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Citations to this article

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
D G Dyer, … , D R McCance, J W Baynes
D G Dyer, … , D R McCance, J W Baynes
Published June 1, 1993
Citation Information: J Clin Invest. 1993;91(6):2463-2469. https://doi.org/10.1172/JCI116481.
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Research Article Article has an altmetric score of 12

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

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Abstract

To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 nondiabetic control subjects. Compounds studied included fructoselysine (FL), the initial glycation product, and the glycoxidation products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine, formed during later Maillard reactions. Collagen-linked fluorescence was also studied. In nondiabetic subjects, glycation of collagen (FL content) increased only 33% between 20 and 85 yr of age. In contrast, CML, pentosidine and fluorescence increased five-fold, correlating strongly with age. In diabetic patients, collagen FL was increased threefold compared with nondiabetic subjects, correlating strongly with glycated hemoglobin but not with age. Collagen CML, pentosidine and fluorescence were increased up to twofold in diabetic compared with control patients: this could be explained by the increase in glycation alone, without invoking increased oxidative stress. There were strong correlations among CML, pentosidine and fluorescence in both groups, providing evidence for age-dependent chemical modification of collagen via the Maillard reaction, and acceleration of this process in diabetes. These results support the description of diabetes as a disease characterized by accelerated chemical aging of long-lived tissue proteins.

Authors

D G Dyer, J A Dunn, S R Thorpe, K E Bailie, T J Lyons, D R McCance, J W Baynes

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1979 Total
Citations: 3 4 8 9 13 11 14 17 18 30 12 37 21 23 23 20 20 14 20 14 21 19 22 10 17 20 25 19 25 7 8 6 1 1 532
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Citations to this article in year 2007 (20)

Title and authors Publication Year
Effect of Selenium- and Glutathione-Enriched Yeast Supplementation on a Combined Atherosclerosis and Diabetes Hamster Model
GA Agbor, JA Vinson, S Patel, K Patel, J Scarpati, D Shiner, F Wardrop, TA Tompkins
Journal of Agricultural and Food Chemistry 2007
Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways
M Alikhani, Z Alikhani, C Boyd, CM MacLellan, M Raptis, R Liu, N Pischon, PC Trackman, L Gerstenfeld, DT Graves
Bone 2007
Mechanisms for Oxidative Stress in Diabetic Cardiovascular Disease
S Pennathur, JW Heinecke
Antioxidants & Redox Signaling 2007
Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia
NC Hollander, DJ Mulder, R Graaff, SR Thorpe, JW Baynes, GP Smit, AJ Smit
Journal of Inherited Metabolic Disease 2007
Type II diabetes mellitus and cardiovascular risk factors: Current therapeutic approaches
C Kalofoutis, C Piperi, A Kalofoutis, F Harris, D Phoenix, J Singh
Experimental and clinical cardiology 2007
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts
MS Ahmad, M Pischetsrieder, N Ahmed
European Journal of Pharmacology 2007
Effects of non-enzymatic glycation on cancellous bone fragility
SY Tang, U Zeenath, D Vashishth
Bone 2007
High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure
Y Koyama, Y Takeishi, T Arimoto, T Niizeki, T Shishido, H Takahashi, N Nozaki, O Hirono, Y Tsunoda, J Nitobe, T Watanabe, I Kubota
Journal of Cardiac Failure 2007
Advanced Glycation End-Product Accumulation and Associated Protein Modification in Type II Skeletal Muscle With Aging
LM Snow, NA Fugere, LV Thompson
The Journals of Gerontology Series A Biological Sciences and Medical Sciences 2007
Assessment of temperature effects on β-aggregation of native and glycated albumin by FTIR spectroscopy and PAGE: Relations between structural changes and antioxidant properties
P Rondeau, S Armenta, H Caillens, S Chesne, E Bourdon
Archives of Biochemistry and Biophysics 2007
The effect of nonenzymatic glycation on the stability and conformation of two deoxyoligonucleotide duplexes: A spectroscopic analysis by circular dichroism
U Dutta, MA Cohenford, JA Dain
Analytical Biochemistry 2007
Advanced glycation end-products (AGEs) and heart failure: Pathophysiology and clinical implications
JW Hartog, AA Voors, SJ Bakker, AJ Smit, DJ van Veldhuisen
European Journal of Heart Failure 2007
Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: A study of advanced non-enzymatic glycation like compounds
U Dutta, MA Cohenford, M Guha, JA Dain
Bioorganic chemistry 2007
Evaluation of a gas chromatography/mass spectrometry method for the quantification of carboxymethyllysine in food samples
A Charissou, L Ait-Ameur, I Birlouez-Aragon
Journal of Chromatography A 2007
Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor
M Alikhani, CM MacLellan, M Raptis, S Vora, PC Trackman, DT Graves
American journal of physiology. Cell physiology 2007
Role of Nε-(Carboxymethyl)Lysine in the Development of Ischemic Heart Disease in Type 2 Diabetes Mellitus
KA Ahmed, S Muniandy, IS Ismail
Journal of Clinical Biochemistry and Nutrition 2007
Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch’s membrane leading to accurate, nondestructive prediction of ocular aging
JV Glenn, JR Beattie, L Barrett, N Frizzell, SR Thorpe, ME Boulton, JJ McGarvey, AW Stitt
The FASEB Journal 2007
Vimentin Is the Specific Target in Skin Glycation: STRUCTURAL PREREQUISITES, FUNCTIONAL CONSEQUENCES, AND ROLE IN SKIN AGING
T Kueper, T Grune, S Prahl, H Lenz, V Welge, T Biernoth, Y Vogt, GM Muhr, A Gaemlich, T Jung, G Boemke, HP Elsässer, KP Wittern, H Wenck, F Stäb, T Blatt
The Journal of biological chemistry 2007
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals
AJ Hulbert, R Pamplona, R Buffenstein, WA Buttemer
Physiological reviews 2007
Glycated type 1 collagen induces endothelial dysfunction in culture
PC Kuo, CH Kao, JK Chen
In vitro cellular & developmental biology. Animal 2007

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