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Citations to this article

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
D G Dyer, … , D R McCance, J W Baynes
D G Dyer, … , D R McCance, J W Baynes
Published June 1, 1993
Citation Information: J Clin Invest. 1993;91(6):2463-2469. https://doi.org/10.1172/JCI116481.
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Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

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Abstract

To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 nondiabetic control subjects. Compounds studied included fructoselysine (FL), the initial glycation product, and the glycoxidation products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine, formed during later Maillard reactions. Collagen-linked fluorescence was also studied. In nondiabetic subjects, glycation of collagen (FL content) increased only 33% between 20 and 85 yr of age. In contrast, CML, pentosidine and fluorescence increased five-fold, correlating strongly with age. In diabetic patients, collagen FL was increased threefold compared with nondiabetic subjects, correlating strongly with glycated hemoglobin but not with age. Collagen CML, pentosidine and fluorescence were increased up to twofold in diabetic compared with control patients: this could be explained by the increase in glycation alone, without invoking increased oxidative stress. There were strong correlations among CML, pentosidine and fluorescence in both groups, providing evidence for age-dependent chemical modification of collagen via the Maillard reaction, and acceleration of this process in diabetes. These results support the description of diabetes as a disease characterized by accelerated chemical aging of long-lived tissue proteins.

Authors

D G Dyer, J A Dunn, S R Thorpe, K E Bailie, T J Lyons, D R McCance, J W Baynes

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The Association Between Sociodemographic Factors, Common Systemic Diseases, and Keratoconus
MA Woodward, TS Blachley, JD Stein
Ophthalmology 2016
Chemical Synthesis of Peptides Containing Site-Specific Advanced Glycation Endproducts
H Kaur, M Kamalov, MA Brimble
Accounts of Chemical Research 2016
Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats
G Raghu, S Jakhotia, PY Reddy, PA Kumar, GB Reddy
Food & Function 2016
Diabetes mellitus and the skin
E Makrantonaki, D Jiang, AM Hossini, G Nikolakis, M Wlaschek, K Scharffetter-Kochanek, CC Zouboulis
Reviews in Endocrine and Metabolic Disorders 2016
Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs
EJ Lee, JY Kim, SH Oh
Scientific Reports 2016
RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells
AI Serban, L Stanca, OI Geicu, MC Munteanu, A Dinischiotu, D Karamichos
PloS one 2016
Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications
YH Cho, ME Craig, AS Januszewski, P Benitez-Aguirre, S Hing, AJ Jenkins, KC Donaghue
Diabetic Medicine 2016
Beneficial Effects of Acanthopanax senticosus Extract in Type II Diabetes Animal Model via Down-Regulation of Advanced Glycated Hemoglobin and Glycosylation End Products
HO Kwon, M Lee, YJ Kim, E Kim, OK Kim
Journal of the Korean Society of Food Science and Nutrition 2016
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes
PJ Saulnier, KM Wheelock, S Howell, EJ Weil, SK Tanamas, WC Knowler, KV Lemley, M Mauer, B Yee, RG Nelson, PJ Beisswenger
Diabetes 2016
Engineering Foods for Bioactives Stability and Delivery
YH Roos, YD Livney
Engineering Foods for Bioactives Stability and Delivery 2016
Mechanisms Linking Aging, Diseases and Biological Age Estimation
S Zapico
Mechanisms Linking Aging, Diseases and Biological Age Estimation 2016
Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes
H Mori, A Kuroda, M Araki, R Suzuki, S Taniguchi, M Tamaki, Y Akehi, M Matsuhisa
Journal of Diabetes Investigation 2016
Arm, Leg, and Foot Skin Water in Persons With Diabetes Mellitus (DM) in Relation to HbA1c Assessed by Tissue Dielectric Constant (TDC) Technology Measured at 300 MHz
HN Mayrovitz, I Volosko, B Sarkar, N Pandya
Journal of diabetes science and technology 2016
Human Achilles tendon glycation and function in diabetes
C Couppé, RB Svensson, M Kongsgaard, V Kovanen, JF Grosset, O Snorgaard, J Bencke, JO Larsen, T Bandholm, TM Christensen, A Boesen, IC Helmark, P Aagaard, M Kjaer, SP Magnusson
Journal of applied physiology 2016
Diabetic Bone Disease
B Lecka-Czernik, JL Fowlkes
2016
Glycation of the high affinity NGF-receptor and RAGE leads to reduced ligand affinity
D Bennmann, C Kannicht, C Fisseau, K Jacobs, A Navarette-Santos, B Hofmann, R Horstkorte
Mechanisms of Ageing and Development 2015
Skin autofluorescence is associated with carotid intima-media thickness, diabetic microangiopathy, and long-lasting metabolic control in type 1 diabetic patients. Results from Poznan Prospective Study
A Araszkiewicz, D Naskret, D Zozulinska-Ziolkiewicz, S Pilacinski, A Uruska, A Grzelka, M Wegner, B Wierusz-Wysocka
Microvascular Research 2015
Glycation of Human Cortical and Cancellous Bone Captures Differences in the Formation of Maillard Reaction Products between Glucose and Ribose
GE Sroga, A Siddula, D Vashishth, R Nagaraj
PloS one 2015
Effects of Maillard reaction on flavor and safety of Chinese traditional food: roast duck: Effects of Maillard reaction on flavor and safety of roast duck
Y Zhou, F Xie, X Zhou, Y Wang, W Tang, Y Xiao
Journal of the Science of Food and Agriculture 2015
Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function
E Simard, T Söllradl, JS Maltais, J Boucher, P D’Orléans-Juste, M Grandbois, T Abraham
PloS one 2015
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition
RN Bergman, M Ader
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition 2015
Cosmeceuticals and Active Cosmetics, Third Edition
R Muggli
Cosmeceuticals and Active Cosmetics, Third Edition 2015
Review of applications of fluorescence excitation spectroscopy to dermatology
W Franco, E Gutierrez-Herrera, N Kollias, A Doukas
The British journal of dermatology 2015
Non-invasive Measurement of Skin Autofluorescence as a Beneficial Surrogate Marker for Atherosclerosis in Patients with Type 2 Diabetes
J Temma, M Matsuhisa, T Horie, A Kuroda, H Mori, M Tamaki, I Endo, K Aihara, M Abe, T Matsumoto
The Journal of Medical Investigation 2015
Cosmetic Dermatology: Products and Procedures
K Minkis, JH Swary, M Alam
Cosmetic Dermatology: Products and Procedures 2015
Comparing Changes in Plasma and Skin Autofluorescence in Low-Flux versus High-Flux Hemodialysis
B Ramsauer, G Engels, S Arsov, H Hadimeri, A Sikole, R Graaff, B Stegmayr
The International Journal of Artificial Organs 2015
Skin advanced glycation endproducts are elevated at onset of type 1 diabetes in youth
EA Báez, S Shah, D Felipe, J Maynard, S Lefevre, SA Chalew
Journal of Pediatric Endocrinology and Metabolism 2015
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
J Camps
2014
Diabetes Alters Mechanical Properties and Collagen Fiber Re-Alignment in Multiple Mouse Tendons
BK Connizzo, PR Bhatt, KW Liechty, LJ Soslowsky
Annals of Biomedical Engineering 2014
Advanced glycation/glycoxidation endproduct carboxymethyl-lysine and incidence of coronary heart disease and stroke in older adults
JR Kizer, D Benkeser, AM Arnold, JH Ix, KJ Mukamal, L Djousse, RP Tracy, DS Siscovick, BM Psaty, SJ Zieman
Atherosclerosis 2014
GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence
KM Eny, HL Lutgers, J Maynard, BE Klein, KE Lee, G Atzmon, VM Monnier, JV van Vliet-Ostaptchouk, R Graaff, P der Harst, H Snieder, MM van der Klauw, DR Sell, SM Hosseini, PA Cleary, BH Braffett, TJ Orchard, TJ Lyons, K Howard, R Klein, JP Crandall, N Barzilai, S Milman, D Ben-Avraham, BH Wolffenbuttel, AD Paterson
Diabetologia 2014
Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue
C Couppé, RB Svensson, JF Grosset, V Kovanen, RH Nielsen, MR Olsen, JO Larsen, SF Praet, D Skovgaard, M Hansen, P Aagaard, M Kjaer, SP Magnusson
AGE 2014
Does microwave sterilization of growth media involve any non-thermal effect?
