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Citations to this article

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.
W E Carson, … , K Grabstein, M A Caligiuri
W E Carson, … , K Grabstein, M A Caligiuri
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2578-2582. https://doi.org/10.1172/JCI118321.
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Research Article Article has an altmetric score of 6

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

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Abstract

Natural killer (NK) cells are large granular lymphocytes that constitutively express functional IL-2 receptors. We have shown that recombinant human IL-15 uses the IL-2 receptor to activate human NK cells and can synergize with recombinant human IL-12 to stimulate NK cell production of IFN-gamma in vitro. IFN-gamma production by NK cells is critical in the prevention of overwhelming infection by obligate intracellular microbial pathogens in several experimental animal models. Herein, we demonstrate that human monocytes produce IL-15 protein within 5 h of activation with LPS. Using an IL-15-neutralizing antiserum in a coculture of LPS-activated monocytes and NK cells, we demonstrate that monocyte-derived IL-15 is critical for optimal NK cell production of IFN-gamma. Endogenous IL-15 activates NK cells through the IL-2 receptor, and with endogenous IL-12, regulates NK cell IFN-gamma after monocyte activation by LPS. These in vitro studies are the first to characterize a function for endogenous IL-15, and as such, suggest an important role for IL-15 during the innate immune response. IL-15 may be an important ligand for the NK cell IL-2 receptor in vivo.

Authors

W E Carson, M E Ross, R A Baiocchi, M J Marien, N Boiani, K Grabstein, M A Caligiuri

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 3 3 3 3 5 5 8 6 2 5 2 7 8 2 13 2 8 12 5 13 11 13 11 20 17 15 17 13 12 8 252
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Citations to this article in year 2010 (2)

Title and authors Publication Year
Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis
P Saikali, JP Antel, CL Pittet, J Newcombe, N Arbour
Journal of immunology (Baltimore, Md. : 1950) 2010
Natural Killer Cell–Mediated Cytokine Response Among HIV-Positive South Indians With Pulmonary Tuberculosis
PV Rao, S Rajasekaran, A Raja
Journal of Interferon & Cytokine Research 2010

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Referenced in 2 patents
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