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Research Article Free access | 10.1172/JCI113137

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system.

C J Thiele, C McKeon, T J Triche, R A Ross, C P Reynolds, and M A Israel

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Published September 1, 1987 - More info

Published in Volume 80, Issue 3 on September 1, 1987
J Clin Invest. 1987;80(3):804–811. https://doi.org/10.1172/JCI113137.
© 1987 The American Society for Clinical Investigation
Published September 1, 1987 - Version history
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Abstract

We have found highly predictable patterns of protooncogene expression in cell lines and tumor tissue of neuroblastoma (NB), a tumor of the peripheral nervous system (PNS). These patterns make it possible to recognize two different genetically definable subgroups among histopathologically indistinguishable tumors. Additionally, we have identified a difference in neurotransmitter biosynthetic enzyme activity in these two subgroups of NB. The patterns of protooncogene expression and neurotransmitter biosynthetic enzymes suggests that these tumors arise in different cells of the PNS.

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