Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

A Jawien; D F Bowen-Pope; V Lindner; S M Schwartz; A W Clowes

doi:10.1172/JCI115613

Department of Surgery, University of Washington School of Medicine, Seattle 98195.

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Department of Surgery, University of Washington School of Medicine, Seattle 98195.

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Department of Surgery, University of Washington School of Medicine, Seattle 98195.

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Department of Surgery, University of Washington School of Medicine, Seattle 98195.

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Department of Surgery, University of Washington School of Medicine, Seattle 98195.

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Published in Volume 89, Issue 2 on February 1, 1992
J Clin Invest. 1992;89(2):507–511. https://doi.org/10.1172/JCI115613.
© 1992 The American Society for Clinical Investigation

Published February 1, 1992 - Version history

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.

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