MK Bhattacharjee, JK Delsol
Journal of Microbiological Methods 2014
A new approach for evaluating the water resistance of sunscreens on consumers: tap water vs. salt water vs. chlorine water
G Puccetti, H Fares
International Journal of Cosmetic Science 2014
Postprandial oxidative stress is increased after a phytonutrient-poor food but not after a kJ matched phytonutrient-rich food
A Khor, R Grant, C Tung, J Guest, B Pope, M Morris, A Bilgin
Nutrition Research 2014
Degradation of oxidized and glycoxidized collagen: Role of collagen cross-linking
K Nowotny, T Grune
Archives of Biochemistry and Biophysics 2014
Altered vimentin protein expression in human dermal microvascular endothelial cells after ultraviolet or intense pulsed light treatment: ALTERED VIMENTIN PROTEIN EXPRESSION IN HDMEC
JU Shin, WJ Lee, SH Oh, DY Kim, DS Kim, I Jung, JH Lee
Lasers in Surgery and Medicine 2014
The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients
MA Babizhayev, IA Strokov, VV Nosikov, EL Savel’yeva, VF Sitnikov, YE Yegorov, VZ Lankin
Cell Biochemistry and Biophysics 2014
Hidden Complexities in the Measurement of Fructosyl-Lysine and Advanced Glycation End Products for Risk Prediction of Vascular Complications of Diabetes: Figure 1
N Rabbani, PJ Thornalley
Diabetes 2014
Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography–Mass Spectrometry
Y Huang, G Chen, X Liu, Y Shao, P Gao, C Xin, Z Cui, X Zhao, G Xu
Journal of Proteome Research 2014
Development of a direct in-matrix extraction (DIME) protocol for MALDI-TOF-MS detection of glycated phospholipids in heat-treated food samples: Direct in-matrix extraction for glycated lipids
CD Calvano, CD Ceglie, CG Zambonin
Journal of Mass Spectrometry 2014
Relationship of Skin Autofluorescence to Severity of Retinopathy in Type 2 Diabetes
M Yasuda, M Shimura, H Kunikata, H Kanazawa, K Yasuda, Y Tanaka, H Konno, M Takahashi, T Kokubun, K Maruyama, N Sato, M Kakizaki, M Sato, I Tsuji, T Miyata, T Nakazawa
Current Eye Research 2014
Accumulation of advanced glycation end products in the rabbit blastocyst under maternal diabetes
E Haucke, AN Santos, A Simm, C Henning, MA Glomb, J Gurke, M Schindler, B Fischer, AN Santos
Reproduction 2014
A Novel Controllable Hydrogen Sulfide-Releasing Molecule Protects Human Skin Keratinocytes Against Methylglyoxal-Induced Injury and Dysfunction
C Yang, Y Zhao, M Xian, J Li, Q Dong, H Bai, J Xu, M Zhang
Cellular Physiology and Biochemistry 2014
Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice
A Ozer, CZ Altuntas, K Izgi, F Bicer, SJ Hultgren, G Liu, F Daneshgari
Pathogens and Disease 2014
The role of post-translational modifications in acute and chronic cardiovascular disease
LE Smith, MY White
PROTEOMICS – CLINICAL APPLICATIONS 2014
Another Look at the Association Between Diabetes and Keratoconus:
M Kosker, K Suri, KM Hammersmith, AH Nassef, PK Nagra, CJ Rapuano
Cornea 2014
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes
2014
Correlation of Advanced Glycation Endproducts Estimated From Skin Fluorescence in First-Degree Relatives: The Impact of Adjustment for Skin Pigmentation
EA Baez, S Shah, D Felipe, J Maynard, S Chalew
Journal of diabetes science and technology 2014
Perturbation of Human Coronary Artery Endothelial Cell Redox State and NADPH Generation by Methylglyoxal
PE Morgan, PJ Sheahan, MJ Davies, R Nagaraj
PloS one 2014
Skin, Mucosa and Menopause
MA Farage, KW Miller, NF Woods, HI Maibach
2014
Studies in Diabetes
I Obrosova, MJ Stevens, MA Yorek
2014
Mechanical Properties of Aging Soft Tissues
B Derby, R Akhtar
2014
How to help the skin cope with glycoxidation
L Danoux, S Mine, N Abdul-Malak, F Henry, C Jeanmaire, O Freis, G Pauly, L Cittadini, V André-Frei, A Rathjens
Clinical Chemistry and Laboratory Medicine 2014
Advanced glycation end products: role in pathology of diabetic cardiomyopathy
VL Bodiga, SR Eda, S Bodiga
Heart Failure Reviews 2013
Glucose-induced cell signaling in the pathogenesis of diabetic cardiomyopathy
R Mortuza, S Chakrabarti
Heart Failure Reviews 2013
Cross-Sectional Evaluation of Noninvasively Detected Skin Intrinsic Fluorescence and Mean Hemoglobin A1c in Type 1 Diabetes
VR Aroda, BN Conway, SJ Fernandez, NI Matter, JD Maynard, TJ Orchard, RE Ratner
Diabetes Technology & Therapeutics 2013
In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme
PC Lekshmi, R Arimboor, VM Nisha, AN Menon, KG Raghu
Journal of Food Science and Technology 2013
Nutritional Management of Renal Disease
A Molfino, BR Don, GA Kaysen
Nutritional Management of Renal Disease 2013
Applications of physiological bases of ageing to forensic sciences. Estimation of age-at-death
SC Zapico, DH Ubelaker
Ageing Research Reviews 2013
Vitamin D reduces deposition of advanced glycation end-products in the aortic wall and systemic oxidative stress in diabetic rats
E Salum, J Kals, P Kampus, T Salum, K Zilmer, M Aunapuu, A Arend, J Eha, M Zilmer
Diabetes Research and Clinical Practice 2013
Probing non-enzymatic glycation of type I collagen: A novel approach using Raman and infrared biophotonic methods
M Guilbert, G Said, T Happillon, V Untereiner, R Garnotel, P Jeannesson, GD Sockalingum
Biochimica et Biophysica Acta (BBA) - General Subjects 2013
Clinical and Technical Factors Associated with Skin Intrinsic Fluorescence in Subjects with Type 1 Diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
PA Cleary, BH Braffett, T Orchard, TJ Lyons, J Maynard, C Cowie, RA Gubitosi-Klug, J Way, K Anderson, A Barnie, SV Re
Diabetes Technology & Therapeutics 2013
Advanced Glycation Endproducts in Children with Diabetes
S Shah, EA Baez, DL Felipe, JD Maynard, JM Hempe, SA Chalew
The Journal of Pediatrics 2013
Heat- and light-treatment change the visible fluorescence of Akoya cultured pearls
J Hiramatsu, Y Iwahashi, K Nagai
Fisheries Science 2013
Advanced glycation end products acutely impair ca(2+) signaling in bovine aortic endothelial cells
N Naser, AS Januszewski, BE Brown, AJ Jenkins, MA Hill, TV Murphy
Frontiers in physiology 2013
Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence
MJ Mook-Kanamori, MM Selim, AH Takiddin, H Al-Homsi, KA Al-Mahmoud, A Al-Obaidli, MA Zirie, J Rowe, WS Gherbi, OM Chidiac, SA Kader, WA Muftah, C McKeon, K Suhre, DO Mook-Kanamori
Dermato-endocrinology 2013
Advanced glycation end products augment experimental hepatic fibrosis: Advanced glycation end products augment hepatic fibrosis
M Goodwin, C Herath, Z Jia, C Leung, MT Coughlan, J Forbes, P Angus
Journal of Gastroenterology and Hepatology 2013
The glyoxalase pathway: the first hundred years… and beyond
MS Silva, RA Gomes, AE Ferreira, AP Freire, C Cordeiro
Biochemical Journal 2013
A review on plant-based rutin extraction methods and its pharmacological activities
LS Chua
Journal of Ethnopharmacology 2013
Advanced glycation of cellular proteins as a possible basic component of the “master biological clock”
FF Severin, BA Feniouk, VP Skulachev
Biochemistry (Moscow) 2013
The Association of Skin Intrinsic Fluorescence With Type 1 Diabetes Complications in the DCCT/EDIC Study
TJ Orchard, TJ Lyons, PA Cleary, BH Braffett, J Maynard, C Cowie, RA Gubitosi-Klug, J Way, K Anderson, A Barnie, S Villavicencio
Diabetes care 2013
Clinical and technical factors associated with skin intrinsic fluorescence in subjects with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
Patricia A Cleary, Barbara H Braffett, Trevor Orchard, Timothy J Lyons, John Maynard, Catherine Cowie, Rose A Gubitosi-Klug, Jeff Way, Karen Anderson, Annette Barnie, Stephan Villavicencio,
Diabetes Technology & Therapeutics 2013
18 F-Fluorodeoxyglycosylamines: Maillard reaction of 18 F-fluorodeoxyglucose with biological amines †
A Baranwal, HH Patel, J Mukherjee
Journal of labelled compounds & radiopharmaceuticals 2013
Skin mirrors human aging
G Nikolakis, E Makrantonaki, CC Zouboulis
Hormone Molecular Biology and Clinical Investigation 2013
Age-Related Oxidative Stress Compromises Endosomal Proteostasis
ES Cannizzo, CC Clement, K Morozova, R Valdor, S Kaushik, LN Almeida, C Follo, R Sahu, AM Cuervo, F Macian, L Santambrogio
Cell Reports 2012
Anterior Segment Dimensions in Asian and Caucasian Eyes Measured by Optical Coherence Tomography
B Qin, M Tang, Y Li, X Zhang, R Chu, D Huang
Ophthalmic Surgery Lasers and Imaging 2012
Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects
H Hu, C Han, X Hu, W Ye, W Huang, AJ Smit
