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Citations to this article

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
Published February 15, 1996
Citation Information: J Clin Invest. 1996;97(4):1056-1063. https://doi.org/10.1172/JCI118498.
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Research Article Article has an altmetric score of 3

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.

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Abstract

Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role for ICAM-1 in the pathophysiology of ischemic renal failure using mutant mice genetically deficient in ICAM-1. ICAM-1 is undetectable in mutant mice in contrast with normal mice, in which ICAM-1 is prominent in the endothelium of the vasa recta. Mutant mice are protected from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival . Renal leukocyte infiltration, quantitated morphologically and by measuring tissue myeloperoxidase, was markedly less in ICAM-1-deficient than control mice. To evaluate whether prevention of neutrophil infiltration could be responsible for the protection observed in the mutant mice, we treated normal mice with antineutrophil serum to reduce absolute neutrophil counts to < 100 cells/mm3. These neutrophil-depleted animals were protected against ischemic renal failure. Anti-1CAm-1 antibody protected normal mice against renal ischemic injury but did not provide additional protection to neutrophil-depleted animals. Thus, ICAM-1 is a key mediator of ischemic acute renal failure likely acting via potentiation of neutrophilendothelial interactions.

Authors

K J Kelly, W W Williams Jr, R B Colvin, S M Meehan, T A Springer, J C Gutierrez-Ramos, J V Bonventre

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 11 8 10 12 21 34 17 26 15 22 37 19 31 25 19 35 22 22 17 24 20 29 33 32 27 19 16 14 1 619
Citation information
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Citations to this article in year 2009 (35)

