The anti-viral T cell response is believed to play a central role in the pathogenesis of hepatitis C virus infection. Since chronic evolution occurs in > 50% of HCV infections, the sequential analysis of the T cell response from the early clinical stages of disease may contribute to define the features of the T cell response associated with recovery or chronic viral persistence. For this purpose, 21 subjects with acute hepatitis C virus infection were sequentially followed for an average time of 44 wk. Twelve patients normalized transaminase values that remained normal throughout the follow-up period; all but two cleared hepatitis C virus-RNA from serum. The remaining nine patients showed persistent viremia and elevated transaminases. Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not. By sequential evaluation of the T cell response, a difference between the two groups of patients was already detectable at the very early stages of acute infection and then maintained throughout the follow-up period. The results suggest that the vigor of the T cell response during the early stages of infection may be a critical determinant of disease resolution and control of infection.
G Missale, R Bertoni, V Lamonaca, A Valli, M Massari, C Mori, M G Rumi, M Houghton, F Fiaccadori, C Ferrari
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Tumor Microenvironments in Organs: From the Brain to the Skin – Part B
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Tumor Microenvironments in Organs: From the Brain to the Skin – Part B
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Tumor Microenvironments in Organs: From the Brain to the Skin – Part B
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Tumor Microenvironments in Organs: From the Brain to the Skin – Part B
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E Smolle, E Zöhrer, K Bettermann, J Haybaeck |
Hepatitis Monthly | 2012 |
Hepatic stellate cells promote immunotolerance following orthotopic liver transplantation in rats via induction of T cell apoptosis and regulation of Th2/Th3-like cell cytokine production
Z Jiang, Y Chen, X Feng, J Jiang, T Chen, H Xie, L Zhou, S Zheng |
Experimental and therapeutic medicine | 2012 |
Transcriptomic assay of CD8+ T cells in treatment-naïve HIV, HCV-mono-infected and HIV/HCV-co-infected Chinese
J Zhao, L Yi, J Lu, ZR Yang, Y Chen, C Zheng, D Huang, YF Li, L Chen, J Cheng, HF Kung, ML He |
PloS one | 2012 |
Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis
P Farci, K Wollenberg, G Diaz, RE Engle, ME Lai, P Klenerman, RH Purcell, OG Pybus, HJ Alter |
Proceedings of the National Academy of Sciences | 2012 |
A Super TLR Agonist to Improve Efficacy of Dendritic Cell Vaccine in Induction of Anti-HCV Immunity
B Hong, SH Lee, XT Song, L Jones, K Machida, XF Huang, SY Chen, GJ Renukaradhya |
PloS one | 2012 |
Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization
KA Kuhs, R Toporovski, AA Ginsberg, DJ Shedlock, DB Weiner, SJ Polyak |
PloS one | 2012 |
Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses
KA Kuhs, AA Ginsberg, J Yan, RW Wiseman, AS Khan, NY Sardesai, DH O'Connor, DB Weiner |
Molecular Therapy | 2011 |
Effect of Immune Pressure on Hepatitis C Virus Evolution: Insights From a Single-Source Outbreak
S Merani, D Petrovic, I James, A Chopra, D Cooper, E Freitas, A Rauch, J Iulio, M John, M Lucas, K Fitzmaurice, S McKiernan, S Norris, D Kelleher, P Klenerman, S Gaudieri |
Hepatology | 2011 |
Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity
K Pfafferott, S Gaudieri, A Ulsenheimer, I James, M Heeg, D Nolan, M John, A Rauch, S Mallal, A Lucas, P Klenerman, HM Diepolder, M Lucas, JP Vartanian |
PloS one | 2011 |
Different aspects of CD4 T cells that lead to viral clearance or persistence of HCV infection
K Sugimoto, K Shiraki |
Hepatology International | 2011 |
NK Cells, Innate Immunity and Hepatitis C Infection after Liver Transplantation
A Nellore, JA Fishman |
Clinical Infectious Diseases | 2011 |
Genetic Diversity of Near Genome-Wide Hepatitis C Virus Sequences during Chronic Infection: Evidence for Protein Structural Conservation Over Time
H Li, AL Hughes, N Bano, S McArdle, S Livingston, H Deubner, BJ McMahon, L Townshend-Bulson, R McMahan, HR Rosen, DR Gretch, NH Shoukry |
PloS one | 2011 |
Progress in the development of preventive and therapeutic vaccines for hepatitis C virus
J Torresi, D Johnson, H Wedemeyer |
Journal of Hepatology | 2011 |
Host genetics in immune-mediated hepatitis C virus clearance
J Schmidt, R Thimme, C Neumann-Haefelin |
Biomarkers in Medicine | 2011 |
Spontaneous clearance of hepatitis C virus in vertically infected children
S Farmand, S Wirth, H Löffler, T Woltering, S Kenzel, E Lainka, P Henneke |
European Journal of Pediatrics | 2011 |
Impact of HCV genetic differences on pathobiology of disease
M Ripoli, V Pazienza |
Expert Review of Anti-infective Therapy | 2011 |
CD154, a marker of antigen-specific stimulation of CD4 T cells, is associated with response to treatment in patients with chronic HCV infection
JF Möller, B Möller, B Wiedenmann, T Berg, E Schott |
Journal of Viral Hepatitis | 2011 |
A novel assay for detection of hepatitis C virus-specific effector CD4+ T cells via co-expression of CD25 and CD134
E Keoshkerian, K Helbig, M Beard, J Zaunders, N Seddiki, A Kelleher, T Hampartzoumian, A Zekry, AR Lloyd |
Journal of Immunological Methods | 2011 |
Reduced Naive CD4 T Cell Numbers and Impaired Induction of CD27 in Response to T Cell Receptor Stimulation Reflect a State of Immune Activation in Chronic Hepatitis C Virus Infection
NL Yonkers, S Sieg, B Rodriguez, DD Anthony |
The Journal of Infectious Diseases | 2011 |
Strong Hepatitis C Virus (HCV)–specific Cell-mediated Immune Responses in the Absence of Viremia or Antibodies Among Uninfected Siblings of HCV Chronically Infected Children
M Hashem, H El-Karaksy, MT Shata, M Sobhy, H Helmy, S El-Naghi, G Galal, ZZ Ali, G Esmat, SF Abdelwahab, GT Strickland, SS El-Kamary |
The Journal of Infectious Diseases | 2011 |
Hepatitis C virus - T-cell responses and viral escape mutations
D Petrovic, E Dempsey, DG Doherty, D Kelleher, A Long |
European Journal of Immunology | 2011 |
Stromal cell-based immunotherapy in transplantation
R Charles, L Lu, S Qian, JJ Fung |
Immunotherapy | 2011 |
Adaptive immunity to the hepatitis C virus
Christopher M Walker |
Advances in virus research | 2010 |
Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection
VM Fleming, G Harcourt, E Barnes, P Klenerman |
Journal of General Virology | 2010 |
Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity
Y Zhang, Y Liu, KM Moxley, L Golden-Mason, MG Hughes, T Liu, MH Heemskerk, HR Rosen, MI Nishimura |
PLoS pathogens | 2010 |
HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta
CH Hall, R Kassel, RS Tacke, YS Hahn |
PloS one | 2010 |
The role of CCR5 in HCV infection
M Coenen, J Nattermann |
European Journal of Medical Research | 2010 |
Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users
JK Flynn, GJ Dore, M Hellard, B Yeung, WD Rawlinson, PA White, JM Kaldor, AR Lloyd, RA Ffrench |
Journal of Viral Hepatitis | 2010 |
HCV-core and NS3 antigens play disparate role in inducing regulatory or effector T cells in vivo: Implications for viral persistence or clearance
DK Krishnadas, W Li, R Kumar, DL Tyrrell, B Agrawal |
Vaccine | 2010 |
Virus–host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies
P Georgel, C Schuster, MB Zeisel, F Stoll-Keller, T Berg, S Bahram, TF Baumert |
Trends in Molecular Medicine | 2010 |
Experimental models to study the immunobiology of hepatitis C virus
J Jo, V Lohmann, R Bartenschlager, R Thimme |
Journal of General Virology | 2010 |
Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection
DY Gao, GD Jin, BL Yao, DH Zhang, LL Gu, ZM Lu, Q Gong, YC Lone, Q Deng, XX Zhang |
PloS one | 2010 |
T-cell responses at baseline and during therapy with peginterferon-α and ribavirin are not associated with outcome in chronic hepatitis C infected patients
JE Arends, MA Claassen, CH van Berg, NM Nanlohy, KJ van Erpecum, BC Baak, AI Hoepelman, A Boonstra, D Baarle |
Antiviral Research | 2010 |
Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine
C Firbas, T Boehm, V Buerger, E Schuller, N Sabarth, B Jilma, CS Klade |
Vaccine | 2010 |
Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection
T Shen, X Chen, Q Xu, F Lu, S Liu |
Archives of Virology | 2010 |
HCV-related hepatocellular carcinoma: From chronic inflammation to cancer
G Castello, S Scala, G Palmieri, SA Curley, F Izzo |
Clinical Immunology | 2010 |
The potential use of Toll-like receptor agonists to restore the dysfunctional immunity induced by hepatitis C virus
ML Salem, M EL-Demellawy, AR El-Azm |
Cellular Immunology | 2010 |
PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection
T Watanabe, A Bertoletti, TA Tanoto |
Journal of Viral Hepatitis | 2010 |
Direct, help-independent priming of CD8+ T cells by AAV-transduced hepatocytes
SA Wuensch, J Spahn, IN Crispe |
Hepatology | 2010 |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
VG Fowler, WM Scheld, AS Bayer |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases | 2010 |
Methods in Microbiology
V Tchikov, J Fritsch, D Kabelitz, S Schütze |
Methods in Microbiology | 2010 |
Hepatitis C virus infection: A “liaison a trois” amongst the virus, the host, and chronic low-level inflammation for human survival
V Barnaba |
Journal of Hepatology | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity
Y Zhang, Y Liu, KM Moxley, L Golden-Mason, MG Hughes, T Liu, MH Heemskerk, HR Rosen, MI Nishimura, M Gale |
PLoS pathogens | 2010 |
Characterization of the Specific CD4+ T Cell Response against the F Protein during Chronic Hepatitis C Virus Infection
DY Gao, GD Jin, BL Yao, DH Zhang, LL Gu, ZM Lu, Q Gong, YC Lone, Q Deng, XX Zhang, MA Ostrowski |
PloS one | 2010 |
HCV+ Hepatocytes Induce Human Regulatory CD4+ T Cells through the Production of TGF-β