Journal of Zhejiang University. Science. B 2012
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Ellagic acid, a new antiglycating agent: its inhibition of <i>N</i><sup>ϵ</sup>-(carboxymethyl)lysine
P Muthenna, C Akileshwari, GB Reddy
Biochemical Journal 2012
Role of tea catechins in prevention of aging and age-related disorders
A Khanna, PK Maurya
TANG 2012
Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction : Tissue autofluorescence in Type 1 diabetes
AS Januszewski, N Sachithanandan, C Karschimkus, DN O’Neal, CK Yeung, N Alkatib, AJ Jenkins
Diabetic Medicine 2012
Total Synthesis of Pentosidine
AJ Rosenberg, DA Clark
Organic letters 2012
Cosmetics, diet, and the future: Cosmetics, diet, and the future
ZD Draelos
Dermatologic Therapy 2012
Advances in Applied Microbiology
JL Brooks, KK Jefferson
Advances in applied microbiology 2012
Effects of Thai Musa species on prevention of UVB-induced skin damage in mice
J Viyoch, K Mahingsa, K Ingkaninan
Food and Chemical Toxicology 2012
In vitro investigation of fluorescence of carious dentin observed with a Soprolife® camera
I Panayotov, E Terrer, H Salehi, H Tassery, J Yachouh, FJ Cuisinier, B Levallois
Clinical Oral Investigations 2012
Advanced glycation end products
P Gkogkolou, M Böhm
Dermato-endocrinology 2012
Serum Pentosidine, An Advanced Glycation End Product, Indicates Poor Outcomes After Acute Ischemic Stroke
T Ikeda, K Maruyama, N Ito, A Utagawa, M Nagane, Y Shiokawa
Journal of Stroke and Cerebrovascular Diseases 2012
Age‐related expression, enzymatic solubility and modification with advanced glycation end‐products of fibrillar collagens in mouse lung
P Rolewska, S Al-Robaiy, AN Santos, A Simm, RE Silber, B Bartling
Experimental Gerontology 2012
Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression
TL Willett, R Kandel, JN Croos, NC Avery, MD Grynpas
Osteoarthritis and Cartilage 2012
Gingival advanced glycation end-products in diabetes mellitus-associated chronic periodontitis: an immunohistochemical study
A Zizzi, G Tirabassi, SD Aspriello, M Piemontese, C Rubini, G Lucarini
Journal of Periodontal Research 2012
Protein damage, repair and proteolysis
N Chondrogianni, I Petropoulos, S Grimm, K Georgila, B Catalgol, B Friguet, T Grune, ES Gonos
Molecular Aspects of Medicine 2012
In vitro non-enzymatic ribation reduces post-yield strain accommodation in cortical bone
TL Willett, S Sutty, A Gaspar, N Avery, M Grynpas
Bone 2012
Diagnostic opportunities based on skin biomarkers
S Paliwal, BH Hwang, KY Tsai, S Mitragotri
European Journal of Pharmaceutical Sciences 2012
Increased blood glycohemoglobin A1c levels lead to overestimation of arterial oxygen saturation by pulse oximetry in patients with type 2 diabetes
LJ Pu, Y Shen, L Lu, RY Zhang, Q Zhang, WF Shen
Cardiovascular Diabetology 2012
Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice
A Currais, M Prior, D Lo, C Jolivalt, D Schubert, P Maher
Aging Cell 2012
Diabetes: An Old Disease, a New Insight
SI Ahmad
2012
Advanced Glycation End Products Are Direct Modulators of  -Cell Function
MT Coughlan, FY Yap, DC Tong, S Andrikopoulos, A Gasser, V Thallas-Bonke, DE Webster, J Miyazaki, TW Kay, RM Slattery, DM Kaye, BG Drew, BA Kingwell, S Fourlanos, PH Groop, LC Harrison, M Knip, JM Forbes
Diabetes 2011
Advances in Clinical Chemistry
M Mahler
Advances in Clinical Chemistry Volume 54 2011
Susceptibility of LDL and its subfractions to glycation
H Soran, PN Durrington
Current Opinion in Lipidology 2011
Naturally occurring inhibitors against the formation of advanced glycation end-products
X Peng, J Ma, F Chen, M Wang
Food & Function 2011
Ex vivo detection of histone H1 modified with advanced glycation end products
S Pashikanti, GA Boissonneault, D Cervantes-Laurean
Free radical biology & medicine 2011
Temporal Increases in Urinary Carboxymethyllysine Correlate with Albuminuria Development in Diabetes
MT Coughlan, JM Forbes
American Journal of Nephrology 2011
The presence of Nε-(Carboxymethyl) lysine in the human epidermis
K Kawabata, H Yoshikawa, K Saruwatari, Y Akazawa, T Inoue, T Kuze, T Sayo, N Uchida, Y Sugiyama
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 2011
Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and Nε-(carboxymethyl)lysine in human epidermis
S Toyokuni, A Hirao, T Wada, R Nagai, A Date, T Yoshii, S Akatsuka, Y Yamashita, A Kawada
Journal of Clinical Biochemistry and Nutrition 2011
Heat Treatment of Brussels Sprouts Retains Their Ability to Induce Detoxification Enzyme Expression In Vitro and In Vivo
MG Robbins, G Andersen, V Somoza, BD Eshelman, DM Barnes, PR Hanlon
Journal of Food Science 2011
Biomarkers for aging
T Shimizu, T Shirasawa
Folia Pharmacologica Japonica 2011
Effect of Cinnamoyl and Flavonol Glucosides Derived from Cherry Blossom Flowers on the Production of Advanced Glycation End Products (AGEs) and AGE-induced Fibroblast Apoptosis
H Shimoda, S Nakamura, M Morioka, J Tanaka, H Matsuda, M Yoshikawa
Phytotherapy Research 2011
Glycation Stress and Photo-Aging in Skin
M Ichihashi, M Yagi, K Nomoto, Y Yonei
ANTI-AGING MEDICINE 2011
Oxidative stress, inflamm-aging and immunosenescence
ES Cannizzo, CC Clement, R Sahu, C Follo, L Santambrogio
Journal of Proteomics 2011
Role of receptors of advanced glycation end-products (RAGE) in type 2 diabetic and non-diabetic individuals with chronic periodontal disease: an immunohistochemical study
K Rajeev, R Karthika, R Mythili, V Krishnan, M Nirmal
Journal of Investigative and Clinical Dentistry 2011
Biomaterials for Intervertebral Disc Regeneration
B Gantenbein-Ritter, D Sakai
Comprehensive Biomaterials 2011
Two Fluorescent Wavelengths, 440<sub>ex</sub>/520<sub>em</sub> nm and 370<sub>ex</sub>/440<sub>em</sub> nm, Reflect Advanced Glycation and Oxidation End Products in Human Skin Without Diabetes
PJ Beisswenger, S Howell, T Mackenzie, H Corstjens, N Muizzuddin, MS Matsui
Diabetes Technology & Therapeutics 2011
Nω-(carboxymethyl)arginine Accumulates in Glycated Collagen and Klotho-deficient Mouse Skin
S Shimasaki, M Kubota, M Yoshitomi, K Takagi, K Suda, K Mera, Y Fujiwara, R Nagai
ANTI-AGING MEDICINE 2011
IN SITU ACCUMULATION OF ADVANCED GLYCATION ENDPRODUCTS (AGES) IN BONE MATRIX AND ITS CORRELATION WITH OSTEOCLASTIC BONE RESORPTION
XN Dong, A Qin, J Xu, X Wang
Bone 2011
Susceptibility of LDL and its subfractions to glycation:
H Soran, PN Durrington
Current Opinion in Lipidology 2011
Consequences of Advanced Glycation End Products Accumulation in Chronic Kidney Disease and Clinical Usefulness of Their Assessment Using a Non-invasive Technique – Skin Autofluorescence
M Oleniuc, I Secara, M Onofriescu, S Hogas, L Voroneanu, D Siriopol, A Covic
Mædica 2011
Beyond Genetic Factors in Familial Amyloidotic Polyneuropathy: Protein Glycation and the Loss of Fibrinogen's Chaperone Activity
G Costa, RA Gomes, A Guerreiro, É Mateus, E Monteiro, E Barroso, AV Coelho, AP Freire, C Cordeiro, RC Aguilar
PloS one 2011
Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro
Y Yuan, L Zhao, Y Chen, JF Moorhead, Z Varghese, SH Powis, S Minogue, Z Sun, XZ Ruan
American journal of physiology. Renal physiology 2011
Nutrition and Skin
A Pappas
2011
Central Arterial Aging and Angiotensin II Signaling
M Wang, B Khazan, EG Lakatta
Current hypertension reviews 2010
Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse
H Ueno, H Koyama, T Shoji, M Monden, S Fukumoto, S Tanaka, Y Otsuka, Y Mima, T Morioka, K Mori, A Shioi, H Yamamoto, M Inaba, Y Nishizawa
Atherosclerosis 2010
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase
A Soro-Paavonen, WZ Zhang, K Venardos, MT Coughlan, E Harris, DC Tong, D Brasacchio, K Paavonen, J Chin-Dusting, ME Cooper, D Kaye, MC Thomas, JM Forbes
Journal of Hypertension 2010
The Nε-(carboxymethyl)lysine–RAGE axis: putative implications for the pathogenesis of obesity-related complications
KH Gaens, CD Stehouwer, CG Schalkwijk
Expert Review of Endocrinology & Metabolism 2010
How much do we really know about our favorite cosmeceutical ingredients?
J Levin, SB Momin
The Journal of clinical and aesthetic dermatology 2010
FOXO1 plays an essential role in apoptosis of retinal pericytes
M Alikhani, S Roy, DT Graves
Molecular vision 2010
Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis
F Moheimani, PE Morgan, DM van Reyk, MJ Davies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2010
Ectopic fat and cardiovascular disease: What is the link?
