Disulfide-linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders.

H Seki; M Nanno; N K Day; R A Good; C D Platsoucas

doi:10.1172/JCI114348

Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

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Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

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Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

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Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

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Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

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Published in Volume 84, Issue 5 on November 1, 1989
J Clin Invest. 1989;84(5):1679–1682. https://doi.org/10.1172/JCI114348.
© 1989 The American Society for Clinical Investigation

Published November 1, 1989 - Version history

T cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen receptor (TCR) comprised of a gamma-chain polypeptide of 40-43 kD, and a delta-chain polypeptide of 37-40 kD. This gamma delta TCR appears to be similar to that found on T cell clones, and lines derived from peripheral blood lymphocytes from normal donors. Previous studies have shown that T cell lines derived from the peripheral blood of patients with immunodeficiency disorders express non-disulfide-linked gamma delta TCR. In contrast to the latter and coincident with findings in the present study, the vast majority of T cell lines and clones derived from the peripheral blood of normal donors express disulfide-linked gamma delta TCR.

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