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Research Article Free access | 10.1172/JCI114696

The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore.

J C Courvalin, K Lassoued, E Bartnik, G Blobel, and R W Wozniak

Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

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Published July 1, 1990 - More info

Published in Volume 86, Issue 1 on July 1, 1990
J Clin Invest. 1990;86(1):279–285. https://doi.org/10.1172/JCI114696.
© 1990 The American Society for Clinical Investigation
Published July 1, 1990 - Version history
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Abstract

We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.

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