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Citations to this article

Glucocorticoids stimulate rabbit proximal convoluted tubule acidification.
M Baum, R Quigley
M Baum, R Quigley
Published January 1, 1993
Citation Information: J Clin Invest. 1993;91(1):110-114. https://doi.org/10.1172/JCI116158.
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Research Article

Glucocorticoids stimulate rabbit proximal convoluted tubule acidification.

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Abstract

Glucocorticoids have an important role in renal acidification; however, a direct effect of glucocorticoids on proximal convoluted tubule (PCT) acidification has not been directly demonstrated. In the present in vitro microperfusion study PCT from animals receiving dexamethasone (600 micrograms/kg twice daily for 2 d and 2 h before killing) had a significantly higher rate of bicarbonate absorption than did controls (92.0 +/- 13.3 vs 59.9 +/- 3.2 pmol/mm.min, P < 0.01). To examine if glucocorticoids had a direct epithelial action, dexamethasone was added to the bath of PCT perfused in vitro. After 3 h of incubation in paired experiments 10(-6) M and 10(-5) M dexamethasone resulted in an approximately 30% stimulation in the rate of bicarbonate absorption. 10(-7) M dexamethasone and 10(-6) M aldosterone had no effect on bicarbonate absorption. The stimulation of acidification by 10(-5) M dexamethasone was blocked by actinomycin D and cycloheximide. These data are consistent with a direct effect of glucocorticoids on PCT acidification, and this effect is dependent upon protein synthesis.

Authors

M Baum, R Quigley

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Total citations by year

Year: 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2001 1999 1998 1997 1996 1995 Total
Citations: 2 3 1 1 1 2 1 2 3 1 2 1 3 2 2 1 28
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (1)

Title and authors Publication Year
Roles of cortisol and carbonic anhydrase in acid–base compensation in rainbow trout, Oncorhynchus mykiss
KM Gilmour, CL Collier, CJ Dey, SF Perry
Journal of Comparative Physiology B 2010

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