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Citations to this article

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
D G Dyer, … , D R McCance, J W Baynes
D G Dyer, … , D R McCance, J W Baynes
Published June 1, 1993
Citation Information: J Clin Invest. 1993;91(6):2463-2469. https://doi.org/10.1172/JCI116481.
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Research Article Article has an altmetric score of 12

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

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Abstract

To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 nondiabetic control subjects. Compounds studied included fructoselysine (FL), the initial glycation product, and the glycoxidation products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine, formed during later Maillard reactions. Collagen-linked fluorescence was also studied. In nondiabetic subjects, glycation of collagen (FL content) increased only 33% between 20 and 85 yr of age. In contrast, CML, pentosidine and fluorescence increased five-fold, correlating strongly with age. In diabetic patients, collagen FL was increased threefold compared with nondiabetic subjects, correlating strongly with glycated hemoglobin but not with age. Collagen CML, pentosidine and fluorescence were increased up to twofold in diabetic compared with control patients: this could be explained by the increase in glycation alone, without invoking increased oxidative stress. There were strong correlations among CML, pentosidine and fluorescence in both groups, providing evidence for age-dependent chemical modification of collagen via the Maillard reaction, and acceleration of this process in diabetes. These results support the description of diabetes as a disease characterized by accelerated chemical aging of long-lived tissue proteins.

Authors

D G Dyer, J A Dunn, S R Thorpe, K E Bailie, T J Lyons, D R McCance, J W Baynes

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1979 Total
Citations: 5 4 8 9 13 11 14 17 18 30 12 37 21 23 23 20 20 14 20 14 21 19 22 10 17 20 25 19 25 7 8 6 1 1 534
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Citations to this article in year 2016 (30)

