterology | 2016 |
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Cytokine-Induced Modulation of Colorectal Cancer
LF Mager, MH Wasmer, TT Rau, P Krebs |
Frontiers in Oncology | 2016 |
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Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis
KE Cunningham, G Vincent, CP Sodhi, EA Novak, S Ranganathan, CE Egan, DB Stolz, MB Rogers, B Firek, MJ Morowitz, GK Gittes, BS Zuckerbraun, DJ Hackam, KP Mollen |
The Journal of biological chemistry | 2016 |
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Regulatory T Cells and Cancer: A Two-Sided Story
K Wang, AT Vella |
Immunological Investigations | 2016 |
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The 100 classic papers in ulcerative colitis: a bibliometric analysis
TM Connelly, L Devane, JC Kelly, P Wrafter, E Messaris |
Expert Review of Gastroenterology & Hepatology | 2016 |
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IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites
M Wadwa, R Klopfleisch, A Adamczyk, A Frede, E Pastille, K Mahnke, W Hansen, R Geffers, KS Lang, J Buer, J Büning, AM Westendorf |
Mucosal Immunology | 2016 |
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Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects
R Rigoni, E Fontana, S Guglielmetti, B Fosso, AM DErchia, V Maina, V Taverniti, MC Castiello, S Mantero, G Pacchiana, S Musio, R Pedotti, C Selmi, JR Mora, G Pesole, P Vezzoni, PL Poliani, F Grassi, A Villa, B Cassani |
Journal of Experimental Medicine | 2016 |
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Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model
MA Khajah, KV Ananthalakshmi, I Edafiogho, HM Arafa |
PloS one | 2016 |
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The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer
J Geginat, P Larghi, M Paroni, G Nizzoli, A Penatti, M Pagani, N Gagliani, P Meroni, S Abrignani, RA Flavell |
Cytokine & Growth Factor Reviews | 2016 |
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Breastfed at Tiffany's
T Hennet, L Borsig |
Trends in Biochemical Sciences | 2016 |
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Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages
V Frodermann, J Duijn, GH van Puijvelde, PJ van Santbrink, HM Lagraauw, MR de Vries, PH Quax, I Bot, AC Foks, SC de Jager, J Kuiper |
Journal of Internal Medicine | 2016 |
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Feedback mechanisms between M2 macrophages and Th17 cells in colorectal cancer patients
H Mao, F Pan, H Guo, F Bu, T Xin, S Chen, Y Guo |
Tumor Biology | 2016 |
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Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling
C Wu, RB Sartor, K Huang, SL Tonkonogy |
Immunology | 2016 |
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Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
JM Simon, JP Davis, SE Lee, MR Schaner, GR Gipson, M Weiser, RB Sartor, HH Herfarth, R Rahbar, TS Sadiq, MJ Koruda, DP McGovern, JD Lieb, KL Mohlke, TS Furey, SZ Sheikh |
European Journal of Immunology | 2016 |
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Mouse models of ageing and their relevance to disease
S Kõks, S Dogan, BG Tuna, H González-Navarro, P Potter, RE Vandenbroucke |
Mechanisms of Ageing and Development | 2016 |
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The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression
S Hörber, DG Hildebrand, WS Lieb, S Lorscheid, S Hailfinger, K Schulze-Osthoff, F Essmann |
The Journal of biological chemistry | 2016 |
|
The commensal microbiota exacerbate infectious colitis in stressor-exposed mice
JD Galley, NM Parry, BM Ahmer, JG Fox, MT Bailey |
Brain, Behavior, and Immunity | 2016 |
|
S100G expression and function in fibroblasts on colitis induction
K Ishiguro, O Watanabe, M Nakamura, T Yamamura, T Ando, H Goto, Y Hirooka |
International Immunopharmacology | 2016 |
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ROS in gastrointestinal inflammation: Rescue Or Sabotage?: ROS and GI inflammation
G Aviello, UG Knaus |
British Journal of Pharmacology | 2016 |
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Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression
Y Wang, SN Sun, Q Liu, YY Yu, J Guo, K Wang, BC Xing, QF Zheng, MJ Campa, EF Patz, SY Li, YW He |
Cancer Discovery | 2016 |
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Compensatory roles of CD8+ T cells and plasmacytoid dendritic cells in gut immune regulation for reduced function of CD4+ Tregs
Kim YI, Lee BR, Cheon JH, Kwon BE, Kweon MN, Ko HJ, Chang SY |
Oncotarget | 2016 |
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Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line
DB Vendramini-Costa, A Alcaide, KJ Pelizzaro-Rocha, E Talero, J Ávila-Román, S Garcia-Mauriño, RA Pilli, JE de Carvalho, V Motilva |
Toxicology and Applied Pharmacology | 2016 |
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Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10−/− colitis
Y Hagenlocher, A Hösel, SC Bischoff, A Lorentz |
The Journal of Nutritional Biochemistry | 2016 |
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Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice
E Talero, A Alcaide, J Ávila-Román, S García-Mauriño, D Vendramini-Costa, V Motilva |
International Immunopharmacology | 2016 |
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Current Protocols in Pharmacology: Inflammatory Bowel Disease in Mice
B Bang, LM Lichtenberger |
Current Protocols in Pharmacology: Inflammatory Bowel Disease in Mice | 2016 |
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Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
E Viennois, SA Ingersoll, S Ayyadurai, Y Zhao, L Wang, M Zhang, MK Han, P Garg, B Xiao, D Merlin |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2016 |
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Novel immunomodulatory effects of phytanic acid and its related substances in mice
T Nakanishi, M Anraku, R Suzuki, T Kono, L Erickson, S Kawahara |
Journal of Functional Foods | 2016 |
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Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages
A Howes, C Taubert, S Blankley, N Spink, X Wu, CM Graham, J Zhao, M Saraiva, P Ricciardi-Castagnoli, GJ Bancroft, A OGarra |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
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Repression of microRNA Function Mediates Inflammation-associated Colon Tumorigenesis
T Yoshikawa, J Wu, M Otsuka, T Kishikawa, N Suzuki, A Takata, M Ohno, R Ishibashi, M Yamagami, R Nakagawa, N Kato, M Miyazawa, J Han, K Koike |
Gastroenterology | 2016 |
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Future therapeutic potential of SAP-1 in inflammatory bowel diseases
T Kotani, Y Murata, Y Saito, T Matozaki |
Expert Review of Gastroenterology & Hepatology | 2016 |
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Comparative Effect of the I3.1 Probiotic Formula in Two Animal Models of Colitis
V Lorén, J Manyé, MC Fuentes, E Cabré, I Ojanguren, J Espadaler |
Probiotics and Antimicrobial Proteins | 2016 |
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Diet, microorganisms and their metabolites, and colon cancer
SJ O'Keefe |
Nature Reviews Gastroenterology & Hepatology | 2016 |
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Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury
EM Besecker, GM Deiter, N Pironi, TK Cooper, GM Holmes |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2016 |
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Pro-Tumoral Inflammatory Myeloid Cells as Emerging Therapeutic Targets
G Szebeni, C Vizler, L Nagy, K Kitajka, L Puskas |
International journal of molecular sciences | 2016 |
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Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice
T Zhang, C Ding, M Zhao, X Dai, J Yang, Y Li, L Gu, Y Wei, J Gong, W Zhu, N Li, J Li |
Nutrients | 2016 |
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Interleukin-10: An Immune-Activating Cytokine in Cancer Immunotherapy
H Zhang, Y Wang, ES Hwang, YW He |
Journal of Clinical Oncology | 2016 |
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Colitis-Associated Cancer
M Kusunoki |
2016 | |
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Expression of Blimp-1 in Dendritic Cells Modulates the Innate Inflammatory Response in Dextran Sodium Sulfate–Induced Colitis
Sun Jung Kim, Jordan Goldstein, Kimberly Dorso, Miriam Merad, Lloyd Mayer, James M Crawford, Peter K Gregersen, Betty Diamond |
Molecular Medicine | 2015 |
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Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium
Y Murata, T Kotani, Y Supriatna, Y Kitamura, S Imada, K Kawahara, M Nishio, EW Daniwijaya, H Sadakata, S Kusakari, M Mori, Y Kanazawa, Y Saito, K Okawa, M Takeda-Morishita, H Okazawa, H Ohnishi, T Azuma, A Suzuki, T Matozaki |
Proceedings of the National Academy of Sciences | 2015 |
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MUC1-C activates the TAK1 inflammatory pathway in colon cancer
H Takahashi, C Jin, H Rajabi, S Pitroda, M Alam, R Ahmad, D Raina, M Hasegawa, Y Suzuki, A Tagde, RT Bronson, R Weichselbaum, D Kufe |
Oncogene | 2015 |
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Experimental colitis models: Insights into the pathogenesis of inflammatory bowel disease and translational issues
V Valatas, G Bamias, G Kolios |
European Journal of Pharmacology | 2015 |
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The Role of Neuropeptides in Mouse Models of Colitis
D Padua, JP Vu, PM Germano, JR Pisegna |
Journal of Molecular Neuroscience | 2015 |
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Immunopathogenesis of IBD: current state of the art
HS de Souza, C Fiocchi |
Nature Reviews Gastroenterology & Hepatology | 2015 |
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Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth
J Lévy, W Cacheux, MA Bara, A L’Hermitte, P Lepage, M Fraudeau, C Trentesaux, J Lemarchand, A Durand, AM Crain, C Marchiol, G Renault, F Dumont, F Letourneur, M Delacre, A Schmitt, B Terris, C Perret, M Chamaillard, JP Couty, B Romagnolo |
Nature Cell Biology | 2015 |
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Experimental Models of Inflammatory Bowel Diseases
P Kiesler, IJ Fuss, W Strober |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2015 |
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Oral Delivery of Particulate Transforming Growth Factor Beta 1 and All-Trans Retinoic Acid Reduces Gut Inflammation in Murine Models of Inflammatory Bowel Disease
TF Conway, L Hammer, S Furtado, E Mathiowitz, F Nicoletti, K Mangano, NK Egilmez, DL Auci |
Journal of Crohn's & colitis | 2015 |
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A Multihit Model: Colitis Lessons from the Interleukin-10–deficient Mouse
LM Keubler, M Buettner, C Häger, A Bleich |
Inflammatory Bowel Diseases | 2015 |
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Irsogladine Maleate Prevents Colitis in Interleukin-10 Gene-Deficient Mice by Reducing Interleukin-12 and -23 Production
T Nakagawa, T Katsuno, Y Noguchi, Y Mandai, S Yoshihama, K Saito, D Maruoka, T Matsumura, M Arai, O Yokosuka |
Biological & Pharmaceutical Bulletin | 2015 |
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Advances in Cancer Research
K Wang, M Karin |
Advances in cancer research | 2015 |
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Antrum Mucosal Protein-18 Peptide Targets Tight Junctions to Protect and Heal Barrier Structure and Function in Models of Inflammatory Bowel Disease:
P Chen, D Bakke, L Kolodziej, J Lodolce, CR Weber, DL Boone, FG Toback |
Inflammatory Bowel Diseases | 2015 |
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Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production
S Metghalchi, P Ponnuswamy, T Simon, Y Haddad, L Laurans, M Clément, M Dalloz, M Romain, B Esposito, V Koropoulis, B Lamas, JL Paul, Y Cottin, S Kotti, P Bruneval, J Callebert, H den Ruijter, JM Launay, N Danchin, H Sokol, A Tedgui, S Taleb, Z Mallat |
Cell Metabolism | 2015 |
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Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites
P Perng, M Lim |
Frontiers in Oncology | 2015 |
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STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?
PM Nguyen, TL Putoczki, M Ernst |
Journal of Interferon & Cytokine Research | 2015 |
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Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis
H Wang, J Dong, P Shi, J Liu, L Zuo, Y Li, J Gong, L Gu, J Zhao, L Zhang, W Zhang, W Zhu, N Li, J Li |
Immunology | 2015 |
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Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation
YC Li, Y Chen, J Du |
The Journal of Steroid Biochemistry and Molecular Biology | 2015 |
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Transgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency
MA Golan, W Liu, Y Shi, L Chen, J Wang, T Liu, YC Li |
Digestive Diseases and Sciences | 2015 |
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Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease
R Chinnadurai |
World journal of gastroenterology : WJG | 2015 |
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Optical reconstruction of murine colorectal mucosa at cellular resolution
CY Liu, PE Dubé, N Girish, AT Reddy, DB Polk |
AJP Gastrointestinal and Liver Physiology | 2015 |
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IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion
S Abraham, J Choi, C Ye, N Manjunath, P Shankar |
Clinical Immunology | 2015 |
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Genetically engineered mucin mouse models for inflammation and cancer
S Joshi, S Kumar, S Bafna, S Rachagani, KU Wagner, M Jain, SK Batra |
Cancer and Metastasis Reviews | 2015 |
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Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression
SD Lee |
World journal of gastroenterology : WJG | 2015 |
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IL-10/HMOX1 Signaling Modulates Cochlear Inflammation via Negative Regulation of MCP-1/CCL2 Expression in Cochlear Fibrocytes
JI Woo, SH Kil, S Oh, YJ Lee, R Park, DJ Lim, SK Moon |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Role of Dopamine and D2 Dopamine Receptor in the Pathogenesis of Inflammatory Bowel Disease
G Tolstanova, X Deng, A Ahluwalia, B Paunovic, A Prysiazhniuk, L Ostapchenko, A Tarnawski, Z Sandor, S Szabo |
Digestive Diseases and Sciences | 2015 |
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Molecular mechanism and cellular function of MHCII ubiquitination
J Oh, JS Shin |
Immunological Reviews | 2015 |
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Diet-Induced Hyperhomocysteinaemia Increases Intestinal Inflammation in an Animal Model of Colitis
S Zhu, J Li, Y Bing, W Yan, Y Zhu, B Xia, M Chen |
Journal of Crohn's & colitis | 2015 |
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Cutting Edge: Synchronization of IRF1, JunB, and C/EBP Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response
Q Liu, Y Zhu, WK Yong, NS Sze, NS Tan, JL Ding |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Effect of Lactobacillus plantarum on Intestinal Infection in Multiple Drug-Resistant Bacteria Mice
HZ Han, YJ Zhao, CZ Shi, Y Liang, J Yang |
Surgical Infections | 2015 |
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Immunotherapeutic Strategies for Colon Cancer: Monoclonal Antibody Therapy
E Thara, A Barzi |
Current Colorectal Cancer Reports | 2015 |
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Improving healthspan via changes in gut microbiota and fermentation
MJ Keenan, ML Marco, DK Ingram, RJ Martin |
AGE | 2015 |
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The Immunobiology of Interleukin-27
H Yoshida, CA Hunter |
Annual Review of Immunology | 2015 |
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MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections
C Ehlting, M Trilling, C Tiedje, VT Le-Trilling, U Albrecht, S Kluge, A Zimmermann, D Graf, M Gaestel, H Hengel, D Häussinger, JG Bode |
Journal of Hepatology | 2015 |
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Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
K Shailubhai |
World journal of gastrointestinal pharmacology and therapeutics | 2015 |
|
Colitis-associated colon cancer: Is it in your genes?
LV der Kraak |
World journal of gastroenterology : WJG | 2015 |
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Skeletal Muscle Depletion and Markers for Cancer Cachexia Are Strong Prognostic Factors in Epithelial Ovarian Cancer
S Aust, T Knogler, D Pils, E Obermayr, A Reinthaller, L Zahn, I Radlgruber, ME Mayerhoefer, C Grimm, S Polterauer, KK Wong |
PloS one | 2015 |
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Soluble Dextrin Fibers Alter the Intestinal Microbiota and Reduce Proinflammatory Cytokine Secretion in Male IL-10–Deficient Mice
R Valcheva, N Hotte, P Gillevet, M Sikaroodi, A Thiessen, KL Madsen |
The Journal of nutrition | 2015 |
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Image Analysis-Based Approaches for Scoring Mouse Models of Colitis
R Rogers, J Eastham-Anderson, J DeVoss, J Lesch, D Yan, M Xu, M Solon, K Hotzel, L Diehl, JD Webster |
Veterinary pathology | 2015 |
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Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies
TN Burks, R Marx, L Powell, J Rucker, D Bedja, E Heacock, BJ Smith, DB Foster, D Kass, B ORourke, JD Walston, PM Abadir |
Oncotarget | 2015 |
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Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies.
