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Citations to this article

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
K J Kelly, … , J C Gutierrez-Ramos, J V Bonventre
Published February 15, 1996
Citation Information: J Clin Invest. 1996;97(4):1056-1063. https://doi.org/10.1172/JCI118498.
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Research Article Article has an altmetric score of 3

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.

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Abstract

Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role for ICAM-1 in the pathophysiology of ischemic renal failure using mutant mice genetically deficient in ICAM-1. ICAM-1 is undetectable in mutant mice in contrast with normal mice, in which ICAM-1 is prominent in the endothelium of the vasa recta. Mutant mice are protected from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival . Renal leukocyte infiltration, quantitated morphologically and by measuring tissue myeloperoxidase, was markedly less in ICAM-1-deficient than control mice. To evaluate whether prevention of neutrophil infiltration could be responsible for the protection observed in the mutant mice, we treated normal mice with antineutrophil serum to reduce absolute neutrophil counts to < 100 cells/mm3. These neutrophil-depleted animals were protected against ischemic renal failure. Anti-1CAm-1 antibody protected normal mice against renal ischemic injury but did not provide additional protection to neutrophil-depleted animals. Thus, ICAM-1 is a key mediator of ischemic acute renal failure likely acting via potentiation of neutrophilendothelial interactions.

Authors

K J Kelly, W W Williams Jr, R B Colvin, S M Meehan, T A Springer, J C Gutierrez-Ramos, J V Bonventre

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 11 8 10 12 21 34 17 26 15 22 37 19 31 25 19 35 22 22 17 24 20 29 33 32 27 19 16 14 1 619
Citation information
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Citations to this article in year 2007 (22)

Title and authors Publication Year
Myeloperoxidase Is Critically Involved in the Induction of Organ Damage after Renal Ischemia Reperfusion
RA Matthijsen, D Huugen, NT Hoebers, B Vries, CJ Peutz-Kootstra, Y Aratani, MR Daha, JW Tervaert, WA Buurman, P Heeringa
The American Journal of Pathology 2007
Triggers of inflammation after renal ischemia/reperfusion
JM Thurman
Clinical Immunology 2007
C3a Is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renal Ishemia/Reperfusion
JM Thurman, AM Lenderink, PA Royer, KE Coleman, J Zhou, JD Lambris, RA Nemenoff, RJ Quigg, VM Holers
Journal of immunology (Baltimore, Md. : 1950) 2007
Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice
DJ Oh, B Dursun, Z He, L Lu, TS Hoke, D Ljubanovic, S Faubel, CL Edelstein
American journal of physiology. Renal physiology 2007
Melatonin protects from ischemia/reperfusion-induced renal injury in rats: this effect is not mediated by proinflammatory cytokines
Z Kurcer, E Oguz, H Ozbilge, F Baba, N Aksoy, H Çelik, H Çakır, MR Gezen
Journal of Pineal Research 2007
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation
A Zarbock, M Schmolke, SG Bockhorn, M Scharte, K Buschmann, K Ley, K Singbartl
Critical Care Medicine 2007
Early diagnosis of acute kidney injury
SM Bagshaw, R Bellomo
Current Opinion in Critical Care 2007
Decreased renal ischemia–reperfusion injury by IL-16 inactivation
S Wang, H Diao, Q Guan, WW Cruikshank, TL Delovitch, AM Jevnikar, C Du
Kidney International 2007
CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli O157:H7-associated renal inflammation
JK Roche, TR Keepers, LK Gross, RM Seaner, TG Obrig
The American Journal of Pathology 2007
Glibenclamide Effects on Renal Function and Histology after Acute Hemorrhage in Rats under Sevoflurane Anesthesia
LA Diego, CD Marques, PT Vianna, RM Viero, JR Braz, YM Castiglia
Renal Failure 2007
Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast
G Şener, A Sakarcan, Ö Şehirli, E Ekşioğlu-Demiralp, E Şener, F Ercan, N Gedik, BÇ Yeğen
Prostaglandins & Other Lipid Mediators 2007
The Interleukin-12 Family: New Players in Transplantation Immunity?
S Goriely, M Goldman
American Journal of Transplantation 2007
Donor Dopamine Pretreatment Inhibits Tubulitis in Renal Allografts Subjected to Prolonged Cold Preservation
Z Liu, S Hoeger, P Schnuelle, Y Feng, U Goettmann, R Waldherr, FJ van der Woude, B Yard
Transplantation 2007
Renal protection by delayed ischaemic preconditioning is associated with inhibition of the inflammatory response and NF-κB activation
SH Jiang, CF Liu, XL Zhang, XH Xu, JZ Zou, Y Fang, XQ Ding
Cell Biochemistry and Function 2007
TYK2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 CONTRIBUTE TO INTESTINAL I/R INJURY
G Costantino, M Egerbacher, T Kolbe, M Karaghiosoff, B Strobl, C Vogl, M Helmreich, M Müller
Shock 2007
Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion
M Ueki, S Taie, K Chujo, T Asaga, Y Iwanaga, N Maekawa
Journal of Bioscience and Bioengineering 2007
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation:
A Zarbock, M Schmolke, SG Bockhorn, M Scharte, K Buschmann, K Ley, K Singbartl
Critical Care Medicine 2007
Contribution of CD4+ T cells to the early mechanisms of ischemia- reperfusion injury in a mouse model of acute renal failure
HS Pinheiro, NO Camara, IL Noronha, IL Maugeri, MF Franco, JO Medina, A Pacheco-Silva
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2007
The role of ICAM-1 in endotoxin-induced acute renal failure
X Wu, R Guo, Y Wang, PN Cunningham
American journal of physiology. Renal physiology 2007
Rapid determination of renal filtration function using an optical ratiometric imaging approach
W Yu, RM Sandoval, BA Molitoris
American journal of physiology. Renal physiology 2007
L’insuffisance rénale aiguë
L Jacob
2007
Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury
RD Paola, S Cuzzocrea
Naunyn-Schmiedeberg's Archives of Pharmacology 2007

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