Title and authors Publication Year
Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease
NL Reynaert, P Gopal, EP Rutten, EF Wouters, CG Schalkwijk
The International Journal of Biochemistry & Cell Biology 2016
The Course of Skin and Serum Biomarkers of Advanced Glycation Endproducts and Its Association with Oxidative Stress, Inflammation, Disease Severity, and Mortality during ICU Admission in Critically Ill Patients: Results from a Prospective Pilot Study
JH Meertens, HL Nienhuis, JD Lefrandt, CG Schalkwijk, K Nyyssönen, JJ Ligtenberg, AJ Smit, JG Zijlstra, DJ Mulder, R Nagaraj
PloS one 2016
Cellular mechanisms and consequences of glycation in atherosclerosis and obesity
RL Díez, A Shekhtman, R Ramasamy, AM Schmidt
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016
Effect of glycation inhibitors on aging and age-related diseases
I Sadowska-Bartosz, G Bartosz
Mechanisms of Ageing and Development 2016
Antiglycation and Antioxidant Properties of Momordica charantia
A Aljohi, S Matou-Nasri, N Ahmed, C Miele
PloS one 2016
Calcitriol prevents peripheral RSC96 Schwann neural cells from high glucose & methylglyoxal-induced injury through restoration of CBS/H2S expression
H Zhang, X Zhuang, F Meng, L Chen, X Dong, G Liu, J Li, Q Dong, J Xu, C Yang
Neurochemistry International 2016
Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature
WW Fuijkschot, HJ de Graaff, E Berishvili, Z Kakabadze, K Kupreishvili, E Meinster, M Houtman, A Broekhoven, CG Schalkwijk, AB Vonk, PA Krijnen, YM Smulders, HW Niessen
European Journal of Clinical Investigation 2016
Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
KM Heinemeier, P Schjerling, J Heinemeier, MB Moller, MR Krogsgaard, T Grum-Schwensen, MM Petersen, M Kjaer
Science Translational Medicine 2016
Early Formation of Serum Advanced Glycation End-Products in Children with Type 1 Diabetes Mellitus: Relationship with Glycemic Control
S Jaisson, PF Souchon, A Desmons, AS Salmon, B Delemer, P Gillery
The Journal of Pediatrics 2016
Principles of Diabetes Mellitus
A Ohri, S Vergano, R Bhambri, SH Schneider
Principles of Diabetes Mellitus 2016
Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue
A Gautieri, FS Passini, U Silván, M Guizar-Sicairos, G Carimati, P Volpi, M Moretti, A Redaelli, M Berli, JG Snedeker
Matrix Biology 2016
Microfluidic-Based Non-Enzymatic Glycation Enhances Cross-Linking of Human Scleral Tissue Compared to Conventional Soaking: uF-based non-enzymatic glycation method
S Choi, SW Moon, KH Jin, JH Shin
Scanning 2016
Lifestyle and clinical determinants of skin autofluorescence in a population-based cohort study
RP van Waateringe, SN Slagter, MM van der Klauw, JV van Vliet-Ostaptchouk, R Graaff, AD Paterson, HL Lutgers, BH Wolffenbuttel
European Journal of Clinical Investigation 2016
Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF- κ B Pathways in HaCaT Cells
AR Han, MH Nam, KW Lee
Photochemistry and Photobiology 2016
Advances in Neurobiology
S Ahmad, M Farhan
Advances in Neurobiology 2016
The Association Between Sociodemographic Factors, Common Systemic Diseases, and Keratoconus
MA Woodward, TS Blachley, JD Stein
Ophthalmology 2016
Chemical Synthesis of Peptides Containing Site-Specific Advanced Glycation Endproducts
H Kaur, M Kamalov, MA Brimble
Accounts of Chemical Research 2016
Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats
G Raghu, S Jakhotia, PY Reddy, PA Kumar, GB Reddy
Food & Function 2016
Diabetes mellitus and the skin
E Makrantonaki, D Jiang, AM Hossini, G Nikolakis, M Wlaschek, K Scharffetter-Kochanek, CC Zouboulis
Reviews in Endocrine and Metabolic Disorders 2016
Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs
EJ Lee, JY Kim, SH Oh
Scientific Reports 2016
RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells
AI Serban, L Stanca, OI Geicu, MC Munteanu, A Dinischiotu, D Karamichos
PloS one 2016
Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications
YH Cho, ME Craig, AS Januszewski, P Benitez-Aguirre, S Hing, AJ Jenkins, KC Donaghue
Diabetic Medicine 2016
Beneficial Effects of Acanthopanax senticosus Extract in Type II Diabetes Animal Model via Down-Regulation of Advanced Glycated Hemoglobin and Glycosylation End Products
HO Kwon, M Lee, YJ Kim, E Kim, OK Kim
Journal of the Korean Society of Food Science and Nutrition 2016
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes
PJ Saulnier, KM Wheelock, S Howell, EJ Weil, SK Tanamas, WC Knowler, KV Lemley, M Mauer, B Yee, RG Nelson, PJ Beisswenger
Diabetes 2016
Engineering Foods for Bioactives Stability and Delivery
YH Roos, YD Livney
Engineering Foods for Bioactives Stability and Delivery 2016
Mechanisms Linking Aging, Diseases and Biological Age Estimation
S Zapico
Mechanisms Linking Aging, Diseases and Biological Age Estimation 2016
Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes
H Mori, A Kuroda, M Araki, R Suzuki, S Taniguchi, M Tamaki, Y Akehi, M Matsuhisa
Journal of Diabetes Investigation 2016
Arm, Leg, and Foot Skin Water in Persons With Diabetes Mellitus (DM) in Relation to HbA1c Assessed by Tissue Dielectric Constant (TDC) Technology Measured at 300 MHz
HN Mayrovitz, I Volosko, B Sarkar, N Pandya
Journal of diabetes science and technology 2016
Human Achilles tendon glycation and function in diabetes
C Couppé, RB Svensson, M Kongsgaard, V Kovanen, JF Grosset, O Snorgaard, J Bencke, JO Larsen, T Bandholm, TM Christensen, A Boesen, IC Helmark, P Aagaard, M Kjaer, SP Magnusson
Journal of applied physiology 2016
Diabetic Bone Disease
B Lecka-Czernik, JL Fowlkes
2016

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