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Citations to this article

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.
W E Carson, … , K Grabstein, M A Caligiuri
W E Carson, … , K Grabstein, M A Caligiuri
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2578-2582. https://doi.org/10.1172/JCI118321.
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Research Article Article has an altmetric score of 6

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

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Abstract

Natural killer (NK) cells are large granular lymphocytes that constitutively express functional IL-2 receptors. We have shown that recombinant human IL-15 uses the IL-2 receptor to activate human NK cells and can synergize with recombinant human IL-12 to stimulate NK cell production of IFN-gamma in vitro. IFN-gamma production by NK cells is critical in the prevention of overwhelming infection by obligate intracellular microbial pathogens in several experimental animal models. Herein, we demonstrate that human monocytes produce IL-15 protein within 5 h of activation with LPS. Using an IL-15-neutralizing antiserum in a coculture of LPS-activated monocytes and NK cells, we demonstrate that monocyte-derived IL-15 is critical for optimal NK cell production of IFN-gamma. Endogenous IL-15 activates NK cells through the IL-2 receptor, and with endogenous IL-12, regulates NK cell IFN-gamma after monocyte activation by LPS. These in vitro studies are the first to characterize a function for endogenous IL-15, and as such, suggest an important role for IL-15 during the innate immune response. IL-15 may be an important ligand for the NK cell IL-2 receptor in vivo.

Authors

W E Carson, M E Ross, R A Baiocchi, M J Marien, N Boiani, K Grabstein, M A Caligiuri

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 3 3 3 3 5 5 8 6 2 5 2 7 8 2 13 2 8 12 5 13 11 13 11 20 17 15 17 13 12 8 252
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Citations to this article in year 2013 (8)

Title and authors Publication Year
Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15
C Cairo, B Sagnia, G Cappelli, V Colizzi, RG Leke, RJ Leke, CD Pauza
Immunology 2013
Location and cellular stages of natural killer cell development
J Yu, AG Freud, MA Caligiuri
Trends in Immunology 2013
The role of IL15 gene variants in visceral leishmaniasis among Iranian patients
M Rasouli, M Kalani, S Kiany
Molecular Biology Reports 2013
IFN-γ production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells
S Zhang, B Saha, K Kodys, G Szabo
Journal of Hepatology 2013
Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture
H Takeda, T Kikuchi, K Soboku, I Okabe, H Mizutani, A Mitani, Y Ishihara, T Noguchi
Inflammation 2013
Effect of Hibisci Flos on Inflammatory Cytokines Production in lipopolysaccaride-stimulated Raw 264.7 Macrophages
DM Lee, HS Han, YJ Lee
The Korea Journal of Herbology 2013
Soluble MICA-NKG2D interaction upregulates IFN-γ production by activated CD3−CD56+ NK cells: Potential impact on chronic graft versus host disease
W Boukouaci, R Al-Daccak, N Dulphy, L Lauden, K Amokrane, C Fortier, F Marzais, M Bennabi, RP de Latour, G Socie, A Toubert, D Charron, R Krishnamoorthy, R Tamouza
Human Immunology 2013
Production of Bioactive Soluble Interleukin-15 in Complex with Interleukin-15 Receptor Alpha from a Conditionally-Replicating Oncolytic HSV-1
DC Gaston, CI Odom, L Li, JM Markert, JC Roth, KA Cassady, RJ Whitley, JN Parker, B Lichty
PloS one 2013

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