Title and authors Publication Year
Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
M Liu, DN Grigoryev, MT Crow, M Haas, M Yamamoto, SP Reddy, H Rabb
Kidney International 2009
IRF-1 promotes inflammation early after ischemic acute kidney injury
Y Wang, R John, J Chen, JA Richardson, JM Shelton, M Bennett, XJ Zhou, GT Nagami, Y Zhang, QQ Wu, CY Lu
Journal of the American Society of Nephrology : JASN 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The innate immune response in ischemic acute kidney injury
HR Jang, H Rabb
Clinical Immunology 2009
The interaction between ischemia–reperfusion and immune responses in the kidney
HR Jang, GJ Ko, BA Wasowska, H Rabb
Journal of Molecular Medicine 2009
Mediators of Inflammation in Acute Kidney Injury
A Akcay, Q Nguyen, CL Edelstein
Mediators of Inflammation 2009
Lymphocytes and ischemia-reperfusion injury
D Linfert, T Chowdhry, H Rabb
Transplantation reviews (Orlando, Fla.) 2009
Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury
HR Jang, MT Gandolfo, GJ Ko, S Satpute, L Racusen, H Rabb
American journal of physiology. Renal physiology 2009
Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury
GR Kinsey, R Sharma, L Huang, L Li, AL Vergis, H Ye, ST Ju, MD Okusa
Journal of the American Society of Nephrology : JASN 2009
Contribution of T lymphocytes to rat renal ischemia/reperfusion injury
E Noiri, K Doi, R Inagi, M Nangaku, T Fujita
Clinical and Experimental Nephrology 2009
Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury
AS Awad, M Rouse, L Huang, AL Vergis, J Reutershan, HP Cathro, J Linden, MD Okusa
Kidney International 2009
Dexamethasone Ameliorates Renal Ischemia-Reperfusion Injury
S Kumar, DA Allen, JE Kieswich, NS Patel, S Harwood, E Mazzon, S Cuzzocrea, MJ Raftery, C Thiemermann, MM Yaqoob
Journal of the American Society of Nephrology : JASN 2009
Soluble Thrombomodulin Protects Ischemic Kidneys
AA Sharfuddin, RM Sandoval, DT Berg, GE McDougal, SB Campos, CL Phillips, BE Jones, A Gupta, BW Grinnell, BA Molitoris
Journal of the American Society of Nephrology : JASN 2009
Impaired blood flow in acute kidney injury: pathophysiology and potential efficacy of intrarenal vasodilator therapy
JA Tumlin
Current Opinion in Critical Care 2009
Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease
BS van der Veen, MP de Winther, P Heeringa
Antioxidants & Redox Signaling 2009
Protective Effects of Pycnogenol against Ischemia Reperfusion-Induced Oxidative Renal Injury in Rats
AO Şehirli, G Şener, F Ercan
Renal Failure 2009
The role of the microcirculation in acute kidney injury
ML Dorze, M Legrand, D Payen, C Ince
Current Opinion in Critical Care 2009
Alteration of microvascular permeability in acute kidney injury
TA Sutton
Microvascular Research 2009
Amelioration of renal ischaemia-reperfusion injury by synthetic oligopeptides related to human chorionic gonadotropin
NA Khan, D Susa, JW van Berg, M Huisman, MH Ameling, S Engel, HP Roest, JN IJzermans, WA Dik, R Benner, RW de Bruin
Nephrology Dialysis Transplantation 2009
Immune mechanisms and novel pharmacological therapies of acute kidney injury
A Bajwa, GR Kinsey, MD Okusa
Current drug targets 2009
Blockade of KATPChannels Reduces Endothelial Hyperpolarization and Leukocyte Recruitment upon Reperfusion After Hypoxia
M Figura, L Chilton, A Liacini, MM Viskovic, V Phan, D Knight, TM Millar, K Patel, P Kubes, WR Giles, LA Tibbles
American Journal of Transplantation 2009
Comparative proteome analysis of TGF-β1-induced fibrosis processes in normal rat kidney interstitial fibroblast cells in response to ascofuranone
JH Kang, HJ Cho, IS Lee, M Kim, IK Lee, YC Chang
PROTEOMICS 2009
Posttreatment with Aminoguanidine Attenuates Renal Ischemia/Reperfusion Injury in Rats
Y Onem, OM Ipcioglu, A Haholu, H Sen, S Aydinoz, S Suleymanoglu, O Bilgi, I Akyol
Renal Failure 2009
Montelukast Protects Axial Pattern Rat Skin Flaps Against Ischemia/Reperfusion Injury
K Gideroglu, F Yilmaz, F Aksoy, G Bugdayci, I Saglam, F Yimaz
Journal of Surgical Research 2009
Up-Regulation of ICAM-1 During Cold Ischemia Triggers Early Neutrophil Infiltration in Human Pancreas Allograft Reperfusion
R Wiessner, S Eisold, M Linnebacher, C Bünger, H Nizze, R Wacke, S Benz, W Schareck, E Klar
Transplantation Proceedings 2009
Pretreatment With the Tumor Nerosis Factor-α Blocker Etanercept Attenuated Ischemia-Reperfusion Renal Injury
DE Choi, JY Jeong, BJ Lim, KR Na, YT Shin, KW Lee
Transplantation Proceedings 2009
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism
X Wu, R Guo, P Chen, Q Wang, PN Cunningham
American journal of physiology. Renal physiology 2009
Postischemic inflammatory syndrome: a critical mechanism of progression in diabetic nephropathy
KJ Kelly, JL Burford, JH Dominguez
American journal of physiology. Renal physiology 2009
Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo
KJ Kelly, B Kluve-Beckerman, JH Dominguez
American journal of physiology. Renal physiology 2009
Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury
HR Jang, MT Gandolfo, GJ Ko, S Satpute, L Racusen, H Rabb
American journal of physiology. Renal physiology 2009
Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury
YJ Jung, DH Kim, AS Lee, S Lee, KP Kang, SY Lee, KY Jang, MJ Sung, SK Park, W Kim
American journal of physiology. Renal physiology 2009
Early monitoring of acute tubular necrosis in the rat kidney by 23 Na-MRI
BK Atthe, AM Babsky, PN Hopewell, CL Phillips, BA Molitoris, N Bansal
American journal of physiology. Renal physiology 2009
Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery
JY Han, Y Horie, JY Fan, K Sun, J Guo, S Miura, T Hibi
AJP Gastrointestinal and Liver Physiology 2009
Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats
DE Choi, JY Jeong, BJ Lim, S Chung, YK Chang, SJ Lee, KR Na, SY Kim, YT Shin, KW Lee
American journal of physiology. Renal physiology 2009
Management of Acute Kidney Problems
A Jörres, C Ronco, JA Kellum
2009

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