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Research Article Free access | 10.1172/JCI113405

Inhibition of diabetes in BB rats by virus infection.

T Dyrberg, P L Schwimmbeck, and M B Oldstone

Research Institute of Scripps Clinic, La Jolla, California 92037.

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Research Institute of Scripps Clinic, La Jolla, California 92037.

Find articles by Schwimmbeck, P. in: JCI | PubMed | Google Scholar

Research Institute of Scripps Clinic, La Jolla, California 92037.

Find articles by Oldstone, M. in: JCI | PubMed | Google Scholar

Published March 1, 1988 - More info

Published in Volume 81, Issue 3 on March 1, 1988
J Clin Invest. 1988;81(3):928–931. https://doi.org/10.1172/JCI113405.
© 1988 The American Society for Clinical Investigation
Published March 1, 1988 - Version history
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Abstract

BB rats serve as a model for human insulin-dependent diabetes mellitus (IDDM), since without insulin treatment, most 60-140-d-old animals die within 1 to 2 wk of developing polyuria, polydypsia, hyperglycemia, and hypoinsulinemia. Lymphoid cells accumulate in the islets of Langerhans and beta cells undergo destruction. We report that inoculation of such BB rats with lymphocytic choriomeningitis virus (Armstrong strain, clone 13) reduces over a prolonged period the incidence of IDDM, normalizes the concentration of blood sugar and pancreatic insulin, prevents the mononuclear cell infiltration in the islets of Langerhans, and for a short time after inoculation alters T lymphocyte subsets. Thus, a virus might be programmed to carry out useful functions.

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