Burks TN, Marx R, Powell L, Rucker J, Bedja D, Heacock E, Smith BJ, Foster DB, Kass D, O'Rourke B, Walston JD, Abadir PM |
Oncotarget | 2015 |
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Stimulation of lymphatic function and macrophage polarization via VEGFR3 as a novel therapy for chronic experimental intestinal inflammation
Silvia D'Alessio, Carmen Correale, Carlotta Tacconi, Alessandro Gandelli, Giovanni Pietrogrande, Stefania Vetrano, Marco Genua, Vincenzo Arena, Antonino Spinelli, Laurent Peyrin-Biroulet, Claudio Fiocchi, Silvio Danese |
Journal of Clinical Investigation | 2014 |
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Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems
KG Hartman, JD Bortner, GW Falk, GG Ginsberg, N Jhala, J Yu, MG Martin, AK Rustgi, JP Lynch |
Experimental biology and medicine (Maywood, N.J.) | 2014 |
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Interplay between DNA repair and inflammation, and the link to cancer
D Kidane, WJ Chae, J Czochor, KA Eckert, PM Glazer, AL Bothwell, JB Sweasy |
Critical Reviews in Biochemistry and Molecular Biology | 2014 |
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Donor and host B cell-derived IL-10 contributes to suppression of graft-versus-host disease: Clinical immunology
M Weber, P Stein, S Prüfer, B Rudolph, A Kreft, E Schmitt, T Bopp, A Roers, H Schild, S Fillatreau, MP Radsak |
European Journal of Immunology | 2014 |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Interleukin-10 in Health and Disease
S Fillatreau, A O'Garra |
2014 | |
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Chronic Inflammation and Cytokines in the Tumor Microenvironment
G Landskron, MD la Fuente, P Thuwajit, C Thuwajit, MA Hermoso |
Journal of Immunology Research | 2014 |
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Fallen Angels or Risen Apes? A Tale of the Intricate Complexities of Imbalanced Immune Responses in the Pathogenesis and Progression of Immune-Mediated and Viral Cancers
BO Ondondo |
Frontiers in immunology | 2014 |
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Colitis-associated neoplasia: molecular basis and clinical translation
S Foersch, MF Neurath |
Cellular and Molecular Life Sciences | 2014 |
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Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice: SEW2871 ameliorates colitis in IL-10-/- mice
J Dong, H Wang, G Wu, J Zhao, L Zhang, L Zuo, W Zhu, J Gong, Y Li, L Gu, J Li |
Clinical & Experimental Immunology | 2014 |
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Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice
S Bertin, B Lozano-Ruiz, V Bachiller, I García-Martínez, S Herdman, P Zapater, R Francés, J Such, J Lee, E Raz, JM González-Navajas |
Mucosal Immunology | 2014 |
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Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice
MN Kim |
World journal of gastroenterology : WJG | 2014 |
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Modeling the T cell immune response: a fascinating challenge
PA Morel, JR Faeder, WF Hawse, N Miskov-Zivanov |
Journal of Pharmacokinetics and Pharmacodynamics | 2014 |
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Microbiome, Inflammation, and Cancer:
R Francescone, V Hou, SI Grivennikov |
The Cancer Journal | 2014 |
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Disruption of Pten Speeds Onset and Increases Severity of Spontaneous Colitis in Il10(-/-) Mice
E Im, J Jung, C Pothoulakis, SH Rhee |
Gastroenterology | 2014 |
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Animal models of inflammatory bowel disease: a review
N Goyal, A Rana, A Ahlawat, KR Bijjem, P Kumar |
Inflammopharmacology | 2014 |
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MicroRNA-346 Mediates Tumor Necrosis Factor α–Induced Downregulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases:
Y Chen, J Du, Z Zhang, T Liu, Y Shi, X Ge, YC Li |
Inflammatory Bowel Diseases | 2014 |
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IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut
S Sattler, GS Ling, D Xu, L Hussaarts, A Romaine, H Zhao, L Fossati-Jimack, T Malik, HT Cook, M Botto, YL Lau, HH Smits, FY Liew, FP Huang |
Journal of Autoimmunity | 2014 |
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CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development: CXCR2 in Intestinal Tumorigenesis
YS Lee, D Choi, NY Kim, S Yang, E Jung, M Hong, D Yang, HJ Lenz, YK Hong |
International Journal of Cancer | 2014 |
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The gastrointestinal microbiota and colorectal cancer
TO Keku, S Dulal, A Deveaux, B Jovov, X Han |
AJP Gastrointestinal and Liver Physiology | 2014 |
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Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells
D Blat, E Zigmond, Z Alteber, T Waks, Z Eshhar |
Molecular Therapy | 2014 |
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Human milk composition differs in healthy mothers and mothers with celiac disease
M Olivares, S Albrecht, GD Palma, MD Ferrer, G Castillejo, HA Schols, Y Sanz |
European Journal of Nutrition | 2014 |
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Inflammatory Bowel Disease-related Colorectal Cancer in the Asia-Pacific Region: Past, Present, and Future
W Zhiqin, S Palaniappan, RA Ali |
Intestinal Research | 2014 |
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RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase
S Tang, T Chen, Z Yu, X Zhu, M Yang, B Xie, N Li, X Cao, J Wang |
Nature Communications | 2014 |
|
The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor:
KA Steinbrecher |
Current Opinion in Gastroenterology | 2014 |
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Autoimmune animal models in the analysis of the CD47–SIRPα signaling pathway
Y Murata, Y Saito, T Kaneko, T Kotani, Y Kaneko, H Ohnishi, T Matozaki |
Methods | 2014 |
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Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis
XP Xu, LY Hua, HL Chao, ZX Chen, XF Wang, J Ji, N Liu |
Journal of Receptors and Signal Transduction | 2014 |
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Induction of Bacterial Antigen-Specific Colitis by a Simplified Human Microbiota Consortium in Gnotobiotic Interleukin-10-/- Mice
CS Eun, Y Mishima, S Wohlgemuth, B Liu, M Bower, IM Carroll, RB Sartor |
Infection and immunity | 2014 |
|
Immunopathological Characterization of Selected Mouse Models of Inflammatory Bowel Disease: Comparison to Human Disease
YL Jones-Hall, MB Grisham |
Pathophysiology | 2014 |
|
Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors
DW Beury, KH Parker, M Nyandjo, P Sinha, KA Carter, S Ostrand-Rosenberg |
Journal of leukocyte biology | 2014 |
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GM-CSF-Neuroantigen Fusion Proteins Reverse Experimental Autoimmune Encephalomyelitis and Mediate Tolerogenic Activity in Adjuvant-Primed Environments: Association with Inflammation-Dependent, Inhibitory Antigen Presentation
SM Islam, AD Curtis, N Taslim, DS Wilkinson, MD Mannie |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
|
Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice
J Chun, C Lee, SW Hwang, JP Im, JS Kim |
Life Sciences | 2014 |
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A guide to histomorphological evaluation of intestinal inflammation in mouse models
U Erben, C Loddenkemper, K Doerfel, S Spieckermann, D Haller, MM Heimesaat, M Zeitz, B Siegmund, AA Kühl |
International journal of clinical and experimental pathology | 2014 |
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Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice
H Qi, H Yang, G Xu, J Ren, W Hua, Y Shi, M Torsvik, J Florholmen, G Cui |
Immunobiology | 2014 |
|
Breast milk: immunosurveillance in infancy
R Nanda, P Das, PK Tripathy |
Asian Pacific Journal of Tropical Disease | 2014 |
|
Infection with Murine Norovirus 4 Does Not Alter Helicobacter-Induced Inflammatory Bowel Disease in Il10−/− Mice
Charlie C Hsu, Jisun Paik, Piper M Treuting, Audrey Seamons, Stacey M Meeker, Thea L Brabb, Lillian Maggio-Price |
Comparative medicine | 2014 |
|
Infection with murine norovirus 4 does not alter Helicobacter-induced inflammatory bowel disease in Il10(-/-) mice
Charlie C Hsu, Jisun Paik, Piper M Treuting, Audrey Seamons, Stacey M Meeker, Thea L Brabb, Lillian Maggio-Price |
Comparative medicine | 2014 |
|
Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis
ER Kim |
World journal of gastroenterology : WJG | 2014 |
|
Oxidative Stress Mechanisms and their Modulation
M Bansal, N Kaushal |
2014 | |
|
Interferon-dependent IL-10 production by Treg limits tumor Th17 inflammation
C. Andrew Stewart, Hannah Metheny, Noriho Iida, Loretta Smith, Miranda Hanson, Folkert Steinhagan, Robert Leighty, Axel Roers, Christopher Karp, Werner Muller, Giorgio Trinchieri |
Journal of Clinical Investigation | 2013 |
|
Leptin antagonist ameliorates chronic colitis in IL-10−/− mice
UP Singh, NP Singh, H Guan, B Busbee, RL Price, DD Taub, MK Mishra, R Fayad, M Nagarkatti, PS Nagarkatti |
Immunobiology | 2013 |
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Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology--a systematic review
R Klopfleisch |
BMC veterinary research | 2013 |
|
The microbiota and inflammatory bowel disease: Insights from animal models
JM Peloquin, DD Nguyen |
Anaerobe | 2013 |
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IL-10 Restrains IL-17 to Limit Lung Pathology Characteristics following Pulmonary Infection with Francisella tularensis Live Vaccine Strain
SR Slight, L Monin, R Gopal, L Avery, M Davis, H Cleveland, TD Oury, J Rangel-Moreno, SA Khader |
The American Journal of Pathology | 2013 |
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Neutrophils Confer T Cell Resistance to Myeloid-Derived Suppressor Cell–Mediated Suppression To Promote Chronic Inflammation
SO Ryan, JL Johnson, BA Cobb |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Macrophages Are Essential for the Early Wound Healing Response and the Formation of a Fibrovascular Scar
L He, AG Marneros |
The American Journal of Pathology | 2013 |
|
Angiotensin Converting Enzyme-Inhibitor Reduces Colitis Severity in an IL-10 Knockout Model
R Sueyoshi, KM Ignatoski, S Daignault, M Okawada, DH Teitelbaum |
Digestive Diseases and Sciences | 2013 |
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Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis
E Harmel-Laws, EA Mann, MB Cohen, KA Steinbrecher |
PloS one | 2013 |
|
Carbon monoxide attenuates dextran sulfate sodium-induced colitis via inhibition of GSK-3β signaling
MJ Uddin, S Jeong, M Zheng, Y Chen, GJ Cho, HT Chung, Y Joe |
Oxidative Medicine & Cellular Longevity | 2013 |
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Basophils control T-cell responses and limit disease activity in experimental murine colitis
MR Gomez, Y Talke, C Hofmann, I Ketelsen, F Hermann, B Reich, N Goebel, K Schmidbauer, N Dunger, H Brühl, K Renner, SN Syed, M Mack |
Mucosal Immunology | 2013 |
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Heligmosomoides polygyrus bakeri Infection Activates Colonic Foxp3 + T Cells Enhancing Their Capacity To Prevent Colitis
L Hang, AM Blum, T Setiawan, JP Urban, KM Stoyanoff, JV Weinstock |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer
WC Ting, LM Chen, LC Huang, MJ Hour, YH Lan, HZ Lee, BJ You, TY Chang, BY Bao |
Journal of Korean Medical Science | 2013 |
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Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor
DM Zaiss, J van Loosdregt, A Gorlani, CP Bekker, A Gröne, M Sibilia, PM van Bergen en Henegouwen, RC Roovers, PJ Coffer, AJ Sijts |
Immunity | 2013 |
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Bacterial oncogenesis in the colon
C Dejea, E Wick, CL Sears |
Future Microbiology | 2013 |
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Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice
H Wang, Y Xue, H Zhang, Y Huang, G Yang, M Du, MJ Zhu |
Molecular Nutrition & Food Research | 2013 |
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Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function
J van Loosdregt, V Fleskens, MM Tiemessen, M Mokry, R van Boxtel, J Meerding, CE Pals, D Kurek, MR Baert, EM Delemarre, A Gröne, MJ Koerkamp, AJ Sijts, EE Nieuwenhuis, MM Maurice, JH van Es, D ten Berge, FC Holstege, FJ Staal, DM Zaiss, BJ Prakken, PJ Coffer |
Immunity | 2013 |
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Overview of molecular pathways in inflammatory bowel disease associated with colorectal cancer development:
SA Azer |
European Journal of Gastroenterology & Hepatology | 2013 |
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Th17-cell plasticity in Helicobacter hepaticus–induced intestinal inflammation
PJ Morrison, D Bending, LA Fouser, JF Wright, B Stockinger, A Cooke, MC Kullberg |
Mucosal Immunology | 2013 |
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A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner: MINERAL EXTRACT AMELIORATES COLITIS IN IL-10 DEFICIENT MICE
G Aviello, S Amu, SP Saunders, PG Fallon |
Phytotherapy Research | 2013 |
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Interleukin-10 reduces scar formation in both animal and human cutaneous wounds: Results of two preclinical and phase II randomized control studies: Interleukin-10 reduces cutaneous scar formation
I Kieran, A Knock, J Bush, K So, A Metcalfe, R Hobson, T Mason, S O'Kane, M Ferguson |
Wound Repair and Regeneration | 2013 |
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Pegylated IL-10 induces cancer immunity: The surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8 + T cell cytotoxicity
JB Mumm, M Oft |
BioEssays | 2013 |
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Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis
Y Li, Y Tian, W Zhu, J Gong, W Zhang, C Yu, L Gu, N Li, J Li |
International Immunopharmacology | 2013 |
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The guggulsterone derivative GG-52 inhibits NF-κB signaling in bone marrow-derived dendritic cells and attenuates colitis in IL-10 knockout mice
SJ Kang, JM Kim, SJ Koh, SH Kim, JP Im, HC Jung, JS Kim |
Life Sciences | 2013 |
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MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function: miR-146b improves intestinal injury in colitis
T Nata, M Fujiya, N Ueno, K Moriichi, H Konishi, H Tanabe, T Ohtake, K Ikuta, Y Kohgo |
The Journal of Gene Medicine | 2013 |
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Mild gut inflammation modulates the proteome of intestinal Escherichia coli: Inflammation-induced proteome changes in intestinal E. coli
S Schumann, C Alpert, W Engst, R Klopfleisch, G Loh, A Bleich, M Blaut |
Environmental Microbiology | 2013 |
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Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway
R Wu, Y Li, Z Guo, J Gong, W Zhu, N Li, J Li |
Molecular Immunology | 2013 |
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Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition
H Roche, C Phillips |
Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition | 2013 |
|
Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models
A Hansen |
Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models | 2013 |
|
IL-10 inhibits the NF-κB and ERK/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes
E Hovsepian, F Penas, S Siffo, GA Mirkin, NB Goren |
PloS one | 2013 |
|
Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
EA Mann, E Harmel-Laws, MB Cohen, KA Steinbrecher |
BMC Gastroenterology | 2013 |
|
Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
V Andersen, R Holst, TI Kopp, A Tjønneland, U Vogel, X Miao |
PloS one | 2013 |
|
The Effect of Dietary Prebiotics and Probiotics on Body Weight, Large Intestine Indices, and Fecal Bile Acid Profile in Wild Type and IL10−/− Mice
SM Kuo, PM Merhige, LR Hagey, H Smidt |
PloS one | 2013 |
|
Early life stress triggers persistent colonic barrier dysfunction and exacerbates colitis in adult IL-10-/- mice
EM Lennon, N Maharshak, H Elloumi, L Borst, SE Plevy, AJ Moeser |
Inflammatory Bowel Diseases | 2013 |
|
Role of interleukin-10 in the regulation of tumorigenicity of a T cell lymphoma
MR Hassuneh, M Nagarkatti, PS Nagarkatti |
Leukemia & Lymphoma | 2013 |
|
Anti-mouse CD52 monoclonal antibody ameliorates iron-deficient anaemia in IL-10 knockout mice
H Wang, J Dong, L Zuo, J Liu, W Zhu, Y Li, L Gu, J Zhao, L Zhang, J Gong, W Zhang, N Li, J Li |
British Journal of Nutrition | 2013 |
|
Review of the association between meat consumption and risk of colorectal cancer
E Kim, D Coelho, F Blachier |
Nutrition Research | 2013 |
|
Natural Course of Crohn's Disease and Novel Treatment Drugs
JH Lee, JH Cheon |
Korean Journal of Medicine | 2013 |
|
Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10-Producing T Cells
KL Dennis, Y Wang, NR Blatner, S Wang, A Saadalla, E Trudeau, A Roers, CT Weaver, JJ Lee, JA Gilbert, EB Chang, K Khazaie |
Cancer research | 2013 |
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IL-10 Inhibits the NF-κB and ERK/MAPK-Mediated Production of Pro-Inflammatory Mediators by Up-Regulation of SOCS-3 in Trypanosoma cruzi-Infected Cardiomyocytes
E Hovsepian, F Penas, S Siffo, GA Mirkin, NB Goren, ME Rottenberg |
PloS one | 2013 |
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Paraoxonase-1 Suppresses Experimental Colitis via the Inhibition of IFN- Production from CD4 T Cells
J Yamashita, C Iwamura, T Ito, M Narita, Y Hara, T Sasaki, D Masuda, M Takahashi, M Tsuchiya, K Hada, M Ishikawa, T Matsuo, Y Ohno, H Tanaka, H Maruyama, Y Ogawa, T Nakayama |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases
V Valatas, M Vakas, G Kolios |
AJP Gastrointestinal and Liver Physiology | 2013 |
|
Inflammatory Cytokine Gene Expression in Mesenteric Adipose Tissue during Acute Experimental Colitis
WC Mustain, ME Starr, JD Valentino, DA Cohen, D Okamura, C Wang, BM Evers, H Saito, MM Heimesaat |
PloS one | 2013 |
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Wild-Type and IL10-Null Mice Have Differential Colonic Epithelial Gene Expression Responses to Dietary Supplementation with Synbiotic Bifidobacterium animalis Subspecies lactis and Inulin
SM Kuo, WC Chan, Z Hu |
The Journal of nutrition | 2013 |
|
Molecular Genetics of Inflammatory Bowel Disease
M D'Amato, JD Rioux |
2013 | |
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Cytokine Frontiers
T Yoshimoto, T Yoshimoto |
2013 | |
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Molecular Pathogenesis of Colorectal Cancer
KM Haigis |
2013 | |
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SHP-1–Pyk2–Src Protein Complex and p38 MAPK Pathways Independently Regulate IL-10 Production in Lipopolysaccharide-Stimulated Macrophages
C Okenwa, A Kumar, D Rego, Y Konarski, L Nilchi, K Wright, M Kozlowski |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Epidermal growth factor receptor inhibits colitis-associated cancer in mice
Philip Dubé, Fang Yan, Shivesh Punit, Nandini Girish, Steven McElroy, M. Kay Washington, D. Brent Polk |
Journal of Clinical Investigation | 2012 |
|
Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI
DK Kadayakkara, S Ranganathan, WB Young, ET Ahrens |
Laboratory Investigation | 2012 |
|
Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease
F Rieder, S Kessler, M Sans, C Fiocchi |
American journal of physiology. Gastrointestinal and liver physiology | 2012 |
|
p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD
T Goretsky, R Dirisina, P Sinh, N Mittal, E Managlia, DB Williams, D Posca, H Ryu, RB Katzman, TA Barrett |
The American Journal of Pathology | 2012 |
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Downregulation of the NHE3-Binding PDZ-Adaptor Protein PDZK1 Expression during Cytokine-Induced Inflammation in Interleukin-10–Deficient Mice
H Lenzen, M Lünnemann, A Bleich, MP Manns, U Seidler, A Jörns, Y Ishimaru |
PloS one | 2012 |
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Host-microbiota interactions in inflammatory bowel disease
CO Elson, Y Cong |
Gut microbes | 2012 |
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New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa
AC Gomes-Santos, TG Moreira, AB Castro-Junior, BC Horta, L Lemos, DN Cruz, MA Guimarães, DC Cara, DM McCafferty, AM Faria |
Clinical and Developmental Immunology | 2012 |
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Inflammation and colorectal cancer: colitis-associated neoplasia
SI Grivennikov |
Seminars in Immunopathology | 2012 |
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Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice
R Matta, JA Barnard, LM Wancket, J Yan, J Xue, J Grieves, WJ Frazier, L Nelin, AC Cato, Y Liu |
American journal of physiology. Gastrointestinal and liver physiology | 2012 |
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Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency
W Zhang, J Liao, H Li, H Dong, H Bai, A Yang, BD Hammock, GY Yang |
Molecular Carcinogenesis | 2012 |
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Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
K Ludigs, V Parfenov, RA Pasquier, G Guarda |
Cellular and Molecular Life Sciences | 2012 |
|
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
LA Reynolds, KJ Filbey, RM Maizels |
Seminars in Immunopathology | 2012 |
|
Alternative Medicines as Emerging Therapies for Inflammatory Bowel Diseases
UP Singh, NP Singh, B Busbee, H Guan, B Singh, RL Price, DD Taub, MK Mishra, M Nagarkatti, PS Nagarkatti |
International Reviews of Immunology | 2012 |
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A Protective Role for Human IL-10–Expressing CD4 + T Cells in Colitis
DC Ranatunga, A Ramakrishnan, P Uprety, F Wang, H Zhang, JB Margolick, C Brayton, JH Bream |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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Fifteen years of interleukin-27- discovery, advances and translation
CA Hunter, R Kastelein |
Immunity | 2012 |
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Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis
NA Carter, EC Rosser, C Mauri |
Arthritis Research & Therapy | 2012 |
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Cancer in inflammatory bowel disease: lessons from animal models
DA Sussman, R Santaolalla, S Strobel, R Dheer, MT Abreu |
Current Opinion in Gastroenterology | 2012 |
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Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection
K Okamoto, M Fujiya, T Nata, N Ueno, Y Inaba, C Ishikawa, T Ito, K Moriichi, H Tanabe, Y Mizukami, EB Chang, Y Kohgo |
International Journal of Colorectal Disease | 2012 |
|
Altered Oligosaccharide Structures Reduce Colitis Induction in Mice Defective in β-1,4-Galactosyltransferase
S Shinzaki, H Iijima, H Fujii, E Kuroki, N Tatsunaka, T Inoue, S Nakajima, S Egawa, T Kanto, M Tsujii, E Morii, S Takeishi, M Asano, T Takehara, N Hayashi, E Miyoshi |
Gastroenterology | 2012 |
|
A Novel Murine Model of Inflammatory Bowel Disease and Inflammation-Associated Colon Cancer with Ulcerative Colitis-Like Features
LP Hale, PK Greer |
PloS one | 2012 |
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Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer
A Boleij, H Tjalsma |
Biological Reviews | 2012 |
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Inflammation, DNA methylation and colitis-associated cancer
L Hartnett, LJ Egan |
Carcinogenesis | 2012 |
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Regulation of inflammation through JAK3-Stat6 pathway in dendritic cells
K YAMAOKA, K MAESHIMA, S KUBO, Y TANAKA |
Japanese Journal of Clinical Immunology | 2012 |
|
Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis
T Shimizu, H Marusawa, Y Endo, T Chiba |
Cancer Science | 2012 |
|
Loss of IL-10 Decreases Mouse Postpubertal Mammary Gland Development in the Absence of Inflammation
PA Masso-Welch, PM Merhige, OL Veeranki, SM Kuo |
Immunological Investigations | 2012 |
|
Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age
G Sikka, KL Miller, J Steppan, D Pandey, SM Jung, CD Fraser, C Ellis, D Ross, K Vandegaer, D Bedja, K Gabrielson, JD Walston, DE Berkowitz, LA Barouch |
Experimental Gerontology | 2012 |
|
Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice
AM Borowiec, BC Sydora, J Doyle, LL Guan, TA Churchill, K Madsen, RN Fedorak |
Journal of Surgical Research | 2012 |
|
6-(Methylamino)hexane-1,2,3,4,5-pentanol 4-(((1 S ,2 S )-1-Hydroxy-2,3-dihydro-1 H ,1′ H -[2,2-biinden]-2-yl)methyl)benzoate (PH46A): A Novel Small Molecule With Efficacy In Murine Models Of Colitis
N Frankish, H Sheridan |
Journal of Medicinal Chemistry | 2012 |
|
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
S Devkota, Y Wang, MW Musch, V Leone, H Fehlner-Peach, A Nadimpalli, DA Antonopoulos, B Jabri, EB Chang |
Nature | 2012 |
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Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression
J Deng, X Wang, F Qian, S Vogel, L Xiao, R Ranjan, H Park, M Karpurapu, RD Ye, GY Park, JW Christman |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
OB Serebrennikova, C Tsatsanis, C Mao, E Gounaris, W Ren, LD Siracusa, AG Eliopoulos, K Khazaie, PN Tsichlis |
Proceedings of the National Academy of Sciences | 2012 |
|
Regulation generation: the suppressive functions of human regulatory T cells
WA Goodman, KD Cooper, TS McCormick |
Critical reviews in immunology | 2012 |
|
Knockout of Mkp-1 exacerbates colitis in Il-10 -deficient mice
R Matta, JA Barnard, LM Wancket, J Yan, J Xue, J Grieves, WJ Frazier, L Nelin, AC Cato, Y Liu |
AJP Gastrointestinal and Liver Physiology | 2012 |
|
Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease
F Rieder, S Kessler, M Sans, C Fiocchi |
AJP Gastrointestinal and Liver Physiology | 2012 |
|
Mouse Background Strain Profoundly Influences Paneth Cell Function and Intestinal Microbial Composition
AS Gulati, MT Shanahan, JC Arthur, E Grossniklaus, RJ von Furstenberg, L Kreuk, SJ Henning, C Jobin, RB Sartor, S Bereswill |
PloS one | 2012 |
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Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis
S Polyak, A Mach, S Porvasnik, L Dixon, T Conlon, KE Erger, A Acosta, AJ Wright, M Campbell-Thompson, I Zolotukhin, C Wasserfall, C Mah |
AJP Gastrointestinal and Liver Physiology | 2012 |
|
Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis.
Shimizu T, Marusawa H, Endo Y, Chiba T |
Cancer Science | 2012 |
|
Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation
A Takai, H Marusawa, Y Minaki, T Watanabe, H Nakase, K Kinoshita, G Tsujimoto, T Chiba |
Oncogene | 2011 |
|
Pharmacological Intervention Studies Using Mouse Models of the Inflammatory Bowel Diseases: Translating Preclinical Data into New Drug Therapies
I Koboziev, F Karlsson, S Zhang, MB Grisham |
Inflammatory Bowel Diseases | 2011 |
|
Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice
G Tolstanova, X Deng, SW French, W Lungo, B Paunovic, T Khomenko, A Ahluwalia, T Kaplan, M Dacosta-Iyer, A Tarnawski, S Szabo, Z Sandor |
Laboratory Investigation | 2011 |
|
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity
PJ Morrison, SJ Ballantyne, MC Kullberg |
Immunology | 2011 |
|
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
M Mohamadzadeh, EA Pfeiler, JB Brown, M Zadeh, M Gramarossa, E Managlia, P Bere, B Sarraj, MW Khan, KC Pakanati, MJ Ansari, S O'Flaherty, T Barrett, TR Klaenhammer |
Proceedings of the National Academy of Sciences | 2011 |
|
Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial Infection
P Chandrakesan, I Ahmed, A Chinthalapally, P Singh, S Awasthi, S Anant, S Umar, SM Payne |
Infection and immunity | 2011 |
|
Cannabinoids Receptor-2 (CB2) agonist ameliorates colitis in IL-10−/− mice by attenuating the activation of T cells and promoting their apoptosis
UP Singh, NP Singh, B Singh, RL Price, M Nagarkatti, PS Nagarkatti |
Toxicology and Applied Pharmacology | 2011 |
|
Intestinal inflammation and colorectal cancer: A double-edged sword?
A Rizzo, F Pallone, G Monteleone, MC Fantini |
World journal of gastroenterology : WJG | 2011 |
|
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production
T Feng, H Qin, L Wang, EN Benveniste, CO Elson, Y Cong |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function
N Ueno, M Fujiya, S Segawa, T Nata, K Moriichi, H Tanabe, Y Mizukami, N Kobayashi, K Ito, Y Kohgo |
Inflammatory Bowel Diseases | 2011 |
|
Animal Models of Colitis-Associated Carcinogenesis
M Kanneganti, M Mino-Kenudson, E Mizoguchi |
Journal of Biomedicine and Biotechnology | 2011 |
|
TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells
SS Hobbs, JA Goettel, D Liang, F Yan, KL Edelblum, MR Frey, MT Mullane, DB Polk |
AJP Gastrointestinal and Liver Physiology | 2011 |
|
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
A Chow, D Lucas, A Hidalgo, S Méndez-Ferrer, D Hashimoto, C Scheiermann, M Battista, M Leboeuf, C Prophete, N Rooijen, M Tanaka, M Merad, PS Frenette |
Journal of Experimental Medicine | 2011 |
|
Mouse models of colorectal cancer
Y Tong, W Yang, HP Koeffler |
Chinese journal of cancer | 2011 |
|
An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis
SZ Sheikh, RA Hegazi, T Kobayashi, JC Onyiah, SM Russo, K Matsuoka, AR Sepulveda, F Li, LE Otterbein, SE Plevy |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Regulatory B Cells and Allergic Diseases
G Noh, JH Lee |
Allergy, Asthma and Immunology Research | 2011 |
|
Adenoma formation following limited ablation of p120-catenin in the mouse intestine
WG Smalley-Freed, A Efimov, SP Short, P Jia, Z Zhao, MK Washington, S Robine, RJ Coffey, AB Reynolds |
PloS one | 2011 |
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Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease
CM Wilke, L Wang, S Wei, I Kryczek, E Huang, J Kao, Y Lin, J Fang, W Zou |
Journal of Translational Medicine | 2011 |
|
Immunology of Human Milk and Host Immunity
Goldman AS, Chheda S, Keeney SE, Schmalstieg FC |
Fetal and Neonatal Physiology | 2011 |
|
Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10tm1Cgn (IL-10−/−) mice
MT Whary, NS Taylor, Y Feng, Z Ge, S Muthupalani, J Versalovic, JG Fox |
Immunology | 2011 |
|
Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice
B Liu, SL Tonkonogy, RB Sartor |
Gastroenterology | 2011 |
|
Visible Light Promotes Interleukin-10 Secretion by Sublethal Fluences
O Feuerstein, R Assad, E Koren, I Ginsburg, EI Weiss, Y Houri-Haddad |
Photomedicine and Laser Surgery | 2011 |
|
Lessons from probiotic-host interaction studies in murine models of experimental colitis
IJ Claes, SC de Keersmaecker, J Vanderleyden, S Lebeer |
Molecular Nutrition & Food Research | 2011 |
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Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis
M Hoffmann, A Messlik, SC Kim, RB Sartor, D Haller |
Molecular Nutrition & Food Research | 2011 |
|
Infection, immunoregulation, and cancer
GA Rook, A Dalgleish |
Immunological Reviews | 2011 |
|
Intestinal Inflammation and Cancer
TA Ullman, SH Itzkowitz |
Gastroenterology | 2011 |
|
Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway
C Yu, T Shan, A Feng, Y Li, W Zhu, Y Xie, N Li, J Li |
Fitoterapia | 2011 |
|
Effect of Lactobacillus plantarum LP-Onlly on gut flora and colitis in interleukin-10 knockout mice
Y Xia, HQ Chen, M Zhang, YQ Jiang, XM Hang, HL Qin |
Journal of Gastroenterology and Hepatology | 2011 |
|
A review of major Crohn’s disease susceptibility genes and their role in disease pathogenesis
M Barrett, SB Chandra |
Genes & Genomics | 2011 |
|
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
P Kosa, R Szabo, AA Molinolo, TH Bugge |
Oncogene | 2011 |
|
Expression of heparan sulfate proteoglycans in murine models of experimental colitis
AM Patterson, MI Delday, TH Kuppevelt, G Loh, M Blaut, D Haller, G Grant, D Kelly |
Inflammatory Bowel Diseases | 2011 |
|
Preventive and therapeutic effects of tacrolimus in an interleukin-10-deficient mouse model of colitis
Y Okada, N Maeda, S Takakura, K Miyata, M Koshiba |
Inflammation Research | 2011 |
|
Th17 cells express interleukin-10 receptor and are controlled by Foxp3− and Foxp3+ regulatory CD4+ T cells in an interleukin-10 dependent manner
S Huber, N Gagliani, E Esplugues, W O'Connor, FJ Huber, A Chaudhry, M Kamanaka, Y Kobayashi, CJ Booth, AY Rudensky, MG Roncarolo, M Battaglia, RA Flavell |
Immunity | 2011 |
|
The Tripeptide KdPT Protects from Intestinal Inflammation and Maintains Intestinal Barrier Function
D Bettenworth, M Buyse, M Böhm, R Mennigen, I Czorniak, K Kannengiesser, T Brzoska, TA Luger, T Kucharzik, W Domschke, C Maaser, A Lügering |
The American Journal of Pathology | 2011 |
|
LITAF Mediation of Increased TNF-α Secretion from Inflamed Colonic Lamina Propria Macrophages
KN Bushell, SE Leeman, E Gillespie, AC Gower, KL Reed, AF Stucchi, JM Becker, S Amar |
PloS one | 2011 |
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Histidine Decarboxylase Is Identified as a Potential Biomarker of Intestinal Mucosal Injury in Patients with Acute Intestinal Obstruction
JJ Yang, YL Ma, P Zhang, HQ Chen, ZH Liu, HL Qin |
Molecular Medicine | 2011 |
|
Irradiation of light emitting diode at 850nm inhibits T cell-induced cytokine expression
KA Cheong, C Kim, Y Choi, CD Park, AY Lee |
Journal of Dermatological Science | 2011 |
|
Proteomic Analysis of Colon Tissue from Interleukin-10 Gene-deficient Mice Fed Polyunsaturated Fatty Acids with Comparison to Transcriptomic Analysis
JM Cooney, MP Barnett, D Brewster, B Knoch, WC McNabb, WA Laing, NC Roy |
Journal of Proteome Research | 2011 |
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Colorectal cancer mouse models: Integrating inflammation and the stroma : Colorectal cancer mouse models
M Ernst, RG Ramsay |
Journal of Gastroenterology and Hepatology | 2011 |
|
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
|
The inflammasome: an integrated view: The inflammasome: an integrated view
O Gross, CJ Thomas, G Guarda, J Tschopp |
Immunological Reviews | 2011 |
|
Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice
AM Westbrook, B Wei, J Braun, RH Schiestl |
International Journal of Cancer | 2011 |
|
Cytokines, inflammation and colon cancer
L Klampfer |
Current cancer drug targets | 2011 |
|
TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells
SS Hobbs, JA Goettel, D Liang, F Yan, KL Edelblum, MR Frey, MT Mullane, DB Polk |
AJP Gastrointestinal and Liver Physiology | 2011 |
|
Characterization of Chromosomal Instability in Murine Colitis-Associated Colorectal Cancer
M Gerling, R Glauben, JK Habermann, AA Kühl, C Loddenkemper, HA Lehr, M Zeitz, B Siegmund, RA Veitia |
PloS one | 2011 |
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Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway
S Segawa, M Fujiya, H Konishi, N Ueno, N Kobayashi, T Shigyo, Y Kohgo, S Bereswill |
PloS one | 2011 |
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Of Mice and Microflora: Considerations for Genetically Engineered Mice
PM Treuting, CB Clifford, RS Sellers, CF Brayton |
Veterinary pathology | 2011 |
|
Multiple CD4 + T Cell Subsets Produce Immunomodulatory IL-10 During Respiratory Syncytial Virus Infection
KA Weiss, AF Christiaansen, RB Fulton, DK Meyerholz, SM Varga |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Preventive and therapeutic effects of tacrolimus in an interleukin-10-deficient mouse model of colitis.