A Gastaldelli, G Basta
Nutrition, Metabolism and Cardiovascular Diseases 2010
Nicotinamide in dermatology
NH Kim, RS Kirsner
Expert Review of Dermatology 2010
Identification and relative quantification of specific glycation sites in human serum albumin
A Frolov, R Hoffmann
Analytical and Bioanalytical Chemistry 2010
Glycation and biomarkers of vascular complications of diabetes
PJ Beisswenger
Amino Acids 2010
Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy
S Chabroux, F Canouï-Poitrine, S Reffet, G Mills-Joncour, E Morelon, C Colin, C Thivolet
Diabetes & Metabolism 2010
Thermal luminescence spectra of lysine and phenylalanine in O2 measured with a Fourier-transform chemiluminescence spectrometer
H Ishii, C Satoh, T Yamada, T Karakisawa, M Sekine, M Nakata
Chemical Physics Letters 2010
The N ε -(carboxymethyl)lysine–RAGE axis: putative implications for the pathogenesis of obesity-related complications
KH Gaens, CD Stehouwer, CG Schalkwijk
Expert Review of Endocrinology & Metabolism 2010
[Glycation of mitochondrial proteins, oxidative stress and aging]
A Naudí, M Jové, V Ayala, M Portero-Otín, R Pamplona
Revista Española de Geriatría y Gerontología 2010
The Maillard reaction in the human body. The main discoveries and factors that affect glycation
FJ Tessier
Pathologie Biologie 2010
Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology
P Hansen, BT Haraldsson, P Aagaard, V Kovanen, NC Avery, K Qvortrup, JO Larsen, M Krogsgaard, M Kjaer, SP Magnusson
Journal of applied physiology 2010
Sarcopenia – Age-Related Muscle Wasting and Weakness
GS Lynch
2010
Beneficial Effects of Cinnamon Proanthocyanidins on the Formation of Specific Advanced Glycation Endproducts and Methylglyoxal-Induced Impairment on Glucose Consumption
X Peng, J Ma, J Chao, Z Sun, RC Chang, I Tse, ET Li, F Chen, M Wang
Journal of Agricultural and Food Chemistry 2010
Antiglycation Effects of Carnosine and Other Compounds on the Long-Term Survival of Escherichia coli
ED Pepper, MJ Farrell, G Nord, SE Finkel
Applied and environmental microbiology 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
N(epsilon)-(Carboxymethyl)lysine and Coronary Atherosclerosis-Associated Low Density Lipoprotein Abnormalities in Type 2 Diabetes: Current Status
KA Ahmed, S Muniandy, IS Ismail
Journal of Clinical Biochemistry and Nutrition 2009
Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications
JB Lindsey, F Cipollone, SM Abdullah, DK Mcguire
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2009
Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products
K Tsuji-Naito, H Saeki, M Hamano
Food Chemistry 2009
The sour side of neurodegenerative disorders: the effects of protein glycation
HV Miranda, TF Outeiro
The Journal of Pathology 2009
Effects of Short-Term Streptozotocin-Induced Diabetes and Vitamin C on Platelet Non-Enzymatic Glycation
S Batırel, A Yarat, N Emekli
Pathophysiology of Haemostasis and Thrombosis 2009
An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin
ZD Draelos, M Yatskayer, S Raab, C Oresajo
Journal of Cosmetic Dermatology 2009
Calculation of apparent age by linear combination of facial skin parameters: a predictive tool to evaluate the efficacy of cosmetic treatments and to assess the predisposition to accelerated aging
D Dicanio, R Sparacio, L Declercq, H Corstjens, N Muizzuddin, J Hidalgo, PU Giacomoni, L Jorgensen, D Maes
Biogerontology 2009
Noninvasive optical screening for diabetes
MN Ediger, BP Olson, JD Maynard
Journal of diabetes science and technology 2009
Urinary levels of pentosidine and the risk of fracture in postmenopausal women: the OFELY study
E Gineyts, F Munoz, C Bertholon, E Sornay-Rendu, R Chapurlat
Osteoporosis International 2009
AGE-Modified Collagens I and III Induce Keratinocyte Terminal Differentiation through AGE Receptor CD36: Epidermal–Dermal Interaction in Acquired Perforating Dermatosis
E Fujimoto, T Kobayashi, N Fujimoto, M Akiyama, S Tajima, R Nagai
Journal of Investigative Dermatology 2009
Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients
DP Castro, TS Prata, VC Lima, LG Biteli, CG de Moraes, A Paranhos
Journal of Glaucoma 2009
Microwave sterilization of growth medium alleviates inhibition of Aggregatibacter actinomycetemcomitans by Maillard reaction products
MK Bhattacharjee, K Sugawara, OT Ayandeji
Journal of Microbiological Methods 2009
Hyperglycemia and Glycation in Diabetic Complications
A Negre-Salvayre, R Salvayre, N Augé, R Pamplona, M Portero-Otín
Antioxidants & Redox Signaling 2009
Tratado de diálisis peritoneal
IM Fernández, CS González
Tratado de diálisis peritoneal 2009
Handbook of Cosmetic Science and Technology, Third Edition
H Tanojo, G Chang, JW Guo, X Huang
Handbook of Cosmetic Science and Technology, Third Edition 2009
Advanced glycation end-products (AGEs): A novel therapeutic target for osteoporosis in patients with rheumatoid arthritis
JD Ji, JH Woo, SJ Choi, YH Lee, GG Song
Medical Hypotheses 2009
Use of Human Vascular Tissue Microarrays for Measurement of Advanced Glycation Endproducts
MK Halushka, E Selvin, J Lu, AM Macgregor, TC Cornish
Journal of Histochemistry & Cytochemistry 2009
Mechanical properties and collagen cross-linking of the patellar tendon in old and young men
C Couppé, P Hansen, M Kongsgaard, V Kovanen, C Suetta, P Aagaard, M Kjær, SP Magnusson
Journal of applied physiology 2009
Age-associated changes of extracellular matrix collagen impair lung cancer cell migration
B Bartling, M Desole, S Rohrbach, RE Silber, A Simm
The FASEB Journal 2009
Glycation as an atherogenic modification of LDL
N Younis, R Sharma, H Soran, V Charlton-Menys, M Elseweidy, PN Durrington
Current Opinion in Lipidology 2008
Oxidative damage to extracellular matrix and its role in human pathologies
MD Rees, EC Kennett, JM Whitelock, MJ Davies
Free radical biology & medicine 2008
Herbal extracts inhibit Maillard reaction, and reduce chronic diabetic complications risk in streptozotocin-induced diabetic rats
Y Yonei, M Yagi, S Hibino, N Matsuura
ANTI-AGING MEDICINE 2008
Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity
PM Magalhães, HJ Appell, JA Duarte
European Review of Aging and Physical Activity 2008
Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
SY Tang, MR Allen, R Phipps, DB Burr, D Vashishth
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008
Dissociation of functional status from accrual of CML and RAGE in the aged mouse brain
N Thangthaeng, N Sumien, MJ Forster
Experimental Gerontology 2008
Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats
JO Olanlokun
Indian Journal of Clinical Biochemistry 2008
Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects
H Corstjens, D Dicanio, N Muizzuddin, A Neven, R Sparacio, L Declercq, D Maes
Experimental Gerontology 2008
Effect of Extract of Pomegranate (Punica granatum L.) on Glycated Protein-iron Chelate-induced Toxicity: An In Vitro Study on Human Umbilical-vein Endothelial Cells
I Nishigaki, P Rajendran, R Venugopal, G Ekambaram, D Sakthisekaran, Y Nishigaki
JOURNAL OF HEALTH SCIENCE 2008
Weight Increase Is Associated with Skeletal Muscle Immunostaining for Advanced Glycation End Products, Receptor for Advanced Glycation End Products, and Oxidation Injury
MP de la Maza, J Uribarri, D Olivares, S Hirsch, L Leiva, G Barrera, D Bunout
Rejuvenation Research 2008
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
R Pamplona
Biochimica et Biophysica Acta (BBA) - Bioenergetics 2008
Glycation as an atherogenic modification of LDL:
N Younis, R Sharma, H Soran, V Charlton-Menys, M Elseweidy, PN Durrington
Current Opinion in Lipidology 2008
Advanced Glycation End Products in Pregnancies Complicated with Diabetes Mellitus or Preeclampsia
NK Harsem, K Braekke, T Torjussen, K Hanssen, AC Staff
Hypertension in Pregnancy 2008
Atherosclerosis and Oxidant Stress
JL Holtzman
2008
Effect of Selenium- and Glutathione-Enriched Yeast Supplementation on a Combined Atherosclerosis and Diabetes Hamster Model
GA Agbor, JA Vinson, S Patel, K Patel, J Scarpati, D Shiner, F Wardrop, TA Tompkins
Journal of Agricultural and Food Chemistry 2007
Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways
M Alikhani, Z Alikhani, C Boyd, CM MacLellan, M Raptis, R Liu, N Pischon, PC Trackman, L Gerstenfeld, DT Graves
Bone 2007
Mechanisms for Oxidative Stress in Diabetic Cardiovascular Disease
S Pennathur, JW Heinecke
Antioxidants & Redox Signaling 2007
Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia
NC Hollander, DJ Mulder, R Graaff, SR Thorpe, JW Baynes, GP Smit, AJ Smit
Journal of Inherited Metabolic Disease 2007
Type II diabetes mellitus and cardiovascular risk factors: Current therapeutic approaches
C Kalofoutis, C Piperi, A Kalofoutis, F Harris, D Phoenix, J Singh
Experimental and clinical cardiology 2007
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts
MS Ahmad, M Pischetsrieder, N Ahmed
European Journal of Pharmacology 2007
Effects of non-enzymatic glycation on cancellous bone fragility
SY Tang, U Zeenath, D Vashishth
Bone 2007
High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure
Y Koyama, Y Takeishi, T Arimoto, T Niizeki, T Shishido, H Takahashi, N Nozaki, O Hirono, Y Tsunoda, J Nitobe, T Watanabe, I Kubota
Journal of Cardiac Failure 2007
Advanced Glycation End-Product Accumulation and Associated Protein Modification in Type II Skeletal Muscle With Aging
LM Snow, NA Fugere, LV Thompson
The Journals of Gerontology Series A Biological Sciences and Medical Sciences 2007
Assessment of temperature effects on β-aggregation of native and glycated albumin by FTIR spectroscopy and PAGE: Relations between structural changes and antioxidant properties
P Rondeau, S Armenta, H Caillens, S Chesne, E Bourdon
Archives of Biochemistry and Biophysics 2007
The effect of nonenzymatic glycation on the stability and conformation of two deoxyoligonucleotide duplexes: A spectroscopic analysis by circular dichroism
U Dutta, MA Cohenford, JA Dain
Analytical Biochemistry 2007
Advanced glycation end-products (AGEs) and heart failure: Pathophysiology and clinical implications
JW Hartog, AA Voors, SJ Bakker, AJ Smit, DJ van Veldhuisen
European Journal of Heart Failure 2007
Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: A study of advanced non-enzymatic glycation like compounds
U Dutta, MA Cohenford, M Guha, JA Dain
Bioorganic chemistry 2007
Evaluation of a gas chromatography/mass spectrometry method for the quantification of carboxymethyllysine in food samples
A Charissou, L Ait-Ameur, I Birlouez-Aragon
Journal of Chromatography A 2007
Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor
