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Citations to this article

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.
T Morita, S Kourembanas
T Morita, S Kourembanas
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2676-2682. https://doi.org/10.1172/JCI118334.
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Research Article Article has an altmetric score of 9

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

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Abstract

CO is produced in vascular smooth muscle cells (VSMC) by heme oxygenase-1 (HO-1). CO increases cGMP levels in VSMC; however, its possible additional roles in the vasculature have not been examined. We report that a product of HO, released from VSMC and inhibited by hemoglobin, has paracrine effects on endothelial cells: it increases endothelial cGMP content and decreases the expression of the mitogens, endothelin-1 (ET-1) and platelet-derived growth factor-B (PDGF-B). This product has the characteristics of CO, and its production is increased sevenfold under hypoxia. The VSMC-derived CO caused a fourfold rise in endothelial cell cGMP. In addition, it inhibited the hypoxia-induced increases in mRNA levels of the ET-1 and PDGF-B genes. Inhibitors of HO, and hemoglobin, a scavenger of CO, prevented the rise in cGMP and also restored the hypoxic response of these genes. The inhibition of ET-1 and PDGF-B mRNA by CO resulted in decreased production of these endothelial-derived mitogens, and in turn, inhibition of VSMC proliferation. These findings suggest an important physiologic role for VSMC-derived CO in modulating cell-cell interaction and cell proliferation in the vessel wall during hypoxia.

Authors

T Morita, S Kourembanas

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Total citations by year

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Citations: 3 1 2 1 3 3 2 2 2 2 5 4 9 13 11 16 8 8 14 16 19 18 18 31 22 17 16 9 13 288
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Citations to this article in year 2013 (9)

Title and authors Publication Year
The immunomodulatory role of carbon monoxide during transplantation
M Amano, NO Camara
Medical Gas Research 2013
Nrf2 and Cardiovascular Defense
R Howden
Oxidative medicine and cellular longevity 2013
Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model
S Schulz, RJ Wong, KY Jang, F Kalish, KM Chisholm, H Zhao, HJ Vreman, KG Sylvester, DK Stevenson
American journal of physiology. Gastrointestinal and liver physiology 2013
Carbon monoxide: present and future indications for a medical gas
SW Ryter, AM Choi
The Korean Journal of Internal Medicine 2013
Shorter GT repeats in the heme oxygenase-1 gene promoter are associated with a lower severity score in coronary artery disease
KW Liang, WH Sheu, WL Lee, IT Lee, SY Lin, CT Ting, WJ Lee
Journal of the Chinese Medical Association 2013
Hypoxic Pulmonary Vasoconstriction
ER Swenson
High Altitude Medicine & Biology 2013
Carbon monoxide stimulates Ca 2+ -dependent big-conductance K channels in the cortical collecting duct
Z Wang, P Yue, DH Lin, WH Wang
American journal of physiology. Renal physiology 2013
Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model
S Schulz, RJ Wong, KY Jang, F Kalish, KM Chisholm, H Zhao, HJ Vreman, KG Sylvester, DK Stevenson
AJP Gastrointestinal and Liver Physiology 2013
Hydrogen sulfide, another simple gas with complex biology
C Guettler, P Kubes
AJP Gastrointestinal and Liver Physiology 2013

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