Okada Y, Maeda N, Takakura S, Miyata K, Koshiba M |
Inflammation research : official journal of the European Histamine Research Society ... [et al.] | 2011 |
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TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis
Jose M Gonzalez-Navajas, Sean Fine, Jason Law, Sandip Datta, Kim Phung Nguyen, Mandy Yu, Maripat Corr, kyoko katakura, Lars Eckmann, Jongdae Lee, Eyal Raz |
Journal of Clinical Investigation | 2010 |
|
Phosphoinositide 3-Kinase Signaling Mediates □-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
G Lee, T Goretsky, E Managlia, R Dirisina, AP Singh, JB Brown, R May, GY Yang, JW Ragheb, BM Evers, CR Weber, JR Turner, XC He, RB Katzman, L Li, TA Barrett |
Gastroenterology | 2010 |
|
Regulatory T cells in many flavors control asthma
A Ray, A Khare, N Krishnamoorthy, Z Qi, P Ray |
Mucosal Immunology | 2010 |
|
Lactobacillus plantarum Consumption Increases PepT1-Mediated Amino Acid Absorption by Enhancing Protein Kinase C Activity in Spontaneously Colitic Mice
HQ Chen, TY Shen, YK Zhou, M Zhang, ZX Chu, XM Hang, HL Qin |
The Journal of nutrition | 2010 |
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A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis
L Deng, JF Zhou, RS Sellers, JF Li, AV Nguyen, Y Wang, A Orlofsky, Q Liu, DA Hume, JW Pollard, L Augenlicht, EY Lin |
The American Journal of Pathology | 2010 |
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Toll-like receptors in inflammatory bowel diseases: A decade later
E Cario |
Inflammatory Bowel Diseases | 2010 |
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Elevated IL-13Rα2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway
D Mandal, AD Levine |
Inflammatory Bowel Diseases | 2010 |
|
Future biologic targets for IBD: potentials and pitfalls
GY Melmed, SR Targan |
Nature Reviews Gastroenterology & Hepatology | 2010 |
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Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
SI Grivennikov, M Karin |
Cytokine & Growth Factor Reviews | 2010 |
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Colitis and intestinal inflammation in IL10−/− mice results from IL-13Rα2-mediated attenuation of IL-13 activity
MS Wilson, TR Ramalingam, A Rivollier, K Shenderov, MM Mentink-Kane, SK Madala, AW Cheever, D Artis, BL Kelsall, TA Wynn |
Gastroenterology | 2010 |
|
Macrophage Diversity Enhances Tumor Progression and Metastasis
BZ Qian, JW Pollard |
Cell | 2010 |
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Inflammation and Colon Cancer
J Terzić, S Grivennikov, E Karin, M Karin |
Gastroenterology | 2010 |
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Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARalpha
B Knoch, MP Barnett, J Cooney, WC McNabb, D Barraclough, W Laing, S Zhu, ZA Park, P Maclean, SO Knowles, NC Roy |
PPAR Research | 2010 |
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Immunity, Inflammation, and Cancer
SI Grivennikov, FR Greten, M Karin |
Cell | 2010 |
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Genetic and Chemical Models of Colorectal Cancer in Mice
MO Nandan, VW Yang |
Current Colorectal Cancer Reports | 2010 |
|
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
JG Fox, Z Ge, MT Whary, SE Erdman, BH Horwitz |
Mucosal Immunology | 2010 |
|
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli |
Burger's Medicinal Chemistry and Drug Discovery | 2010 |
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Bioactive Foods and Extracts
A Teichert, D Bikle |
Bioactive Foods and Extracts | 2010 |
|
Unifying roles for regulatory T cells and inflammation in cancer
SE Erdman, VP Rao, W Olipitz, CL Taylor, EA Jackson, T Levkovich, CW Lee, BH Horwitz, JG Fox, Z Ge, T Poutahidis |
International Journal of Cancer | 2010 |
|
Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
RS Esworthy, BW Kim, GP Larson, ML Yip, DD Smith, M Li, FF Chu |
Inflammatory Bowel Diseases | 2010 |
|
Dietary arachidonic acid-mediated effects on colon inflammation using transcriptome analysis
B Knoch, MP Barnett, WC McNabb, S Zhu, ZA Park, A Khan, NC Roy |
Molecular Nutrition & Food Research | 2010 |
|
Genetic Susceptibility in Inflammatory Bowel Disease
JK Yamamoto-Furusho |
Clinical Reviews in Bone and Mineral Metabolism | 2010 |
|
Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice
M Claudino, TP Garlet, CR Cardoso, GF de Assis, R Taga, FQ Cunha, JS Silva, GP Garlet |
European Journal of Oral Sciences | 2010 |
|
Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer
S Danese, A Mantovani |
Oncogene | 2010 |
|
FoxP3+ CD4+ T cells in systemic autoimmune diseases: the delicate balance between true regulatory T cells and effector Th-17 cells
WH Abdulahad, AM Boots, CG Kallenberg |
Rheumatology | 2010 |
|
Role of SIRPα in regulation of mucosal immunity in the intestine
Y Kanazawa, Y Saito, Y Supriatna, H Tezuka, T Kotani, Y Murata, H Okazawa, H Ohnishi, Y Kinouchi, Y Nojima, T Ohteki, T Shimosegawa, T Matozaki |
Genes to Cells | 2010 |
|
Expression of the antimicrobial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
Y Inaba, T Ashida, T Ito, C Ishikawa, H Tanabe, A Maemoto, J Watari, T Ayabe, Y Mizukami, M Fujiya, Y Kohgo |
Inflammatory Bowel Diseases | 2010 |
|
B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer
DJ DiLillo, T Matsushita, TF Tedder |
Annals of the New York Academy of Sciences | 2010 |
|
Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
ME Bonet, O Meson, AM de LeBlanc, CA Dogi, S Chaves, A Kortsarz, A Grau, G Perdigón |
Food and Agricultural Immunology | 2010 |
|
Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species
MP Barnett, WC McNabb, AL Cookson, S Zhu, M Davy, B Knoch, K Nones, AJ Hodgkinson, NC Roy |
BMC Immunology | 2010 |
|
Stem cells as potential therapeutic targets for inflammatory bowel disease
UP Singh, NP Singh, B Singh, MK Mishra, M Nagarkatti, PS Nagarkatti, SR Singh |
Frontiers in bioscience (Scholar edition) | 2010 |
|
Molecular Diagnostics
A Athanassiadou, EF Stavrou, A Papachatzopoulou, GP Patrinos |
Molecular Diagnostics | 2010 |
|
New molecular mechanisms of the unexpectedly complex role of VEGF in ulcerative colitis
G Tolstanova, T Khomenko, X Deng, S Szabo, Z Sandor |
Biochemical and Biophysical Research Communications | 2010 |
|
Cytokines in Human Milk
R Garofalo |
The Journal of Pediatrics | 2010 |
|
Neutralization of interleukin (IL)-10 released by monocytes/macrophages enhances the up-regulatory effect of monocyte/macrophage-derived IL-6 on expressions of IL-6 and MUC1, and migration in HT-29 colon cancer cells
YY Li, JW Chang, LL Hsieh, KY Yeh |
Cellular Immunology | 2010 |
|
Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice
HQ Chen, J Yang, M Zhang, YK Zhou, TY Shen, ZX Chu, M Zhang, XM Hang, YQ Jiang, HL Qin |
AJP Gastrointestinal and Liver Physiology | 2010 |
|
cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation
E Albert, J Walker, A Thiesen, T Churchill, K Madsen, D Unutmaz |
PloS one | 2010 |
|
Metabolomic Analysis Identifies Inflammatory and Noninflammatory Metabolic Effects of Genetic Modification in a Mouse Model of Crohn’s Disease
HM Lin, MP Barnett, NC Roy, NI Joyce, S Zhu, K Armstrong, NA Helsby, LR Ferguson, DD Rowan |
Journal of Proteome Research | 2010 |
|
A Two-Locus System Controls Susceptibility to Colitis-Associated Colon Cancer in Mice
LV Kraak, C Meunier, C Turbide, S Jothy, L Gaboury, V Marcus, SY Chang, N Beauchemin, P Gros |
Oncotarget | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Intestinal Effector T Cells in Health and Disease
CL Maynard, CT Weaver |
Immunity | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis
SH Davé, JS Tilstra, K Matsuoka, F Li, RA DeMarco, D Beer-Stolz, AR Sepulveda, MP Fink, MT Lotze, SE Plevy |
Journal of leukocyte biology | 2009 |
|
HDAC inhibitors in models of inflammation-related tumorigenesis
R Glauben, E Sonnenberg, M Zeitz, B Siegmund |
Cancer Letters | 2009 |
|
Gatekeepers of intestinal inflammation
HA Arnett, JL Viney |
Inflammation Research | 2009 |
|
Alterations in myeloid dendritic cell innate immune responses in the Gαi2-deficient mouse model of colitis
JA Peña, L Thompson-Snipes, PR Calkins, N Tatevian, M Puppi, MJ Finegold |
Inflammatory Bowel Diseases | 2009 |
|
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
AH Clementi, AM Gaudy, N Rooijen, RH Pierce, RA Mooney |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2009 |
|
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
J Bollrath, TJ Phesse, VA von Burstin, T Putoczki, M Bennecke, T Bateman, T Nebelsiek, T Lundgren-May, Ö Canli, S Schwitalla, V Matthews, RM Schmid, T Kirchner, MC Arkan, M Ernst, FR Greten |
Cancer Cell | 2009 |
|
Inflammation and proliferation act together to mediate intestinal cell fusion
PS Davies, AE Powell, JR Swain, MH Wong |
PloS one | 2009 |
|
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
AJ Schetter, NH Heegaard, CC Harris |
Carcinogenesis | 2009 |
|
Colitis-associated cancer: the role of T cells in tumor development
MJ Waldner, MF Neurath |
Seminars in Immunopathology | 2009 |
|
IL-10 Induction by Bordetella parapertussis Limits a Protective IFN- Response
DN Wolfe, AT Karanikas, SE Hester, MJ Kennett, ET Harvill |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
Nontargeted Urinary Metabolite Profiling of a Mouse Model of Crohn’s Disease
HM Lin, SJ Edmunds, NA Helsby, LR Ferguson, DD Rowan |
Journal of Proteome Research | 2009 |
|
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
WS Garrett, S Punit, CA Gallini, M Michaud, D Zhang, KS Sigrist, GM Lord, JN Glickman, LH Glimcher |
Cancer Cell | 2009 |
|
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
MA Brockman, DS Kwon, DP Tighe, DF Pavlik, PC Rosato, J Sela, F Porichis, SL Gall, MT Waring, K Moss, H Jessen, F Pereyra, DG Kavanagh, BD Walker, DE Kaufmann |
Blood | 2009 |
|
An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth
T Liu, AK Chopra |
Cancer Gene Therapy | 2009 |
|
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
I Isomura, S Palmer, RJ Grumont, K Bunting, G Hoyne, N Wilkinson, A Banerjee, A Proietto, R Gugasyan, L Wu, W Li, A McNally, RJ Steptoe, R Thomas, MF Shannon, S Gerondakis |
Journal of Experimental Medicine | 2009 |
|
Association ofIL10and Other immune response- and obesity-related genes with prostate cancer in CLUE II
MH Wang, KJ Helzlsouer, MW Smith, JA Hoffman-Bolton, SL Clipp, V Grinberg, AM de Marzo, WB Isaacs, CG Drake, YY Shugart, EA Platz |
The Prostate | 2009 |
|
Infection with murine gammaherpesvirus 68 exacerbates inflammatory bowel disease in IL-10-deficient mice
DA Nelson, CC Petty, KL Bost |
Inflammation Research | 2009 |
|
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
T Okamura, K Fujio, M Shibuya, S Sumitomo, H Shoda, S Sakaguchi, K Yamamoto |
Proceedings of the National Academy of Sciences | 2009 |
|
Interleukin-10 G-1082A and C-819T Polymorphisms as Possible Molecular Markers of Urothelial Bladder Cancer
D Ahirwar, A Mandhani, RD Mittal |
Archives of Medical Research | 2009 |
|
Balancing inflammatory, lipid, and xenobiotic signaling pathways by VSL#3, a biotherapeutic agent, in the treatment of inflammatory bowel disease
C Reiff, M Delday, G Rucklidge, M Reid, G Duncan, S Wohlgemuth, G Hörmannsperger, G Loh, M Blaut, E Collie-Duguid, D Haller, D Kelly |
Inflammatory Bowel Diseases | 2009 |
|
Attenuated Salmonella typhimurium-Mediated Interleukin-10 Delivery is Beneficial for Dextran Sodium Sulfate-Induced Murine Colitis
J Lan, TF Warner, CP Heise |
Diseases of the Colon & Rectum | 2009 |
|
Mouse Models of Colon Cancer
MM Taketo, W Edelmann |
Gastroenterology | 2009 |
|
Towards a molecular risk map—Recent advances on the etiology of inflammatory bowel disease
P Rosenstiel, C Sina, A Franke, S Schreiber |
Seminars in Immunology | 2009 |
|
Suppression of experimental colitis in mice by CD11c+dendritic cells
JE Qualls, H Tuna, AM Kaplan, DA Cohen |
Inflammatory Bowel Diseases | 2009 |
|
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis
JB Brown, G Lee, E Managlia, GR Grimm, R Dirisina, T Goretsky, P Cheresh, NR Blatner, K Khazaie, GY Yang, L Li, TA Barrett |
Gastroenterology | 2009 |
|
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
JM Uronis, M Mühlbauer, HH Herfarth, TC Rubinas, GS Jones, C Jobin |
PloS one | 2009 |
|
Transcription Factors
IM Adcock, G Caramori |
Asthma and COPD | 2009 |
|
T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade
DV Ostanin, J Bao, I Koboziev, L Gray, SA Robinson-Jackson, M Kosloski-Davidson, VH Price, MB Grisham |
AJP Gastrointestinal and Liver Physiology | 2009 |
|
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice
M Pini, ME Gove, R Fayad, RJ Cabay, G Fantuzzi |
AJP Gastrointestinal and Liver Physiology | 2009 |
|
Gastrointestinal microflora, food components and colon cancer prevention
CD Davis, JA Milner |
The Journal of Nutritional Biochemistry | 2009 |
|
Partial Replacement of Dietary (n-6) Fatty Acids with Medium-Chain Triglycerides Decreases the Incidence of Spontaneous Colitis in Interleukin-10–Deficient Mice
J Mañé, E Pedrosa, V Lorén, I Ojanguren, L Fluvià, E Cabré, G Rogler, MA Gassull |
The Journal of nutrition | 2009 |
|
Effect of Yoghurt on the Cytokine Profile using a Murine Model of Intestinal Inflammation
AD de Leblanc, S Chaves, G Perdigón |
EUR J INFLAMM | 2009 |
|
The Biology of Gastric Cancers
TC Wang, JG Fox, AS Giraud |
2009 | |
|
Genetics of Colorectal Cancer
JD Potter, NM Lindor |
2009 | |
|
Resveratrol (Trans-3,5,4′-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor-κB Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis
UP Singh, NP Singh, B Singh, LJ Hofseth, RL Price, M Nagarkatti, PS Nagarkatti |
The Journal of pharmacology and experimental therapeutics | 2009 |
|
Mucosal IL-10 and TGFbeta play crucial roles in preventing LPS-driven, IFNgamma-mediated epithelial damage in human colon
Anne Jarry, Céline Bossard, Chantal Bou-Hanna, Damien Masson, Eric Espaze, Marc G. Denis, and Christian L. Laboisse |