CH Hall, R Kassel, RS Tacke, YS Hahn, D Unutmaz |
PloS one | 2010 |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients
CN de Morais, BM Carvalho, WG de Melo, FL de Melo, EP de Lopes, AL Domingues, N Jucá, JR Martins, GT Diniz, SM Montenegro |
Memórias do Instituto Oswaldo Cruz | 2010 |
Hepatitis C virus versus innate and adaptive immune responses: a tale of co-evolution and coexistence
Barbara Rehermann |
Journal of Clinical Investigation | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
MJ Fuller, NH Shoukry, T Gushima, DG Bowen, B Callendret, KJ Campbell, DL Hasselschwert, AL Hughes, CM Walker |
Hepatology | 2009 |
A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection
HR Yang, CC Hsieh, L Wang, JJ Fung, L Lu, S Qian |
Microsurgery | 2009 |
Mechanistic insights into immunomodulation by hepatic stellate cells in mice: A critical role of interferon-γ signaling
HR Yang, HS Chou, X Gu, L Wang, KE Brown, JJ Fung, L Lu, S Qian |
Hepatology | 2009 |
Level, phenotype and activation status of CD4+FoxP3+ regulatory T cells in patients chronically infected with human immunodeficiency virus and/or hepatitis C virus
NI Rallón, M López, V Soriano, J García-Samaniego, M Romero, P Labarga, P García-Gasco, J González-Lahoz, JM Benito |
Clinical & Experimental Immunology | 2009 |
Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response
L Tang, J Yang, W Liu, X Tang, J Chen, D Zhao, M Wang, F Xu, Y Lu, B Liu, Q Sun, L Zhang, F He |
Gastroenterology | 2009 |
Comprehensive longitudinal analysis of hepatitis C virus (HCV)-specific T cell responses during acute HCV infection in the presence of existing HIV-1 infection
CH van Berg, TA Ruys, NM Nanlohy, SE Geerlings, JT van der Meer, JW Mulder, JA Lange, D Baarle |
Journal of Viral Hepatitis | 2009 |
New insights into the immunopathogenesis of chronic hepatitis C
HM Diepolder |
Antiviral Research | 2009 |
Measurements of HCV neutralizing antibodies and of HCV-specific CD4+ and CD8+ cells using hepatitis C virus pseudo-particles (HCVpp)
A Berger, T Giroglou, A Leutz, H Ogbomo, K Pfaff, G Teuber, J Cinatl, D Laer, HW Doerr |
Journal of Clinical Virology | 2009 |
In vitro activation and differentiation of naïve CD4+ and CD8+ T cells into HCV Core- and NS3-specific armed effector cells: A new role for CD4+ T cells
DK Krishnadas, W Li, R Kumar, LJ Tyrrell, B Agrawal |
Cellular Immunology | 2009 |
Host genetic determinants of spontaneous hepatitis C clearance
A Rauch, S Gaudieri, C Thio, PY Bochud |
Pharmacogenomics | 2009 |
Immunogenicity of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a Phase I clinical trial
L Alvarez-Lajonchere, NH Shoukry, B Grá, Y Amador-Cañizares, F Helle, N Bédard, I Guerra, C Drouin, J Dubuisson, EE González-Horta, G Martínez, J Marante, Z Cinza, M Castellanos, S Dueñas-Carrera |
Journal of Viral Hepatitis | 2009 |
Serum BLyS/BAFF predicts the outcome of acute hepatitis C virus infection
G Tarantino, VD Marco, S Petta, PL Almasio, F Barbaria, A Licata, GL Bosco, C Tripodo, RD Stefano, A Craxì |
Journal of Viral Hepatitis | 2009 |
Recombinant retrovirus-like particle forming DNA vaccines in prime-boost immunization and their use for hepatitis C virus vaccine development
D Desjardins, C Huret, C Dalba, F Kreppel, S Kochanek, FL Cosset, F Tangy, D Klatzmann, B Bellier |
The Journal of Gene Medicine | 2009 |
HCV reinfection studies and the door to vaccine development
J Grebely, DL Thomas, GJ Dore |
Journal of Hepatology | 2009 |
CpG ODN TRIGGERS LIVER INFLMMATORY REACTION AND ABROGATES SPONTANEOUS TOLERANCE*
LL Ma, X Gao, L Liu, Z Xiang, TS Blackwell, P Williams, RS Chari, DP Yin |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2009 |
PD1/B7-H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft
M Morita, M Fujino, G Jiang, Y Kitazawa, L Xie, M Azuma, H Yagita, S Nagao, A Sugioka, Y Kurosawa, S Takahara, J Fung, S Qian, L Lu, XK Li |
American Journal of Transplantation | 2009 |
High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice
G Marodon, D Desjardins, L Mercey, C Baillou, P Parent, M Manuel, C Caux, B Bellier, N Pasqual, D Klatzmann |
European Journal of Immunology | 2009 |
Effects of the CCR5-Δ32 Mutation on Hepatitis C Virus-Specific Immune Responses in Patients with Haemophilia
G Ahlenstiel, RP Woitas, A Iwan, J Nattermann, G Feldmann, JK Rockstroh, J Oldenburg, B Kupfer, T Sauerbruch, U Spengler |
Immunological Investigations | 2009 |
Effects of the CCR5-Δ32 Mutation on Hepatitis C Virus-Specific Immune Responses in Patients with Haemophilia
G Ahlenstiel, RP Woitas, A Iwan, J Nattermann, G Feldmann, JK Rockstroh, J Oldenburg, B Kupfer, T Sauerbruch, U Spengler |
Immunological Investigations | 2009 |
The hepatitis C virus enigma
H Myrmel, E Ulvestad, B Åsjø |
APMIS | 2009 |
Liver under Constant Attack — From Fat to Viruses
CP Day, AW Lohse, PR Galle, SS Thorgeirsson |
2009 | |
Impaired Hepatitis C Virus (HCV)-Specific Effector CD8 + T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection
H Radziewicz, CC Ibegbu, H Hon, MK Osborn, K Obideen, M Wehbi, GJ Freeman, JL Lennox, KA Workowski, HL Hanson, A Grakoui |
Journal of virology | 2008 |
Immune responses during acute and chronic infection with hepatitis C virus
S Ishii, MJ Koziel |
Clinical Immunology | 2008 |
Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells
D Tokita, TL Sumpter, G Raimondi, AF Zahorchak, Z Wang, A Nakao, GV Mazariegos, M Abe, AW Thomson |
Journal of Hepatology | 2008 |
Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis
DE Kaplan, F Ikeda, Y Li, N Nakamoto, S Ganesan, ME Valiga, FA Nunes, KR Reddy, KM Chang |
Journal of Hepatology | 2008 |
Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine
KA Lang, J Yan, R Draghia-Akli, A Khan, DB Weiner |
Vaccine | 2008 |
Monocyte-derived dendritic cells from HCV-infected patients transduced with an adenovirus expressing NS3 are functional when stimulated with the TLR3 ligand poly(I:C)
I Echeverra, A Zabaleta, L Silva, N Daz-Valds, JI Riezu-Boj, JJ Lasarte, F Borrs-Cuesta, MP Civeira, J Prieto, P Sarobe |
Journal of Viral Hepatitis | 2008 |
Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors
SB Missiha, M Ostrowski, EJ Heathcote |
Gastroenterology | 2008 |
Immunotherapy for HCV infection: next steps
K Lang, DB Weiner |
Expert Review of Vaccines | 2008 |
Enhanced IL-10 production in response to hepatitis C virus proteins by peripheral blood mononuclear cells from human immunodeficiency virus-monoinfected individuals
L Barrett, M Gallant, C Howley, MI Bowmer, G Hirsch, K Peltekian, M Grant |
BMC Immunology | 2008 |
Characterization of virus-specific T-cell immunity in liver allograft recipients with HCV-induced cirrhosis
A Bharat, F Barros, K Narayanan, B Borg, M Lisker-Melman, S Shenoy, J Lowell, J Crippin, W Chapman, T Mohanakumar |
American Journal of Transplantation | 2008 |
Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans
RA Harris, K Sugimoto, DE Kaplan, F Ikeda, M Kamoun, KM Chang |
Hepatology | 2008 |
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
Q You, L Cheng, RM Kedl, C Ju |
Hepatology | 2008 |
Increased soluble IL-2 receptor levels during interferon and ribavirin treatment are associated with a good response in genotype 2a/2b patients with chronic hepatitis C
S Abe, R Narita, T Matsuhashi, T Oto, A Tabaru, M Otsuki |
European Journal of Gastroenterology & Hepatology | 2008 |
Host neutralizing responses and pathogenesis of hepatitis C virus infection
MB Zeisel, FL Cosset, TF Baumert |
Hepatology | 2008 |
Immunology of hepatitis B and hepatitis C virus infections
A Boonstra, AM Woltman, HL Janssen |
Best Practice & Research Clinical Gastroenterology | 2008 |
Viral hepatitis in African Americans
AE Reid |
Current Hepatitis Reports | 2008 |
Hepatitis C Virus (HCV)–Specific T Cell Responses in Injection Drug Users with Apparent Resistance to HCV Infection
PH Thurairajah, D Hegazy, S Chokshi, S Shaw, A Demaine, ER Kaminski, NV Naoumov, ME Cramp |
The Journal of Infectious Diseases | 2008 |
PTPN22 C1858T Polymorphism and the Outcome of Hepatitis C Virus Infection
MA Montes-Cano, JR García-Lozano, J Aguilar-Reina, M Romero-Gómez, N Barroso, A Nuñez-Roldán, J Martín, MF González-Escribano |
Viral Immunology | 2008 |
Hepatitis C Virus Entry and Neutralization
Z Stamataki, J Grove, P Balfe, JA McKeating |
Clinics in Liver Disease | 2008 |
Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China
RJ Garten, SH Lai, JB Zhang, W Liu, J Chen, XF Yu |
World journal of gastroenterology : WJG | 2008 |
Pathogenesis and Clinical Practice in Gastroenterology
I Ferkolj, A Gangl, PR Galle, B Vucelic |
2008 | |
Hepatitis C Virus Disease
E Jirillo |
2008 | |
Liver Cirrhosis: From Pathophysiology to Disease Management
J Bosch, F Lammert, AK Burroughs, D Lebrec, T Sauerbruch |
2008 | |
Hepatitis C Virus-Specific T-Cell Gamma Interferon and Proliferative Responses Are More Common in Perihepatic Lymph Nodes than in Peripheral Blood or Liver
D Moonka, KA Milkovich, B Rodriguez, M Abouljoud, MM Lederman, DD Anthony |
Journal of virology | 2008 |
Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance
D Yerly, D Heckerman, TM Allen, JV Chisholm, K Faircloth, CH Linde, N Frahm, J Timm, WJ Pichler, A Cerny, C Brander |
Journal of virology | 2008 |
Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses
N Alatrakchi, CS Graham, HJ van der Vliet, KE Sherman, MA Exley, MJ Koziel |
Journal of virology | 2007 |
Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics
O Wald, ID Weiss, E Galun, A Peled |
Cytokine | 2007 |
Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses
V Pillai, WM Lee, DL Thiele, NJ Karandikar |
Journal of Viral Hepatitis | 2007 |
Differential dysfunction in dendritic cell subsets during chronic HCV infection
L Averill, WM Lee, NJ Karandikar |
Clinical Immunology | 2007 |
Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection
M Lucas, A Ulsenheimer, K Pfafferot, MH Heeg, S Gaudieri, N Grüner, A Rauch, JT Gerlach, MC Jung, R Zachoval, GR Pape, W Schraut, T Santantonio, H Nitschko, M Obermeier, R Phillips, TJ Scriba, N Semmo, C Day, JN Weber, S Fidler, R Thimme, A Haberstroh, TF Baumert, P Klenerman, HM Diepolder, S Bowyer |
PloS one | 2007 |
Inflammation and Repair in Viral Hepatitis C
MG Neuman, K Sha, R Esguerra, S Zakhari, RE Winkler, N Hilzenrat, J Wyse, CL Cooper, D Seth, MD Gorrell, PS Haber, GW McCaughan, MA Leo, CS Lieber, M Voiculescu, E Buzatu, C Ionescu, J Dudas, B Saile, G Ramadori |
Digestive Diseases and Sciences | 2007 |
Acute hepatitis C virus infection: A chronic problem
JT Blackard, MT Shata, NJ Shire, KE Sherman |
Hepatology | 2007 |
HCV-HIV coinfection: simple messages from a complex disease
P Klenerman, A Kim |
PLoS Medicine | 2007 |
CD4+ T cell responses in hepatitis C virus infection
Semmo N, Klenerman P |
World journal of gastroenterology : WJG | 2007 |
Vaccination Against Hepatitis C Virus With Dendritic Cells Transduced With an Adenovirus Encoding NS3 Protein
A Zabaleta, D Llopiz, L Arribillaga, L Silva, JI Riezu-Boj, JJ Lasarte, F Borrás-Cuesta, J Prieto, P Sarobe |
Molecular Therapy | 2007 |
Therapeutic vaccines: challenges of chronic viral infections
M Sällberg, M Weiland, L Frelin |
Drug Discovery Today: Therapeutic Strategies | 2007 |
FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts
A Miyagawa-Hayashino, T Tsuruyama, H Egawa, H Haga, H Sakashita, T Okuno, S Toyokuni, K Tamaki, H Yamabe, T Manabe, S Uemoto |
The American Journal of Pathology | 2007 |
Elevated Soluble CD30 Characterizes Patients With Hepatitis C Virus-Induced Liver Allograft Cirrhosis
A Bharat, K Narayanan, A Golocheikine, N Steward, J Crippin, M Lisker-Melman, S Shenoy, J Lowell, WC Chapman, T Mohanakumar |
Transplantation | 2007 |
Clinical course and outcome of a nosocomial outbreak of hepatitis C in a urology ward
LM Pekova, P Teocharov, A Sakarev |
Journal of Hospital Infection | 2007 |
Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients
V Schlaphoff, CS Klade, B Jilma, SB Jelovcan, M Cornberg, E Tauber, MP Manns, H Wedemeyer |
Vaccine | 2007 |
Hepatitis C in African Americans
N Pyrsopoulos, L Jeffers |
Journal of Clinical Gastroenterology | 2007 |
Hepatitis C virus infection in dialysis patients
W SUŁOWICZ, A RADZISZEWSKI, E CHOWANIEC |
Hemodialysis International | 2007 |
A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virus
J Torresi, OM Stock, AE Fischer, L Grollo, H Drummer, I Boo, W Zeng, L Earnest-Silveira, DC Jackson |
Hepatology | 2007 |
T and B Cells in Hepatitis C Virus Control: What They Do and When They Fail
C Ferrari |
Gastroenterology | 2007 |
Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies
Z Stamataki, S Coates, MJ Evans, M Wininger, K Crawford, C Dong, Y Fong, D Chien, S Abrignani, P Balfe, CM Rice, JA McKeating, M Houghton |
Vaccine | 2007 |
Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection
C Neumann-Haefelin, R Thimme |
Genes and Immunity | 2007 |
The role of chemokines as inflammatory mediators in chronic hepatitis C virus infection
M Zeremski, LM Petrovic, AH Talal |
Journal of Viral Hepatitis | 2007 |
Differential capacity of T cell priming in naive donors of promiscuous CD4+ T cell epitopes of HCV NS3 and Core proteins
FA Castelli, M Leleu, S Pouvelle-Moratille, S Farci, HM Zarour, M Andrieu, C Auriault, A Ménez, B Georges, B Maillere |
European Journal of Immunology | 2007 |
Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function
M Shiina, B Rehermann |
Hepatology | 2007 |
Changing Treatment Paradigms: Hepatitis C Virus in HIV-Infected Patients
JS Kadam, AH Talal |
AIDS Patient Care and STDs | 2007 |
Neutralizing antibodies in patients with chronic hepatitis C infection treated with (Peg)-interferon/ribavirin
I Boo, AE Fischer, D Johnson, R Chin, M Giourouki, M Bharadwaj, S Bowden, J Torresi, H Drummer |
Journal of Clinical Virology | 2007 |
The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy
JW Mosley, EA Operskalski, LH Tobler, ZJ Buskell, WW Andrews, B Phelps, J Dockter, C Giachetti, LB Seeff, MP Busch |
Journal of Viral Hepatitis | 2007 |
Clearance and Persistence of Hepatitis C Virus in a Tunisian Population: Association with HLA Class I and Class II
L Ksiaa, S Ayed-Jendoubi, I Sfar, Y Gorgi, HA Najjar, TB Abdallah, K Ayed |
Viral Immunology | 2007 |
Mission poorly accomplished: The protective role of natural killer cells in recurrent hepatitis C after liver transplantation
NN Zein |
Liver Transplantation | 2007 |
Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection
E Schott, H Witt, H Hinrichsen, K Neumann, V Weich, A Bergk, J Halangk, T Müller, S Tinjala, G Puhl, P Neuhaus, B Wiedenmann, T Berg |
Journal of Hepatology | 2007 |
Kupffer cell heterogeneity: functional properties of bone marrow–derived and sessile hepatic macrophages
I Klein, JC Cornejo, NK Polakos, B John, SA Wuensch, DJ Topham, RH Pierce, IN Crispe |
Blood | 2007 |
Perspectives in Medical Virology
KD Mena |
Perspectives in Medical Virology | 2007 |
Priming and stimulation of hepatitis C virus-specific CD4+ and CD8+ T cells against HCV antigens NS4, NS5a or NS5b from HCV-naive individuals: implications for prophylactic vaccine
W Li, DK Krishnadas, R Kumar, DL Tyrrell, B Agrawal |
International Immunology | 2007 |
CD4+ T cell responses in hepatitis C virus infection
Nasser Semmo, Paul Klenerman |
World journal of gastroenterology : WJG | 2007 |
Liver Immunology
ME Gershwin, JM Vierling, MP Manns |
2007 | |
Role of the HLA Class II: HCV-Related Disorders
VD Re, L Caggiari, MP Simula, SD VITA, C Mazzaro, M Lenzi, GM Massimo, G Monti, C Ferri, AL Zignego, A Gabrielli, D Sansonno, F Dammacco, M Libra, N Sacchi, R Talamini, M Spina, U Tirelli, R Cannizzaro, R Dolcetti |
Annals of the New York Academy of Sciences | 2007 |
Genetics in Liver Diseases
HE Blum, D Häussinger, DW Cox, PL Jansen, GA Kullak-Ublick |
2007 | |
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
E Larrea, JI Riezu-Boj, L Gil-Guerrero, N Casares, R Aldabe, P Sarobe, MP Civeira, JL Heeney, C Rollier, B Verstrepen, T Wakita, F Borrás-Cuesta, JJ Lasarte, J Prieto |
Journal of virology | 2007 |
In Vivo Electroporation Enhances the Immunogenicity of Hepatitis C Virus Nonstructural 3/4A DNA by Increased Local DNA Uptake, Protein Expression, Inflammation, and Infiltration of CD3 + T Cells
G Ahlén, J Söderholm, T Tjelle, R Kjeken, L Frelin, U Höglund, P Blomberg, M Fons, I Mathiesen, M Sällberg |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Vaccines to prevent chronic hepatitis C virus infection: current experimental and preclinical developments
P Wintermeyer, JR Wands |
Journal of Gastroenterology | 2007 |
Vaccination With Protein-Transduced Dendritic Cells Elicits a Sustained Response to Hepatitis C Viral Antigens
N Kuzushita, SH Gregory, NA Monti, R Carlson, S Gehring, JR Wands |
Gastroenterology | 2006 |
Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses
S Urbani, B Amadei, P Fisicaro, D Tola, A Orlandini, L Sacchelli, C Mori, G Missale, C Ferrari |
Hepatology | 2006 |
Discordant Role of CD4 T-Cell Response Relative to Neutralizing Antibody and CD8 T-Cell Responses in Acute Hepatitis C
DE Kaplan, K Sugimoto, K Newton, ME Valiga, F Ikeda, A Aytaman, FA Nunes, MR Lucey, BA Vance, RH Vonderheide, KR Reddy, JA McKeating, KM Chang |
Gastroenterology | 2006 |
Early impairment of virus-specific CD4+ and CD8+ T cell proliferation during acute HCV infection leads to failure of viral clearance
A. Folgori, M. Pezzanera, L. Ruggeri, E. Spada, A. Mele, AR Garbuglia, M. Perrone, P. Del Porto, E. Piccolella, R. Cortese, A. Nicosia, A Vitelli |
Gut | 2006 |
Transplant tolerance: models, concepts and facts
NJ Monk, RE Hargreaves, E Simpson, JP Dyson, S Jurcevic |
Journal of Molecular Medicine | 2006 |
Cellular immune responses against persistent hepatitis C virus: gone but not forgotten
P Klenerman, N Semmo |
Gut | 2006 |
Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses
A Ulsenheimer, M Lucas, NP Seth, JT Gerlach, NH Gruener, A Loughry, GR Pape, KW Wucherpfennig, HM Diepolder, P Klenerman |
Journal of Viral Hepatitis | 2006 |
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
T Manigold, EC Shin, E Mizukoshi, K Mihalik, KK Murthy, CM Rice, CA Piccirillo, B Rehermann |
Blood | 2006 |
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection
S Gaudieri, A Rauch, LP Park, E Freitas, S Herrmann, G Jeffrey, W Cheng, K Pfafferott, K Naidoo, R Chapman, M Battegay, R Weber, A Telenti, H Furrer, I James, M Lucas, SA Mallal |
Journal of virology | 2006 |
Complete differentiation of CD8 + T cells activated locally within the transplanted liver
I Klein, IN Crispe |
Journal of Experimental Medicine | 2006 |
The influence of T cell cross-reactivity on HCV-peptide specific human T cell response
PT Kennedy, S Urbani, RA Moses, B Amadei, P Fisicaro, J Lloyd, MK Maini, G Dusheiko, C Ferrari, A Bertoletti |
Hepatology | 2006 |
Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection
JH Aberle, E Formann, P Steindl-Munda, L Weseslindtner, C Gurguta, G Perstinger, E Grilnberger, H Laferl, HP Dienes, T Popow-Kraupp, P Ferenci, H Holzmann |
Journal of Clinical Virology | 2006 |
Induction of Strong Cytotoxic T-Lymphocyte Responses to Hepatitis C Virus with Recombinant Poly-epitope in BALB/c Mice
J Yan, S Ling, H Liu, H Zhang, X Song, B Xiu, K Chen, G Wang, C Zhu |
Viral Immunology | 2006 |
Resistance of hepatitis C virus to the host antiviral response
SJ Polyak |
Future Virology | 2006 |
Decreased NK cell frequency in chronic hepatitis C does not affectex vivo cytolytic killing
C Morishima, DM Paschal, CC Wang, CS Yoshihara, BL Wood, AE Yeo, SS Emerson, MC Shuhart, DR Gretch |
Hepatology | 2006 |
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
H Radziewicz, CC Ibegbu, ML Fernandez, KA Workowski, K Obideen, M Wehbi, HL Hanson, JP Steinberg, D Masopust, EJ Wherry, JD Altman, BT Rouse, GJ Freeman, R Ahmed, A Grakoui |
Journal of virology | 2006 |
Acute hepatitis C virus infection: a neglected disease?
