Citations to this article

Glucocorticoids stimulate rabbit proximal convoluted tubule acidification.
M Baum, R Quigley
M Baum, R Quigley
Published January 1, 1993
Citation Information: J Clin Invest. 1993;91(1):110-114. https://doi.org/10.1172/JCI116158.
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Research Article

Glucocorticoids stimulate rabbit proximal convoluted tubule acidification.

Abstract

Glucocorticoids have an important role in renal acidification; however, a direct effect of glucocorticoids on proximal convoluted tubule (PCT) acidification has not been directly demonstrated. In the present in vitro microperfusion study PCT from animals receiving dexamethasone (600 micrograms/kg twice daily for 2 d and 2 h before killing) had a significantly higher rate of bicarbonate absorption than did controls (92.0 +/- 13.3 vs 59.9 +/- 3.2 pmol/mm.min, P < 0.01). To examine if glucocorticoids had a direct epithelial action, dexamethasone was added to the bath of PCT perfused in vitro. After 3 h of incubation in paired experiments 10(-6) M and 10(-5) M dexamethasone resulted in an approximately 30% stimulation in the rate of bicarbonate absorption. 10(-7) M dexamethasone and 10(-6) M aldosterone had no effect on bicarbonate absorption. The stimulation of acidification by 10(-5) M dexamethasone was blocked by actinomycin D and cycloheximide. These data are consistent with a direct effect of glucocorticoids on PCT acidification, and this effect is dependent upon protein synthesis.

Authors

M Baum, R Quigley

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Year: 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2001 1999 1998 1997 1996 1995 Total
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Citations to this article (28)

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Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation
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J Loffing, M Lötscher, B Kaissling, J Biber, H Murer, M Seikaly, RJ Alpern, M Levi, M Baum, OW Moe 		Journal of the American Society of Nephrology : JASN 1998
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