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Citations to this article

Quantitative contribution of systemic vascular autoregulation in acute hypertension in conscious dogs.
P J Metting, … , B A Stoos, S L Britton
P J Metting, … , B A Stoos, S L Britton
Published December 1, 1989
Citation Information: J Clin Invest. 1989;84(6):1900-1905. https://doi.org/10.1172/JCI114377.
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Research Article Article has an altmetric score of 3

Quantitative contribution of systemic vascular autoregulation in acute hypertension in conscious dogs.

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Abstract

Experiments were performed in nine conscious dogs to quantitate the contribution of systemic vascular autoregulation to the increases in total peripheral resistance (TPR) and mean arterial pressure (MAP) produced by angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE). We hypothesized that if autoregulatory vasoconstriction is significant, then the increase in TPR produced by vasoconstrictor infusion will be greater when MAP is controlled at hypertensive values than when the increase in pressure is prevented by controlling MAP at the animal's normotensive value. Each drug was infused at a dose sufficient to increase MAP by 50%. Then, a constant rate of vasoconstrictor infusion was maintained while MAP was controlled at hypertensive or normotensive levels for 15-min periods using a gravity reservoir connected to the left common carotid artery. During AVP infusion, TPR was significantly greater when MAP was controlled at hypertensive than at normotensive values. This autoregulatory-mediated vasoconstriction accounted for approximately three-fourths of the increase in MAP produced by AVP. No significant autoregulatory component was identified for the increases in TPR and MAP produced by ANG II or NE. We conclude that systemic vascular autoregulation is a powerful physiological property that contributes to the hemodynamic response to pressor doses of AVP.

Authors

P J Metting, K A Kostrzewski, P M Stein, B A Stoos, S L Britton

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Total citations by year

Year: 2020 2017 2015 2012 Total
Citations: 2 1 1 1 5
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Citations to this article in year 2015 (1)

Title and authors Publication Year
Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries
S Hui, AS Levy, DL Slack, MJ Burnstein, L Errett, D Bonneau, D Latter, OD Rotstein, SS Bolz, D Lidington, J Voigtlaender-Bolz, A Cowart
PloS one 2015

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