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Citations to this article

Myelin in multiple sclerosis is developmentally immature.
M A Moscarello, … , C Ackerley, C Boulias
M A Moscarello, … , C Ackerley, C Boulias
Published July 1, 1994
Citation Information: J Clin Invest. 1994;94(1):146-154. https://doi.org/10.1172/JCI117300.
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Research Article Article has an altmetric score of 9

Myelin in multiple sclerosis is developmentally immature.

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Abstract

The etiology of multiple sclerosis (MS) is considered to involve genetic, environmental, infective, and immunological factors which affect the integrity of a normally assembled myelin sheath, either directly or indirectly resulting in demyelination. In a correlative study involving protein chemical, mass spectrometric, and electron microscopic techniques we have determined that myelin obtained from victims of MS is arrested at the level of the first growth spurt (within the first 6 yr of life) and is therefore developmentally immature. The data supporting this conclusion include (a) the pattern of microheterogeneity of myelin basic protein (MBP); (b) the NH2-terminal acylation of the least cationic component of MBP ("C-8"); (c) the phase transition temperature (Tc) of myelin isolated from victims of MS correlated with the increased proportion of the least cationic component of MBP; and (d) immunogold electron microscopy using an antibody specific for "C-8" showed that the distribution of gold particles in a 2-yr-old infant was similar to the distribution found in a victim of MS. We postulate that this developmentally immature myelin is more susceptible to degradation by one or a combination of factors mentioned above, providing the initial antigenic material to the immune system.

Authors

M A Moscarello, D D Wood, C Ackerley, C Boulias

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1960 Total
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Citations to this article in year 2004 (7)

Title and authors Publication Year
Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
M Polanczyk, S Yellayi, A Zamora, S Subramanian, M Tovey, AA Vandenbark, H Offner, JF Zachary, PD Fillmore, EP Blankenhorn, JA Gustafsson, C Teuscher
The American Journal of Pathology 2004
Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis
AP Nicholas, T Sambandam, JD Echols, WW Tourtellotte
The Journal of Comparative Neurology 2004
Post-translational modifications of self antigens: implications for autoimmunity
SM Anderton
Current Opinion in Immunology 2004
Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker
S Nijenhuis, AJ Zendman, ER Vossenaar, GJ Pruijn, WJ vanVenrooij
Clinica Chimica Acta 2004
Clinical and pathophysiological significance of the autoimmune response to citrullinated proteins in rheumatoid arthritis
M Sebbag, S Chapuy-Regaud, I Auger, E Petit-Texeira, C Clavel, L Nogueira, C Vincent, F Cornélis, J Roudier, G Serre
Joint Bone Spine 2004
Intérêt clinique et rôle physiopathologique de la réponse auto-immune contre les protéines citrullinées dans la polyarthrite rhumatoïde
M Sebbag, S Chapuy-Regaud, I Auger, E Petit-Texeira, C Clavel, L Nogueira, C Vincent, F Cornélis, J Roudier, G Serre
Revue du Rhumatisme 2004
Myelin basic protein—diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis
G Harauz, N Ishiyama, CM Hill, IR Bates, DS Libich, C Farès
Micron 2004

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