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Citations to this article

Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.
J D Veldhuis, … , M Mercado, G Baumann
J D Veldhuis, … , M Mercado, G Baumann
Published February 1, 1993
Citation Information: J Clin Invest. 1993;91(2):629-641. https://doi.org/10.1172/JCI116243.
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Research Article

Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.

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Abstract

The discovery of a specific high-affinity growth hormone (GH) binding protein (GH-BP) in plasma adds complexity to the dynamics of GH secretion and clearance. Intuitive predictions are that such a protein would damp sharp oscillations in GH concentrations otherwise caused by bursts of GH secretion into the blood volume, prolong the apparent half-life of circulating GH, and contribute a reservoir function. To test these implicit considerations, we formulated an explicit mathematical model of pulsatile GH secretion and clearance in the presence of absence of a specific high-affinity GH-BP. Simulation experiments revealed that the pulsatile mode of physiological GH secretion creates a highly dynamic (nonequilibrium) system, in which the half-life of free GH, its instantaneous secretion rate, and the GH-BP affinity and capacity all contribute to defining momentary levels of free, bound, and total GH, the percentage of GH bound to protein, and the percentage occupancy of GH-BP [corrected]. In contrast, the amount of free GH at equilibrium is specified only by the GH distribution volume and secretion rate and the half-life of free hormone. We conclude that the in vivo dynamics of GH secretion, trapping, and clearance from the circulation offer a variety of regulatory loci at which the time structure of free, bound, and total GH delivery to target tissues can be controlled physiologically.

Authors

J D Veldhuis, M L Johnson, L M Faunt, M Mercado, G Baumann

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Total citations by year

Year: 2020 2019 2014 2012 2011 2009 2008 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 Total
Citations: 1 1 1 3 4 4 4 3 2 4 3 3 3 2 2 2 2 3 1 6 54
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Citations to this article (54)

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Comprehensive Physiology 2014
The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormone
B Salgin, ML Marcovecchio, N Hill, DB Dunger, J Frystyk
Growth Hormone & IGF Research 2012
Measurement of free GH and bioactive IGF-I in non-diabetic haemodialysis patients treated with GH for 7 days
J Frystyk, CB Djurhuus, T Johansen, M Lange, K Smidt, JS Christiansen
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E Graaf-Roelfsema, PP Veldhuis, KG van Dam, PP Menheere, HA Keizer, ML Johnson, E Breda, ID Wijnberg, JH van der Kolk
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Overtrained horses alter their resting pulsatile growth hormone secretion
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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
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Human GH pulsatility: An ensemble property regulated by age and gender
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Sex-Steroid Modulation of Growth Hormone (GH) Secretory Control: Three-Peptide Ensemble Regulation Under Dual Feedback Restraint by GH and IGF-I
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