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Citations to this article

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
Published February 15, 1996
Citation Information: J Clin Invest. 1996;97(4):1056-1063. https://doi.org/10.1172/JCI118498.
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Research Article Article has an altmetric score of 3

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.

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Abstract

Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role for ICAM-1 in the pathophysiology of ischemic renal failure using mutant mice genetically deficient in ICAM-1. ICAM-1 is undetectable in mutant mice in contrast with normal mice, in which ICAM-1 is prominent in the endothelium of the vasa recta. Mutant mice are protected from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival . Renal leukocyte infiltration, quantitated morphologically and by measuring tissue myeloperoxidase, was markedly less in ICAM-1-deficient than control mice. To evaluate whether prevention of neutrophil infiltration could be responsible for the protection observed in the mutant mice, we treated normal mice with antineutrophil serum to reduce absolute neutrophil counts to < 100 cells/mm3. These neutrophil-depleted animals were protected against ischemic renal failure. Anti-1CAm-1 antibody protected normal mice against renal ischemic injury but did not provide additional protection to neutrophil-depleted animals. Thus, ICAM-1 is a key mediator of ischemic acute renal failure likely acting via potentiation of neutrophilendothelial interactions.

Authors

K J Kelly, W W Williams Jr, R B Colvin, S M Meehan, T A Springer, J C Gutierrez-Ramos, J V Bonventre

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 11 8 10 12 21 34 17 26 15 22 37 19 31 25 19 35 22 22 17 24 20 29 33 32 27 19 16 14 1 619
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Citations to this article in year 2017 (26)

Title and authors Publication Year
Arginase-2 mediates renal ischemia-reperfusion injury
WM Raup-Konsavage, T Gao, TK Cooper, SM Morris, WB Reeves, AS Awad
American journal of physiology. Renal physiology 2017
Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
A Kezić, N Stajic, F Thaiss
Journal of Immunology Research 2017
A review of the role of immune cells in acute kidney injury
A Bonavia, K Singbartl
Pediatric Nephrology 2017
Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia–Reperfusion Injury
L Danelli, LC Madjene, I Madera-Salcedo, G Gautier, E Pacreau, SB Mkaddem, N Charles, E Daugas, P Launay, U Blank
Journal of immunology (Baltimore, Md. : 1950) 2017
Impact of steroids on the inflammatory response after ischemic acute kidney injury in rats
J Fontana, A Vogt, A Hohenstein, U Vettermann, E Doroshenko, E Lammer, BA Yard, S Hoeger
Indian journal of nephrology 2017
Urinary IL-8 is a marker of early and long-term graft function after renal transplantation
E Kwiatkowska, L Domański, J Bober, K Safranow, J Szymańska-Pasternak, A Sulecka, A Pawlik, K Ciechanowski, S Kwiatkowski
Renal Failure 2017
Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
SC Kim, YS Ko, HY Lee, MG Kim, SK Jo, WY Cho
The Korean Journal of Internal Medicine 2017
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury
N Maicas, J der Vlag, J Bublitz, S Florquin, MB Bebber, CA Dinarello, V Verweij, R Masereeuw, LA Joosten, LB Hilbrands, JC Dussaule
PloS one 2017
The JNK Signaling Pathway in Renal Fibrosis
K Grynberg, FY Ma, DJ Nikolic-Paterson
Frontiers in physiology 2017
Single emergency room measurement of neutrophil/lymphocyte ratio for early detection of acute kidney injury (AKI)
MA Alfeilat, I Slotki, L Shavit
Internal and Emergency Medicine 2017
Osteopontin Blockade Attenuates Renal Injury After Ischemia Reperfusion by Inhibiting NK Cell Infiltration:
C Cen, M Aziz, WL Yang, JM Nicastro, GF Coppa, P Wang
Shock 2017
Quantified kidney echogenicity in mice with renal ischemia reperfusion injury: evaluation as a noninvasive biomarker of acute kidney injury
S Murata, N Sugiyama, K Maemura, Y Otsuki
Medical Molecular Morphology 2017
Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury
W Cho, JY Song, SW Oh, MG Kim, YS Ko, HY Lee, SK Jo
Journal of Korean Medical Science 2017
Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury
S Dube, T Matam, J Yen, HE Mang, PC Dagher, T Hato, TA Sutton
Journal of Immunology Research 2017
Protective Role for Antioxidants in Acute Kidney Disease.
Dennis JM, Witting PK
Nutrients 2017
Biomarkers of Kidney Disease
A Grubb
Biomarkers of Kidney Disease 2017
Mycophenolate mofetil improves renal haemodynamics, microvascular oxygenation, and inflammation in a rat model of supra-renal aortic clamping-mediated renal ischaemia reperfusion injury
B Ergin, M Heger, A Kandil, C Demirci-Tansel, C Ince
Clinical and Experimental Pharmacology and Physiology 2017
Imaging Leukocyte Responses in the Kidney:
M Finsterbusch, AR Kitching, MJ Hickey
Transplantation 2017
Complement in renal transplantation: The road to translation
NM Jager, F Poppelaars, MR Daha, MA Seelen
Molecular Immunology 2017
A Critical Evaluation of Vitamin D - Clinical Overview
S Gowder
A Critical Evaluation of Vitamin D - Clinical Overview 2017
Anti-inflammatory and protective effects of saffron extract in ischaemia/reperfusion-induced acute kidney injury: AKI: Anti inflammatory effect of saffron
L Mahmoudzadeh, H Najafi, SC Ashtiyani, ZM Yarijani
Nephrology 2017
Immunologic Mechanism of Ischemia Reperfusion Injury in Transplantation
JS Lee
The Journal of the Korean Society for Transplantation 2017
Protective effect of Malva sylvestris L. extract in ischemia-reperfusion induced acute kidney and remote liver injury
H Najafi, ZM Yarijani, S Changizi-Ashtiyani, K Mansouri, M Modarresi, SH Madani, B Bastani, F Gallyas
PloS one 2017
Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries
Zeynab Mohamadi Yarijani, Ali Pourmotabbed, Tayebeh Pourmotabbed, Houshang Najafi
Iranian Journal of Basic Medical Sciences 2017
Mycophenolate mofetil attenuates uterine ischaemia/reperfusion injury in a rat model
GS Ersoy, MK Eken, O Cevik, OT Cilingir, R Tal
Reproductive BioMedicine Online 2017
Estradiol Modulates Local Gut Injury Induced by Intestinal Ischemia-Reperfusion in Male Rats:
FY Ricardo-da-Silva, ET Fantozzi, S Rodrigues-Garbin, RM Oliveira-Filho, BB Vargaftig, AC Breithaupt-Faloppa, WT de Lima
Shock 2017

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