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Citations to this article

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
D G Dyer, … , D R McCance, J W Baynes
D G Dyer, … , D R McCance, J W Baynes
Published June 1, 1993
Citation Information: J Clin Invest. 1993;91(6):2463-2469. https://doi.org/10.1172/JCI116481.
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Research Article Article has an altmetric score of 12

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

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Abstract

To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 nondiabetic control subjects. Compounds studied included fructoselysine (FL), the initial glycation product, and the glycoxidation products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine, formed during later Maillard reactions. Collagen-linked fluorescence was also studied. In nondiabetic subjects, glycation of collagen (FL content) increased only 33% between 20 and 85 yr of age. In contrast, CML, pentosidine and fluorescence increased five-fold, correlating strongly with age. In diabetic patients, collagen FL was increased threefold compared with nondiabetic subjects, correlating strongly with glycated hemoglobin but not with age. Collagen CML, pentosidine and fluorescence were increased up to twofold in diabetic compared with control patients: this could be explained by the increase in glycation alone, without invoking increased oxidative stress. There were strong correlations among CML, pentosidine and fluorescence in both groups, providing evidence for age-dependent chemical modification of collagen via the Maillard reaction, and acceleration of this process in diabetes. These results support the description of diabetes as a disease characterized by accelerated chemical aging of long-lived tissue proteins.

Authors

D G Dyer, J A Dunn, S R Thorpe, K E Bailie, T J Lyons, D R McCance, J W Baynes

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1979 Total
Citations: 5 4 8 9 13 11 14 17 18 30 12 37 21 23 23 20 20 14 20 14 21 19 22 10 17 20 25 19 25 7 8 6 1 1 534
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Citations to this article in year 2019 (14)

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N Chidi-Ogbolu, K Baar
Frontiers in physiology 2019
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E Tani, T Ohnuma, H Hirose, K Nakayama, W Mao, M Nakadaira, N Orimo, H Yamashita, Y Takebayashi, Y Miki, N Katsuta, S Nishimon, T Hasegawa, E Komiyama, Y Suga, S Ikeda, H Arai
International Journal of Methods in Psychiatric Research 2019
The LepR db/db mice model for studying glycation in the context of diabetes
A Guilbaud, M Howsam, C Niquet-Léridon, F Delguste, E Boulanger, FJ Tessier
Diabetes/Metabolism Research and Reviews 2019
Diabetic skin and UV light: Protection by antioxidants
A Dimaki, M Kyriazi, G Leonis, I Sfiniadakis, GT Papaioannou, E Ioannou, V Roussis, M Rallis
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019
Structural architectures with toughening mechanisms in Nature: A review of the materials science of Type-I collagenous materials
W Yang, MA Meyers, RO Ritchie
Progress in Materials Science 2019
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J Becker, NS Mahlke, A Reckert, SB Eickhoff, S Ritz-Timme
International Journal of Legal Medicine 2019
Biocatalytic Reversal of Advanced Glycation End Product Modification
NY Kim, TN Goddard, S Sohn, DA Spiegel, JM Crawford
Chembiochem : a European journal of chemical biology 2019
Characterisation of structural changes in collagen with Raman spectroscopy
MG Martinez, AJ Bullock, S MacNeil, IU Rehman
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EA Shirshin, BP Yakimov, ME Darvin, NP Omelyanenko, SA Rodionov, YI Gurfinkel, J Lademann, VV Fadeev, AV Priezzhev
Biochemistry (Moscow) 2019
Carbamylation and glycation compete for collagen molecular aging in vivo
C Nicolas, S Jaisson, L Gorisse, FJ Tessier, C Niquet-Léridon, P Jacolot, C Pietrement, P Gillery
Scientific Reports 2019
Oral intake of lingonberry and amla fruit extract improves skin conditions in healthy female subjects: A randomized, double‐blind, placebo‐controlled clinical trial
T Uchiyama, M Tsunenaga, M Miyanaga, O Ueda, M Ogo
Biotechnology and Applied Biochemistry 2019
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E Bejarano, A Taylor
Experimental Eye Research 2019

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