Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role for ICAM-1 in the pathophysiology of ischemic renal failure using mutant mice genetically deficient in ICAM-1. ICAM-1 is undetectable in mutant mice in contrast with normal mice, in which ICAM-1 is prominent in the endothelium of the vasa recta. Mutant mice are protected from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival . Renal leukocyte infiltration, quantitated morphologically and by measuring tissue myeloperoxidase, was markedly less in ICAM-1-deficient than control mice. To evaluate whether prevention of neutrophil infiltration could be responsible for the protection observed in the mutant mice, we treated normal mice with antineutrophil serum to reduce absolute neutrophil counts to < 100 cells/mm3. These neutrophil-depleted animals were protected against ischemic renal failure. Anti-1CAm-1 antibody protected normal mice against renal ischemic injury but did not provide additional protection to neutrophil-depleted animals. Thus, ICAM-1 is a key mediator of ischemic acute renal failure likely acting via potentiation of neutrophilendothelial interactions.
K J Kelly, W W Williams Jr, R B Colvin, S M Meehan, T A Springer, J C Gutierrez-Ramos, J V Bonventre
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American journal of physiology. Renal physiology | 2007 |
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A Zarbock, M Schmolke, SG Bockhorn, M Scharte, K Buschmann, K Ley, K Singbartl |
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Current Opinion in Critical Care | 2007 |
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S Wang, H Diao, Q Guan, WW Cruikshank, TL Delovitch, AM Jevnikar, C Du |
Kidney International | 2007 |
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JK Roche, TR Keepers, LK Gross, RM Seaner, TG Obrig |
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LA Diego, CD Marques, PT Vianna, RM Viero, JR Braz, YM Castiglia |
Renal Failure | 2007 |
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G Şener, A Sakarcan, Ö Şehirli, E Ekşioğlu-Demiralp, E Şener, F Ercan, N Gedik, BÇ Yeğen |
Prostaglandins & Other Lipid Mediators | 2007 |
The Interleukin-12 Family: New Players in Transplantation Immunity?
S Goriely, M Goldman |
American Journal of Transplantation | 2007 |
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Z Liu, S Hoeger, P Schnuelle, Y Feng, U Goettmann, R Waldherr, FJ van der Woude, B Yard |
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SH Jiang, CF Liu, XL Zhang, XH Xu, JZ Zou, Y Fang, XQ Ding |
Cell Biochemistry and Function | 2007 |
TYK2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 CONTRIBUTE TO INTESTINAL I/R INJURY
G Costantino, M Egerbacher, T Kolbe, M Karaghiosoff, B Strobl, C Vogl, M Helmreich, M Müller |
Shock | 2007 |
Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion
M Ueki, S Taie, K Chujo, T Asaga, Y Iwanaga, N Maekawa |
Journal of Bioscience and Bioengineering | 2007 |
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation:
A Zarbock, M Schmolke, SG Bockhorn, M Scharte, K Buschmann, K Ley, K Singbartl |
Critical Care Medicine | 2007 |
Contribution of CD4+ T cells to the early mechanisms of ischemia- reperfusion injury in a mouse model of acute renal failure
HS Pinheiro, NO Camara, IL Noronha, IL Maugeri, MF Franco, JO Medina, A Pacheco-Silva |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2007 |
The role of ICAM-1 in endotoxin-induced acute renal failure
X Wu, R Guo, Y Wang, PN Cunningham |
American journal of physiology. Renal physiology | 2007 |
Rapid determination of renal filtration function using an optical ratiometric imaging approach
W Yu, RM Sandoval, BA Molitoris |
American journal of physiology. Renal physiology | 2007 |
L’insuffisance rénale aiguë
L Jacob |
2007 | |
Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury
RD Paola, S Cuzzocrea |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2007 |