M Alikhani, CM MacLellan, M Raptis, S Vora, PC Trackman, DT Graves
American journal of physiology. Cell physiology 2007
Role of Nε-(Carboxymethyl)Lysine in the Development of Ischemic Heart Disease in Type 2 Diabetes Mellitus
KA Ahmed, S Muniandy, IS Ismail
Journal of Clinical Biochemistry and Nutrition 2007
Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch’s membrane leading to accurate, nondestructive prediction of ocular aging
JV Glenn, JR Beattie, L Barrett, N Frizzell, SR Thorpe, ME Boulton, JJ McGarvey, AW Stitt
The FASEB Journal 2007
Vimentin Is the Specific Target in Skin Glycation: STRUCTURAL PREREQUISITES, FUNCTIONAL CONSEQUENCES, AND ROLE IN SKIN AGING
T Kueper, T Grune, S Prahl, H Lenz, V Welge, T Biernoth, Y Vogt, GM Muhr, A Gaemlich, T Jung, G Boemke, HP Elsässer, KP Wittern, H Wenck, F Stäb, T Blatt
The Journal of biological chemistry 2007
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals
AJ Hulbert, R Pamplona, R Buffenstein, WA Buttemer
Physiological reviews 2007
Glycated type 1 collagen induces endothelial dysfunction in culture
PC Kuo, CH Kao, JK Chen
In vitro cellular & developmental biology. Animal 2007
Diabetic Cardiomyopathy
GC Fonarow, P Srikanthan
Endocrinology & Metabolism Clinics of North America 2006
Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes
Y Yu, SR Thorpe, AJ Jenkins, JN Shaw, MA Sochaski, D McGee, CE Aston, TJ Orchard, N Silvers, YG Peng, JA McKnight, JW Baynes, TJ Lyons
Diabetologia 2006
Skin Autofluorescence, a Novel Marker for Glycemic and Oxidative Stress-Derived Advanced Glycation Endproducts: An Overview of Current Clinical Studies, Evidence, and Limitations
DJ Mulder, TV de Water, HL Lutgers, R Graaff, RO Gans, F Zijlstra, AJ Smit
Diabetes Technology & Therapeutics 2006
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats
KC Chang, KL Hsu, CD Tseng, YD Lin, YL Cho, YZ Tseng
British Journal of Pharmacology 2006
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection
GT Wondrak, MK Jacobson, EL Jacobson
Photochemical & Photobiological Sciences 2006
Degradation of glycated bovine serum albumin in microglial cells
A Stolzing, R Widmer, T Jung, P Voss, T Grune
Free radical biology & medicine 2006
Reactions of a modified lysine with aldehydic and diketonic dicarbonyl compounds: an electrospray mass spectrometry structure/activity study
MA Saraiva, CM Borges, MH Florêncio
Journal of Mass Spectrometry 2006
Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: Characterization of major epitope structures
S Puttaiah, Y Zhang, HA Pilch, C Pfahler, T Oya-Ito, LM Sayre, RH Nagaraj
Archives of Biochemistry and Biophysics 2006
Mitochondrial Medicine
V Carelli, P Barboni, A Sadun
Mitochondrial Medicine 2006
Expression and purification of recombinant human receptor for advanced glycation endproducts in Escherichia coli
R Wilton, MA Yousef, P Saxena, M Szpunar, FJ Stevens
Protein Expression and Purification 2006
Skin Autofluorescence as a Noninvasive Marker of Vascular Damage in Patients With Type 2 Diabetes
HL Lutgers, R Graaff, TP Links, LJ Ubink-Veltmaat, HJ Bilo, RO Gans, AJ Smit
Diabetes care 2006
Nitrite-Induced Cross-Linking Alters Remodeling and Mechanical Properties of Collagenous Engineered Tissues
DC Paik, LY Saito, DD Sugirtharaj, JW Holmes
Connective Tissue Research 2006
Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites
D Cervantes-Laurean, DD Schramm, EL Jacobson, I Halaweish, GG Bruckner, GA Boissonneault
The Journal of Nutritional Biochemistry 2006
Differences in Expression of Cardiovascular Risk Factors among Type 2 Diabetes Mellitus Patients of Different Age
C Kalofoutis, C Piperi, A Zisaki, J Singh, F Harris, D Phoenix, A Alaveras, A Kalofoutis
Annals of the New York Academy of Sciences 2006
Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets
H Farhangkhoee, ZA Khan, H Kaur, X Xin, S Chen, S Chakrabarti
Pharmacology & Therapeutics 2005
The Receptor for Advanced Glycation End Products Is Highly Expressed in the Skin and Upregulated by Advanced Glycation End Products and Tumor Necrosis Factor-Alpha
C Lohwasser, D Neureiter, B Weigle, T Kirchner, D Schuppan
Journal of Investigative Dermatology 2005
The Receptor for Advanced Glycation End Products Is Highly Expressed in the Skin and Upregulated by AGE and Tumor Necrosis Factor-alpha
C Lohwasser, D Neureiter, B Weigle, T Kirchner, D Schuppan
Journal of Investigative Dermatology 2005
A Lethal Tetrad in Diabetes: Hyperglycemia, Dyslipidemia, Oxidative Stress, and Endothelial Dysfunction
Y Yu, TJ Lyons
The American Journal of the Medical Sciences 2005
Migration of keratinocytes is impaired on glycated collagen I
K Morita, K Urabe, Y Moroi, T Koga, R Nagai, S Horiuchi, M Furue
Wound Repair and Regeneration 2005
Oxidative stress and uremia
F Floccari, C Aloisi, E Crascì, T Sofi, S Campo, D Tripodo, M Criseo, N Frisina, M Buemi
Medicinal Research Reviews 2005
Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
O El-Kabbani, V Carbone, C Darmanin, S Ishikura, A Hara
Proteins: Structure, Function, and Bioinformatics 2005
Structure-based discovery of human l-xylulose reductase inhibitors from database screening and molecular docking
V Carbone, S Ishikura, A Hara, O El-Kabbani
Bioorganic & Medicinal Chemistry 2005
Effect of N-benzoyl-d-phenylalanine and metformin on carbohydrate metabolic enzymes in neonatal streptozotocin diabetic rats
N Ashokkumar, L Pari
Clinica Chimica Acta 2005
Rapid and simple method for determination of Nɛ-(carboxymethyl)lysine and Nɛ-(carboxyethyl)lysine in urine using gas chromatography[sol ]mass spectrometry
R Petrovič, J Futas, J Chandoga, V Jakuš
Biomedical Chromatography 2005
Advanced Glycation End Products and Diabetic Nephropathy
MC Thomas, JM Forbes, ME Cooper
American Journal of Therapeutics 2005
Synthesis, tandem MS- and NMR-based characterization, and quantification of the carbon 13-labeled advanced glycation endproduct, 6-N-carboxymethyllysine
T Delatour, F Fenaille, V Parisod, FA Vera, T Buetler
Amino Acids 2005
Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance
DL Bissett, JE Oblong, CA Berge
Dermatologic Surgery 2005
Advanced glycation endproducts—role in pathology of diabetic complications
N Ahmed
Diabetes Research and Clinical Practice 2005
Advanced Glycation End Products and Diabetic Nephropathy:
MC Thomas, JM Forbes, ME Cooper
American Journal of Therapeutics 2005
Capillary electrophoretic analysis of advanced glycation endproducts formed from the reaction of reducing sugars with the amino group of glucosamine
U Dutta, JA Dain
Analytical Biochemistry 2005
Cross-Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on “a Puzzle Nearing Resolution”
VM Monnier, GT Mustata, KL Biemel, O Reihl, MO Lederer, D Zhenyu, DR Sell
Annals of the New York Academy of Sciences 2005
Accumulation of Advanced Glycation End Products, Measured as Skin Autofluorescence, in Renal Disease
JW Hartog, AP de Vries, HL Lutgers, R Meerwaldt, RM Huisman, WJ van Son, PE de Jong, AJ Smit
Annals of the New York Academy of Sciences 2005
Tissue-Specific Variation in Glycation of Proteins in Diabetes: Evidence for a Functional Role of Amadoriase Enzymes
SM Brown, DM Smith, N Alt, SR Thorpe, JW Baynes
Annals of the New York Academy of Sciences 2005
Advanced glycation end products and the kidney
JM Bohlender, S Franke, G Stein, G Wolf
American journal of physiology. Renal physiology 2005
Dermatoses em pacientes com diabetes mellitus
NT Foss, DP Polon, MH Takada, MC Foss-Freitas, MC Foss
Revista de Saúde Pública 2005
Advanced glycation end products in kidney transplant patients: a putative role in the development of chronic renal transplant dysfunction
JW Hartog, AJ Smit, WJ van Son, G Navis, RO Gans, BH Wolffenbuttel, PE de Jong
American Journal of Kidney Diseases 2004
Tomato Paste Fraction Inhibiting the Formation of Advanced Glycation End-products
T KIHO, S USUI, K HIRANO, K AIZAWA, T INAKUMA
Bioscience, Biotechnology, and Biochemistry 2004
Effect of dicarbonyl-induced browning on alpha-crystallin chaperone-like activity: physiological significance and caveats of in vitro aggregation assays
MS Kumar, PY Reddy, PA Kumar, I Surolia, GB Reddy
Biochemical Journal 2004
Encyclopedia of Biological Chemistry
S DiMauro
Encyclopedia of Biological Chemistry 2004
The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes
JM Forbes, MC Thomas, SR Thorpe, NL Alderson, ME Cooper
Kidney International 2004
Advanced glycation and endothelial functions: A link towards vascular complications in diabetes
A Rojas, MA Morales
Life Sciences 2004
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin1
DL Bissett, K Miyamoto, P Sun, J Li, CA Berge
International Journal of Cosmetic Science 2004
Galectin-3 in osteoarthritis: when the fountain of youth doesn???t deliver its promises
P Reboul, J Martel-Pelletier, JP Pelletier
Current Opinion in Rheumatology 2004
Chemical modification of muscle protein in diabetes
N Alt, JA Carson, NL Alderson, Y Wang, R Nagai, T Henle, SR Thorpe, JW Baynes
Archives of Biochemistry and Biophysics 2004
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis
Josephine M Forbes, Louis Teo Loon Yee, Vicki Thallas, Markus Lassila, Riccardo Candido, Karin A Jandeleit-Dahm, Merlin C Thomas, Wendy C Burns, Elizabeth K Deemer, Susan R Thorpe, Susan M Thorpe, Mark E Cooper, Terri J Allen
Diabetes 2004
Concentrations of Pentosidine, an Advanced Glycation End-product, in Umbilical Cord Blood
H Tsukahara, N Ohta, S Sato, M Hiraoka, K Shukunami, M Uchiyama, H Kawakami, K Sekine, M Mayumi
Free Radical Research 2004
Advanced Glycation End Products Enhance Expression of Pro-apoptotic Genes and Stimulate Fibroblast Apoptosis through Cytoplasmic and Mitochondrial Pathways
Z Alikhani, M Alikhani, CM Boyd, K Nagao, PC Trackman, DT Graves
The Journal of biological chemistry 2004
Simple non-invasive assessment of advanced glycation endproduct accumulation
R Meerwaldt, R Graaff, PH Oomen, TP Links, JJ Jager, NL Alderson, SR Thorpe, JW Baynes, RO Gans, AJ Smit
Diabetologia 2004
3-Hydroxypyridine Chromophores Are Endogenous Sensitizers of Photooxidative Stress in Human Skin Cells
GT Wondrak, MJ Roberts, MK Jacobson, EL Jacobson
The Journal of biological chemistry 2004
Increased accumulation of the glycoxidation product Nε-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody
CG Schalkwijk, A Baidoshvili, CD Stehouwer, VW van Hinsbergh, HW Niessen
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2004
Glucose, glycation and aging
G Suji, S Sivakami
Biogerontology 2004
Use of fluorescence and near-infrared spectroscopies for noninvasive measurement of skin-collagen Advanced Glycation Endproducts: a feasibility study