Journal of Clinical Investigation | 2008 |
|
CD133 expression is not restricted to stem cells and both CD133+ and CD133- cells initiate metastatic colon carcinomas
Sergey V. Shmelkov1,4, Jason Butler1,4, Andrea T. Hooper1, Adilia Hormigo1, Jared Kushner1, Till Milde1, Ryan St. Clair1, Muhamed Baljevic1, Ian White1, David K. Jin1, Amy Chadburn1, Andrew J. Murphy2, David M. Valenzuela2, Nicholas W. Gale2, Gavin Thurston2, George D. Yancopoulos2, Michael D’Angelica3, Nancy Kemeny3, David Lyden1 and Shahin Rafii1,5 |
Journal of Clinical Investigation | 2008 |
|
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice
MK Ohman, Y Shen, CI Obimba, AP Wright, M Warnock, DA Lawrence, DT Eitzman |
Circulation | 2008 |
|
Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB
KL Edelblum, MK Washington, T Koyama, S Robine, M Baccarini, DB Polk |
Gastroenterology | 2008 |
|
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited
K Boniface, B Blom, YJ Liu, R de Waal Malefyt |
Immunological Reviews | 2008 |
|
Therapeutic benefit of pentostatin in severe IL-10−/− Colitis
JB Brown, G Lee, GR Grimm, TA Barrett |
Inflammatory Bowel Diseases | 2008 |
|
Fc Gamma Receptor Signaling in Mast Cells Links Microbial Stimulation to Mucosal Immune Inflammation in the Intestine
X Chen, BS Feng, PY Zheng, XQ Liao, J Chong, SG Tang, PC Yang |
The American Journal of Pathology | 2008 |
|
Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation
H Takedatsu, KD Taylor, L Mei, DP McGovern, CJ Landers, R Gonsky, Y Cong, EA Vasiliauskas, A Ippoliti, CO Elson, JI Rotter, SR Targan |
Gut | 2008 |
|
Bacteria and Bacterial rRNA Genes Associated with the Development of Colitis in IL-10–/– Mice
J Ye, JW Lee, LL Presley, E Bent, B Wei, J Braun, NL Schiller, DS Straus, J Borneman |
Inflammatory Bowel Diseases | 2008 |
|
T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade
DV Ostanin, J Bao, I Koboziev, L Gray, SA Robinson-Jackson, M Kosloski-Davidson, VH Price, MB Grisham |
American journal of physiology. Gastrointestinal and liver physiology | 2008 |
|
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice
M Mühlbauer, PM Chilton, TC Mitchell, C Jobin |
The Journal of biological chemistry | 2008 |
|
An antibiotic-responsive mouse model of fulminant ulcerative colitis
SS Kang, SM Bloom, LA Norian, MJ Geske, RA Flavell, TS Stappenbeck, PM Allen |
PLoS Medicine | 2008 |
|
Recombinant human granulocyte colony-stimulating factor reduces colonic epithelial cell apoptosis and ameliorates murine dextran sulfate sodium-induced colitis
T Kudo, T Matsumoto, I Nakamichi, S Yada, M Esaki, Y Jo, Y Ohji, T Yao, M Iida |
Scandinavian Journal of Gastroenterology | 2008 |
|
Cytokine signaling modules in inflammatory responses
JJ O'Shea, PJ Murray |
Immunity | 2008 |
|
Genes contributing to prion pathogenesis
G Tamgüney, K Giles, DV Glidden, P Lessard, H Wille, P Tremblay, DF Groth, F Yehiely, C Korth, RC Moore, J Tatzelt, E Rubinstein, C Boucheix, X Yang, P Stanley, MP Lisanti, RA Dwek, PM Rudd, J Moskovitz, CJ Epstein, TD Cruz, WA Kuziel, N Maeda, J Sap, KH Ashe, GA Carlson, I Tesseur, T Wyss-Coray, L Mucke, KH Weisgraber, RW Mahley, FE Cohen, SB Prusiner |
Journal of General Virology | 2008 |
|
Colon cancer stem cells: implications for prevention and therapy
EH Huang, MS Wicha |
Trends in Molecular Medicine | 2008 |
|
Role of IL-10 in the Resolution of Airway Inflammation
Ogawa Y, Duru EA, Ameredes BT |
Current molecular medicine | 2008 |
|
Is there a link between food and intestinal microbes and the occurrence of Crohn's disease and ulcerative colitis?
H Asakura, K Suzuki, T Kitahora, T Morizane |
Journal of Gastroenterology and Hepatology | 2008 |
|
Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha−/− mice
RA Edwards, K Wang, JS Davis, L Birnbaumer |
Inflammatory Bowel Diseases | 2008 |
|
CXCL10-Producing Mucosal CD4+T Cells, NK Cells, and NKT Cells Are Associated with Chronic Colitis in IL-10−/−Mice, Which Can Be Abrogated by Anti-CXCL10 Antibody Inhibition
UP Singh, S Singh, R Singh, Y Cong, DD Taub, JW Lillard |
Journal of Interferon & Cytokine Research | 2008 |
|
Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients
T Ohama, M Hori, M Fujisawa, M Kiyosue, M Hashimoto, Y Ikenoue, Y Jinno, H Miwa, T Matsumoto, T Murata, H Ozaki |
Journal of Gastroenterology | 2008 |
|
Paracellular entry of interleukin-10 producingLactococcus lactis in inflamed intestinal mucosa in mice
A Waeytens, L Ferdinande, S Neirynck, P Rottiers, MD Vos, L Steidler, CA Cuvelier |
Inflammatory Bowel Diseases | 2008 |
|
Immunoglobulin and Cytokine Production from Mesenteric Lymph Node Lymphocytes Is Regulated by Extracts ofCordyceps sinensisin C57Bl/6N Mice
DK Park, WS Choi, PJ Park, EK Kim, YJ Jeong, SY Choi, K Yamada, JD Kim, BO Lim |
Journal of Medicinal Food | 2008 |
|
The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 deficient mice
X Wei, J Gong, J Zhu, P Wang, N Li, W Zhu, J Li |
Clinical Immunology | 2008 |
|
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
M der Sluis, J Bouma, A Vincent, A Velcich, KL Carraway, HA Büller, AW Einerhand, JB van Goudoever, IV Seuningen, IB Renes |
Laboratory Investigation | 2008 |
|
Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-β and IL-10-mediated regulation of IFN-γ production
BF Qian, SL Tonkonogy, RB Sartor |
Inflammatory Bowel Diseases | 2008 |
|
IL-23 and Th17 cytokines in intestinal homeostasis
KJ Maloy, MC Kullberg |
Mucosal Immunology | 2008 |
|
Developing smart foods using models of intestinal health
RC Anderson, NC Roy, MP Barnett, MJ McCann, WC McNabb |
Food Science & Technology Bulletin: Functional Foods | 2008 |
|
Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells
BF Qian, SL Tonkonogy, RB Sartor |
Inflammatory Bowel Diseases | 2008 |
|
Do different animal models of IBD serve different purposes?
MB Grisham |
Inflammatory Bowel Diseases | 2008 |
|
Study of the effects of dietary polyunsaturated fatty acids: Molecular mechanisms involved in intestinal inflammation
B Knoch, MP Barnett, NC Roy, WC McNabb |
Grasas y Aceites | 2008 |
|
Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases
D Sugiura, S Aida, K Denda-Nagai, K Takeda, M Kamata-Sakurai, H Yagita, T Irimura |
Cancer Science | 2008 |
|
Therapeutic impact of toll-like receptors on inflammatory bowel diseases: A multiple-edged sword
E Cario |
Inflammatory Bowel Diseases | 2008 |
|
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice
M Pini, ME Gove, R Fayad, RJ Cabay, G Fantuzzi |
American journal of physiology. Gastrointestinal and liver physiology | 2008 |
|
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
MC Arrieta, K Madsen, J Doyle, J Meddings |
Gut | 2008 |
|
CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells
T Dasu, JE Qualls, H Tuna, C Raman, DA Cohen, S Bondada |
Immunology Letters | 2008 |
|
Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice
M Chichlowski, JM Sharp, DA Vanderford, MH Myles, LP Hale |
Comparative medicine | 2008 |
|
Prediction of nitric oxide concentrations in colonic crypts during inflammation
MP Chin, DB Schauer, WM Deen |
Nitric Oxide | 2008 |
|
Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis
X Wei, J Gong, J Zhu, L Niu, W Zhu, N Li, J Li |
International Immunopharmacology | 2008 |
|
Immunogenicity and pathogenicity of Helicobacter infections of veterinary animals
S Harbour, P Sutton |
Veterinary Immunology and Immunopathology | 2008 |
|
ω３脂肪酸系メディエーターと炎症反応の収束
M ARITA, Y ISOBE |
KAGAKU TO SEIBUTSU | 2008 |
|
Do different animal models of IBD serve different purposes?:
MB Grisham |
Inflammatory Bowel Diseases | 2008 |
|
Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10 –/– Mice
M Mühlbauer, PM Chilton, TC Mitchell, C Jobin |
The Journal of biological chemistry | 2008 |
|
5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10 −/− mice
S Narushima, D DiMeo, J Tian, J Zhang, D Liu, DJ Berg |
AJP Gastrointestinal and Liver Physiology | 2008 |
|
Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition
X Sun, H Yang, K Nose, S Nose, EQ Haxhija, H Koga, Y Feng, DH Teitelbaum |
AJP Gastrointestinal and Liver Physiology | 2008 |
|
Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection
CB Larmonier, JK Uno, KM Lee, T Karrasch, D Laubitz, R Thurston, MT Midura-Kiela, FK Ghishan, RB Sartor, C Jobin, PR Kiela |
AJP Gastrointestinal and Liver Physiology | 2008 |
|
Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-α), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis
T Shea-Donohue, K Thomas, MJ Cody, A Zhao, LJ DeTolla, KM Kopydlowski, M Fukata, SA Lira, SN Vogel |
Innate immunity | 2008 |
|
Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation
CP Krzyszton, NL Sparkman, RW Grant, JB Buchanan, SR Broussard, J Woods, RW Johnson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
|
The physical and biological characterization of a frail mouse model
Jeremy Walston, Neal Fedarko, Huanle Yang, Sean Leng, Brock Beamer, Sara Espinoza, Anne Lipton, Howie Zheng, Kevin Becker |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2008 |
|
Campylobacter
I Nachamkin, CM Szymanski, MJ Blaser |
Campylobacter | 2008 |
|
Influence of Host Interleukin-10 Polymorphisms on Development of Traveler's Diarrhea Due to Heat-Labile Enterotoxin-Producing Escherichia coli in Travelers from the United States Who Are Visiting Mexico
J Flores, HL DuPont, SA Lee, J Belkind-Gerson, M Paredes, JA Mohamed, LY Armitige, DC Guo, PC Okhuysen |
Clinical and vaccine immunology : CVI | 2008 |
|
Molecular Interactions of Commensal Enteric Bacteria with the Intestinal Epithelium and the Mucosal Immune System
D Haller |
Bioscience and Microflora | 2008 |
|
Microbial Imprinting in Gut Development and Health
JJ Dibner, JD Richards, CD Knight |
J APPL POULTRY RES | 2008 |
|
The Physical and Biological Characterization of a Frail Mouse Model
Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2008 |
|
A cytokine-mediated link between innate immunity, inflammation, and cancer
Wan-Wan Lin1 and Michael Karin2 |
Journal of Clinical Investigation | 2007 |
|
Series overview: Harnessing the immune system to treat cancer
Nina Bhardwaj |
Journal of Clinical Investigation | 2007 |
|
Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells
W Zhou, K Hashimoto, K Goleniewska, JF O'Neal, S Ji, TS Blackwell, GA Fitzgerald, KM Egan, MW Geraci, RS Peebles |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
Massive but selective cytokine dysregulation in the colon of IL-10-/- mice revealed by multiplex analysis
D Montufar-Solis, J Schaefer, MJ Hicks, JR Klein |
International Immunology | 2007 |
|
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
T Poutahidis, KM Haigis, VP Rao, PR Nambiar, CL Taylor, Z Ge, K Watanabe, A Davidson, BH Horwitz, JG Fox, SE Erdman |
Carcinogenesis | 2007 |
|
Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice
W Reindl, S Weiss, HA Lehr, I Förster |
Immunology | 2007 |
|
Negative regulation of Th17 responses
JS Stumhofer, J Silver, CA Hunter |
Seminars in Immunology | 2007 |
|
Novel genetic markers in inflammatory bowel disease.
Rodriguez-Bores L, Fonseca GC, Villeda MA, Yamamoto-Furusho JK |
World Journal of Gastroenterology | 2007 |
|
The Immune Response in Inflammatory Bowel Disease
SJ Brown, L Mayer |
The American Journal of Gastroenterology | 2007 |
|
Therapeutic effect of a new immunosuppressive agent, everolimus, on interleukin-10 gene-deficient mice with colitis
C Matsuda, T Ito, J Song, T Mizushima, H Tamagawa, Y Kai, Y Hamanaka, M Inoue, T Nishida, H Matsuda, Y Sawa |
Clinical & Experimental Immunology | 2007 |
|
Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase
D DiMeo, J Tian, J Zhang, S Narushima, DJ Berg |
Immunology | 2007 |
|
INTESTINE-SPECIFIC OVEREXPRESSION OF IL-10 IMPROVES SURVIVAL IN POLYMICROBIAL SEPSIS
S Rajan, D Vyas, AT Clark, CA Woolsey, JA Clark, RS Hotchkiss, TG Buchman, CM Coopersmith |
Shock | 2007 |
|
The Genetics of Inflammatory Bowel Disease
JH Cho, CT Weaver |
Gastroenterology | 2007 |
|
Swords into plowshares: IL-23 repurposes tumor immune surveillance
JL Langowski, RA Kastelein, M Oft |
Trends in Immunology | 2007 |
|
Fenofibrate Represses Interleukin-17 and Interferon-γ Expression and Improves Colitis in Interleukin-10–Deficient Mice
JW Lee, PJ Bajwa, MJ Carson, DR Jeske, Y Cong, CO Elson, C Lytle, DS Straus |
Gastroenterology | 2007 |
|
Nutrigenomics applied to an animal model of Inflammatory Bowel Diseases: Transcriptomic analysis of the effects of eicosapentaenoic acid- and arachidonic acid-enriched diets
N Roy, M Barnett, B Knoch, Y Dommels, W McNabb |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2007 |
|
Multistep carcinogenesis of the colon in ApcMin/+mouse
Y Yamada, H Mori |
Cancer Science | 2007 |
|
Therapeutic effects of roxithromycin in interleukin-10-deficient colitis
H Tamagawa, T Hiroi, T Mizushima, T Ito, H Matsuda, H Kiyono |
Inflammatory Bowel Diseases | 2007 |
|
Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: Implications for chronic inflammation
T Clavel, D Haller |
Inflammatory Bowel Diseases | 2007 |
|
Apoptosis Inhibitor Expressed by Macrophages Tempers Autoimmune Colitis and the Risk of Colitis-Based Carcinogenesis in TCRα−/− Mice
I Haruta, N Shibata, Y Kato, M Tanaka, M Kobayashi, H Oguma, K Shiratori |
Journal of Clinical Immunology | 2007 |
|
Neonatal Co-Infection with Helicobacter Species Markedly Accelerates the Development of Inflammation-Associated Colonic Neoplasia in IL-10−/-Mice
LP Hale, D Perera, MR Gottfried, L Maggio-Price, S Srinivasan, D Marchuk |
Helicobacter | 2007 |
|
Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice
J Alayan, S Ivanovski, CS Farah |
Journal of Periodontal Research | 2007 |
|
R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice
J Zhao, J Vera, S Narushima, EX Beck, S Palencia, P Shinkawa, KA Kim, Y Liu, MD Levy, DJ Berg, A Abo, WD Funk |
Gastroenterology | 2007 |
|
‘One medicine—one pathology’: are veterinary and human pathology prepared?
