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Citations to this article

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.
B M Johnston, … , C E Williams, P D Gluckman
B M Johnston, … , C E Williams, P D Gluckman
Published January 15, 1996
Citation Information: J Clin Invest. 1996;97(2):300-308. https://doi.org/10.1172/JCI118416.
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Research Article Article has an altmetric score of 6

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.

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Abstract

This study was designed to determine the potential of IGF-1 as a neuronal rescue agent after cerebral ischemia. Unanesthetized late gestation fetal sheep were subjected to 30-min cerebral ischemia by inflation of carotid artery occluder cuffs. 2 h later either 0.1 microgram rhIGF-1, 1 microgram rhIGF-1, 10 micrograms rhIGF-1, or vehicle was infused into a lateral cerebral ventricle over 1 h. Histologic outcome was assessed 5 d later. Overall neuronal loss was reduced with 0.1 microgram (P < 0.05) and 1 microgram (P < 0.002) rhIGF-1, but treatment with 10 micrograms was not effective. With 1 microgram rhIGF-1 neuronal loss scores were significantly lower in brain regions examined including cortex, hippocampus, and striatum, whereas with 0.1 microgram rhIGF-1 the parietal cortex and thalamus were not improved and the improvement seen in other regions was less than with 1 microgram rhIGF-1. Treatment with 1 microgram rhIGF-1 also delayed the onset of seizures and reduced their incidence. Moreover, the secondary phase of cytotoxic edema was reduced and delayed in onset. We conclude that low dose rhIGF-1 therapy promotes neuronal rescue after cerebral hypoxic-ischemic injury in utero, but the effect is dose dependent. Importantly, rhIGF-1 is effective and nontoxic when administered 2 h after the hypoxic ischemic insult. This distinguishes IGF-1 from most other neuroprotective therapies and suggests clinical application may be possible.

Authors

B M Johnston, E C Mallard, C E Williams, P D Gluckman

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Total citations by year

Year: 2024 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1993 Total
Citations: 2 1 1 4 3 2 2 3 3 2 6 5 2 7 8 7 5 10 7 5 7 13 9 10 12 12 1 1 150
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 1997 (12)

Title and authors Publication Year
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs
AJ Gunn, TR Gunn, HH de Haan, CE Williams, PD Gluckman
Journal of Clinical Investigation 1997
Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain
P Gressens, S Marret, JM Hill, DE Brenneman, I Gozes, M Fridkin, P Evrard
Journal of Clinical Investigation 1997
The Spatial and Temporal Distribution of Insulin-Like Growth Factor-1 Following Experimental Myocardial Infarction in the Rat
RV MApplSc, LM PhD, NS PhD, JB DSc, PD DSc, BM DPhil
Cardiovascular Pathology 1997
Ethanol Promotes Cell Death by Inhibition of the Insulin-Like Growth Factor I Receptor
S Cui, M Tewari, T Schneider, R Rubin
Alcoholism, clinical and experimental research 1997
The effect of insulin-like growth factors on brain myelination and their potential therapeutic application in myelination disorders
W Zumkeller
European Journal of Paediatric Neurology 1997
Brief Repeated Umbilical Cord Occlusions Cause Sustained Cytotoxic Cerebral Edema and Focal Infarcts in Near-Term Fetal Lambs
HH de Haan, AJ Gunn, CE Williams, PD Gluckman
Pediatric Research 1997
Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity
WC Wallace, CA Akar, WE Lyons, HK Kole, JM Egan, B Wolozin
Molecular Brain Research 1997
Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus
B Connor, EJ Beilharz, C Williams, B Synek, PD Gluckman, RL Faull, M Dragunow
Molecular Brain Research 1997
rhIGF-I administration in humans: differential metabolic effects of bolus vs. continuous subcutaneous delivery
N Mauras, PM Martha, V Quarmby, MW Haymond
American journal of physiology. Endocrinology and metabolism 1997
Plasma Insulin-like Growth Factor I and IGF Binding Protein 3 Levels in Patients With Acute Cerebral Ischemic Injury
S Schwab, M Spranger, S Krempien, W Hacke, M Bettendorf
Stroke; a journal of cerebral circulation 1997
Selective expression of insulin-like growth factor II in the songbird brain
M Holzenberger, E D Jarvis, C Chong, M Grossman, F Nottebohm, C Scharff
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
Selective Expression of Insulin-Like Growth Factor II in the Songbird Brain
Holzenberger M, Jarvis ED, Chong C, Grossman M, Nottebohm F, Scharff C
Journal of Neuroscience 1997

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