WL Irving |
Gut | 2006 |
Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction
A Karrar, U Broomé, M Uzunel, AR Qureshi, S Sumitran-Holgersson |
Gut | 2006 |
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
A Folgori, S Capone, L Ruggeri, A Meola, E Sporeno, BB Ercole, M Pezzanera, R Tafi, M Arcuri, E Fattori, A Lahm, A Luzzago, A Vitelli, S Colloca, R Cortese, A Nicosia |
Nature Medicine | 2006 |
Interferon gamma-secreting HCV-specific CD8+ T cells in the liver of patients with chronic C hepatitis: relation to liver fibrosis - ANRS HC EP07 study*
N Bonilla, N Barget, M Andrieu, D Roulot, P Letoumelin, V Grando, JC Trinchet, N Ganne-Carrie, M Beaugrand, P Deny, J Choppin, J Guillet, M Ziol |
Journal of Viral Hepatitis | 2006 |
Hepatitis C virus: new advances trap an age-old killer
U Desselberger |
Future Virology | 2006 |
HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4+ Th1 cell responses in vivo
M Gao, HP Wang, YN Wang, Y Zhou, QL Wang |
Vaccine | 2006 |
HLA-DRB1 Donor-Recipient Mismatch Affects the Outcome of Hepatitis C Disease Recurrence After Liver Transplantation
LS Belli, P Burra, F Poli, AB Alberti, E Silini, C Zavaglia, S Fagiuoli, D Prando, AE de Arias, S Boninsegna, C Tinelli, M Scalamogna, L Carlis, G Pinzello |
Gastroenterology | 2006 |
Individualization of antiviral treatment regimens for chronic hepatitis C
E Paulon, NV Naoumov |
European Journal of Gastroenterology & Hepatology | 2006 |
Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins
P Sarobe, JJ Lasarte, N Garcia, MP Civeira, F Borras-Cuesta, J Prieto |
Journal of Viral Hepatitis | 2006 |
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies
JM Micallef, JM Kaldor, GJ Dore |
Journal of Viral Hepatitis | 2006 |
Target HCV NS3 CD4+ Th1 Epitope to Major Histocompatibility Complex Class II Pathway
M Gao, HP Wang, YN Wang, Y Zhou, QL Wang |
Biotechnology Letters | 2006 |
Virus-specific T-cell responses associated with hepatitis C virus (HCV) persistence in the liver after apparent recovery from HCV infection
JA Quiroga, S Llorente, I Castillo, E Rodríguez-Iñigo, JM López-Alcorocho, M Pardo, V Carreño |
Journal of Medical Virology | 2006 |
CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virus
M Puig, K Mihalik, JC Tilton, O Williams, M Merchlinsky, M Connors, SM Feinstone, ME Major |
Hepatology | 2006 |
Hepatitis C Virus Core Protein: An Update on Its Molecular Biology, Cellular Functions and Clinical Implications
M Irshad, I Dhar |
Medical Principles and Practice | 2006 |
Current status of vaccine therapy for hepatitis c infection
DE Kaplan, KM Chang |
Current Hepatitis Reports | 2006 |
Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: A randomized, placebo controlled trial for dose optimization in 128 healthy subjects
C Firbas, B Jilma, E Tauber, V Buerger, S Jelovcan, K Lingnau, M Buschle, J Frisch, CS Klade |
Vaccine | 2006 |
Hepatitis C Virus Infection in African Americans
BL Pearlman |
Clinical Infectious Diseases | 2006 |
Tratamiento de la hepatitis aguda C
RS Lamoglia |
Gastroenterología y Hepatología | 2006 |
HCV Immunopathogenesis: Virus-Induced Strategies against Host Immunity
G Szabo, A Dolganiuc |
Clinics in Liver Disease | 2006 |
Different outcomes of nosocomial infection with hepatitis C virus from the same origin
S Kakizaki, H Takagi, Y Yamazaki, N Sohara, K Sato, T Nagamine, M Mori |
World journal of gastroenterology : WJG | 2006 |
Genetic vaccination by gene electro-transfer in non-human primates
I Zampaglione, AJ Simon, S Capone, AC Finnefrock, DR Casimiro, GS Kath, A Tang, A Folgori, NL Monica, J Shiver, A Nicosia, G Ciliberto, R Cortese, E Fattori |
Journal of drug delivery science and technology | 2006 |
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs
HY Lu |
World journal of gastroenterology : WJG | 2006 |
Disease Progression and Disease Prevention in Hepatology and Gastroenterology
PR Galle, WE Schmidt, G Gerken, B Wiedenmann |
2006 | |
A Novel Adenovirus Type 6 (Ad6)-Based Hepatitis C Virus Vector That Overcomes Preexisting Anti-Ad5 Immunity and Induces Potent and Broad Cellular Immune Responses in Rhesus Macaques
S Capone, A Meola, BB Ercole, A Vitelli, M Pezzanera, L Ruggeri, ME Davies, R Tafi, C Santini, A Luzzago, TM Fu, A Bett, S Colloca, R Cortese, A Nicosia, A Folgori |
Journal of virology | 2006 |
Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses
M Vajdy, M Selby, A Medina-Selby, D Coit, J Hall, L Tandeske, D Chien, C Hu, D Rosa, M Singh, J Kazzaz, S Nguyen, S Coates, P Ng, S Abrignani, YL Lin, M Houghton, DT O'Hagan |
Journal of General Virology | 2006 |
Modulation of the Immune Response Induced by Gene Electrotransfer of a Hepatitis C Virus DNA Vaccine in Nonhuman Primates
S Capone, I Zampaglione, A Vitelli, M Pezzanera, L Kierstead, J Burns, L Ruggeri, M Arcuri, M Cappelletti, A Meola, BB Ercole, R Tafi, C Santini, A Luzzago, TM Fu, S Colloca, G Ciliberto, R Cortese, A Nicosia, E Fattori, A Folgori |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection
V Dutoit, D Ciuffreda, D Comte, JJ Gonvers, G Pantaleo |
European Journal of Immunology | 2005 |
Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection
S Guglietta, AR Garbuglia, V Pacciani, C Scottà, MP Perrone, L Laurenti, E Spada, A Mele, MR Capobianchi, G Taliani, A Folgori, A Vitelli, L Ruggeri, A Nicosia, E Piccolella, PD Porto |
European Journal of Immunology | 2005 |
Broad Repertoire of the CD4 + Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes
JS zur Wiesch, GM Lauer, CL Day, AY Kim, K Ouchi, JE Duncan, AG Wurcel, J Timm, AM Jones, B Mothe, TM Allen, B McGovern, L Lewis-Ximenez, J Sidney, A Sette, RT Chung, BD Walker |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection
K Sugimoto, DE Kaplan, F Ikeda, J Ding, J Schwartz, FA Nunes, HJ Alter, KM Chang |
Journal of virology | 2005 |
T Cells with a CD4 + CD25 + Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8 + T Cells during Chronic Hepatitis C Virus Infection
T Boettler, HC Spangenberg, C Neumann-Haefelin, E Panther, S Urbani, C Ferrari, HE Blum, F von Weizsäcker, R Thimme |
Journal of virology | 2005 |
T cell immunity in hepatitis B and hepatitis C virus infection: implications for autoimmunity
Y Ichiki, XS He, S Shimoda, H Ishibashi, EB Keeffe, L Rossaro, ME Gershwin |
Autoimmunity Reviews | 2005 |
Blocking of interleukin-10 receptor—a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus
EI Rigopoulou, WG Abbott, P Haigh, NV Naoumov |
Clinical Immunology | 2005 |
T cell response in hepatitis C virus infection
C Neumann-Haefelin, HE Blum, FV Chisari, R Thimme |
Journal of Clinical Virology | 2005 |
Adaptive immune responses in acute and chronic hepatitis C virus infection
DG Bowen, CM Walker |
Nature | 2005 |
Cellular Immune Responses against Hepatitis C Virus
MJ Koziel |
Clinical Infectious Diseases | 2005 |
HCV-hepatocellular carcinoma: New findings and hope for effective treatment
S Dash, S Haque, V Joshi, R Prabhu, S Hazari, C Fermin, R Garry |
Microscopy Research and Technique | 2005 |
Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction
K Iken, L Huang, H Bekele, EV Schmidt, MJ Koziel |
Virology | 2005 |
Liver-directed gamma interferon gene delivery in chronic hepatitis C
EC Shin, U Protzer, A Untergasser, SM Feinstone, CM Rice, D Hasselschwert, B Rehermann |
Journal of virology | 2005 |
Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity
MM Tiao, L Lu, R Tao, L Wang, JJ Fung, S Qian |
Annals of Surgery | 2005 |
Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
AL Rothman, C Morishima, HL Bonkovsky, SJ Polyak, R Ray, AM di Bisceglie, KL Lindsay, PF Malet, M Chang, DR Gretch, DG Sullivan, AK Bhan, EC Wright, MJ Koziel |
Hepatology | 2005 |
Recognition of endogenously synthesized HLA-DR4 restricted HCV epitopes presented by autologous EBV transformed B-lymphoblastoid cell line
M Yang, F Zhu, G Sønderstrup, DD Eckels |
Vaccine | 2005 |
Dynamics of viremia in early hepatitis C virus infection
SA Glynn, DJ Wright, SH Kleinman, D Hirschkorn, Y Tu, C Heldebrant, R Smith, C Giachetti, J Gallarda, MP Busch |
Transfusion | 2005 |
Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection
A Ulsenheimer, JT Gerlach, MC Jung, N Gruener, M W�chtler, M Backmund, T Santantonio, W Schraut, MH Heeg, CA Schirren, R Zachoval, GR Pape, HM Diepolder |
Hepatology | 2005 |
MMF and Calcineurin Taper in Recurrent Hepatitis C After Liver Transplantation: Impact on Histological Course
M Bahra, UI Neumann, D Jacob, G Puhl, J Klupp, JM Langrehr, T Berg, P Neuhaus |
American Journal of Transplantation | 2005 |
Induction therapy with either anti-CD25 monoclonal antibodies or rabbit antithymocyte globulins in liver transplantation for hepatitis C
N Kamar, JS Borde, K Sandres-Saune, B Suc, K Barange, O Cointault, L Lavayssiere, D Durand, J Izopet, L Rostaing |
Clinical Transplantation | 2005 |
Host immune responses in hepatitis C virus clearance
S Barrett, M Sweeney, J Crowe |
European Journal of Gastroenterology & Hepatology | 2005 |
Prospects for a vaccine against the hepatitis C virus
M Houghton, S Abrignani |
Nature | 2005 |
Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection
N Semmo, CL Day, SM Ward, M Lucas, G Harcourt, A Loughry, P Klenerman |
Hepatology | 2005 |
Hepatitis C virus and the immune system: a concise review
C Gremion, A Cerny |
Reviews in Medical Virology | 2005 |
Development of prophylactic and therapeutic vaccines against hepatitis C virus
G Leroux-Roels |
Expert Review of Vaccines | 2005 |
Treatment of hepatitis C
AI Kim, S Saab |
The American Journal of Medicine | 2005 |
The core-specific precursor T cell response is directed to the N-terminal and central parts of the protein and positively correlates to the viral load in chronically HCV-infected patients
G Janvier, ML Chaix, H Fontaine, JL Bresson, S Pol, Y Riviere |
Virology | 2005 |
Chronic Hepatitis C in African Americans
N Pyrsopoulos, L Jeffers |
Clinics in Liver Disease | 2005 |
Acute hepatitis C: diagnosis and management
MU Mondelli, A Cerino, A Cividini |
Journal of Hepatology | 2005 |
Stable human lymphoblastoid cell lines constitutively expressing hepatitis C virus proteins
B Wölk, C Gremion, N Ivashkina, OB Engler, B Grabscheid, E Bieck, HE Blum, A Cerny, D Moradpour |
Journal of General Virology | 2005 |
T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C
DE Kaplan, K Sugimoto, F Ikeda, J Stadanlick, M Valiga, K Shetty, KR Reddy, KM Chang |
Hepatology | 2005 |
Effect of operation-synchronizing transfusion of apoptotic spleen cells from donor rats on acute rejection of recipient rats after liver transplantation
J Liu |
World journal of gastroenterology : WJG | 2005 |
Hepatitis C Virus Core Protein Induces an Anergic State Characterized by Decreased Interleukin-2 Production and Perturbation of Mitogen-Activated Protein Kinase Responses
S Sundström, S Ota, LY Dimberg, MG Masucci, A Bergqvist |
Journal of virology | 2005 |
Minimal T-Cell-Stimulatory Sequences and Spectrum of HLA Restriction of Immunodominant CD4 + T-Cell Epitopes within Hepatitis C Virus NS3 and NS4 Proteins
JT Gerlach, A Ulsenheimer, NH Grüner, MC Jung, W Schraut, CA Schirren, M Heeg, S Scholz, K Witter, R Zahn, A Vogler, R Zachoval, GR Pape, HM Diepolder |
Journal of virology | 2005 |
Immunogenic Properties of a Chimeric Plant Virus Expressing a Hepatitis C Virus (HCV)-Derived Epitope: New Prospects for an HCV Vaccine
G Piazzolla, M Nuzzaci, C Tortorella, E Panella, A Natilla, D Boscia, AD Stradis, P Piazzolla, S Antonaci |
Journal of Clinical Immunology | 2005 |
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
David G. Bowen, Monica Zen, Lauren Holz, Thomas Davis, Geoffrey W. McCaughan & Patrick J. Bertolino |
Journal of Clinical Investigation | 2004 |
Effects of antiviral therapy on the cellular immune response in acute hepatitis C
F Rahman, T Heller, Y Sobao, E Mizukoshi, M Nascimbeni, H Alter, S Herrine, J Hoofnagle, TJ Liang, B Rehermann |
Hepatology | 2004 |
Direct Binding of Hepatitis C Virus Core to gC1qR on CD4 + and CD8 + T Cells Leads to Impaired Activation of Lck and Akt
ZQ Yao, A Eisen-Vandervelde, SN Waggoner, EM Cale, YS Hahn |
Journal of virology | 2004 |
Progress on new vaccine strategies against chronic viral infections
JA Berzofsky, JD Ahlers, J Janik, J Morris, SK Oh, M Terabe, IM Belyakov |
Journal of Clinical Investigation | 2004 |
Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigen
P Martin, P Parroche, L Chatel, C Barretto, A Beck, C Tr�po, C Bain, YC Lone, G Inchausp�, A Fournillier |
Journal of Medical Virology | 2004 |
CELL-MEDIATED IMMUNITY AND THE OUTCOME OF HEPATITIS C VIRUS INFECTION
NH Shoukry, AG Cawthon, CM Walker |
Annual Review of Microbiology | 2004 |
Long-term immune response after liver transplantation in patients with spontaneous or post-treatment HCV-RNA clearance
T Casanovas-Taltavull, MG Ercilla, CP Gonzalez, E Gil, O Vi�as, C Ca�as, A Casanova, J Figueras, T Serrano, LA Casais |
Liver Transplantation | 2004 |
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
E Spada, A Mele, A Berton, L Ruggeri, L Ferrigno, AR Garbuglia, MP Perrone, G Girelli, PD Porto, E Piccolella, MU Mondelli, P Amoroso, R Cortese, A Nicosia, A Vitelli, A Folgori |
Gut | 2004 |
Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response
C Rollier, E Depla, JA Drexhage, EJ Verschoor, BE Verstrepen, A Fatmi, C Brinster, A Fournillier, JA Whelan, M Whelan, D Jacobs, G Maertens, G Inchauspé, JL Heeney |
Journal of virology | 2004 |
Memory T-cell-mediated immune responses specific to an alternative core protein in hepatitis C virus infection
C Bain, P Parroche, JP Lavergne, B Duverger, C Vieux, V Dubois, F Komurian-Pradel, C Trépo, L Gebuhrer, G Paranhos-Baccala, F Penin, G Inchauspé |
Journal of virology | 2004 |
Cellular immune responses against HCV: T cells take a diversion in the liver
P Klenerman, N Semmo, S Ward |
Hepatology | 2004 |
Effects of interferon and ribavirin combination therapy on CD4+ proliferation, lymphocyte activation, and Th1 and Th2 cytokine profiles in chronic hepatitis C
RT Marinho, R Pinto, ML Santos, IV Lobos, MC Moura |
Journal of Viral Hepatitis | 2004 |
Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies?