RD Cardiff, JM Ward, SW Barthold |
Laboratory Investigation | 2007 |
|
Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice
CM Nagamine, AB Rogers, JG Fox, DB Schauer |
International Journal of Cancer | 2007 |
|
Inflammation and cancer: a failure of resolution?
T Lawrence |
Trends in Pharmacological Sciences | 2007 |
|
Benefits and Risks of Breastfeeding
AS Goldman, JM Hopkinson, DK Rassin |
Advances in Pediatrics | 2007 |
|
Selective decrease in colonic CD56+ T and CD161+ T cells in the inflamed mucosa of patients with ulcerative colitis
Masaru Shimamoto, Yoshitaka Ueno, Shinji Tanaka, Toshiko Onitake, Rie Hanaoka, Kyoko Yoshioka, Tsuyoshi Hatakeyama, Kazuaki Chayama |
World journal of gastroenterology : WJG | 2007 |
|
Novel genetic markers in inflammatory bowel disease
L Rodríguez-Bores |
World journal of gastroenterology : WJG | 2007 |
|
IL-10 Gene Transfer Attenuates P. gingivalis -induced Inflammation
Y Houri-Haddad, WA Soskolne, A Halabi, L Shapira |
Journal of dental research | 2007 |
|
Maturation of the mucosal immune system underlies colitis susceptibility in interleukin-10-deficient (IL-10 −/− ) mice
MR Etling, S Davies, M Campbell, RW Redline, P Fu, AD Levine |
Journal of leukocyte biology | 2007 |
|
Avaliação do dano oxidativo ao DNA de células normais e neoplásicas da mucosa cólica de doentes com câncer colorretal
ML Ribeiro, DG Priolli, DD da Miranda, DA Paiva, JP Júnior, CA Martinez |
Revista Brasileira de Coloproctologia | 2007 |
|
Immunomodulatory Effects of (n-3) Fatty Acids: Putative Link to Inflammation and Colon Cancer
RS Chapkin, LA Davidson, L Ly, BR Weeks, JR Lupton, DN McMurray |
The Journal of nutrition | 2007 |
|
ABIN-3: a Molecular Basis for Species Divergence in Interleukin-10-Induced Anti-Inflammatory Actions
BK Weaver, E Bohn, BA Judd, MP Gil, RD Schreiber |
Molecular and cellular biology | 2007 |
|
C57BL/6 and Congenic Interleukin-10-Deficient Mice Can Serve as Models of Campylobacter jejuni Colonization and Enteritis
LS Mansfield, JA Bell, DL Wilson, AJ Murphy, HM Elsheikha, VA Rathinam, BR Fierro, JE Linz, VB Young |
Infection and immunity | 2007 |
|
A Novel Sphingosine 1-Phosphate Receptor Agonist, 2-Amino-2-propanediol Hydrochloride (KRP-203), Regulates Chronic Colitis in Interleukin-10 Gene-Deficient Mice
J Song, C Matsuda, Y Kai, T Nishida, K Nakajima, T Mizushima, M Kinoshita, T Yasue, Y Sawa, T Ito |
The Journal of pharmacology and experimental therapeutics | 2007 |
|
Influence of Mycobacterium avium subsp. paratuberculosis on Colitis Development and Specific Immune Responses during Disease
UP Singh, S Singh, R Singh, RK Karls, FD Quinn, ME Potter, JW Lillard |
Infection and immunity | 2007 |
|
Cutting Edge: Transgenic Expression of Human MUC1 in IL-10 −/− Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer
PL Beatty, SE Plevy, AR Sepulveda, OJ Finn |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
Amelioration of Chronic Murine Colitis by Peptide-Mediated Transduction of the IκB Kinase Inhibitor NEMO Binding Domain Peptide
SH Davé, JS Tilstra, K Matsuoka, F Li, T Karrasch, JK Uno, AR Sepulveda, C Jobin, AS Baldwin, PD Robbins, SE Plevy |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
'One medicine---one pathology': are veterinary and human pathology prepared?
Cardiff RD, Ward JM, Barthold SW |
Laboratory Investigation | 2007 |
|
Apoptosis inhibitor expressed by macrophages tempers autoimmune colitis and the risk of colitis-based carcinogenesis in TCRalpha-/- mice.
Haruta I, Shibata N, Kato Y, Tanaka M, Kobayashi M, Oguma H, Shiratori K |
Journal of Clinical Immunology | 2007 |
|
IL-23 is essential for T-cell mediated colitis and promotes inflammation via IL-6 and IL-17
David Yen, Jeanne Cheung, Heleen Scheerens, Frederique Poulet, Terri McClanahan, Brent McKenzie, Melanie A. Kleinschek, Alex Owyang, Jeanine Mattson, Wendy Blumenschein, Erin Murphy, Manjiri Sathe, Daniel Cua, Robert A Kastelein, Donna Rennick |
Journal of Clinical Investigation | 2006 |
|
Intestinal helminths protect in a murine model of asthma
K Kitagaki, TR Businga, D Racila, DE Elliott, JV Weinstock, JN Kline |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
MC Kullberg, D Jankovic, CG Feng, S Hue, PL Gorelick, BS McKenzie, DJ Cua, F Powrie, AW Cheever, KJ Maloy, A Sher |
Journal of Experimental Medicine | 2006 |
|
Effect of Rebamipide on the Colonic Barrier in Interleukin-10-Deficient Mice
D Laharie, S Ménard, C Asencio, T Vidal-Martinez, A Rullier, F Zerbib, C Candalh, F Mégraud, M Heyman, T Matysiak-Budnik |
Digestive Diseases and Sciences | 2006 |
|
IL-10 deficiency leads to somatic mutations in a model of IBD
Y Sato, S Takahashi, Y Kinouchi, M Shiraki, K Endo, Y Matsumura, Y Kakuta, M Tosa, A Motida, H Abe, G Imai, H Yokoyama, E Nomura, K Negoro, S Takagi, H Aihara, K Masumura, T Nohmi, T Shimosegawa |
Carcinogenesis | 2006 |
|
Current Protocols in Pharmacology
JP Renninger |
Current Protocols in Pharmacology | 2006 |
|
Modern Nutrition Science
C Cooper, E Tredget, C Watters |
Nutrition and Wound Healing | 2006 |
|
Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice
B Sheil, J MacSharry, L O'Callaghan, A O'Riordan, A Waters, J Morgan, JK Collins, L O'Mahony, F Shanahan |
Clinical & Experimental Immunology | 2006 |
|
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
S Rakoff-Nahoum, L Hao, R Medzhitov |
Immunity | 2006 |
|
Mouse models of gastrointestinal tumors
MM Taketo |
Cancer Science | 2006 |
|
The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation
K Kikly, L Liu, S Na, JD Sedgwick |
Current Opinion in Immunology | 2006 |
|
The roles for cytokines in the generation and maintenance of regulatory T cells
YY Wan, RA Flavell |
Immunological Reviews | 2006 |
|
Host Gene Expression in the Colon of Gnotobiotic Interleukin-2-Deficient Mice Colonized with Commensal Colitogenic or Noncolitogenic Bacterial Strains
E Bohn, O Bechtold, N Zahir, JS Frick, J Reimann, B Jilge, IB Autenrieth |
Inflammatory Bowel Diseases | 2006 |
|
Dietary fatty acids modulate chronic colitis, colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice
RA Hegazi, RS Saad, H Mady, LE Matarese, S O’Keefe, HM Kandil |
Nutrition | 2006 |
|
Induction of chronic colitis in IL-10 deficient mice requires IL-4
S Specht, S Arriens, A Hoerauf |
Microbes and Infection | 2006 |
|
Receptor for Advanced Glycation Endproducts and Murine ColitisLimited Project Grant #066
EH Huang |
Seminars in Colon and Rectal Surgery | 2006 |
|
Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10
DR Jeyarajah, ML Kielar, H Saboorian, P Karimi, N Frantz, CY Lu |
AJP Gastrointestinal and Liver Physiology | 2006 |
|
Suppression of experimental colitis by intestinal mononuclear phagocytes
JE Qualls, AM Kaplan, NV Rooijen, DA Cohen |
Journal of leukocyte biology | 2006 |
|
Toll-Like Receptor Signaling and its Relevance to Intestinal Inflammation
E Cario, DK Podolsky |
Annals of the New York Academy of Sciences | 2006 |
|
Highlights in Gastrointestinal Oncology
E van Cutsem, W Schmiegel, AK Rustgi, M Zeitz |
2006 | |
|
Rapid Onset of Ulcerative Typhlocolitis in B6.129P2-IL10 tm1Cgn (IL-10 −/− ) Mice Infected with Helicobacter trogontum Is Associated with Decreased Colonization by Altered Schaedler's Flora
MT Whary, SJ Danon, Y Feng, Z Ge, N Sundina, V Ng, NS Taylor, AB Rogers, JG Fox |
Infection and immunity | 2006 |
|
Resistance of C57BL/6 Mice to Amoebiasis Is Mediated by Nonhemopoietic Cells but Requires Hemopoietic IL-10 Production
S Hamano, A Asgharpour, SE Stroup, TA Wynn, EH Leiter, E Houpt |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Campylobacter jejuni Colonization of Mice with Limited Enteric Flora
C Chang, JF Miller |
Infection and immunity | 2006 |
|
CD8αα-Mediated Intraepithelial Lymphocyte Snatching of Thymic Leukemia MHC Class Ib Molecules In Vitro and In Vivo
N Pardigon, K Takeda, B Saunier, F Hornung, J Gibbs, A Weisberg, N Contractor, B Kelsall, JR Bennink, JW Yewdell |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Cutting Edge: Critical Role for A 2A Adenosine Receptors in the T Cell-Mediated Regulation of Colitis
M Naganuma, EB Wiznerowicz, CM Lappas, J Linden, MT Worthington, PB Ernst |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Multistep carcinogenesis of the colon in Apc Min/+ mouse
Yamada Y, Mori H |
Cancer Science | 2006 |
|
Growth Hormone Inhibits Signal Transducer and Activator of Transcription 3 Activation and Reduces Disease Activity in Murine Colitis
X Han, D Sosnowska, EL Bonkowski, LA Denson |
Gastroenterology | 2005 |
|
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway
RA Hegazi, KN Rao, A Mayle, AR Sepulveda, LE Otterbein, SE Plevy |
Journal of Experimental Medicine | 2005 |
|
Trichuris suis therapy in Crohn's disease
RW Summers, DE Elliott, JF Urban, R Thompson, JV Weinstock |
Gut | 2005 |
|
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
LE Harrington, RD Hatton, PR Mangan, H Turner, TL Murphy, KM Murphy, CT Weaver |
Nature Immunology | 2005 |
|
The role of mucosal T lymphocytes in regulating intestinal inflammation
HH Uhlig, F Powrie |
Springer Seminars in Immunopathology | 2005 |
|
STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells
F Hoentjen, RB Sartor, M Ozaki, C Jobin |
Blood | 2005 |
|
The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria
T Hirotani, PY Lee, H Kuwata, M Yamamoto, M Matsumoto, I Kawase, S Akira, K Takeda |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
|
Animal models of intestinal inflammation: ineffective communication between coalition members
RG Lorenz, VJ McCracken, CO Elson |
Springer Seminars in Immunopathology | 2005 |
|
Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor?
Meier CB, Hegazi RA, Aisenberg J, Legnani PE, Nilubol N, Cobrin GM, Duerr RH, Gorfine SR, Bauer JJ, Sachar DB, Plevy SE |
Inflammatory Bowel Diseases | 2005 |
|
Interleukin-10 in murine metal-induced systemic autoimmunity
B Häggqvist, P Hultman |
Clinical & Experimental Immunology | 2005 |
|
NF-κB: linking inflammation and immunity to cancer development and progression
M Karin, FR Greten |
Nature Reviews Immunology | 2005 |
|
Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors
C Becker, S Wirtz, MF Neurath |
Inflammatory Bowel Diseases | 2005 |
|
The peroxisome proliferator-activated receptor γ ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency
C Lytle, TJ Tod, KT Vo, JW Lee, RD Atkinson, DS Straus |
Inflammatory Bowel Diseases | 2005 |
|
Cdcs1, a Major Colitogenic Locus in Mice, Regulates Innate and Adaptive Immune Response to Enteric Bacterial Antigens
J Beckwith, Y Cong, JP Sundberg, CO Elson, EH Leiter |
Gastroenterology | 2005 |
|
Eradication of Helicobacter pylori and Resolution of Gastritis in the Gastric Mucosa of IL-10-Deficient Mice
Y Matsumoto, TG Blanchard, ML Drakes, M Basu, RW Redline, AD Levine, SJ Czinn |
Helicobacter | 2005 |
|
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
SC Kim, SL Tonkonogy, CA Albright, J Tsang, EJ Balish, J Braun, MM Huycke, RB Sartor |
Gastroenterology | 2005 |
|
Tumor Necrosis Factor α Blockade Restores Growth Hormone Signaling in Murine Colitis
LM Difedele, J He, EL Bonkowski, X Han, MA Held, A Bohan, RK Menon, LA Denson |
Gastroenterology | 2005 |
|
Single-dose therapy for lupus nephritis: C-reactive protein, nature's own dual scavenger and immunosuppressant
CA Ogden, KB Elkon |
Arthritis & Rheumatism | 2005 |
|
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
CO Elson, Y Cong, VJ McCracken, RA Dimmitt, RG Lorenz, CT Weaver |
Immunological Reviews | 2005 |
|
Natural Colonization with Helicobacter species and the Development of Inflammatory Bowel Disease in Interleukin-10-deficient Mice
L Zhang, SJ Danon, M Grehan, V Chan, A Lee, H Mitchell |
Helicobacter | 2005 |
|
Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria
LP Hale, MR Gottfried, A Swidsinski |
Inflammatory Bowel Diseases | 2005 |
|
Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice
JG Hyun, G Lee, JB Brown, GR Grimm, Y Tang, N Mittal, R Dirisina, Z Zhang, JP Fryer, JV Weinstock, AD Luster, TA Barrett |
Inflammatory Bowel Diseases | 2005 |
|
Bacterial-induced inflammation in germ-free rabbit appendix
M Shanmugam, P Sethupathi, KJ Rhee, S Yong, KL Knight |
Inflammatory Bowel Diseases | 2005 |
|
Development and validation of a novel IL-10 deficient cell transfer model for colitis
Y Ikenoue, T Tagami, M Murata |
International Immunopharmacology | 2005 |
|
Role of toll-like receptor–commensal interactions in intestinal inflammation
S Rakoff-Nahoum, R Medzhitov |
International Congress Series | 2005 |
|
Measuring Immunity
MT Stang, JH Yim |
Measuring Immunity | 2005 |
|
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
|
Intestinal inflammation induces adaptation of P-glycoprotein expression and activity
M Buyse, G Radeva, A Bado, R Farinotti |
Biochemical Pharmacology | 2005 |
|
Colonization of Mucosal Surfaces
JP Nataro, PS Cohen, HL Mobley, JN Weiser |
2005 | |
|
Role of EspA and Intimin in Expression of Proinflammatory Cytokines from Enterocytes and Lymphocytes by Rabbit Enteropathogenic Escherichia coli -Infected Rabbits
K Ramirez, R Huerta, E Oswald, C Garcia-Tovar, JM Hernandez, F Navarro-Garcia |
Infection and immunity | 2005 |
|
Bacterial Flagellin is a Dominant Antigen in Crohn’s Disease
Michael J. Lodes, Yingzi Cong, Charles O. Elson, Raodoh Mohamath, Carol J. Landers, Stephan R. Targan, Madeline Fort, Robert M. Hershberg |
Journal of Clinical Investigation | 2004 |
|
IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice
M Shiraki, H Aihara, Y Kinouchi, S Takahashi, M Oki, M Noguchi, K Takahashi, J Miyazaki, T Shimosegawa |
Laboratory Investigation | 2004 |
|
IL-10 modulates intestinal damage and epithelial cell apoptosis in T cell-mediated enteropathy
P Zhou, C Streutker, R Borojevic, Y Wang, K Croitoru |
AJP Gastrointestinal and Liver Physiology | 2004 |
|
CD4+ Tregs and immune control
Z Fehérvari, S Sakaguchi |
Journal of Clinical Investigation | 2004 |
|
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia
O Brenner, D Levanon, V Negreanu, O Golubkov, O Fainaru, E Woolf, Y Groner |
Proceedings of the National Academy of Sciences | 2004 |
|
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
F Yan, SK John, G Wilson, DS Jones, MK Washington, DB Polk |
Journal of Clinical Investigation | 2004 |
|
Reduced ratio of protectiveversusproinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats
LA Dieleman, F Hoentjen, BF Qian, D Sprengers, E Tjwa, MF Torres, CD Torrice, RB Sartor, SL Tonkonogy |
Clinical & Experimental Immunology | 2004 |
|
DNA from probiotic bacteria modulates murine and human epithelial and immune function
H Jijon, J Backer, H Diaz, H Yeung, D Thiel, C McKaigney, CD Simone, K Madsen |
Gastroenterology | 2004 |
|
Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones
R Dresner-Pollak, N Gelb, D Rachmilewitz, F Karmeli, M Weinreb |
Gastroenterology | 2004 |
|
Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers
S Colnot, M Niwa-Kawakita, G Hamard, C Godard, SL Plenier, C Houbron, B Romagnolo, D Berrebi, M Giovannini, C Perret |
Laboratory Investigation | 2004 |
|
IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii
U Wille, M Nishi, L Lieberman, EH Wilson, DS Roos, CA Hunter |
Parasite Immunology | 2004 |
|
Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis
T Mizushima, T Ito, D Kishi, Y Kai, H Tamagawa, R Nezu, H Kiyono, H Matsuda |
Inflammatory Bowel Diseases | 2004 |
|
Interleukin 10-deficient mice exhibit defective colonic Muc2 synthesis before and after induction of colitis by commensal bacteria
NM Schwerbrock, MK Makkink, M der Sluis, HA Büller, AW Einerhand, RB Sartor, J Dekker |
Inflammatory Bowel Diseases | 2004 |
|
Interleukin-10 knockout mouse: A model for studying bone metabolism during intestinal inflammation
SL Cohen, AM Moore, WE Ward |
Inflammatory Bowel Diseases | 2004 |
|
New cytokine therapeutics for inflammatory bowel disease
PC Stokkers, DW Hommes |
Cytokine | 2004 |
|
Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis
B Sheil, J McCarthy, L O'Mahony, MW Bennett, P Ryan, JJ Fitzgibbon, B Kiely, JK Collins, F Shanahan |
Gut | 2004 |
|
Infection and Autoimmunity
C Dugué, Y Renaudineau, P Youinou |
Infection and Autoimmunity | 2004 |
|
Gene Disruption and Immunity in Experimental Colitis:
CO Elson, A Konrad, Y Cong, CT Weaver |
Inflammatory Bowel Diseases | 2004 |
|
STAT3 activation in macrophages following infection with Salmonella
T Lin, KL Bost |
Biochemical and Biophysical Research Communications | 2004 |
|
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
MM Huycke, HR Gaskins |
Experimental biology and medicine (Maywood, N.J.) | 2004 |
|
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
SH Itzkowitz, X Yio |
AJP Gastrointestinal and Liver Physiology | 2004 |
|
CD4 + T cells from IL-10-deficient mice transfer susceptibility to NSAID-induced Rag colitis
AM Blum, A Metwali, DE Elliott, DJ Berg, JV Weinstock |
AJP Gastrointestinal and Liver Physiology | 2004 |
|
Insulin-like growth factor-I stimulates IL-10 production in human T cells
R Kooijman, A Coppens |
Journal of leukocyte biology | 2004 |
|
Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
VS Carl, JK Gautam, LD Comeau, MF Smith |
Journal of leukocyte biology | 2004 |
|
Sequential Analysis of Development of Invasive Thyroid Follicular Cell Carcinomas in Inflamed Capsular Regions of Rats Treated with Sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
T Imai, JI Onose, M Hasumura, M Ueda, T Takizawa, M Hirose |
Toxicologic pathology | 2004 |
|
Cancer and Inflammation
DW Morgan, UJ Forssmann, MT Nakada |
2004 | |
|
Suppression of CD4 + T Lymphocyte Effector Functions by CD4 + CD25 + Cells In Vivo
B Martin, A Banz, B Bienvenu, C Cordier, N Dautigny, C Bécourt, B Lucas |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
|
Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune Uveoretinitis via IL-10
T Kezuka, M Takeuchi, H Keino, Y Usui, A Takeuchi, N Yamakawa, M Usui |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
|
Regulation of Allergy and Autoimmunity in Helminth Infection
MS Wilson, RM Maizels |
Clinical Reviews in Allergy & Immunology | 2004 |
|
Refined histopathologic scoring system improves power todetect colitis QTL in mice
A Bleich, M Mähler, C Most, EH Leiter, E LieblerTenorio, CO Elson, HJ Hedrich, B Schlegelberger, JP Sundberg |
Mammalian Genome | 2004 |
|
Maintenance of remission in Crohn's disease: current and emerging therapeutic options.
