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Research Article Free access | 10.1172/JCI115869

Effects of atrial natriuretic peptide and vasopressin on chloride transport in long- and short-looped medullary thick ascending limbs.

H Nonoguchi, K Tomita, and F Marumo

Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.

Find articles by Nonoguchi, H. in: PubMed | Google Scholar

Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.

Find articles by Tomita, K. in: PubMed | Google Scholar

Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.

Find articles by Marumo, F. in: PubMed | Google Scholar

Published August 1, 1992 - More info

Published in Volume 90, Issue 2 on August 1, 1992
J Clin Invest. 1992;90(2):349–357. https://doi.org/10.1172/JCI115869.
© 1992 The American Society for Clinical Investigation
Published August 1, 1992 - Version history
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Abstract

Recent studies have suggested a selective effect of atrial natriuretic peptide (ANP) in regulating NaCl reabsorption in juxtamedullary nephrons. We examined (a) functional differences between medullary thick ascending limbs from long and short loops of Henle (lMAL and sMAL, respectively) and (b) the interaction of ANP and arginine vasopressin (AVP) on Cl- transport (JCl) in these two segments. AVP-, glucagon-, and calcitonin-stimulated cAMP accumulation was higher in lMAL than in sMAL. 10(-10) M AVP increased JCl in lMAL but not in sMAL. ANP-stimulated cGMP production was higher in lMAL than in sMAL. 10(-10) and 10(-8) M ANP inhibited AVP-stimulated JCl in lMAL by 26-30% (from 70.3 +/- 11.4 to 51.7 +/- 13.6 pmol/mm per min and from 88.1 +/- 10.1 to 61.8 +/- 11.7 pmol/mm per min, respectively), and this effect was mimicked by 10(-5) to 10(-4) M cGMP. This effect of ANP in lMAL could account for a large part of the ANP-induced natriuresis and diuresis in vivo, in that the rate of NaCl reabsorption in MAL is the largest among distal nephron segments, providing the chemical potential energy for the renal countercurrent multiplication system.

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