G Missale, E Cariani, C Ferrari |
Digestive and Liver Disease | 2004 |
Identification of a new autoantibody in patients with chronic hepatitis
Y Fukuda, H Yotsuyanagi, S Ooka, T Sekine, J Koike, T Takano, M Suzuki, F Itoh, K Nishioka, T Kato |
Human Immunology | 2004 |
Analysis of hepatitis C virus quasispecies transmission and evolution in patients infected through blood transfusion
T Laskus, J Wilkinson, JF Gallegos-Orozco, M Radkowski, DM Adair, M Nowicki, E Operskalski, Z Buskell, LB Seeff, H Vargas, J Rakela |
Gastroenterology | 2004 |
Humoral immunity to immunodominant epitopes of Hepatitis C virus in individuals infected with genotypes 1a or 1b
MP Carlos, Y Yamamura, Q Vu, K Conzen, DE Anderson, JV Torres |
Clinical Immunology | 2004 |
Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population
BA Piasecki, JD Lewis, KR Reddy, SL Bellamy, SB Porter, RM Weinrieb, DD Stieritz, KM Chang |
Hepatology | 2004 |
Viral hepatitis: virus/host interaction
D Vergani, G Mieli-Vergani |
Journal of Gastroenterology and Hepatology | 2004 |
Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes
GC Harcourt, M Lucas, I Sheridan, E Barnes, R Phillips, P Klenerman |
Journal of Viral Hepatitis | 2004 |
DNA immunization encoding the secreted nonstructural protein 3 (NS3) of hepatitis C virus and enhancing the Th1 type immune response*
X Jiao, RY Wang, Z Feng, G Hu, HJ Alter, JW Shih |
Journal of Viral Hepatitis | 2004 |
Cationic microparticles are a potent delivery system for a HCV DNA vaccine
DT O’Hagan, M Singh, C Dong, M Ugozzoli, K Berger, E Glazer, M Selby, M Wininger, P Ng, K Crawford, X Paliard, S Coates, M Houghton |
Vaccine | 2004 |
Immune responses in hepatitis C: is virus or host the problem?:
JM Darling, TL Wright |
Current Opinion in Infectious Diseases | 2004 |
Analysis of T cell responses against hepatitis C virus genotype 4 in Egypt
M Elrefaei, N El-sheikh, K Kamal, H Cao |
Journal of Hepatology | 2004 |
Mechanisms of HCV reinfection and allograft damage after liver transplantation
GW McCaughan, A Zekry |
Journal of Hepatology | 2004 |
The use of class-I HLA tetramers for the detection of hepatitis C virus NS3-specific CD8(+) T cells in patients with chronic infection
FX López-Labrador, XS He, M Berenguer, RC Cheung, TL Wright, HB Greenberg |
Journal of Immunological Methods | 2004 |
Efficacy and safety of induction therapy with rabbit antithymocyte globulins in liver transplantation for hepatitis C
N Kamar, D Ribes, K Sandres-Saune, B Suc, K Barange, O Cointault, L Lavayssiere, D Durand, J Izopet, L Rostaing |
Transplantation Proceedings | 2004 |
Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides
Ming-Qing Xu, Yu-Ping Suo, Jian-Ping Gong, Ming-Man Zhang, Lu-Nan Yan |
World journal of gastroenterology : WJG | 2004 |
Prolongation of liver allograft survival by dendritic cells modified with NF-κB decoy oligodeoxynucleotides
MQ Xu |
World journal of gastroenterology : WJG | 2004 |
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals
F Thorén, A Romero, M Lindh, C Dahlgren, K Hellstrand |
Journal of leukocyte biology | 2004 |
Hepatitis Prevention and Treatment
JM Colacino, BA Heinz |
2004 | |
Cellular Immune Responses in Seronegative Sexual Contacts of Acute Hepatitis C Patients
SM Kamal, A Amin, M Madwar, CS Graham, Q He, AA Tawil, J Rasenack, T Nakano, B Robertson, A Ismail, MJ Koziel |
Journal of virology | 2004 |
Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation
IS Ludwig, AN Lekkerkerker, E Depla, F Bosman, RJ Musters, S Depraetere, Y van Kooyk, TB Geijtenbeek |
Journal of virology | 2004 |
Ex vivo Analysis of Human Memory CD4 T cells to Hepatitis C Virus using MHC class II Tetramers
Cheryl L. Day, Nilufer Seth, Michaela Lucas, Heiner Appel, Laurent Gauthier, Georg M. Lauer, Gregory K. Robbins, Zbigniew M. Szczepiorkowski, Deborah R. Casson, Raymond T. Chung, Shannon Bell, Bruce D. Walker, Paul Klenerman, Kai W. Wucherpfennig |
Journal of Clinical Investigation | 2003 |
Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection
K Murata, M Lechmann, M Qiao, T Gunji, HJ Alter, TJ Liang |
Proceedings of the National Academy of Sciences | 2003 |
Kinetics of the immune response during HBV and HCV infection
A Bertoletti |
Hepatology | 2003 |
Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections: Figure 1
CL Day, BD Walker |
Journal of Experimental Medicine | 2003 |
Hepatitis c virus-specific cytolytic t cell responses after antiviral therapy
C Morishima, L Musey, M Elizaga, K Gaba, M Allison, RL Carithers, DR Gretch, MJ McElrath |
Clinical Immunology | 2003 |
Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C
T H�gle, A Cerny |
Reviews in Medical Virology | 2003 |
Mechanisms of Alcohol-Induced Tissue Injury
PE Molina, JB Hoek, S Nelson, DM Guidot, CH Lang, JR Wands, JM Crawford |
Alcoholism: Clinical & Experimental Research | 2003 |
The nature of interferon-?? resistance in hepatitis C virus infection
JM Pawlotsky |
Current Opinion in Infectious Diseases | 2003 |
Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection
GC Harcourt, M Lucas, AJ Godkin, M Kantzanou, RE Phillips, P Klenerman |
Clinical & Experimental Immunology | 2003 |
Dendritic cells and immune regulation in the liver
AH Lau, AW Thomson |
Gut | 2003 |
DNA immunization efficiently targets conserved functional domains of protease and ATPase/helicase of nonstructural 3 protein (NS3) of human hepatitis C virus
MG Isaguliants, NV Petrakova, VV Mokhonov, K Pokrovskaya, YG Suzdaltzeva, AV Krivonos, AD Zaberezhny, MM Garaev, VD Smirnov, E Nordenfelt |
Immunology Letters | 2003 |
Candida oesophagitis with hepatitis C virus
J Yakoob, W Jafri, AS Hussainy |
European Journal of Gastroenterology & Hepatology | 2003 |
Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication
JT Gerlach, HM Diepolder, R Zachoval, NH Gruener, MC Jung, A Ulsenheimer, WW Schraut, C Schirren, M Waechtler, M Backmund, GR Pape |
Gastroenterology | 2003 |
Detection of IgE anti-parvovirus B19 and increased CD23+ B cells in parvovirus B19 infection: relation to Th2 cytokines
MH Bluth, KB Norowitz, S Chice, VN Shah, M Nowakowski, AS Josephson, HG Durkin, TA Smith-Norowitz |
Clinical Immunology | 2003 |
Virus-specific effector CD4+ T-cell responses in hemodialysis patients with hepatitis C virus infection
MA Rico, S Ruiz, D Subir�, G Barril, S Cigarr�n, S Casta��n, JA Quiroga, R Selgas, V Carre�o |
Journal of Medical Virology | 2003 |
Immunity and persistence in hepatitis C virus infection
AM Wertheimer, HR Rosen |
Current Hepatitis Reports | 2003 |
Of chimps and men-finding the path to an HCV vaccine
HM Diepolder, NH Gruener, J Heeney |
Hepatology | 2003 |
Efficient induction of T helper 1 CD4+ T-cell responses to hepatitis C virus core and E2 by a DNA prime–adenovirus boost
SH Park, SH Yang, CG Lee, JW Youn, J Chang, YC Sung |
Vaccine | 2003 |
Hepatitis C virus-associated tubulointerstitial injury
K Kasuno, T Ono, A Matsumori, F Nogaki, H Kusano, H Watanabe, J Yodoi, E Muso |
American Journal of Kidney Diseases | 2003 |
Mechanisms Inducing or Controlling CD8+T Cell Responses against Self- or Non-Self-Antigens
D Accapezzato, V Francavilla, A Propato, M Paroli, V Barnaba |
Annals of the New York Academy of Sciences | 2003 |
Natural course of acute hepatitis C: a long-term prospective study
T Santantonio, E Sinisi, A Guastadisegni, C Casalino, M Mazzola, A Gentile, G Leandro, G Pastore |
Digestive and Liver Disease | 2003 |
Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-α and ribavirin treatment for chronic hepatitis C virus infection
J Sreenarasimhaiah, A Jaramillo, J Crippin, M Lisker-Melman, WC Chapman, T Mohanakumar |
Human Immunology | 2003 |
Frontiers in Viral Hepatitis
GJ Webster, GM Dusheiko |
Frontiers in Viral Hepatitis | 2003 |
Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation: association of a strong, multispecific, and long-lasting CD4+ T cell response with HCV-elimination
CA Schirren, R Zachoval, JT Gerlach, A Ulsenheimer, NH Gruener, HM Diepolder, G Baretton, W Schraut, HG Rau, H Nitschko, GR Pape, MC Jung |
Journal of Hepatology | 2003 |
Hepatitis C virus–cell interactions and their role in pathogenesis
SJ Polyak |
Clinics in Liver Disease | 2003 |
Living donor liver transplantation and hepatitis C
AC Baltz, JF Trotter |
Clinics in Liver Disease | 2003 |
Apoptosis-inducing protein derived from hepatocyte selectively induces apoptosis in lymphocytes
M Ikeda, H Yoshikawa, J Liu, Y Nakajima, Y Akahane, K Tasaka |
Immunology | 2003 |
TUMOR-ASSOCIATED ANTIGENS: FROM DISCOVERY TO IMMUNITY
JD Lewis, BD Reilly, RK Bright |
International Reviews of Immunology | 2003 |
Suppression of HCV-specific T cells without differential hierarchy demonstrated in persistent HCV infection
K Sugimoto, F Ikeda, J Stadanlick, FA Nunes, HJ Alter, KM Chang |
Hepatology | 2003 |
Hepatitis C virus–like particles combined with novel adjuvant systems enhance virus-specific immune responses
M Qiao |
Hepatology | 2003 |
Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response
K Sugimoto |
Hepatology | 2003 |
Hepatitis C pathogenesis: Mechanisms of viral clearance and liver injury
HR Rosen |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2003 |
Characterization of HCV-specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee
D Woollard |
Hepatology | 2003 |
Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C
A Ulsenheimer |
Hepatology | 2003 |
Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo
L Frelin, M Alheim, A Chen, J Söderholm, B Rozell, C Barnfield, P Liljeström, M Sällberg |
Gene Therapy | 2003 |
Nonimmune Complexed HCV RNA Titer in Serum as a Predictor of Interferon Response in Patients With Chronic Hepatitis C
N Fujita, M Kaito, M Takeo, M Iwasa, J Ikoma, S Watanabe, Y Adachi |
The American Journal of Gastroenterology | 2003 |
Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses
P Sarobe, JJ Lasarte, A Zabaleta, L Arribillaga, A Arina, I Melero, F Borrás-Cuesta, J Prieto |
Journal of virology | 2003 |
Kinetics of CD4 + and CD8 + Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees
M Nascimbeni, E Mizukoshi, M Bosmann, ME Major, K Mihalik, CM Rice, SM Feinstone, B Rehermann |
Journal of virology | 2003 |
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
A Grakoui, NH Shoukry, DJ Woollard, JH Han, HL Hanson, J Ghrayeb, KK Murthy, CM Rice, CM Walker |
Science | 2003 |
The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity
M Thomson, M Nascimbeni, MB Havert, M Major, S Gonzales, H Alter, SM Feinstone, KK Murthy, B Rehermann, TJ Liang |
Journal of virology | 2003 |
DNA Vaccination Protects Mice against Challenge with Listeria monocytogenes Expressing the Hepatitis C Virus NS3 Protein