Brookes MJ, Green JR |
Drugs | 2004 |
|
Immunology of Human Milk and Host Immunity
Chheda S, Keeney SE, Goldman AS |
Fetal and Neonatal Physiology | 2004 |
|
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
Masaya Kobayashi, Mi-Na Kweon, Hirotaka Kuwata, Robert D. Schreiber, Hiroshi Kiyono, Kiyoshi Takeda, and Shizuo Akira |
Journal of Clinical Investigation | 2003 |
|
Radical causes of cancer
SP Hussain, LJ Hofseth, CC Harris |
Nature Reviews Cancer | 2003 |
|
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages
H Kuwata, Y Watanabe, H Miyoshi, M Yamamoto, T Kaisho, K Takeda, S Akira |
Blood | 2003 |
|
A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses
Z Fehérvári, S Sakaguchi |
Arthritis Research & Therapy | 2003 |
|
Evidence for the critical role of interleukin-12 but not interferon-γ in the pathogenesis of experimental colitis in mice
K Tozawa, H Hanai, K Sugimoto, S Baba, H Sugimura, T Aoshi, M Uchijima, T Nagata, Y Koide |
Journal of Gastroenterology and Hepatology | 2003 |
|
Interleukin-10-based therapy for inflammatory bowel disease
H Braat, MP Peppelenbosch, DW Hommes |
Expert Opinion on Biological Therapy | 2003 |
|
Tnfa andIl-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency
H Bernert, K Sekikawa, RA Radcliffe, F Iraqi, M You, AM Malkinson |
Molecular Carcinogenesis | 2003 |
|
CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines
DC Macdonald, SH Leir, C Brooks, E Sanders, P Lackie, W Rosenberg |
European Journal of Gastroenterology & Hepatology | 2003 |
|
Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment
J Onose, T Imai, M Hasumura, M Ueda, M Hirose |
Cancer Letters | 2003 |
|
Immune Networks in Animal Models of Inflammatory Bowel Disease
A Mizoguchi, E Mizoguchi, AK Bhan |
Inflammatory Bowel Diseases | 2003 |
|
Evidence for oxidative stress in NSAID-induced colitis in IL10−/− mice
S Narushima, DR Spitz, LW Oberley, S Toyokuni, T Miyata, CA Gunnett, GR Buettner, J Zhang, H Ismail, RG Lynch, DJ Berg |
Free radical biology & medicine | 2003 |
|
CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice
SE Erdman, T Poutahidis, M Tomczak, AB Rogers, K Cormier, B Plank, BH Horwitz, JG Fox |
The American Journal of Pathology | 2003 |
|
Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis
T Scheinin, DM Butler, F Salway, B Scallon, M Feldmann |
Clinical & Experimental Immunology | 2003 |
|
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
JO Lindsay, CJ Ciesielski, T Scheinin, FM Brennan, HJ Hodgson |
Gut | 2003 |
|
Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice
F Hoentjen, HJ Harmsen, H Braat, CD Torrice, BA Mann, RB Sartor, LA Dieleman |
Gut | 2003 |
|
Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance
J McCarthy, L O'Mahony, L O'Callaghan, B Sheil, EE Vaughan, N Fitzsimons, J Fitzgibbon, GC O'Sullivan, B Kiely, JK Collins, F Shanahan |
Gut | 2003 |
|
Immune Networks in Animal Models of Inflammatory Bowel Disease:
A Mizoguchi, E Mizoguchi, AK Bhan |
Inflammatory Bowel Diseases | 2003 |
|
Celecoxib and Rofecoxib Potentiate Chronic Colitis and Premalignant Changes in Interleukin 10 Knockout Mice:
RA Hegazi, HH Mady, MF Melhem, AR Sepulveda, M Mohi, HM Kandil |
Inflammatory Bowel Diseases | 2003 |
|
Lack of Interleukin-10 Leads to Intestinal Inflammation, Independent of the Time at Which Luminal Microbial Colonization Occurs:
BC Sydora, MM Tavernini, A Wessler, LD Jewell, RN Fedorak |
Inflammatory Bowel Diseases | 2003 |
|
Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I)
P Chandran, S Satthaporn, A Robins, O Eremin |
The Surgeon | 2003 |
|
Pathology of mouse models of intestinal cancer: Consensus report and recommendations
GP Boivin, K Washington, K Yang, JM Ward, TP Pretlow, R Russell, DG Besselsen, VL Godfrey, T Doetschman, WF Dove, HC Pitot, RB Halberg, SH Itzkowitz, J Groden, RJ Coffey |
Gastroenterology | 2003 |
|
Immunomodulatory cytokines in asthmatic inflammation
Elizabeth L Lynch, Frédéric F Little, Kevin C Wilson, David M Center, William W Cruikshank |
Cytokine & Growth Factor Reviews | 2003 |
|
Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion
J Walker, HB Jijon, T Churchill, M Kulka, KL Madsen |
AJP Gastrointestinal and Liver Physiology | 2003 |
|
Accelerated Alveolar Bone Loss in Mice Lacking Interleukin-10
A Al-Rasheed, H Scheerens, DM Rennick, HM Fletcher, DN Tatakis |
Journal of dental research | 2003 |
|
(n-3) Polyunsaturated Fatty Acids Promote Activation-Induced Cell Death in Murine T Lymphocytes
KC Switzer, DN McMurray, JS Morris, RS Chapkin |
The Journal of nutrition | 2003 |
|
Inflammatory Bowel Disease: From Bench to Bedside
SR Targan, F Shanahan, LC Karp |
2003 | |
|
Cytokines and Chemokines in Autoimmune Disease
P Santamaria |
2003 | |
|
Helicobactor pylori
RH Hunt, GN Tytgat |
2003 | |
|
Role for Complement in Development of Helicobacter -Induced Gastritis in Interleukin-10-Deficient Mice
HF Ismail, J Zhang, RG Lynch, Y Wang, DJ Berg |
Infection and immunity | 2003 |
|
Granulomatous Infections and Inflammations: Cellular and Molecular Mechanisms
DL Boros |
2003 | |
|
NF-κB Is Required Within the Innate Immune System to Inhibit Microflora-Induced Colitis and Expression of IL-12 p40
MF Tomczak, SE Erdman, T Poutahidis, AB Rogers, H Holcombe, B Plank, JG Fox, BH Horwitz |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
B Cell Developmental Requirement for the G α i2 Gene
H Dalwadi, B Wei, M Schrage, TT Su, DJ Rawlings, J Braun |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10 −/− Mice
UP Singh, S Singh, DD Taub, JW Lillard |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
Depletion of Neutrophils in IL-10 −/− Mice Delays Clearance of Gastric Helicobacter Infection and Decreases the Th1 Immune Response to Helicobacter
HF Ismail, P Fick, J Zhang, RG Lynch, DJ Berg |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
Altered glycosylation in inflammatory bowel disease: a possible role in cancer development
B J Campbell, L G Yu, J M Rhodes |
Glycoconjugate Journal | 2003 |
|
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis.
Lindsay JO, Ciesielski CJ, Scheinin T, Brennan FM, Hodgson HJ |
Gut | 2003 |
|
Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.
Watanabe N, Ikuta K, Okazaki K, Nakase H, Tabata Y, Matsuura M, Tamaki H, Kawanami C, Honjo T, Chiba T |
Digestive Diseases and Sciences | 2003 |
|
Impaired mucosal integrity and enhanced immune response in colitis in mice lacking prostaglandin E receptor EP4
Kenji Kabashima, Tomomi Saji, Takahiko Murata, Miyako Nagamachi, Toshiyuki Matsuoka, Eri Segi, Kazuhito Tsuboi, Yukihiko Sugimoto, Takuya Kobayashi, Yoshiki Miyachi, Atsushi Ichikawa, Shuh Narumiya |
Journal of Clinical Investigation | 2002 |
|
IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation
N Ohta, T Hiroi, MN Kweon, N Kinoshita, MH Jang, T Mashimo, JI Miyazaki, H Kiyono |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
|
Role of Hypolipidemic Drug Clofibrate in Altering Iron Regulatory Proteins IRP1 and IRP2 Activities and Hepatic Iron Metabolism in Rats Fed a Low-Iron Diet
HL Huang, NS Shaw |
Toxicology and Applied Pharmacology | 2002 |
|
Decreased Lamina Propria Effector Cell Responsiveness to Interleukin-10 in Ileal Crohn's Disease
S Colpaert, K Vanstraelen, Z Liu, F Penninckx, K Geboes, P Rutgeerts, J Ceuppens |
Clinical Immunology | 2002 |
|
Colitis-Related Public T Cells Are Selected in the Colonic Lamina Propria of IL-10-Deficient Mice
I Takahashi, J Matsuda, L Gapin, H DeWinter, Y Kai, H Tamagawa, M Kronenberg, H Kiyono |
Clinical Immunology | 2002 |
|
Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared
JM Rhodes, BJ Campbell |
Trends in Molecular Medicine | 2002 |
|
Distinct inflammatory mechanisms mediate early versus late colitis in mice
DM Spencer, GM Veldman, S Banerjee, J Willis, AD Levine |
Gastroenterology | 2002 |
|
Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice
R Eliakim, QX Fan, MW Babyatsky |
European Journal of Gastroenterology & Hepatology | 2002 |
|
ASSOCIATION OF IL-10 EXPRESSION BY MUCOSAL LYMPHOCYTES WITH INCREASED EXPRESSION OF CRYPTOSPORIDIUM PARVUM EPITOPES IN INFECTED EPITHELIUM
CR Wyatt, WJ Barrett, EJ Brackett, DA Schaefer, MW Riggs |
Journal of Parasitology | 2002 |
|
Genetics of Colitis Susceptibility in IL-10-Deficient Mice: Backcross versus F2 Results Contrasted by Principal Component Analysis
M Mähler, C Most, S Schmidtke, JP Sundberg, R Li, HJ Hedrich, GA Churchill |
Genomics | 2002 |
|
Lactobacillus plantarum 299V in the Treatment and Prevention of Spontaneous Colitis in Interleukin-10-Deficient Mice
M Schultz, C Veltkamp, LA Dieleman, WB Grenther, PB Wyrick, SL Tonkonogy, RB Sartor |
Inflammatory Bowel Diseases | 2002 |
|
Treating Crohn's Disease by Inducing T Lymphocyte Apoptosis
JM Brande, MP Peppelenbosch, SJ Deventer |
Annals of the New York Academy of Sciences | 2002 |
|
Helicobacter bilis Infection Accelerates and H. hepaticus Infection Delays the Development of Colitis in Multiple Drug Resistance-Deficient (mdr1a−/−) Mice
L Maggio-Price, D Shows, K Waggie, A Burich, W Zeng, S Escobar, P Morrissey, JL Viney |
The American Journal of Pathology | 2002 |
|
Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance
I Gjertsson, OH Hultgren, A Tarkowski |
Clinical & Experimental Immunology | 2002 |
|
Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice
U Wille, EN Villegas, L Craig, R Peach, CA Hunter |
Infection and immunity | 2002 |
|
Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
S Schreiber, P Rosenstiel, J Hampe, S Nikolaus, B Groessner, A Schottelius, T Kühbacher, J Hämling, UR Fölsch, D Seegert |
Gut | 2002 |
|
Mucosal tolerance to a bacterial superantigen indicates a novel pathway to prevent toxic shock
LV Collins, K Eriksson, RG Ulrich, A Tarkowski |
Infection and immunity | 2002 |
|
Genetic and Environmental Context Determines the Course of Colitis Developing in IL???10-Deficient Mice:
M M??hler, EH Leiter |
Inflammatory Bowel Diseases | 2002 |
|
Toll-like receptors as potential therapeutic targets for multiple diseases
C Zuany-Amorim, J Hastewell, C Walker |
Nature Reviews Drug Discovery | 2002 |
|
Lung Biology in Health and Disease: Biotherapeutic Management
F Cuss |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2002 |
|
Microbial factors in inflammatory bowel disease
RJ Farrell, JT LaMont |
Gastroenterology Clinics of North America | 2002 |
|
Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice
HD Winter, D Elewaut, O Turovskaya, M Huflejt, C Shimeld, A Hagenbaugh, S Binder, I Takahashi, M Kronenberg, H Cheroutre |
Gastroenterology | 2002 |
|
Rapid development of colitis in NSAID-treated IL-10–deficient mice
DJ Berg, J Zhang, JV Weinstock, HF Ismail, KA Earle, H Alila, R Pamukcu, S Moore, RG Lynch |
Gastroenterology | 2002 |
|
Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons
K Bielefeldt, N Ozaki‡, GF Gebhart |
Gastroenterology | 2002 |
|
Bacteria-triggered CD4 + T Regulatory Cells Suppress Helicobacter hepaticus –induced Colitis
MC Kullberg, D Jankovic, PL Gorelick, P Caspar, JJ Letterio, AW Cheever, A Sher |
Journal of Experimental Medicine | 2002 |
|
IL-10 gene therapy prevents TNBS-induced colitis
J Lindsay, C Montfrans, F Brennan, S Deventer, P Drillenburg, H Hodgson, A Velde, MS Pena |
Gene Therapy | 2002 |
|
Antisense Oligonucleotides to poly(ADP-ribose) Polymerase-2 Ameliorate Colitis in Interleukin-10-Deficient Mice
I Popoff, H Jijon, B Monia, M Tavernini, M Ma, R McKay, K Madsen |
The Journal of pharmacology and experimental therapeutics | 2002 |
|
Fate of goblet cells in experimental colitis
Mireille K Makkink, Nicole M J Schwerbrock, Michael Mähler, Jos A Boshuizen, Ingrid B Renes, Markus Cornberg, Hans J Hedrich, Alexandra W C Einerhand, Hans A Büller, Siegfried Wagner, Marie-Luise Enss, Jan Dekker |
Digestive Diseases and Sciences | 2002 |
|
Murine monoclonal anti-tNF antibody administration has a beneficial effect on inflammatory bowel disease that develops in IL-10 knockout mice.
