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Citations to this article

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
G Missale, … , F Fiaccadori, C Ferrari
G Missale, … , F Fiaccadori, C Ferrari
Published August 1, 1996
Citation Information: J Clin Invest. 1996;98(3):706-714. https://doi.org/10.1172/JCI118842.
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Research Article Article has an altmetric score of 12

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

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Abstract

The anti-viral T cell response is believed to play a central role in the pathogenesis of hepatitis C virus infection. Since chronic evolution occurs in > 50% of HCV infections, the sequential analysis of the T cell response from the early clinical stages of disease may contribute to define the features of the T cell response associated with recovery or chronic viral persistence. For this purpose, 21 subjects with acute hepatitis C virus infection were sequentially followed for an average time of 44 wk. Twelve patients normalized transaminase values that remained normal throughout the follow-up period; all but two cleared hepatitis C virus-RNA from serum. The remaining nine patients showed persistent viremia and elevated transaminases. Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not. By sequential evaluation of the T cell response, a difference between the two groups of patients was already detectable at the very early stages of acute infection and then maintained throughout the follow-up period. The results suggest that the vigor of the T cell response during the early stages of infection may be a critical determinant of disease resolution and control of infection.

Authors

G Missale, R Bertoni, V Lamonaca, A Valli, M Massari, C Mori, M G Rumi, M Houghton, F Fiaccadori, C Ferrari

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1994 1988 1961 Total
Citations: 1 1 3 4 32 10 8 8 9 13 15 21 18 16 25 23 25 40 42 35 32 41 36 37 41 28 19 9 2 1 1 596
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Citations to this article in year 2004 (32)