BE Simon, KA Cornell, TR Clark, S Chou, HR Rosen, RA Barry |
Infection and immunity | 2003 |
Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: functional characterization in patients with chronic hepatitis C
A Penna, G Missale, V Lamonaca, M Pilli, C Mori, P Zanelli, A Cavalli, G Elia, C Ferrari |
Hepatology | 2002 |
Immunological and virological effects of ribavirin in hepatitis C after liver transplantation
R Quadri, E Giostra, T Roskams, JM Pawlotsky, G Mentha, L Rubbia-Brandt, L Perrin, A Hadengue, F Negro |
Transplantation | 2002 |
Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins
P Sarobe, JJ Lasarte, N Casares, AL de Cerio, E Baixeras, P Labarga, N García, F Borrás-Cuesta, J Prieto |
Journal of virology | 2002 |
Recipient iNOS but not eNOS deficiency reduces luminal narrowing in tracheal allografts
K Minamoto, DJ Pinsky |
Journal of Experimental Medicine | 2002 |
Impaired Effector Function of Hepatitis C Virus-Specific CD8 + T Cells in Chronic Hepatitis C Virus Infection
H Wedemeyer, XS He, M Nascimbeni, AR Davis, HB Greenberg, JH Hoofnagle, TJ Liang, H Alter, B Rehermann |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Virus-Specific CD8 + Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C
S Urbani, C Boni, G Missale, G Elia, C Cavallo, M Massari, G Raimondo, C Ferrari |
Journal of virology | 2002 |
Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virus
L Arribillaga, AL de Cerio, P Sarobe, N Casares, M Gorraiz, A Vales, O Bruna-Romero, F Borrás-Cuesta, G Paranhos-Baccala, J Prieto, J Ruiz, JJ Lasarte |
Vaccine | 2002 |
Quantitative and functional differences in CD8+ lymphocyte responses in resolved acute and chronic hepatitis C virus infection
T Lancaster, E Sanders, JM Christie, C Brooks, S Green, WM Rosenberg |
Journal of Viral Hepatitis | 2002 |
Acute hepatitis C: To treat or not to treat?
BA Piasecki, KR Reddy, KM Chang |
Hepatology | 2002 |
The saga of liver replacement, with particular reference to the reciprocal influence of liver and kidney transplantation (1955-1967)
TE Starzl |
Journal of the American College of Surgeons | 2002 |
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
R Thimme, J Bukh, HC Spangenberg, S Wieland, J Pemberton, C Steiger, S Govindarajan, RH Purcell, FV Chisari |
Proceedings of the National Academy of Sciences | 2002 |
Cellular immune responses against hepatitis C virus: the evidence base 2002
S Ward, G Lauer, R Isba, B Walker, P Klenerman |
Clinical & Experimental Immunology | 2002 |
Optimal clinical trial designs for immune-based therapies in persistent viral infections
KA Smith |
Medical immunology (London, England) | 2002 |
T helper, cytotoxic T lymphocyte, NK cell and NK-T cell subpopulations in patients with chronic hepatitis C
R Amaraa, H Marečková, P Urbánek, T Fučíková |
Folia Microbiologica | 2002 |
Strong CD4 Th1 responses to HIV and hepatitis C virus in HIV-infected long-term non-progressors co-infected with hepatitis C virus
N Alatrakchi, VD Martino, V Thibault, B Autran |
AIDS | 2002 |
Immunity to hepatitis C virus: stunned but not defeated
P Klenerman, M Lucas, E Barnes, G Harcourt |
Microbes and Infection | 2002 |
A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C
Y Sugimoto, N Kuzushita, T Takehara, T Kanto, T Tatsumi, T Miyagi, M Jinushi, K Ohkawa, M Horimoto, A Kasahara, M Hori, Y Sasaki, N Hayashi |
Journal of Viral Hepatitis | 2002 |
Is severe liver disease a common outcome for people with chronic hepatitisC?
GJ Dore, AJ Freeman, M Law, JM Kaldor |
Journal of Gastroenterology and Hepatology | 2002 |
Immunological markers predicting outcome in patients with hepatitis C treated with interferon-alpha and ribavirin
S Lee, GC Macquillan, NM Keane, J Flexman, GP Jeffrey, MA French, J Brochier, P Price |
Immunology and Cell Biology | 2002 |
Bridge over troubled water: Protection against hepatitis C virus persistence?
R Thimme, HC Spangenberg, HE Blum |
Hepatology | 2002 |
T Cell Failure in Hepatitis C Virus Infection
E Barnes, G Lauer, B Walker, P Klenerman |
Viral Immunology | 2002 |
Decrease in hepatic CD56+ T cells and Vα24+ natural killer T cells in chronic hepatitis C viral infection
T Deignan, MP Curry, DG Doherty, L Golden-Mason, Y Volkov, S Norris, N Nolan, O Traynor, G McEntee, JE Hegarty, C O'Farrelly |
Journal of Hepatology | 2002 |
The challenge of developing a vaccine against hepatitis C virus
X Forns, J Bukh, RH Purcell |
Journal of Hepatology | 2002 |
Hepatitis C virus eradication associated with hepatitis B virus superinfection and development of a hepatitis B virus specific T cell response
NH Gruener, MC Jung, A Ulsenheimer, TJ Gerlach, HM Diepolder, CA Schirren, R Hoffmann, M Wächtler, M Backmund, GR Pape |
Journal of Hepatology | 2002 |
Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells
T Okuda, T Ishikawa, O Azhipa, N Ichikawa, AJ Demetris, TE Starzl, N Murase |
Transplantation | 2002 |
Crucial Fas-Fas ligand interaction in spontaneous acceptance of hepatic allografts in mice
H Uchiyama, K Kishihara, R Minagawa, K Hashimoto, K Sugimachi, K Nomoto |
Immunology | 2002 |
Early Passenger Leukocyte Migration and Acute Immune Reactions in the Rat Recipient Spleen During Liver Engraftment: With Particular Emphasis on Donor Major Histocompatibility Complex Class II+ Cells1
T Okuda, T Ishikawa, O Azhipa, N Ichikawa, AJ Demetris, TE Starzl, N Murase |
Transplantation | 2002 |
Crucial Fas–Fas ligand interaction in spontaneous acceptance of hepatic allografts in mice
H Uchiyama, K Kishihara, R Minagawa, K Hashimoto, K Sugimachi, K Nomoto |
Immunology | 2002 |
Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies
A Larghi |
Hepatology | 2002 |
Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages
H Rosen |
Hepatology | 2002 |
Pathogenesis of hepatitis C virus recurrence in the liver allograft
G McCaughan |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2002 |
Hepatitis Viruses
JH Ou |
2002 | |
Impaired Effector Function of Hepatitis C Virus-Specific CD8 + T Cells in Chronic Hepatitis C Virus Infection
H Wedemeyer, XS He, M Nascimbeni, AR Davis, HB Greenberg, JH Hoofnagle, TJ Liang, H Alter, B Rehermann |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Broad Specificity of Virus-Specific CD4 + T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection
CL Day, GM Lauer, GK Robbins, B McGovern, AG Wurcel, RT Gandhi, RT Chung, BD Walker |
Journal of virology | 2002 |
Evidence for prostaglandin-producing supressor cells in HCV patients with normal ALT
Rui Marinho, Ruth Pinto, Maria Livia Santos, MouraMiguelCarneiro de |
Digestive Diseases and Sciences | 2002 |
Interferon-??-2b Plus Ribavirin: A Review of its Use in the Management of Chronic Hepatitis C
LJ Scott, CM Perry |
Drugs | 2002 |
Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway
ZQ Yao, DT Nguyen, AI Hiotellis, YS Hahn |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Recovery from Mouse Hepatitis Virus Infection Depends on Recruitment of CD8+ Cells Rather Than Activation of Intrahepatic CD4+αβ−TCRinter or NK-T Cells
L Lamontagne, S Lusignan, C Page |
Clinical Immunology | 2001 |
Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection
KQ Hu, JM Vierling, AG Redeker |
Journal of Viral Hepatitis | 2001 |
Immunopathogenesis of hepatitis C virus infection
AJ Freeman, G Marinos, RA Ffrench, AR Lloyd |
Immunology and Cell Biology | 2001 |
The birth of clinical organ transplantation
TE Starzl |
Journal of the American College of Surgeons | 2001 |
Lack of evidence for the Th2 predominance in patients with chronic hepatitis C
A Bergamini, F Bolacchi, G Cerasari, C Carvelli, E Faggioli, M Cepparulo, F Demin, I Uccella, B Bongiovanni, P Niutta, M Capozzi, M Lupi, E Piscitelli, G Rocchi, M Angelico |
Clinical & Experimental Immunology | 2001 |
Determinants of viral clearance and persistence during acute hepatitis C virus infection
R Thimme, D Oldach, KM Chang, C Steiger, SC Ray, FV Chisari |
Journal of Experimental Medicine | 2001 |
Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines
PJ Brown |
Clinical Biochemistry | 2001 |
Borderline and/or discordant Cobas Amplicor™ HCV Test version 2.0 results: clinical significance
E Valentine-Thon |
Journal of Clinical Virology | 2001 |
Sequence evolution and cross-reactive antibody responses to hypervariable region 1 in acute hepatitis C virus infection
S Hjalmarsson, J Blomberg, L Grillner, R Pipkorn, T Allander |
Journal of Medical Virology | 2001 |
Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection
G Harcourt, S Hellier, M Bunce, J Satsangi, J Collier, R Chapman, R Phillips, P Klenerman |
Journal of Viral Hepatitis | 2001 |
Virus-specific CD8+ T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection
C Prezzi, MA Casciaro, V Francavilla, E Schiaffella, L Finocchi, LV Chircu, G Bruno, A Sette, S Abrignani, V Barnaba |
European Journal of Immunology | 2001 |
Comparative pathogenesis of HBV and HCV
G Missale, A Penna, C Boni, M Malpeli, A Zerbini, M Pilli, S Urbani, C Ferrari |
Virus Research | 2001 |
Quantitative analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in interferon-?-treated patients with chronic hepatitis C
G Hempel, PR Galle, HF L�hr |
Journal of Medical Virology | 2001 |
Treatment of Acute Hepatitis C with Interferon Alfa-2b
E Jaeckel, M Cornberg, H Wedemeyer, T Santantonio, J Mayer, M Zankel, G Pastore, M Dietrich, C Trautwein, MP Manns |
New England Journal of Medicine | 2001 |
Positively selected amino acid sites in the entire coding region of hepatitis C virus subtype 1b
Y Suzuki, T Gojobori |
Gene | 2001 |
The Chimpanzee Model of Hepatitis C Virus Infections
RE Lanford, C Bigger, S Bassett, G Klimpel |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2001 |
Biología molecular del virus de la hepatitis C: implicaciones para el desarrollo de nuevas terapias y de una vacuna profiláctica
X Forns |
Medicina Clínica | 2001 |
Ribavirin enhances interferon-gamma levels in patients with chronic hepatitis C treated with interferon-alpha
SH Fang, MY Lai, LH Hwang, PM Yang, PJ Chen, BL Chiang, DS Chen |
Journal of Biomedical Science | 2001 |
HEPATITIS C VIRUS
P Farci |
Clinics in Liver Disease | 2001 |
Oral immunization with HCV-NS3—transformed Salmonella: Induction of HCV-specific CTL in a transgenic mouse model
H Wedemeyer, S Gagneten, A Davis, R Bartenschlager, S Feinstone, B Rehermann |
Gastroenterology | 2001 |
THE IMMUNOPATHOGENESIS OF HEPATITIS C VIRUS INFECTION
DR Nelson |
Clinics in Liver Disease | 2001 |
Acute hepatitis C without and with schistosomiasis: Correlation with hepatitis C–Specific CD4+ T-cell and cytokine response
SM Kamal, JW Rasenack, L Bianchi, AA Tawil, KE Khalifa, T Peter, H Mansour, W Ezzat, M Koziel |
Gastroenterology | 2001 |
