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Citations to this article

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.
B M Johnston, … , C E Williams, P D Gluckman
B M Johnston, … , C E Williams, P D Gluckman
Published January 15, 1996
Citation Information: J Clin Invest. 1996;97(2):300-308. https://doi.org/10.1172/JCI118416.
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Research Article Article has an altmetric score of 6

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.

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Abstract

This study was designed to determine the potential of IGF-1 as a neuronal rescue agent after cerebral ischemia. Unanesthetized late gestation fetal sheep were subjected to 30-min cerebral ischemia by inflation of carotid artery occluder cuffs. 2 h later either 0.1 microgram rhIGF-1, 1 microgram rhIGF-1, 10 micrograms rhIGF-1, or vehicle was infused into a lateral cerebral ventricle over 1 h. Histologic outcome was assessed 5 d later. Overall neuronal loss was reduced with 0.1 microgram (P < 0.05) and 1 microgram (P < 0.002) rhIGF-1, but treatment with 10 micrograms was not effective. With 1 microgram rhIGF-1 neuronal loss scores were significantly lower in brain regions examined including cortex, hippocampus, and striatum, whereas with 0.1 microgram rhIGF-1 the parietal cortex and thalamus were not improved and the improvement seen in other regions was less than with 1 microgram rhIGF-1. Treatment with 1 microgram rhIGF-1 also delayed the onset of seizures and reduced their incidence. Moreover, the secondary phase of cytotoxic edema was reduced and delayed in onset. We conclude that low dose rhIGF-1 therapy promotes neuronal rescue after cerebral hypoxic-ischemic injury in utero, but the effect is dose dependent. Importantly, rhIGF-1 is effective and nontoxic when administered 2 h after the hypoxic ischemic insult. This distinguishes IGF-1 from most other neuroprotective therapies and suggests clinical application may be possible.

Authors

B M Johnston, E C Mallard, C E Williams, P D Gluckman

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Total citations by year

Year: 2024 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1993 Total
Citations: 2 1 1 4 3 2 2 3 3 2 6 5 2 7 8 7 5 10 7 5 7 13 9 10 12 12 1 1 150
Citation information
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Citations to this article in year 1998 (12)

Title and authors Publication Year
Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke
SA Loddick, XJ Liu, ZX Lu, C Liu, DP Behan, DC Chalmers, AC Foster, WW Vale, N Ling, EB de Souza
Proceedings of the National Academy of Sciences 1998
Asphyxial brain injury—the role of the IGF system
PD Gluckman, J Guan, C Williams, A Scheepens, R Zhang, L Bennet, A Gunn
Molecular and Cellular Endocrinology 1998
The role of neuronal growth factors in neurodegenerative disorders of the human brain
B Connor, M Dragunow
Brain Research Reviews 1998
Effects of Chronic Placental Insufficiency on Brain Development in Fetal Sheep
EC Mallard, S Rees, M Stringer, ML Cock, R Harding
Pediatric Research 1998
Maturational Change in the Cortical Response to Hypoperfusion Injury in the Fetal Sheep
K Reddy, C Mallard, J Guan, K Marks, L Bennet, M Gunning, A Gunn, P Gluckman, C Williams
Pediatric Research 1998
Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors
M Tamatani, S Ogawa, M Tohyama
Molecular Brain Research 1998
Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic–ischemic injury
EJ Beilharz, VC Russo, G Butler, NL Baker, B Connor, ES Sirimanne, M Dragunow, GA Werther, PD Gluckman, CE Williams, A Scheepens
Molecular Brain Research 1998
Les leucomalacies périventriculaires. I. Aspects histologiques et étiopathogéniques
S Marret, V Zupan, P Gressens, H Lagercrantz, P Evrard
Archives de Pédiatrie 1998
Pharmacological strategies for the prevention of perinatal brain damage
AJ Gunn, PD Gluckman
Seminars in Neonatology 1998
The insulin-like growth factor-I receptor: Implications for the aging process
D Lcroith, A Butler, VA Blakesley
The Aging Male 1998
Ischemia and Reperfusion Injury: The Ultimate Pathophysiologic Paradox
C Hammerman, M Kaplan
Clinics in Perinatology 1998
IGFs in the Nervous System
EE Müller
1998

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