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Citations to this article

Myelin in multiple sclerosis is developmentally immature.
M A Moscarello, … , C Ackerley, C Boulias
M A Moscarello, … , C Ackerley, C Boulias
Published July 1, 1994
Citation Information: J Clin Invest. 1994;94(1):146-154. https://doi.org/10.1172/JCI117300.
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Research Article Article has an altmetric score of 9

Myelin in multiple sclerosis is developmentally immature.

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Abstract

The etiology of multiple sclerosis (MS) is considered to involve genetic, environmental, infective, and immunological factors which affect the integrity of a normally assembled myelin sheath, either directly or indirectly resulting in demyelination. In a correlative study involving protein chemical, mass spectrometric, and electron microscopic techniques we have determined that myelin obtained from victims of MS is arrested at the level of the first growth spurt (within the first 6 yr of life) and is therefore developmentally immature. The data supporting this conclusion include (a) the pattern of microheterogeneity of myelin basic protein (MBP); (b) the NH2-terminal acylation of the least cationic component of MBP ("C-8"); (c) the phase transition temperature (Tc) of myelin isolated from victims of MS correlated with the increased proportion of the least cationic component of MBP; and (d) immunogold electron microscopy using an antibody specific for "C-8" showed that the distribution of gold particles in a 2-yr-old infant was similar to the distribution found in a victim of MS. We postulate that this developmentally immature myelin is more susceptible to degradation by one or a combination of factors mentioned above, providing the initial antigenic material to the immune system.

Authors

M A Moscarello, D D Wood, C Ackerley, C Boulias

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1960 Total
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Citations to this article in year 2020 (10)

Title and authors Publication Year
Pre-clinical and Clinical Implications of “Inside-Out” vs. “Outside-In” Paradigms in Multiple Sclerosis Etiopathogenesis
HE Titus, Y Chen, JR Podojil, AP Robinson, R Balabanov, B Popko, SD Miller
Frontiers in cellular neuroscience 2020
Myelin Basic Protein Phospholipid Complexation Likely Competes with Deimination in Experimental Autoimmune Encephalomyelitis Mouse Model
AO Valdivia, PK Agarwal, SK Bhattacharya
ACS Omega 2020
Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination
RP Gorter, W Baron
Neuroscience Letters 2020
Myelin basic protein (MBP) charge variants show different sphingomyelin-mediated interactions with myelin-like lipid monolayers
K Widder, G Harauz, D Hinderberger
Biochimica et Biophysica Acta (BBA) - Biomembranes 2020
In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
O Mahneva, MG Risley, C John, SL Milton, K Dawson-Scully, WW Ja, EM Skoulakis
PloS one 2020
The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses
VR Lezhnyova, EV Martynova, TI Khaiboullin, RA Urbanowicz, SF Khaiboullina, AA Rizvanov
Biology : open access journal 2020
Effect of Cholesterol and Myelin Basic Protein (MBP) Content on Lipid Monolayers Mimicking the Cytoplasmic Membrane of Myelin
J Träger, K Widder, A Kerth, G Harauz, D Hinderberger
Cells 2020
Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions
I Fischer, B Barak
Biomolecules 2020
DNA methylation in Schwann cells and in oligodendrocytes
P ArthurFarraj, S Moyon
Glia 2020
Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis
CC Huizar, I Raphael, TG Forsthuber
Cellular Immunology 2020

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