MN Ediger, EL Hull, AH Unione, EK Deemer, ML Stroman, JW Baynes
2004
In Vitro Quantitation of Advanced Glycation Endproducts in Porcine Dermis using Raman Spectroscopy
ZJ Smith, AJ Berger, EL Hull, MN Ediger, JW Baynes
2004
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat
NL Alderson, ME Chachich, N Frizzell, P Canning, TO Metz, AS Januszewski, NN Youssef, AW Stitt, JW Baynes, SR Thorpe
Diabetologia 2004
The breakdown of pre‐existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
JM Forbes, V Thallas, MC Thomas, HW Founds, WC Burns, G Jerums, ME Cooper
The FASEB Journal 2003
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini
International Textbook of Diabetes Mellitus 2003
Carbonyl Stress and Diabetic Complications
T Miyata, N Ishikawa, CY de Strihou
Clinical Chemistry and Laboratory Medicine 2003
Advanced glycation endproducts and osteoarthritis
DM Saudek, J Kay
Current Rheumatology Reports 2003
A quantitative model of the generation of N(epsilon)-(carboxymethyl)lysine in the Maillard reaction between collagen and glucose
AE Ferreira, AM Freire, EO Voit
Biochemical Journal 2003
Glucose-mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues
GK Reddy
Journal of Orthopaedic Research 2003
Proteins of the Extracellular Matrix Are Sensitizers of Photo-oxidative Stress in Human Skin Cells
GT Wondrak, MJ Roberts, D Cervantes-Laurean, MK Jacobson, EL Jacobson
Journal of Investigative Dermatology 2003
DNA damage by carbonyl stress in human skin cells
MJ Roberts, GT Wondrak, DC Laurean, MK Jacobson, EL Jacobson
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2003
Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes
TA Gardiner, HR Anderson, AW Stitt
The Journal of Pathology 2003
The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats
NL Alderson, ME Chachich, NN Youssef, RJ Beattie, M Nachtigal, SR Thorpe, JW Baynes
Kidney International 2003
AGEing and osteoarthritis: a different perspective
N Verzijl, RA Bank, JM TeKoppele, J DeGroot
Current Opinion in Rheumatology 2003
N(carboxymethyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients
MP Wautier, P Massin, PJ Guillausseau, M Huijberts, B Levy, E Boulanger, M Laloi-Michelin, JL Wautier
Diabetes & Metabolism 2003
Increased level of glycoxidation product Nε-(carboxymethyl)lysine in rat serum and urine proteins with aging: Link with glycoxidative damage accumulation in kidney
M Hamelin, C Borot-Laloi, B Friguet, H Bakala
Archives of Biochemistry and Biophysics 2003
Therapeutic potential of breakers of advanced glycation end product–protein crosslinks
S Vasan, P Foiles, H Founds
Archives of Biochemistry and Biophysics 2003
Medical Pearl: Scleroderma-like skin changes in patients with diabetes mellitus
G Yosipovitch, KC Loh, OB Hock
Journal of the American Academy of Dermatology 2003
Does dietary sugar and fat influence longevity?
VE Archer
Medical Hypotheses 2003
Protein oxidation in aging: endoplasmic reticulum as a target
D der Vlies, J Woudenberg, JA Post
Amino Acids 2003
The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates
David R Sell, Mark A Lane, Mark E Obrenovich, Julie A Mattison, April Handy, Donald K Ingram, Richard G Cutler, George S Roth, Vincent M Monnier
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2003
Modification of Proteins In Vitro by Physiological Levels of Glucose: PYRIDOXAMINE INHIBITS CONVERSION OF AMADORI INTERMEDIATE TO ADVANCED GLYCATION END-PRODUCTS THROUGH BINDING OF REDOX METAL IONS
PA Voziyan, RG Khalifah, C Thibaudeau, A Yildiz, J Jacob, AS Serianni, BG Hudson
The Journal of biological chemistry 2003
Modulating Aging and Longevity
SI Rattan
2003
Changes in Glycation of Fibrous Type I Collagen During Long-Term In Vitro Incubation with Glucose
M Meli, R Granouillet, E Reynaud, A Chamson, J Frey, C Perier
Journal of Protein Chemistry 2003
Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug
TA Gardiner, HR Anderson, T Degenhardt, SR Thorpe, JW Baynes, DB Archer, AW Stitt
Diabetologia 2003
Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: Insights into the pathogenesis of macrovascular complications in diabetes
T Wendt, L Bucciarelli, W Qu, Y Lu, SF Yan, DM Stern, AM Schmidt
Current Atherosclerosis Reports 2002
Neurovascular disease, antioxidants and glycation in diabetes
PJ Dickinson, AL Carrington, GS Frost, AJ Boulton
Diabetes/Metabolism Research and Reviews 2002
Sugar-Induced Modification of Fibroblast Growth Factor 2 Reduces Its Angiogenic Activity in Vivo
F Facchiano, A Lentini, V Fogliano, S Mancarella, C Rossi, A Facchiano, MC Capogrossi
The American Journal of Pathology 2002
Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat
TP Degenhardt, NL Alderson, DD Arrington, RJ Beattie, JM Basgen, MW Steffes, SR Thorpe, JW Baynes
Kidney International 2002
Photosensitized Growth Inhibition of Cultured Human Skin Cells: Mechanism and Suppression of Oxidative Stress from Solar Irradiation of Glycated Proteins
GT Wondrak, MJ Roberts, MK Jacobson, EL Jacobson
Journal of Investigative Dermatology 2002
Effect of Carnosine and Related Compounds on the Inactivation of Human Cu,Zn-Superoxide Dismutase by Modification of Fructose and Glycolaldehyde
H UKEDA, Y HASEGAWA, Y HARADA, M SAWAMURA
Bioscience, Biotechnology, and Biochemistry 2002
CML: a brief history
SR Thorpe, JW Baynes
International Congress Series 2002
Diabetes, Oxidative Stress and Physical Exercise
M Atalay, DE Laaksonen
Journal of sports science & medicine 2002
Molecular Characterization of Mammalian Dicarbonyl/l-Xylulose Reductase and Its Localization in Kidney
J Nakagawa, S Ishikura, J Asami, T Isaji, N Usami, A Hara, T Sakurai, K Tsuritani, K Oda, M Takahashi, M Yoshimoto, N Otsuka, K Kitamura
The Journal of biological chemistry 2002
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE: A Mechanism for Amplification of Inflammatory Responses
G Basta, G Lazzerini, M Massaro, T Simoncini, P Tanganelli, C Fu, T Kislinger, DM Stern, AM Schmidt, RD Caterina
Circulation 2002
A hydroxyl radical-like species oxidizes artery wall proteins in hyperglycemic cynomolgus monkeys: evidence for localized damage in early diabetic vascular disease
Subramaniam Pennathur, Janice D. Wagner, Christiaan Leeuwenburgh, Kenneth N. Litwak, Jay W. Heinecke
Journal of Clinical Investigation 2001
N-phenacylthiazolium bromide decreases renal and increases urinary advanced glycation end products excretion without ameliorating diabetic nephropathy in C57BL/6 mice
SB Schwedler, P Verbeke, H Bakala, MF Weiss, J Vilar, P Depreux, E Fourmaintraux, LJ Striker, GE Striker
Diabetes, Obesity and Metabolism 2001
Two advanced glycation molecules, carboxymethyllysine and pentosidine, and dialysis membrane in dialysis-related amyloidosis
Y Motomiya, Y Uji, T Uchimura, H Iwamoto, M Miura, I Maruyama
Journal of Artificial Organs 2001
Protein Oxidation in Aging and Age-Related Diseases
ER Stadtman
Annals of the New York Academy of Sciences 2001
Degradation of the cartilage collagen matrix associated with changes in chondrocytes in osteoarthrosis. Assessment by loss of background fluorescence and immunodetection of matrix components
GJ Gibson, JJ Verner, FR Nelson, DL Lin
Journal of Orthopaedic Research 2001
Protein oxidation and ageing
S Linton, MJ Davies, RT Dean
Experimental Gerontology 2001
Effect of Chronic Aminoguanidine Treatment on Age-Related Glycation, Glycoxidation, and Collagen Cross-linking in the Fischer 344 Rat
DR Sell, JF Nelson, VM Monnier
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001
Aging and Effects of Ultraviolet A Exposure may be Quantified by Fluorescence Excitation Spectroscopy In Vivo
WD Tian, R Gillies, L Brancaleon, N Kollias
Journal of Investigative Dermatology 2001
Autofluorescence of Human Skin is Age-Related After Correction for Skin Pigmentation and Redness
R Na, IM Stender, M Henriksen, HC Wulf
Journal of Investigative Dermatology 2001
Cosmetic Science and Technology
M Denda
Cosmetic Science and Technology 2001
Reactive carbonyl compounds related uremic toxicity (“carbonyl stress”)
T Miyata, S Sugiyama, A Saito, K Kurokawa
Kidney International 2001
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
MP Wautier, O Chappey, S Corda, DM Stern, AM Schmidt, JL Wautier
American journal of physiology. Endocrinology and metabolism 2001
A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation
PA Voziyan, TO Metz, JW Baynes, BG Hudson
The Journal of biological chemistry 2001
Body-Site Variation of Skin Autofluorescence
MA Davies, MP Hogan
Applied Spectroscopy 2001
Characterization of a Novel Hemoglobin-Glutathione Adduct That Is Elevated in Diabetic Patients
Y Al-Abed, S VanPatten, H Li, JA Lawson, GA FitzGerald, KR Manogue, R Bucala
Molecular Medicine 2001
Inflammation and Stroke
GZ Feuerstein
2001
Glycoscience: Chemistry and Chemical Biology I–III
BO Fraser-Reid, K Tatsuta, J Thiem
2001
Relevance of oxidative and carbonyl stress to long-term uremic complications
T Miyata, K Kurokawa, CV de Strihou
Kidney International 2000
Differential scanning calorimetry, biochemical, and biomechanical analysis of human skin from individuals with diabetes mellitus
M Melling, W Pfeiler, D Karimian-Teherani, M Schnallinger, G Sobal, C Zangerle, EJ Menzel
The Anatomical Record 2000
Mechanisms for the formation of glycoxidation products in end-stage renal disease
MF Weiss, P Erhard, FA Kader-Attia, YC Wu, PB Deoreo, A Araki, MA Glomb, VM Monnier
Kidney International 2000
Effect of Age and Menopause on Serum Concentrations of Pentosidine, an Advanced Glycation End Product
M Takahashi, M Oikawa, A Nagano
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2000
Glycoxidation and lipoxidation in atherogenesis
JW Baynes, SR Thorpe
Free radical biology & medicine 2000
Age-related accumulation of Maillard reaction products in human articular cartilage collagen
N Verzijl, J DeGroot, E Oldehinkel, RA Bank, SR Thorpe, JW Baynes, MT Bayliss, JW Bijlsma, FP Lafeber, JM Tekoppele
Biochemical Journal 2000
Identification of N(omega)-carboxymethylarginine as a novel acid-labileadvanced glycation end product in collagen
K Iijima, M Murata, H Takahara, S Irie, D Fujimoto
Biochemical Journal 2000
In vitro glycoxidation alters the interactions between collagens and human polymorphonuclear leucocytes
JC Monboisse, L Rittie, H Lamfarraj, R Garnotel, P Gillery
Biochemical Journal 2000
Scanning force microscopy reveals structural alterations in diabetic rat collagen fibrils: role of protein glycation
P Odetti, I Aragno, R Rolandi, S Garibaldi, S Valentini, L Cosso, N Traverso, D Cottalasso, MA Pronzato, UM Marinari
Diabetes/Metabolism Research and Reviews 2000
What is oxidative stress?