Insights into the epidemiology, natural history and pathogenesis of hepatitis C virus infection from studies of infected donors and blood product recipients
MP Busch |
Transfusion Clinique et Biologique | 2001 |
New approaches to inducing the death of alloreactive lymphocytes
SM Krams |
Clinical & Experimental Immunology | 2001 |
Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720
XK Li, A Tamura, M Fujino, L Guo, T Kakefuda, N Funeshima, S Enosawa, M Amari, S Naoe, H Amemiya, S Suzuki |
Clinical & Experimental Immunology | 2001 |
ELISPOT Analysis of Hepatitis C Virus Protein-Specific IFN-γ-Producing Peripheral Blood Lymphocytes in Infected Humans with and without Cirrhosis
DD Anthony, AB Post, H Valdez, DL Peterson, M Murphy, PS Heeger |
Clinical Immunology | 2001 |
Humoral and CD4+ T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein
M Sällberg, JA Quiroga, C Hultgren, K Lodin, O Weiland, L Frelin, M Chen, DL Peterson, DR Milich, U Lazdina, G Leroux-Roels |
Journal of General Virology | 2001 |
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
R Thimme, D Oldach, KM Chang, C Steiger, SC Ray, FV Chisari |
Journal of Experimental Medicine | 2001 |
Acute Self-limiting Hepatitis C after Possible Sexual Exposure: Sequence Analysis of the E-2 Region of the Infected Patient and Sexual Partner
GM Mar |
Scandinavian Journal of Infectious Diseases | 2001 |
Hepatite C
E Strauss |
Revista da Sociedade Brasileira de Medicina Tropical | 2001 |
THE ROLE OF DIFFERENT IMMUNOSUPPRESSION IN THE LONG-TERM HISTOLOGICAL OUTCOME OF HCV REINFECTION AFTER LIVER TRANSPLANTATION FOR HCV CIRRHOSIS:
GV Papatheodoridis, S Davies, AP Dhillon, R Teixeira, J Goulis, B Davidson, K Rolles, G Dusheiko, AK Burroughs |
Transplantation | 2001 |
Hepatitis C viral genotype influences the clinical outcome of patients with acute posttransfusion hepatitis C
SJ Hwang, SD Lee, RH Lu, CW Chu, JC Wu, ST Lai, FY Chang |
Journal of Medical Virology | 2001 |
30th Hemophilia Symposium Hamburg 1999
I Scharrer, W Schramm |
2001 | |
Characterization of Hepatitis C Virus Core-Specific Immune Responses Primed in Rhesus Macaques by a Nonclassical ISCOM Vaccine
NK Polakos, D Drane, J Cox, P Ng, MJ Selby, D Chien, DT OHagan, M Houghton, X Paliard |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Induction of Hepatitis C Virus E1 Envelope Protein-Specific Immune Response Can Be Enhanced by Mutation of N-Glycosylation Sites
A Fournillier, C Wychowski, D Boucreux, TF Baumert, JC Meunier, D Jacobs, S Muguet, E Depla, G Inchauspé |
Journal of virology | 2001 |
Fas (CD95, Apo-1) ligand gene transfer
S E Lamhamedi-Cherradi, Y Chen |
Journal of Clinical Immunology | 2001 |
Human allograft acceptance is associated with immune regulation
AM VanBuskirk, WJ Burlingham, E Jankowska-Gan, T Chin, S Kusaka, F Geissler, RP Pelletier, CG Orosz |
Journal of Clinical Investigation | 2000 |
Hepatitis C
SA Sarbah, ZM Younossi |
Journal of Clinical Gastroenterology | 2000 |
The role of CD4+ T helper cells in the cytotoxic T lymphocyte response to HIV-1
M Altfeld, ES Rosenberg |
Current Opinion in Immunology | 2000 |
Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?
A Bertoletti, MK Maini |
Current Opinion in Immunology | 2000 |
Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection
GW McCaughan, A Zekry |
Transplant Infectious Disease | 2000 |
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
X Forns, R Thimme, S Govindarajan, SU Emerson, RH Purcell, FV Chisari, J Bukh |
Proceedings of the National Academy of Sciences | 2000 |
Analysis of successful immune responses in persons infected with hepatitis C virus
F Lechner, DK Wong, PR Dunbar, R Chapman, RT Chung, P Dohrenwend, G Robbins, R Phillips, P Klenerman, BD Walker |
Journal of Experimental Medicine | 2000 |
Clinical significance of hepatitis C virus genotypes
NN Zein |
Clinical microbiology reviews | 2000 |
Recurrent hepatitis C after liver transplantation
R Teixeira, S Pastacaldi, GV Papatheodoridis, AK Burroughs |
Journal of Medical Virology | 2000 |
Vigorous Peripheral Blood Cytotoxic T Cell Response during the Acute Phase of Hepatitis C Virus Infection
M Cucchiarini, AR Kammer, B Grabscheid, HM Diepolder, TJ Gerlach, N Grüner, T Santantonio, J Reichen, GR Pape, A Cerny |
Cellular Immunology | 2000 |
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization
AY Lee, NK Polakos, GR Otten, JB Ulmer, M Houghton, X Paliard |
Vaccine | 2000 |
The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C
SM McKiernan, R Hagan, M Curry, GS McDonald, N Nolan, J Crowley, J Hegarty, E Lawlor, D Kelleher |
Gastroenterology | 2000 |
Ethanol Inhibition: The Humoral and Cellular Immune Response to Hepatitis C Virus NS5 Protein After Genetic Immunization
J Encke, JR Wands |
Alcoholism, clinical and experimental research | 2000 |
Asian perspectives on viral hepatitis: Hepatitis C virus infection
GW Mccaughan |
Journal of Gastroenterology and Hepatology | 2000 |
Immunology of hepatitis C virus infection
L Huang, MJ Koziel |
Current Opinion in Gastroenterology | 2000 |
Host–microbe interactions: viruses
SS Cooper, J Glenn, HB Greenberg |
Current Opinion in Microbiology | 2000 |
Immunological Responses in Patients Who Have Spontaneously Eradicated Hepatitis C Virus Infection
IM Zitron, M Laurinaitis, L Qu, AL Silverman, SC Gordon |
Viral Immunology | 2000 |
SOLUBLE CD30 SERUM LEVEL IN HCV-POSITIVE CHRONIC ACTIVE HEPATITIS: A SURROGATE MARKER OF DISEASE ACTIVITY?
FG Foschi, A Gramenzi, E Castelli, C Cursaro, S Pagani, M Margotti, A D'Errico, P Andreone, GF Stefanini, M Bernardi |
Cytokine | 2000 |
VIRAL HEPATITIS IN THE LIVER TRANSPLANT RECIPIENT
HR Rosen, P Martin |
Infectious Disease Clinics of North America | 2000 |
HEPATITIS C
CP Cheney, S Chopra, C Graham |
Infectious Disease Clinics of North America | 2000 |
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
F Lechner, DK Wong, PR Dunbar, R Chapman, RT Chung, P Dohrenwend, G Robbins, R Phillips, P Klenerman, BD Walker |
Journal of Experimental Medicine | 2000 |
Use of Conventional or Replicating Nucleic Acid-Based Vaccines and Recombinant Semliki Forest Virus-Derived Particles for the Induction of Immune Responses Against Hepatitis C Virus Core and E2 Antigens
O Vidalin, A Fournillier, N Renard, M Chen, E Depla, D Boucreux, C Brinster, T Baumert, I Nakano, Y Fukuda, P Liljeström, C Trépo, G Inchauspé |
Virology | 2000 |
Biomedical Research Reports
JY Lau, DN Standring |
Biomedical Research Reports | 2000 |
Activation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis
DI Tai, SL Tsai, YM Chen, YL Chuang, CY Peng, IS Sheen, CT Yeh, KS Chang, SN Huang, GC Kuo, YF Liaw |
Hepatology | 2000 |
Ethanol Inhibition: The Humoral and Cellular Immune Response to Hepatitis C Virus NS5 Protein After Genetic Immunization:
J Encke, JR Wands |
Alcoholism, clinical and experimental research | 2000 |
Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
M E Cramp, S Rossol, S Chokshi, P Carucci, R Williams, N V Naoumov |
Gastroenterology | 2000 |
Eradication of Hepatitis C Virus 1b by Interferon in a Health Care Worker with Acute Hepatitis following Needlestick Transmission from a Patient with Chronic Hepatitis C Unresponsive to Interferon
HT Mizuno |
Scandinavian Journal of Gastroenterology | 2000 |
Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients:
H Valdez, D Anthony, F Farukhi, A Patki, J Salkowitz, P Heeger, DL Peterson, AB Post, R Asaad, MM Lederman |
AIDS | 2000 |
Donor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: With particular reference to chronic rejection
N Ichikawa, AJ Demetris, TE Starzl, Q Ye, T Okuda, HJ Chun, K Liu, YM Kim, N Murase |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2000 |
Priming of hepatitis C virus-specific cytotoxic t lymphocytes in mice following portal vein injection of a liver-specific plasmid DNA: Priming of Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in Mice Following Portal Vein Injection of a Liver-Specific Plasmid DNA
AY Lee, WC Manning, CL Arian, NK Polakos, JL Barajas, JB Ulmer, M Houghton, X Paliard |
Hepatology | 2000 |
Liver-Derived Hepatitis C Virus(HCV)-Specific CD4+ T Cells Recognize Multiple HCV Epitopes and Produce Interferon Gamma
CA Schirren, MC Jung, JT Gerlach, T Worzfeld, G Baretton, M Mamin, NH Gruener, M Houghton, GR Pape |
Hepatology | 2000 |
Human leukocyte antigen DR markers as predictors of progression to liver transplantation in patients with chronic hepatitis C
DJ Brandhagen, JB Gross, JJ Poterucha, JJ Germer, AJ Czaja, CI Smith, AC Ribeiro, RB Guerrero, TM Therneau, E Schiff, FD Gordon, RH Wiesner, DH Persing |
The American Journal of Gastroenterology | 2000 |
The Hepatitis C Viruses
CH Hagedorn, CM Rice |
2000 | |
Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C
TJ Liang, B Rehermann, LB Seeff, JH Hoofnagle |
Annals of internal medicine | 2000 |
Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus? Lessons from studies using major histocompatibility complex class I peptide tetramers
CR Bangham, RM May, MA Novak, F Lechner, J Sullivan, H Spiegel, DF Nixon, B Ferrari, A Davis, B Borkowsky, H Pollack, E Barnes, G Dusheiko, P Klenerman |
Philosophical Transactions of The Royal Society B Biological Sciences | 2000 |
Immunology and Liver
MP Manns, G Paumgartner, U Leuschner |
2000 | |
The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies
P Farci, A Shimoda, A Coiana, G Diaz, G Peddis, JC Melpolder, A Strazzera, DY Chien, SJ Munoz, A Balestrieri, RH Purcell, HJ Alter |
Science | 2000 |
Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen
TM Allen, TU Vogel, DH Fuller, BR Mothé, S Steffen, JE Boyson, T Shipley, J Fuller, T Hanke, A Sette, JD Altman, B Moss, AJ McMichael, DI Watkins |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
L’hépatite C et la santé publique
DM Patrick, JA Buxton, M Bigham, RG Mathias |
Canadian journal of public health. Revue canadienne de sante publique | 2000 |
Immunopathogenesis of Viral Hepatitis
MU Mondelli |
Clinical Reviews in Allergy & Immunology | 2000 |
Public Health and Hepatitis C
Patrick DM, Buxton JA, Bigham M, Mathias RG |
2000 | |
Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization
JH Cho, SW Lee, YC Sung |
Vaccine | 1999 |
Analysis of a Successful Immune Response against Hepatitis C Virus
S Cooper, AL Erickson, EJ Adams, J Kansopon, AJ Weiner, DY Chien, M Houghton, P Parham, CM Walker |
Immunity | 1999 |
Targeting of Hepatitis C Virus Core Protein for MHC I or MHC II Presentation Does Not Enhance Induction of Immune Responses to DNA Vaccination
O Vidalin, E Tanaka, U Spengler, C Trepo, G Inchauspe |
DNA and Cell Biology | 1999 |
Hepatitis C virus–specific CD4+ T cells: Do they help or damage?