Title and authors Publication Year
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
David G. Bowen, Monica Zen, Lauren Holz, Thomas Davis, Geoffrey W. McCaughan & Patrick J. Bertolino
Journal of Clinical Investigation 2004
Effects of antiviral therapy on the cellular immune response in acute hepatitis C
F Rahman, T Heller, Y Sobao, E Mizukoshi, M Nascimbeni, H Alter, S Herrine, J Hoofnagle, TJ Liang, B Rehermann
Hepatology 2004
Direct Binding of Hepatitis C Virus Core to gC1qR on CD4 + and CD8 + T Cells Leads to Impaired Activation of Lck and Akt
ZQ Yao, A Eisen-Vandervelde, SN Waggoner, EM Cale, YS Hahn
Journal of virology 2004
Progress on new vaccine strategies against chronic viral infections
JA Berzofsky, JD Ahlers, J Janik, J Morris, SK Oh, M Terabe, IM Belyakov
Journal of Clinical Investigation 2004
Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigen
P Martin, P Parroche, L Chatel, C Barretto, A Beck, C Tr�po, C Bain, YC Lone, G Inchausp�, A Fournillier
Journal of Medical Virology 2004
CELL-MEDIATED IMMUNITY AND THE OUTCOME OF HEPATITIS C VIRUS INFECTION
NH Shoukry, AG Cawthon, CM Walker
Annual Review of Microbiology 2004
Long-term immune response after liver transplantation in patients with spontaneous or post-treatment HCV-RNA clearance
T Casanovas-Taltavull, MG Ercilla, CP Gonzalez, E Gil, O Vi�as, C Ca�as, A Casanova, J Figueras, T Serrano, LA Casais
Liver Transplantation 2004
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
E Spada, A Mele, A Berton, L Ruggeri, L Ferrigno, AR Garbuglia, MP Perrone, G Girelli, PD Porto, E Piccolella, MU Mondelli, P Amoroso, R Cortese, A Nicosia, A Vitelli, A Folgori
Gut 2004
Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response
C Rollier, E Depla, JA Drexhage, EJ Verschoor, BE Verstrepen, A Fatmi, C Brinster, A Fournillier, JA Whelan, M Whelan, D Jacobs, G Maertens, G Inchauspé, JL Heeney
Journal of virology 2004
Memory T-cell-mediated immune responses specific to an alternative core protein in hepatitis C virus infection
C Bain, P Parroche, JP Lavergne, B Duverger, C Vieux, V Dubois, F Komurian-Pradel, C Trépo, L Gebuhrer, G Paranhos-Baccala, F Penin, G Inchauspé
Journal of virology 2004
Cellular immune responses against HCV: T cells take a diversion in the liver
P Klenerman, N Semmo, S Ward
Hepatology 2004
Effects of interferon and ribavirin combination therapy on CD4+ proliferation, lymphocyte activation, and Th1 and Th2 cytokine profiles in chronic hepatitis C
RT Marinho, R Pinto, ML Santos, IV Lobos, MC Moura
Journal of Viral Hepatitis 2004
Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies?
G Missale, E Cariani, C Ferrari
Digestive and Liver Disease 2004
Identification of a new autoantibody in patients with chronic hepatitis
Y Fukuda, H Yotsuyanagi, S Ooka, T Sekine, J Koike, T Takano, M Suzuki, F Itoh, K Nishioka, T Kato
Human Immunology 2004
Analysis of hepatitis C virus quasispecies transmission and evolution in patients infected through blood transfusion
T Laskus, J Wilkinson, JF Gallegos-Orozco, M Radkowski, DM Adair, M Nowicki, E Operskalski, Z Buskell, LB Seeff, H Vargas, J Rakela
Gastroenterology 2004
Humoral immunity to immunodominant epitopes of Hepatitis C virus in individuals infected with genotypes 1a or 1b
MP Carlos, Y Yamamura, Q Vu, K Conzen, DE Anderson, JV Torres
Clinical Immunology 2004
Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population
BA Piasecki, JD Lewis, KR Reddy, SL Bellamy, SB Porter, RM Weinrieb, DD Stieritz, KM Chang
Hepatology 2004
Viral hepatitis: virus/host interaction
D Vergani, G Mieli-Vergani
Journal of Gastroenterology and Hepatology 2004
Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes
GC Harcourt, M Lucas, I Sheridan, E Barnes, R Phillips, P Klenerman
Journal of Viral Hepatitis 2004
DNA immunization encoding the secreted nonstructural protein 3 (NS3) of hepatitis C virus and enhancing the Th1 type immune response*
X Jiao, RY Wang, Z Feng, G Hu, HJ Alter, JW Shih
Journal of Viral Hepatitis 2004
Cationic microparticles are a potent delivery system for a HCV DNA vaccine
DT O’Hagan, M Singh, C Dong, M Ugozzoli, K Berger, E Glazer, M Selby, M Wininger, P Ng, K Crawford, X Paliard, S Coates, M Houghton
Vaccine 2004
Immune responses in hepatitis C: is virus or host the problem?:
JM Darling, TL Wright
Current Opinion in Infectious Diseases 2004
Analysis of T cell responses against hepatitis C virus genotype 4 in Egypt
M Elrefaei, N El-sheikh, K Kamal, H Cao
Journal of Hepatology 2004
Mechanisms of HCV reinfection and allograft damage after liver transplantation
GW McCaughan, A Zekry
Journal of Hepatology 2004
The use of class-I HLA tetramers for the detection of hepatitis C virus NS3-specific CD8(+) T cells in patients with chronic infection
FX López-Labrador, XS He, M Berenguer, RC Cheung, TL Wright, HB Greenberg
Journal of Immunological Methods 2004
Efficacy and safety of induction therapy with rabbit antithymocyte globulins in liver transplantation for hepatitis C
N Kamar, D Ribes, K Sandres-Saune, B Suc, K Barange, O Cointault, L Lavayssiere, D Durand, J Izopet, L Rostaing
Transplantation Proceedings 2004
Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides
Ming-Qing Xu, Yu-Ping Suo, Jian-Ping Gong, Ming-Man Zhang, Lu-Nan Yan
World journal of gastroenterology : WJG 2004
Prolongation of liver allograft survival by dendritic cells modified with NF-κB decoy oligodeoxynucleotides
MQ Xu
World journal of gastroenterology : WJG 2004
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals
F Thorén, A Romero, M Lindh, C Dahlgren, K Hellstrand
Journal of leukocyte biology 2004
Hepatitis Prevention and Treatment
JM Colacino, BA Heinz
2004
Cellular Immune Responses in Seronegative Sexual Contacts of Acute Hepatitis C Patients
SM Kamal, A Amin, M Madwar, CS Graham, Q He, AA Tawil, J Rasenack, T Nakano, B Robertson, A Ismail, MJ Koziel
Journal of virology 2004
Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation
IS Ludwig, AN Lekkerkerker, E Depla, F Bosman, RJ Musters, S Depraetere, Y van Kooyk, TB Geijtenbeek
Journal of virology 2004

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