DJ Betteridge
Metabolism 2000
Advanced glycation end products: A nephrologist's perspective
DS Raj, D Choudhury, TC Welbourne, M Levi
American Journal of Kidney Diseases 2000
Increased Expression of Lysyl Oxidase mRNA in Progressive Mesangial Proliferative Nephritis in the Rat
Y LIU, A YOSHIMURA, K INUI, N YOKOTA, S WATANABE, H MORITA, T IDEURA
The Showa University Journal of Medical Sciences 2000
Effects of Advanced Glycation End-products on the Proliferation and Fibronectin Production of Smooth Muscle Cells
N Sakata, J Meng, S Takebayashi
Journal of Atherosclerosis and Thrombosis 2000
Handbook of Oxidants and Antioxidants in Exercise
RR Jenkins, J Beard
Handbook of Oxidants and Antioxidants in Exercise 2000
The biology of the receptor for advanced glycation end products and its ligands
A M Schmidt, S D Yan, S F Yan, D M Stern
Biochimica et Biophysica Acta 2000
Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice
DA Sell, NR Kleinman, VI Monnier
The FASEB Journal 2000
The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen
2000
Oxidative Stress and Vascular Disease
JF Keaney
2000
Intraperitoneal Infusion of Glucose-Based Dialysate in the Rat—An Animal Model for the Study of Peritoneal Advanced Glycation End-Products Formation and Effect on Peritoneal Transport
E Zeltzer, O Klein, G Rashid, D Katz, Z Korzets, J Bernheim
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2000
Advanced Glycation and Lipoxidation End Products: Role of Reactive Carbonyl Compounds Generated during Carbohydrate and Lipid Metabolism
T Miyata, K Kurokawa, CV Strihou
Journal of the American Society of Nephrology : JASN 2000
The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation
MM Anderson, JR Requena, JR Crowley, SR Thorpe, JW Heinecke
Journal of Clinical Investigation 1999
Nichtenzymatische Glykierung und oxidativer Streß bei chronischen Erkrankungen und Diabetes mellitus
PP Nawroth, A Bierhaus, GE Vogel, MA Hofmann, M Zumbach, P Wahl, R Ziegler
Medizinische Klinik 1999
Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction
N Kawada, T Moriyama, A Ando, M Fukunaga, T Miyata, K Kurokawa, E Imai, M Hori
Kidney International 1999
Alterations in nonenzymatic biochemistry in uremia: Origin and significance of "carbonyl stress" in long-term uremic complications
T Miyata, CV de Strihou, K Kurokawa, JW Baynes
Kidney International 1999
Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats
T Degenhardt
Diabetes Research and Clinical Practice 1999
Emerging therapeutic targets in diabetic vascular disease
AM Schmidt, DM Stern
Expert Opinion on Therapeutic Targets 1999
Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy
T Miyata, S Sugiyama, D Suzuki, R Inagi, K Kurokawa
Kidney International 1999
Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial
VM Monnier, O Bautista, D Kenny, DR Sell, J Fogarty, W Dahms, PA Cleary, J Lachin, S Genuth
Diabetes 1999
Protein Aging by Carboxymethylation of Lysines Generates Sites for Divalent Metal and Redox Active Copper Binding: Relevance to Diseases of Glycoxidative Stress
AK Saxena, P Saxena, X Wu, M Obrenovich, MF Weiss, VM Monnier
Biochemical and Biophysical Research Communications 1999
Oxygen is not required for the browning and crosslinking of protein by pentoses: relevance to Maillard reactions in vivo
JE Litchfield, SR Thorpe, JW Baynes
The International Journal of Biochemistry & Cell Biology 1999
Amadorins: Novel Post-Amadori Inhibitors of Advanced Glycation Reactions
RG Khalifah, JW Baynes, BG Hudson
Biochemical and Biophysical Research Communications 1999
Conversion of Lysine to Nϵ-(Carboxymethyl)lysine Increases Susceptibility of Proteins to Metal-Catalyzed Oxidation
JR Requena, ER Stadtman
Biochemical and Biophysical Research Communications 1999
Effect of aminophospholipid glycation on order parameter and hydration of phospholipid bilayer
T Obsil
Biophysical Chemistry 1999
Protein Crosslinking by the Maillard Reaction: Dicarbonyl-Derived Imidazolium Crosslinks in Aging and Diabetes
P Chellan, RH Nagaraj
Archives of Biochemistry and Biophysics 1999
Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions
D Suzuki, T Miyata, N Saotome, K Horie, R Inagi, Y Yasuda, K Uchida, Y Izuhara, M Yagame, H Sakai, K Kurokawa
Journal of the American Society of Nephrology : JASN 1999
Management of the stiff shoulder**Presented at the 47th Annual Meeting of the Eastern Japan Association of Orthopaedics and Traumatology in Akita on September 4, 1998
BA Goldberg, MM Scarlat, DT Harryman
Journal of Orthopaedic Science 1999
Nε -(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression
T Kislinger, C Fu, B Huber, W Qu, A Taguchi, SD Yan, M Hofmann, SF Yan, M Pischetsrieder, D Stern, AM Schmidt
The Journal of biological chemistry 1999
Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis
JR Chen, M Takahashi, M Suzuki, K Kushida, S Miyamoto, T Inoue
Rheumatology (Oxford, England) 1999
Glomerulosclerosis in Captive Cheetahs ( Acinonyx jubatus )
LA Bolton, L Munson
Veterinary pathology 1999
Mass Spectrometric Quantification of 3-Nitrotyrosine, ortho -Tyrosine, and o , o′ -Dityrosine in Brain Tissue of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Mice, a Model of Oxidative Stress in Parkinson's Disease
S Pennathur, V Jackson-Lewis, S Przedborski, JW Heinecke
The Journal of biological chemistry 1999
Pathogenesis and Management of Dialysis-Related Amyloid Bone Disease:
M Nangaku, T Miyata, K Kurokawa
The American Journal of the Medical Sciences 1999
Carbonyl Stress: Increased Carbonyl Modification of Proteins by Autoxidation Products of Carbohydrates and Lipids in Uremia
T Miyata, K Kurokawa
The International Journal of Artificial Organs 1999
Activation of Receptor for Advanced Glycation End Products: A Mechanism for Chronic Vascular Dysfunction in Diabetic Vasculopathy and Atherosclerosis
AM Schmidt, SD Yan, JL Wautier, D Stern
Circulation research 1999
Pain and Neurogenic Inflammation
SD Brain, PK Moore
1999
Maillard Reaction and Age Formation in Glucose and Polyglucose Dialysis Solutions
T Tomo, T Shibata, M Nasu
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999
Renal catabolism of advanced glycation end products: The fate of pentosidine
T Miyata, Y Ueda, K Horie, M Nangaku, S Tanaka, CY de Strihou, K Kurokawa
Kidney International 1998
Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes
M Bendayan
Kidney International 1998
Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus
IMAKADO, SATOMI, ISKIKAWA, IWATA, TSUBOUCHI, AND F.OTSUKA
Clinical and Experimental Dermatology 1998
Immunohistochemical and ELISA Assays for Biomarkers of Oxidative Stress in Aging and Diseasea
JM Onorato, SR Thorpe, JW Baynes
Annals of the New York Academy of Sciences 1998
The Maillard Reaction in Foods and Medicine
TP Degenhardt, E Brinkmann-Frye, SR Thorpe, JW Baynes
The Maillard Reaction in Foods and Medicine 1998
Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products
X Wang, R Bucala, R Milne
Proceedings of the National Academy of Sciences 1998
Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?