Gratz R, Becker S, Sokolowski N, Schumann M, Bass D, Malnick SD |
Digestive Diseases and Sciences | 2002 |
|
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta deficient mice
Anne Bertolotti, XiaoZhong Wang, Isabel Novoa, Rivka Jungreis, Karni Schlessinger, Judy H. Cho, A. Brian West, David Ron |
Journal of Clinical Investigation | 2001 |
|
Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis
K Emmanuilidis, H Weighardt, S Maier, K Gerauer, T Fleischmann, XX Zheng, WW Hancock, B Holzmann, CD Heidecke |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding IL-10
JO Lindsay, CJ Ciesielski, T Scheinin, HJ Hodgson, FM Brennan |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
Current Protocols in Immunology
EH Leiter |
Current Protocols in Immunology | 2001 |
|
Immunological Basis of Inflammatory Bowel Disease: Role of the Microcirculation
FS Laroux, MB Grisham |
Microcirculation | 2001 |
|
Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii
U Wille, EN Villegas, B Striepen, DS Roos, CA Hunter |
Parasite Immunology | 2001 |
|
Establishment of a Tcrb and Trp53 Genes Deficient Mouse Strain as an Animal Model for Spontaneous Colorectal Cancer
H FUNABASHI, K UCHIDA, S KADO, Y MATSUOKA, M OHWAKI |
Experimental Animals | 2001 |
|
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tgε26 mice
C Veltkamp, SL Tonkonogy, YP de Jong, C Albright, WB Grenther, E Balish, C Terhorst, RB Sartor |
Gastroenterology | 2001 |
|
The immunoregulatory cytokine interleukin-10-a therapy for Crohn's disease?
JO Lindsay, HJ Hodgson |
Alimentary Pharmacology & Therapeutics | 2001 |
|
An accessory role of TCRγ δ+ cells in the exacerbation of inflammatory bowel disease in TCRα mutant mice
M Kawaguchi-Miyashita, S Shimada, H Kurosu, N Kato-Nagaoka, Y Matsuoka, M Ohwaki, H Ishikawa, M Nanno |
European Journal of Immunology | 2001 |
|
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
MA Farmer, JP Sundberg, IJ Bristol, GA Churchill, R Li, CO Elson, EH Leiter |
Proceedings of the National Academy of Sciences | 2001 |
|
Inflammatory Bowel Disease
KD Taylor, H Yang, JI Rotter |
Molecular Genetics and Metabolism | 2001 |
|
Microbiological and immunological strategies for treatment of inflammatory bowel disease
L Steidler |
Microbes and Infection | 2001 |
|
Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development
S Sturlan, G Oberhuber, BG Beinhauer, B Tichy, S Kappel, J Wang, MA Rogy |
Carcinogenesis | 2001 |
|
Inflammatory Cytokines and Mucosal Injury
DA Williams |
JNCI Monographs | 2001 |
|
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Y Ogura, DK Bonen, N Inohara, DL Nicolae, FF Chen, R Ramos, H Britton, T Moran, R Karaliuskas, RH Duerr, JP Achkar, SR Brant, TM Bayless, BS Kirschner, SB Hanauer, G Nuñez, JH Cho |
Nature | 2001 |
|
Interleukin-10 and the interleukin-10 receptor
KW Moore, RW Malefyt, RL Coffman, A O'Garra |
Annual Review of Immunology | 2001 |
|
IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice
KG Tournoy, JC Kips, RA Pauwels |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
|
Macrophage-derived IL-18–mediated intestinal inflammation in the murine model of Crohn's disease
T Kanai, M Watanabe, A Okazawa, T Sato, M Yamazaki, S Okamoto, H Ishii, T Totsuka, R Iiyama, R Okamoto, M Ikeda, M Kurimoto, K Takeda, S Akira, T Hibi |
Gastroenterology | 2001 |
|
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
K Madsen, A Cornish, P Soper, C McKaigney, H Jijon, C Yachimec, J Doyle, L Jewell, CD Simone |
Gastroenterology | 2001 |
|
Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells
E Suri-Payer, H Cantor |
Journal of Autoimmunity | 2001 |
|
ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease
K D Taylor, S E Plevy, H Yang, C J Landers, M J Barry, J I Rotter, S R Targan |
Gastroenterology | 2001 |
|
The Crohn's disease-associated bacterial protein I2 is a novel enteric t cell superantigen
H Dalwadi, B Wei, M Kronenberg, C L Sutton, J Braun |
Immunity | 2001 |
|
Brain Endothelial Adhesion Molecule Expression in Experimental Colitis
M Sans, S Kawachi, A Soriano, A Palacín, Z Morise, DN Granger, JM Piqué, MB Grisham, J Panés |
Microcirculation | 2001 |
|
Helicobacter -induced inflammatory bowel disease in IL-10- and T cell-deficient mice
A Burich, R Hershberg, K Waggie, W Zeng, T Brabb, G Westrich, JL Viney, L Maggio-Price |
AJP Gastrointestinal and Liver Physiology | 2001 |
|
Green Tea Polyphenol Extract Attenuates Inflammation in Interleukin-2–Deficient Mice, a Model of Autoimmunity
GW Varilek, F Yang, EY Lee, WJ deVilliers, J Zhong, HS Oz, KF Westberry, CJ McClain |
The Journal of nutrition | 2001 |
|
Chronisch entzündliche Darmerkrankungen
J Stein, A Dignass |
2001 | |
|
IL-10 Is a Central Regulator of Cyclooxygenase-2 Expression and Prostaglandin Production
DJ Berg, J Zhang, DM Lauricella, SA Moore |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis
MM Fort, R Lesley, NJ Davidson, S Menon, F Brombacher, MW Leach, DM Rennick |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
Cutting Edge: Typhlocolitis in NF-κB-Deficient Mice
SE Erdman, JG Fox, CA Dangler, D Feldman, BH Horwitz |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
Helicobacter hepaticus -Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation
WA Petri, MC Kullberg, AG Rothfuchs, D Jankovic, P Caspar, TA Wynn, PL Gorelick, AW Cheever, A Sher |
Infection and immunity | 2001 |
|
The Peyer’s Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli
SA Kellermann, LM McEvoy |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
IL-10-Deficient B10.Q Mice Develop More Severe Collagen-Induced Arthritis, but Are Protected from Arthritis Induced with Anti-Type II Collagen Antibodies
ÅC Johansson, AS Hansson, KS Nandakumar, J Bäcklund, R Holmdahl |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
YR Mahida |
Inflammatory Bowel Diseases | 2000 |
|
Pathways of T cell Pathology in Models of Chronic Intestinal Inflammation
SJ Simpson, YP de Jong, M Comiskey, C Terhorst |
International Reviews of Immunology | 2000 |
|
Conversion of Human Colonic Adenoma Cells to Adenocarcinoma Cells Through Inflammation in Nude Mice
F Okada, T Kawaguchi, H Habelhah, T Kobayashi, H Tazawa, N Takeichi, T Kitagawa, M Hosokawa |
Laboratory Investigation | 2000 |
|
Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice
Oldenburg, van Berge Henegouwen, Rennick, van Asbeck, Koningsberger |
European Journal of Clinical Investigation | 2000 |
|
Heritable susceptibility for colitis in mice induced by IL-10 deficiency
IJ Bristol, MA Farmer, Y Cong, XX Zheng, TB Strom, CO Elson, JP Sundberg, EH Leiter |
Inflammatory Bowel Diseases | 2000 |
|
Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL–10−/− mice
RL Shattuck-Brandt, GW Varilek, A Radhika, F Yang, MK Washington, RN DuBois |
Gastroenterology | 2000 |
|
Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage
M Grilli, I Barbieri, H Basudev, R Brusa, C Casati, G Lozza, E Ongini |
European Journal of Neuroscience | 2000 |
|
B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS IN TCRα-DEFICIENT MICE PERSISTENTLY INFECTED WITHCRYPTOSPORIDIUM PARVUM
WR Waters, MV Palmer, MJ Wannemuehler, RE Sacco, JA Harp |
Journal of Parasitology | 2000 |
|
Pouchitis is associated with mucosal imbalance between interleukin-8 and interleukin-10
P Bulois, WJ Tremaine, V Maunoury, L Gambiez, S Hafraoui, E Leteurtre, A Cortot, WJ Sandborn, JF Colombel, P Desreumaux |
Inflammatory Bowel Diseases | 2000 |
|
Spontaneous Chronic Colitis in TCRα-Mutant Mice; an Experimental Model of Human Ulcerative Colitis
AK Bhan, E Mizoguchi, RN Smith, A Mizoguchi |
International Reviews of Immunology | 2000 |
|
Interleukin 10 gene transfer prevents experimental colitis in rats
G Barbara, Z Xing, CM Hogaboam, J Gauldie, SM Collins |
Gut | 2000 |
|
Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation
HS Cooper, S Murthy, K Kido, H Yoshitake, A Flanigan |
Carcinogenesis | 2000 |
|
Role of cytokines in the pathogenesis of inflammatory bowel disease
KA Papadakis, SR Targan |
Annual Review of Medicine | 2000 |
|
The Key Role of Macrophages in the Immunopathogenesis of Inflammatory Bowel Disease:
YR Mahida |
Inflammatory Bowel Diseases | 2000 |
|
Pouchitis Is Associated with Mucosal Imbalance Between Interleukin-8 and Interleukin-10:
P Bulois, WJ Tremaine, V Maunoury, L Gambiez, S Hafraoui, E Leteurtre, A Cortot, WJ Sandborn, JF Colombel, P Desreumaux |
Inflammatory Bowel Diseases | 2000 |
|
Heritable Susceptibility for Colitis in Mice Induced by IL-10 Deficiency:
IJ Bristol, MA Farmer, Y Cong, XX Zheng, TB Strom, CO Elson, JP Sundberg, EH Leiter |
Inflammatory Bowel Diseases | 2000 |
|
Cytokine Inhibitors: A Cytokine With Multiple Anti- Inflammatory And Some Proinflammatory Activities
T der Poll, S Deventer |
Cytokine Inhibitors | 2000 |
|
Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response
NJ Davidson, MM Fort, W Müller, MW Leach, DM Rennick |
International Reviews of Immunology | 2000 |
|
Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
KL Madsen, JS Doyle, MM Tavernini, LD Jewell, RP Rennie, RN Fedorak |
Gastroenterology | 2000 |
|
NECROTIZING ENTEROCOLITIS AND HEMATOPOIETIC CYTOKINES
DJ Ledbetter, SE Juul |
Clinics in Perinatology | 2000 |
|
Control of Experimental Inflammatory Bowel Disease by Regulatory T cells
C Asseman, S Fowler, F Powrie |
American journal of respiratory and critical care medicine | 2000 |
|
Secretion of biologically active murine interleukin-10 by Lactococcus lactis
L Schotte, L Steidler, J Vandekerckhove, E Remaut |
Enzyme and microbial technology | 2000 |
|
INCREASED SERUM AMYLOID A LEVELS REFLECT COLITIS SEVERITY AND PRECEDE AMYLOID FORMATION IN IL-2 KNOCKOUT MICE
WJ de Villiers, GW Varilek, FC de Beer, JT Guo, MS Kindy |
Cytokine | 2000 |
|
XII. IL-10-deficient (IL-10 −/− ) mice and intestinal inflammation
DM Rennick, MM Fort |
AJP Gastrointestinal and Liver Physiology | 2000 |
|
Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice
S Kawachi, S Jennings, J Panes, A Cockrell, FS Laroux, L Gray, M Perry, H der Heyde, E Balish, DN Granger, RA Specian, MB Grisham |
AJP Gastrointestinal and Liver Physiology | 2000 |
|
Interleukin 10-deficient colitis: new similarities to human inflammatory bowel disease
RJ Kennedy, M Hoper, K Deodhar, PJ Erwin, SJ Kirk, KR Gardiner |
The British journal of surgery | 2000 |
|
Modulation of the Gastrointestinal Tract of Infants by Human Milk. Interfaces and Interactions. An Evolutionary Perspective
AS Goldman |
The Journal of nutrition | 2000 |
|
Does the failure to acquire helminthic parasites predispose to Crohn’s disease?
DA Elliott, JF Urban, CK Argo, JV Weinstock |
The FASEB Journal | 2000 |
|
Crucial Role of Endogenous Interleukin-10 Production in Myocardial Ischemia/Reperfusion Injury
Z Yang, B Zingarelli, C Szabó |
Circulation | 2000 |
|
Drug Development
TS Gaginella, A Guglietta |
2000 | |
|
Immune Response in the Critically Ill
JC Marshall, J Cohen |
2000 | |
|
New Cytokines as Potential Drugs
SK Narula, R Coffman |
2000 | |
|
Staphylococcal Enterotoxin B Stimulates Expansion of Autoreactive T Cells That Induce Apoptosis in Intestinal Epithelial Cells: Regulation of Autoreactive Responses by IL-10
K Ito, H Takaishi, Y Jin, F Song, TL Denning, PB Ernst |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii
Y Suzuki, A Sher, G Yap, D Park, LE Neyer, O Liesenfeld, M Fort, H Kang, E Gufwoli |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
L Steidler, W Hans, L Schotte, S Neirynck, F Obermeier, W Falk, W Fiers, E Remaut |
Science | 2000 |
|
Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1 + Lymphocyte-Associated Th2-Type Immune Response in the Intestine
PG Andres, PL Beck, E Mizoguchi, A Mizoguchi, AK Bhan, T Dawson, WA Kuziel, N Maeda, RP MacDermott, DK Podolsky, HC Reinecker |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
Blockade of Costimulation Prevents Infection-Induced Immunopathology in Interleukin-10-Deficient Mice
TR Kozel, EN Villegas, U Wille, L Craig, PS Linsley, DM Rennick, R Peach, CA Hunter |
Infection and immunity | 2000 |
|
Helicobacter hepaticus Does Not Induce or Potentiate Colitis in Interleukin-10-Deficient Mice
JD Clements, LA Dieleman, A Arends, SL Tonkonogy, MS Goerres, DW Craft, W Grenther, RK Sellon, E Balish, RB Sartor |
Infection and immunity | 2000 |
|
Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis
SR Holdsworth, AR Kitching, PG Tipping |
Kidney International | 1999 |
|
Serologic testing in inflammatory bowel disease: Its value in indeterminate colitis
KA Papadakis, SR Targan |
Current Gastroenterology Reports | 1999 |
|
Genetic Analysis of Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice
M Mähler, IJ Bristol, JP Sundberg, GA Churchill, EH Birkenmeier, CO Elson, EH Leiter |
Genomics | 1999 |
|
Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
K Takeda, BE Clausen, T Kaisho, T Tsujimura, N Terada, I Förster, S Akira |
Immunity | 1999 |
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