NV Naoumov |
Gastroenterology | 1999 |
Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia
ME Cramp, P Carucci, S Rossol, S Chokshi, G Maertens, R Williams, NV Naoumov |
Gut | 1999 |
Mechanisms of immune escape in viral hepatitis
W Rosenberg |
Gut | 1999 |
Longitudinal variation in hepatitis C virus (HCV) viraemia and early course of HCV infection after liver transplantation for HCV cirrhosis: the role of different immunosuppressive regimens
GV Papatheodoridis, SG Barton, D Andrew, G Clewley, S Davies, AP Dhillon, G Dusheiko, B Davidson, K Rolles, AK Burroughs |
Gut | 1999 |
Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy
SC Ray, YM Wang, O Laeyendecker, JR Ticehurst, SA Villano, DL Thomas |
Journal of virology | 1999 |
Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate
TF Baumert, J Vergalla, J Satoi, M Thomson, M Lechmann, D Herion, HB Greenberg, S Ito, TJ Liang |
Gastroenterology | 1999 |
Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation
HR Rosen, DJ Hinrichs, DR Gretch, MJ Koziel, S Chou, M Houghton, J Rabkin, CL Corless, HG Bouwer |
Gastroenterology | 1999 |
Hepatitis C virus: current understanding and prospects for future therapies
HR Rosen, DR Gretch |
Molecular Medicine Today | 1999 |
Stimulating protection
SJ Polyak, DR Gretch |
Trends in Microbiology | 1999 |
Influence of HLA alleles on outcome of hepatitis C virus infection
HM Diepolder, S Scholz, GR Pape |
The Lancet | 1999 |
Summary of the first international symposium on viral hepatitis
RP González-Peralta, GJ Galasso, T Poynard, S Schalm, HC Thomas, TL Wright |
Antiviral Research | 1999 |
Origin and Evolution of Viruses
JI Esteban, M Martell, WF Carman, J Gómez |
Origin and Evolution of Viruses | 1999 |
The outcome of hepatitis C virus infection after liver transplantation - is it influenced by the type of immunosuppression?
GV Papatheodoridis, D Patch, GM Dusheiko, AK Burroughs |
Journal of Hepatology | 1999 |
DNA vaccine strategies for hepatitis C
G Inchauspé |
Journal of Hepatology | 1999 |
Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C
HC Thomas, ME Török, DM Forton, SD Taylor-Robinson |
Journal of Hepatology | 1999 |
Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C
JT Gerlach, HM Diepolder, MC Jung, NH Gruener, WW Schraut, R Zachoval, R Hoffmann, CA Schirren, T Santantonio, GR Pape |
Gastroenterology | 1999 |
Regulation of immune reactivity and tolerance by antigen migration and localization: with particular reference to allo- and xenotransplantation
TE Starzl, N Murase, AW Thomson, M Trucco, A Rao |
Transplantation Proceedings | 1999 |
Immunity and tolerance are related, and governed by antigen migration and localization
TE Starzl, N Murase, AW Thomson, M Trucco, A Rao |
Transplantation Proceedings | 1999 |
Regulation of Immune Reactivity and Tolerance by Antigen Migration and Localization: With Particular Reference to Allo– and Xenotransplantation
TE Starzl, N Murase, AW Thomson, M Trucco, A Rao |
Transplantation Proceedings | 1999 |
Immunity and Tolerance Are Related, and Governed by Antigen Migration and Localization
TE Starzl, N Murase, AW Thomson, M Trucco, A Rao |
Transplantation Proceedings | 1999 |
Functionally distinct T-cell epitopes within the hepatitis C virus non-structural 3 protein
N M Tabatabai, T H Bian, C M Rice, Yoshizawa, J Gill, D D Eckels |
Human Immunology | 1999 |
Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells: Implications for vaccine development
V Lamonaca, G Missale, S Urbani, M Pilli, C Boni, C Mori, A Sette, M Massari, S Southwood, R Bertoni, A Valli, F Fiaccadori, C Ferrari |
Hepatology | 1999 |
Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease
M Asti, M Martinetti, C Zavaglia, MC Cuccia, L Gusberti, C Tinelli, A Cividini, S Bruno, L Salvaneschi, G Ideo, MU Mondelli, EM Silini |
Hepatology | 1999 |
Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection
SA Villano, D Vlahov, KE Nelson, S Cohn, DL Thomas |
Hepatology | 1999 |
INCREASED APOPTOSIS OF IMMUNOREACTIVE HOST CELLS AND AUGMENTED DONOR LEUKOCYTE CHIMERISM, NOT SUSTAINED INHIBITION OF B7 MOLECULE EXPRESSION ARE ASSOCIATED WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL IN MICE PRECONDITIONED WITH IMMATURE DONOR DENDRITIC CELLS PLUS ANTI-CD40L mAb1,2:
L Lu, W Li, C Zhong, S Qian, JJ Fung, AW Thomson, TE Starzl |
Transplantation | 1999 |
Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
SL Tsai, YM Chen, MH Chen, CY Huang, IS Sheen, CT Yeh, JH Huang, GC Kuo, YF Liaw |
Gastroenterology | 1998 |
Response to treatment of chronic hepatitis C with interferon α in patients infected with HIV-1 is associated with higher CD4+ cell count
S Mauss, H Klinker, A Ulmer, R Willers, B Weißbrich, H Albrecht, D Häussinger, H Jablonowski |
Infection | 1998 |
Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection
T Höhler, A Kruger, G Gerken, PM Schneider, KH Büschenfelde, C Rittner |
Journal of Medical Virology | 1998 |
Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity
J Alexander, MF Guercio, JD Fikes, RW Chesnut, FV Chisari, KM Chang, E Appella, A Sette |
Human Immunology | 1998 |
Evidence That both HIV and HIV-Induced Immunodeficiency Enhance HCV Replication among HCV Seroconverters
M Beld, M Penning, V Lukashov, M McMorrow, M Roos, N Pakker, A Hoek, J Goudsmit |
Virology | 1998 |
Inefficient Recognition of Autologous Viral Sequences by Intrahepatic Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in Chronically Infected Subjects
VM Giuggio, HL Bonkovsky, J Smith, AL Rothman |
Virology | 1998 |
Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs
M Geissler, K Tokushige, T Wakita, VR Zurawski, JR Wands |
Vaccine | 1998 |
Development of a multigenic plasmid vector for HCV DNA immunization
S Papa, M Rinaldi, A Mangia, P Parrella, E Signori, L Lombardi, VM Fazio |
Research in Virology | 1998 |
Decreased expression of the interleukin 2 receptor on CD8 recipient lymphocytes in intestinal grafts rendered tolerant by liver transplantation in rats
S Sarnacki, H Nakai, D Calise, T Azuma, N Brousse, Y Révillon, N Cerf-Bensussan |
Gut | 1998 |
Paradoxical early immune activation during acceptance of liver allografts compared with rejection of skin grafts in a rat model of transplantation
KL Rokahr, AF Sharland, J Sun, C Wang, AG Sheil, Y Yan, GW McCaughan, GA Bishop |
Immunology | 1998 |
Human and murine antibody recognition is focused on the ATPase/Helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein: Human and Murine Antibody Recognition Is Focused on the ATPase/Helicase, But Not the Protease Domain of the Hepatitis C Virus Nonstructural 3 Protein
M Chen, M Sällberg, A Sönnerborg, L Jin, A Birkett, D Peterson, O Weiland, DR Milich |
Hepatology | 1998 |
Cellular immunity to hepatitis C virus core protein and the response to interferon in patients with chronic hepatitis C: Cellular Immunity to Hepatitis C Virus Core Protein and the Response to Interferon in Patients With Chronic Hepatitis C
JJ Lasarte, M García-Granero, A López, N Casares, N García, MP Civeira, F Borrás-Cuesta, J Prieto |
Hepatology | 1998 |
Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C
DR Nelson, CG Marousis, T Ohno, GL Davis, JY Lau |
Hepatology | 1998 |
Interferon alfa treatment of HCV RNA carriers with persistently normal transaminase levels: A pilot randomized controlled study
A Sangiovanni, R Morales, GC Spinzi, MG Rumi, A Casiraghi, R Ceriani, E Colombo, M Fossati, A Prada, E Tavani, G Minoli |
Hepatology | 1998 |
DONOR PRETREATMENT WITH Flt-3 LIGAND AUGMENTS ANTIDONOR CYTOTOXIC T LYMPHOCYTE, NATURAL KILLER, AND LYMPHOKINE-ACTIVATED KILLER CELL ACTIVITIES WITHIN LIVER ALLOGRAFTS AND ALTERS THE PATTERN OF INTRAGRAFT APOPTOTIC ACTIVITY1,2:
S Qian, L Lu, F Fu, W Li, F Pan, RJ Steptoe, FG Chambers, TE Starzl, JJ Fung, AW Thomson |
Transplantation | 1998 |
Gene Vaccination: Theory and Practice
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1998 | |
Genes and Environment in Cancer
M Schwab, HM Rabes, K Munk, HP Hofschneider |
1998 | |
Human Tumor Viruses
DJ McCance |
1998 | |
Efficient Class II Major Histocompatibility Complex Presentation of Endogenously Synthesized Hepatitis C Virus Core Protein by Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Lines to CD4 + T Cells
M Chen, M Shirai, Z Liu, T Arichi, H Takahashi, M Nishioka |
Journal of virology | 1998 |
T cell mechanisms in the immunopathogenesis of viral hepatitis B and C
S Tsai, S Huang |
Journal of Gastroenterology and Hepatology | 1997 |
Future approaches to treatment of chronic hepatitis B and hepatitis C infection
HC Thomas, JA Waters |
Journal of Viral Hepatitis | 1997 |
The role of immune responses in the pathogenesis of hepatitis C virus infection
MJ Koziel |
Journal of Viral Hepatitis | 1997 |
In situ simultaneous detection of hepatitis C virus RNA and hepatitis C virus-related antigens in hepatocellular carcinoma
D Sansonno, V Cornacchiulo, V Racanelli, F Dammacco |
Cancer | 1997 |
Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
HM Diepolder, JT Gerlach, R Zachoval, RM Hoffmann, MC Jung, EA Wierenga, S Scholz, T Santantonio, M Houghton, S Southwood, A Sette, GR Pape |
Journal of virology | 1997 |
Role for CD4 positive T cell response in the pathogenesis of hepatitis B
GR Pape, MC Jung |
Journal of Hepatology | 1997 |
Comparative features of hepatitis C virus infection in humans and chimpanzees
CM Walker |
Springer Seminars in Immunopathology | 1997 |
Immunopathology of hepatitis C
KM Chang, B Rehermann, FV Chisari |
Springer Seminars in Immunopathology | 1997 |
Gene vaccination for hepatitis C
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Springer Seminars in Immunopathology | 1997 |
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