T Miyata, MX Fu, K Kurokawa, CY de Strihou, SR Thorpe, JW Baynes
Kidney International 1998
Implication of Altered Redox Regulation by Antioxidant Enzymes in the Increased Plasma Pentosidine, an Advanced Glycation End Product, in Uremia
Y Ueda, T Miyata, T Hashimoto, H Yamada, Y Izuhara, H Sakai, K Kurokawa
Biochemical and Biophysical Research Communications 1998
Increased Pentosidine, an Advanced Glycation End Product, in Plasma and Synovial Fluid from Patients with Rheumatoid Arthritis and Its Relation with Inflammatory Markers
T Miyata, N Ishiguro, Y Yasuda, T Ito, M Nangaku, H Iwata, K Kurokawa
Biochemical and Biophysical Research Communications 1998
The Advanced Glycation Endproduct Pentosidine Induces the Expression of PDGF-B in Human Retinal Pigment Epithelial Cells
JT Handa, KM Reiser, H Matsunaga, LM Hjelmeland
Experimental Eye Research 1998
Oral administration of methylglyoxal leads to kidney collagen accumulation in the mouse
J Golej, H Hoeger, W Radner, G Unfried, G Lubec
Life Sciences 1998
Diabetes-induced impairment of macrophage cytokine release in a rat model: Potential role of serum lipids
DL Doxey, S Nares, B Park, C Trieu, CW Cutler, AM Iacopino
Life Sciences 1998
Conversion of Amadori product of Maillard reaction to Nϵ-(carboxymethyl)lysine in alkaline condition
R Nagai, K Ikeda, Y Kawasaki, H Sano, M Yoshida, T Araki, S Ueda, S Horiuchi
FEBS Letters 1998
Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids
T Miyata, R Inagi, K Asahi, Y Yamada, K Horie, H Sakai, K Uchida, K Kurokawa
FEBS Letters 1998
Immunological Evidence for Methylglyoxal-derived Modifications in Vivo: DETERMINATION OF ANTIGENIC EPITOPES
FA Shamsi, A Partal, C Sady, MA Glomb, RH Nagaraj
The Journal of biological chemistry 1998
Mechanisms of maturation and ageing of collagen
AJ Bailey, RG Paul, L Knott
Mechanisms of Ageing and Development 1998
Role of the Maillard Reaction in Aging of Tissue Proteins: ADVANCED GLYCATION END PRODUCT-DEPENDENT INCREASE IN IMIDAZOLIUM CROSS-LINKS IN HUMAN LENS PROTEINS
EB Frye, TP Degenhardt, SR Thorpe, JW Baynes
The Journal of biological chemistry 1998
Aromatic hydroxylation in animal models of diabetes mellitus
B Lubec, M Hermon, H Hoeger, G Lubec
The FASEB Journal 1998
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler
1998
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging
ED Schleicher, E Wagner, AG Nerlich
Journal of Clinical Investigation 1997
Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes
MC Wells-Knecht, TJ Lyons, DR McCance, SR Thorpe, JW Baynes
Journal of Clinical Investigation 1997
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy
K Horie, T Miyata, K Maeda, S Miyata, S Sugiyama, H Sakai, CY de Strihou, VM Monnier, JL Witztum, K Kurokawa
Journal of Clinical Investigation 1997
Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure
T Miyata, Y Wada, Z Cai, Y Iida, K Horie, Y Yasuda, K Maeda, K Kurokawa, CV de Strihou
Kidney International 1997
Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy
T Miyata, Y Ueda, A Yoshida, S Sugiyama, Y Iida, M Jadoul, K Maeda, K Kurokawa, CY de Strihou
Kidney International 1997
Influence of risk factors on the pathogenesis of periodontitis
GE Salvi, HP Lawrence, S Offenbacher, JD Beck
Periodontology 2000 1997
Photo-Enhanced Modification of Human Skin Elastin in Actinic Elastosis by NE-(Carboxymethyl)lysine, One of the Glycoxidation Products of the Maillard Reaction
K Mizutari, T Ono, K Ikeda, K Kayashima, S Horiuchi
Journal of Investigative Dermatology 1997
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins
MU Ahmed, EB Frye, TP Degenhardt, SR Thorpe, JW Baynes
Biochemical Journal 1997
Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells
B Smedsrød, J Melkko, N Araki, H Sano, S Horiuchi
Biochemical Journal 1997
Immunohistochemical Localization of Advanced Glycation End Products, Pentosidine, and Carboxymethyllysine in Lipofuscin Pigments of Alzheimer's Disease and Aged Neurons
K Horie, T Miyata, T Yasuda, A Takeda, Y Yasuda, K Maeda, G Sobue, K Kurokawa
Biochemical and Biophysical Research Communications 1997
Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice
IA Darby, T Bisucci, TD Hewitson, DG MacLellan
The International Journal of Biochemistry & Cell Biology 1997
Reversed-phase chromatography of pentosidine-containing CNBr peptides from collagen
Z Deyl
Analytica Chimica Acta 1997
1997 Volvo Award Winner in Basic Science Studies
AG Nerlich, ED Schleicher, N Boos
Spine 1997
Age-related discontinuous changes in the in vivo fluorescence of human facial skin
Y Takema, Y Yorimoto, H Ohsu, O Osanai, M Kawai
Journal of Dermatological Science 1997
Glycation of collagen in hypertriglyceridemic rats
I Mikšík, J Zicha, J Kuneš, Z Deyl
Life Sciences 1997
Evidence against increased glycoxidation in patients with Alzheimer's disease
R Seidl
Neuroscience Letters 1997
Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct
IN Shipanova, MA Glomb, RH Nagaraj
Archives of Biochemistry and Biophysics 1997
Post-translational non-enzymatic modification of proteins II. Separation of selected protein species after glycation and other carbonyl-mediated modifications
I Mikšík, Z Deyl
Journal of Chromatography B Biomedical Sciences and Applications 1997
Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis
Timothy J. Lyons, Alicia J. Jenkins
Diabetes reviews (Alexandria, Va.) 1997
The serum concentration of the advanced glycation end-product Nε-(carboxymethyl)lysine is increased in uremia: Technical Note
TP Degenhardt, L Grass, S Reddy, SR Thorpe, EP Diamandis, JW Baynes
Kidney International 1997
Accumulation of Advanced Glycation Endproducts in the Rat Nephron: Link with Circulating AGEs During Aging
P Verbeke, M Perichon, C BorotLaloi, J Schaeverbeke, H Bakala
Journal of Histochemistry & Cytochemistry 1997
Carboxymethylethanolamine, a Biomarker of Phospholipid Modification during the Maillard Reaction in Vivo
JR Requena, MU Ahmed, CW Fountain, TP Degenhardt, S Reddy, C Perez, TJ Lyons, AJ Jenkins, JW Baynes, SR Thorpe
The Journal of biological chemistry 1997
In Vitro Kinetic Studies of Formation of Antigenic Advanced Glycation End Products (AGEs): NOVEL INHIBITION OF POST-AMADORI GLYCATION PATHWAYS
AA Booth, RG Khalifah, P Todd, BG Hudson
The Journal of biological chemistry 1997
Ageing promotes the increase of early glycation Amadori product as assessed by ϵ-N-(2-furoylmethyl)-l-lysine (furosine) levels in rodent skin collagen
DR Sell
Mechanisms of Ageing and Development 1997
Inhibitory Effects of Tenilsetam on the Maillard Reaction
H Shoda, S Miyata, BF Liu, H Yamada, T Ohara, K Suzuki, M Oimomi, M Kasuga
Endocrinology 1997
Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment
T Soulis, ME Cooper, D Vranes, R Bucala, G Jerums
Kidney International 1996
Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes
RG Paul, AJ Bailey
The International Journal of Biochemistry & Cell Biology 1996
Monocyte/macrophage response to β2-microglobulin modified with advanced glycation end products
T Miyata, Y Iida, Y Ueda, T Shinzato, H Seo, VM Monnier, K Maeda, Y Wada
Kidney International 1996
Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis
T Miyata, S Taneda, R Kawai, Y Ueda, S Horiuchi, M Hara, K Maeda, VM Monnier
Proceedings of the National Academy of Sciences 1996
Experimental nonenzymatic glycosylation of vitreous collagens occurs by two pathways
JS Pulido
Transactions of the American Ophthalmological Society 1996
Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain
A Takeda, T Yasuda, T Miyata, K Mizuno, M Li, S Yoneyama, K Horie, K Maeda, G Sobue
Neuroscience Letters 1996
Role of the Maillard Reaction in Diabetes Mellitus and Diseases of Aging:
SR Thorpe, JW Baynes
Drugs & Aging 1996
Diabetic periodontitis: possible lipid-induced defect in tissue repair through alteration of macrophage phenotype and function
AM Iacopino
Oral Diseases 1995
The effects of ageing on cutaneous wound healing in mammals
GS Ashcroft, MA Horan, MW Ferguson
Journal of Anatomy 1995
Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex
H Vlassara, YM Li, F Imani, D Wojciechowicz, Z Yang, FT Liu, A Cerami
Molecular Medicine 1995
The Maillard reaction and oxidative stress during aging of soybean seeds
WQ Sun, AC Leopold
Physiologia Plantarum 1995
Evidence for the Maillard reaction in rat lung collagen and its relationship with solubility and age
M J Bellmunt, M Portero, R Pamplona, L Cosso, P Odetti, J Prat
Biochimica et Biophysica Acta 1995
Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose
KJ Wells-Knecht, DV Zyzak, JE Litchfield, SR Thorpe, JW Baynes
Biochemistry 1995
N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins
S Reddy, J Bichler, KJ Wells-Knecht, SR Thorpe, JW Baynes
Biochemistry 1995
Free Radicals Generated during the Glycation Reaction of Amino Acids by Methylglyoxal
HS Yim, SO Kang, YC Hah, PB Chock, MB Yim
The Journal of biological chemistry 1995
Maillard Reactions in Chemistry, Food and Health
AM Schmidt, DM Stern
Maillard Reactions in Chemistry, Food and Health 1994
Protein glycation and fluorescent material in human atheroma
JV Hunt, JT Skamarauskas, MJ Mitchinson
Atherosclerosis 1994
Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins
AM Schmidt, M Hasu, D Popov, JH Zhang, J Chen, SD Yan, J Brett, R Cao, K Kuwabara, G Costache
Proceedings of the National Academy of Sciences 1994
Natural Antioxidants in Human Health and Disease
M Levine, KR Dhariwal, Y Wang, JB Park, RW Welch
Natural Antioxidants in Human Health and Disease 1994
Role of metal-catalyzed autoxidation in Maillard reaction damage to proteins in vivo
JW Baynes
Redox Report 1994
Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions
AM Schmidt, O Hori, J Brett, SD Yan, JL Wautier, D Stern
Arteriosclerosis Thrombosis and Vascular Biology 1994
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus
DR McCance, DG Dyer, JA Dunn, KE Bailie, SR Thorpe, JW Baynes, TJ Lyons
Journal of Clinical Investigation 1993
Replacement of Renal Function by Dialysis
W Drukker, FM Parsons, JF Maher
1979

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