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Citations to this article

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.
T Morita, S Kourembanas
T Morita, S Kourembanas
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2676-2682. https://doi.org/10.1172/JCI118334.
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Research Article Article has an altmetric score of 9

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

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Abstract

CO is produced in vascular smooth muscle cells (VSMC) by heme oxygenase-1 (HO-1). CO increases cGMP levels in VSMC; however, its possible additional roles in the vasculature have not been examined. We report that a product of HO, released from VSMC and inhibited by hemoglobin, has paracrine effects on endothelial cells: it increases endothelial cGMP content and decreases the expression of the mitogens, endothelin-1 (ET-1) and platelet-derived growth factor-B (PDGF-B). This product has the characteristics of CO, and its production is increased sevenfold under hypoxia. The VSMC-derived CO caused a fourfold rise in endothelial cell cGMP. In addition, it inhibited the hypoxia-induced increases in mRNA levels of the ET-1 and PDGF-B genes. Inhibitors of HO, and hemoglobin, a scavenger of CO, prevented the rise in cGMP and also restored the hypoxic response of these genes. The inhibition of ET-1 and PDGF-B mRNA by CO resulted in decreased production of these endothelial-derived mitogens, and in turn, inhibition of VSMC proliferation. These findings suggest an important physiologic role for VSMC-derived CO in modulating cell-cell interaction and cell proliferation in the vessel wall during hypoxia.

Authors

T Morita, S Kourembanas

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Citations to this article in year 2008 (8)

Title and authors Publication Year
Pharmacological and Clinical Aspects of Heme Oxygenase
NG Abraham, A Kappas
Pharmacological reviews 2008
Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology: Focus on Angiogenesis
J Dulak, J Deshane, A Jozkowicz, A Agarwal
Circulation 2008
Hemoxygenase-1 in Cardiovascular Disease
NK Idriss, AD Blann, GY Lip
Journal of the American College of Cardiology 2008
The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells
J Guan, X Wu, E Arons, H Christou
Journal of Cellular Biochemistry 2008
Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities
A Loboda, A Jazwa, A Grochot-Przeczek, AJ Rutkowski, J Cisowski, A Agarwal, A Jozkowicz, J Dulak
Antioxidants & Redox Signaling 2008
Protection Against Blast-Induced Mortality in Rats by Hemin
M Chavko, WK Prusaczyk, RM McCarron
The Journal of Trauma: Injury, Infection, and Critical Care 2008
Iron chelators can protect against oxidative stress through ferryl heme reduction
BJ Reeder, RC Hider, MT Wilson
Free radical biology & medicine 2008
Ischemia-Induced Up-Regulation of Heme Oxygenase-1 Protects From Apoptotic Cell Death and Tissue Necrosis
Y Harder, M Amon, R Schramm, M Rücker, C Scheuer, B Pittet, D Erni, MD Menger
Journal of Surgical Research 2008

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Referenced in 15 patents
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